Mehdi Farokhnia

2024

Gut microbial diversity and functional characterization in people with alcohol use disorder: A case-control study

Piacentino, D., Vizioli, C., Barb, J. J., Grant-Beurmann, S., Bouhlal, S., Battista, J. T., Jennings, O., Lee, M. R., Schwandt, M. L., Walter, P., Henderson, W. A., Chen, K., Turner, S., Yang, S., Fraser, C. M., Farinelli, L. A., Farokhnia, M. & Leggio, L., Jun 2024, In: PloS one. 19, 6 June, e0302195.

Research output: Contribution to journal › Article › peer-review

Open Access

International perspectives on opioid use disorder and treatment: Results from an online convenience sample

Melby, K., Farokhnia, M., Tolomeo, S., Bhad, R., Bramnes, J. G., Baldacchino, A., Rao, R., Kandasami, G., Butner, J. L., Phan, V., Fonseca, F., Rafei, P., Long, J., Tzeferakos, G. & Dom, G., 2024, In: Heroin Addiction and Related Clinical Problems. 26, 1, 5.

Research output: Contribution to journal › Article › peer-review

Open Access

Reduced drug use as an alternative valid outcome in individuals with stimulant use disorders: Findings from 13 multisite randomized clinical trials

Amin-Esmaeili, M., Farokhnia, M., Susukida, R., Leggio, L., Johnson, R. M., Crum, R. M. & Mojtabai, R., May 2024, In: Addiction. 119, 5, p. 833-843 11 p.

Research output: Contribution to journal › Article › peer-review

2023

A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder

Farokhnia, M., Wang, T., Jourdan, T., Godlewski, G., Farinelli, L. A., Kunos, G. & Leggio, L., Apr 1 2023, In: Drug and alcohol dependence. 245, 109809.

Research output: Contribution to journal › Article › peer-review

Open Access

Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor

Deschaine, S. L., Hedegaard, M. A., Pince, C. L., Farokhnia, M., Moose, J. E., Stock, I. A., Adusumalli, S., Akhlaghi, F., Hougland, J. L., Sulima, A., Rice, K. C., Koob, G. F., Vendruscolo, L. F., Holst, B. & Leggio, L., Aug 1 2023, In: Journal of Pharmacology and Experimental Therapeutics. 386, 2, p. 117-128 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigating the relationship between early life adversity, inflammation and alcohol use

Battista, J. T., Piacentino, D., Schwandt, M. L., Lee, M. R., Faulkner, M. L., Farokhnia, M. & Leggio, L., May 2023, In: Addiction Biology. 28, 5, e13274.

Research output: Contribution to journal › Article › peer-review

Open Access

Relationship between self-stigma about alcohol dependence and severity of alcohol drinking and craving

Crozier, M. E., Farokhnia, M., Persky, S., Leggio, L. & Curtis, B., Nov 22 2023, In: BMJ Mental Health. 26, 1, 300852.

Research output: Contribution to journal › Article › peer-review

Open Access

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

Chuong, V., Farokhnia, M., Khom, S., Pince, C. L., Elvig, S. K., Vlkolinsky, R., Marchette, R. C. N., Koob, G. F., Roberto, M., Vendruscolo, L. F. & Leggio, L., 2023, In: JCI Insight. 8, 12, e170671.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data

Deschaine, S. L., Farokhnia, M., Gregory-Flores, A., Zallar, L. J., You, Z. B., Sun, H., Harvey, D. M., Marchette, R. C. N., Tunstall, B. J., Mani, B. K., Moose, J. E., Lee, M. R., Gardner, E., Akhlaghi, F., Roberto, M., Hougland, J. L., Zigman, J. M., Koob, G. F., Vendruscolo, L. F. & Leggio, L., Jan 2022, In: Addiction Biology. 27, 1, e13033.

Research output: Contribution to journal › Article › peer-review

Open Access

Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use

Farokhnia, M., Fede, S. J., Grodin, E. N., Browning, B. D., Crozier, M. E., Schwandt, M. L., Hodgkinson, C. A., Momenan, R. & Leggio, L., Dec 2022, In: Scientific reports. 12, 1, 13027.

Research output: Contribution to journal › Article › peer-review

Open Access

Racial Differences in the Association between Alcohol Drinking and Cigarette Smoking: Preliminary Findings from an Alcohol Research Program

Harris, J. C., Mereish, E. H., Faulkner, M. L., Assari, S., Choi, K., Leggio, L. & Farokhnia, M., May 1 2022, In: Alcohol and Alcoholism. 57, 3, p. 330-339 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review^S

Nicolas, C., Zlbnik, N. E., Farokhnia, M., Lggio, L., Ikmoto, S. & Shaham, Y., Jan 1 2022, In: Pharmacological reviews. 74, 1, p. 119-140 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies

Farokhnia, M., Rentsch, C. T., Chuong, V., McGinn, M. A., Elvig, S. K., Douglass, E. A., Gonzalez, L. A., Sanfilippo, J. E., Marchette, R. C. N., Tunstall, B. J., Fiellin, D. A., Koob, G. F., Justice, A. C., Leggio, L. & Vendruscolo, L. F., Nov 2022, In: Molecular psychiatry. 27, 11, p. 4642-4652 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The glucagon-like peptide-1 system is modulated by acute and chronic alcohol exposure: Findings from human laboratory experiments and a post-mortem brain study

Farokhnia, M., Browning, B. D., Crozier, M. E., Sun, H., Akhlaghi, F. & Leggio, L., Sep 2022, In: Addiction Biology. 27, 5, e13211.

Research output: Contribution to journal › Article › peer-review

The Mineralocorticoid Receptor: An Emerging Pharmacotherapeutic Target for Alcohol Use Disorder?

Lékó, A. H., McGinn, M. A. & Farokhnia, M., Jul 6 2022, In: ACS Chemical Neuroscience. 13, 13, p. 1832-1834 3 p.

Research output: Contribution to journal › Article › peer-review

2021

A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation

Farokhnia, M., Deschaine, S. L., Sadighi, A., Farinelli, L. A., Lee, M. R., Akhlaghi, F. & Leggio, L., Feb 2021, In: Molecular psychiatry. 26, 2, p. 545-555 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A population-based investigation of the association between alcohol intake and serum total ghrelin concentrations among cigarette-smoking, non-alcohol-dependent male individuals

Farokhnia, M., Murphy, G., Weinstein, S. J., Shah, N. N., Parisi, D., Albanes, D. & Leggio, L., Sep 1 2021, In: Drug and alcohol dependence. 226, 108835.

Research output: Contribution to journal › Article › peer-review

Open Access

Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use

Ehinger, Y., Phamluong, K., Darevesky, D., Welman, M., Moffat, J. J., Sakhai, S. A., Whiteley, E. L., Berger, A. L., Laguesse, S., Farokhnia, M., Leggio, L., Lordkipanidzé, M. & Ron, D., Mar 2021, In: Addiction Biology. 26, 2, e12890.

Research output: Contribution to journal › Article › peer-review

Open Access

Effectiveness of spironolactone dispensation in reducing weekly alcohol use: a retrospective high-dimensional propensity score-matched cohort study

Palzes, V. A., Farokhnia, M., Kline-Simon, A. H., Elson, J., Sterling, S., Leggio, L., Weisner, C. & Chi, F. W., Nov 2021, In: Neuropsychopharmacology. 46, 12, p. 2140-2147 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effect of intravenous ghrelin administration, combined with alcohol, on circulating metabolome in heavy drinking individuals with alcohol use disorder

Kärkkäinen, O., Farokhnia, M., Klåvus, A., Auriola, S., Lehtonen, M., Deschaine, S. L., Piacentino, D., Abshire, K. M., Jackson, S. N. & Leggio, L., Nov 2021, In: Alcoholism: Clinical and Experimental Research. 45, 11, p. 2207-2216 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effect of oral alcohol administration on plasma cytokine concentrations in heavy drinking individuals

Lee, M. R., Abshire, K. M., Farokhnia, M., Akhlaghi, F. & Leggio, L., Aug 1 2021, In: Drug and alcohol dependence. 225, 108771.

Research output: Contribution to journal › Article › peer-review

Leptin Gene and Leptin Receptor Gene Polymorphisms in Alcohol Use Disorder: Findings Related to Psychopathology

Browning, B. D., Schwandt, M. L., Farokhnia, M., Deschaine, S. L., Hodgkinson, C. A. & Leggio, L., Aug 6 2021, In: Frontiers in Psychiatry. 12, 723059.

Research output: Contribution to journal › Article › peer-review

Open Access

Neuroendocrine Response to Exogenous Ghrelin Administration, Combined with Alcohol, in Heavy-Drinking Individuals: Findings from a Randomized, Double-Blind, Placebo-Controlled Human Laboratory Study

Farokhnia, M., Abshire, K. M., Hammer, A., Deschaine, S. L., Saravanakumar, A., Cobbina, E., You, Z. B., Haass-Koffler, C. L., Lee, M. R., Akhlaghi, F. & Leggio, L., Jun 1 2021, In: International Journal of Neuropsychopharmacology. 24, 6, p. 464-476 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Patterns of reduced use and abstinence in multi-site randomized controlled trials of pharmacotherapies for cocaine and methamphetamine use disorders

Amin-Esmaeili, M., Susukida, R., Johnson, R. M., Farokhnia, M., Crum, R. M., Thrul, J. & Mojtabai, R., Sep 1 2021, In: Drug and alcohol dependence. 226, 108904.

Research output: Contribution to journal › Article › peer-review

2020

Effects of exogenous ghrelin administration and ghrelin receptor blockade, in combination with alcohol, on peripheral inflammatory markers in heavy-drinking individuals: Results from two human laboratory studies

Farokhnia, M., Portelli, J., Lee, M. R., McDiarmid, G. R., Munjal, V., Abshire, K. M., Battista, J. T., Browning, B. D., Deschaine, S. L., Akhlaghi, F. & Leggio, L., Aug 1 2020, In: Brain research. 1740, 146851.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: a randomized, double-blind, placebo-controlled, human laboratory study

Farokhnia, M., McDiarmid, G. R., Newmeyer, M. N., Munjal, V., Abulseoud, O. A., Huestis, M. A. & Leggio, L., Dec 1 2020, In: Translational psychiatry. 10, 1, 71.

Research output: Contribution to journal › Article › peer-review

Open Access

Endocrine effects of the novel ghrelin receptor inverse agonist PF-5190457: Results from a placebo-controlled human laboratory alcohol co-administration study in heavy drinkers

Lee, M. R., Farokhnia, M., Cobbina, E., Saravanakumar, A., Li, X., Battista, J. T., Farinelli, L. A., Akhlaghi, F. & Leggio, L., Jun 15 2020, In: Neuropharmacology. 170, 107788.

Research output: Contribution to journal › Article › peer-review

Open Access

Investigating the link between serum concentrations of brain-derived neurotrophic factor and behavioral measures in anxious alcohol-dependent individuals

Portelli, J., Farokhnia, M., Deschaine, S. L., Battista, J. T., Lee, M. R., Li, X., Ron, D. & Leggio, L., Dec 2020, In: Alcohol. 89, p. 75-83 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats

Marty, V. N., Farokhnia, M., Munier, J. J., Mulpuri, Y., Leggio, L. & Spigelman, I., Dec 23 2020, In: Frontiers in Neuroscience. 14, 599646.

Research output: Contribution to journal › Article › peer-review

Open Access

The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

Lee, M. R., Tapocik, J. D., Ghareeb, M., Schwandt, M. L., Dias, A. A., Le, A. N., Cobbina, E., Farinelli, L. A., Bouhlal, S., Farokhnia, M., Heilig, M., Akhlaghi, F. & Leggio, L., Feb 1 2020, In: Molecular psychiatry. 25, 2, p. 461-475 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The Promise of Neuroimmune Targets for Treating Drug Addiction and Other Psychiatric Disorders: Granulocyte-Colony Stimulating Factor Exemplification

Farokhnia, M., Berger, A. L., Karoly, H. C., Hwa, L. S. & Varodayan, F. P., Mar 17 2020, In: Frontiers in Psychiatry. 11, 220.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Education attainment and alcohol binge drinking: Diminished returns of Hispanics in Los Angeles

Assari, S., Farokhnia, M. & Mistry, R., Jan 2019, In: Behavioral Sciences. 9, 1, 9.

Research output: Contribution to journal › Article › peer-review

Open Access

Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study

Haass-Koffler, C. L., Long, V. M., Farokhnia, M., Magill, M., Kenna, G. A., Swift, R. M. & Leggio, L., Nov 1 2019, In: Neuropharmacology. 158, 107711.

Research output: Contribution to journal › Article › peer-review

Open Access

Substance use among economically disadvantaged african american older adults; objective and subjective socioeconomic status

Assari, S., Smith, J., Mistry, R., Farokhnia, M. & Bazargan, M., May 2 2019, In: International journal of environmental research and public health. 16, 10, 1826.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Exogenous ghrelin administration increases alcohol self-administration and modulates brain functional activity in heavy-drinking alcohol-dependent individuals

Farokhnia, M., Grodin, E. N., Lee, M. R., Oot, E. N., Blackburn, A. N., Stangl, B. L., Schwandt, M. L., Farinelli, L. A., Momenan, R., Ramchandani, V. A. & Leggio, L., Oct 1 2018, In: Molecular psychiatry. 23, 10, p. 2029-2038 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Extracellular esterase activity as an indicator of endoplasmic reticulum calcium depletion

Trychta, K. A., Heathward, E. J., Sulima, A., Bäck, S., Farokhnia, M., Richie, C. T., Leggio, L., Rice, K. C. & Harvey, B. K., Nov 17 2018, In: Biomarkers. 23, 8, p. 756-765 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Identifying and characterizing subpopulations of heavy alcohol drinkers via a sucrose preference test: A sweet road to a better phenotypic characterization?

Bouhlal, S., Farokhnia, M., Lee, M. R., Akhlaghi, F. & Leggio, L., Sep 1 2018, In: Alcohol and Alcoholism. 53, 5, p. 560-569 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Impulsive Personality Traits Mediate the Relationship Between Adult Attention-Deficit/Hyperactivity Symptoms and Alcohol Dependence Severity

Daurio, A. M., Aston, S. A., Schwandt, M. L., Bukhari, M. O., Bouhlal, S., Farokhnia, M., Lee, M. R. & Leggio, L., Jan 2018, In: Alcoholism: Clinical and Experimental Research. 42, 1, p. 173-183 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Neuroendocrine response to GABA-B receptor agonism in alcohol-dependent individuals: Results from a combined outpatient and human laboratory experiment

Farokhnia, M., Sheskier, M. B., Lee, M. R., Le, A. N., Singley, E., Bouhlal, S., Ton, T., Zhao, Z. & Leggio, L., Jul 15 2018, In: Neuropharmacology. 137, p. 230-239 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study

Lee, M. R., Sheskier, M. B., Farokhnia, M., Feng, N., Marenco, S., Lipska, B. K. & Leggio, L., Oct 2018, In: Psychoneuroendocrinology. 96, p. 143-147 5 p.

Research output: Contribution to journal › Article › peer-review

Pharmacological manipulation of the ghrelin system and alcohol hangover symptoms in heavy drinking individuals: Is there a link?

Farokhnia, M., Lee, M. R., Farinelli, L. A., Ramchandani, V. A., Akhlaghi, F. & Leggio, L., Sep 2018, In: Pharmacology Biochemistry and Behavior. 172, p. 39-49 11 p.

Research output: Contribution to journal › Article › peer-review

2017

Biobehavioral effects of baclofen in anxious alcohol-dependent individuals: A randomized, double-blind, placebo-controlled, laboratory study

Farokhnia, M., Schwandt, M. L., Lee, M. R., Bollinger, J. W., Farinelli, L. A., Amodio, J. P., Sewell, L., Lionetti, T. A., Spero, D. E. & Leggio, L., 2017, In: Translational psychiatry. 7, 4, e1108.

Research output: Contribution to journal › Article › peer-review

Open Access

The Validity of the Montgomery–Asberg Depression Rating Scale in an Inpatient Sample with Alcohol Dependence

Hobden, B., Schwandt, M. L., Carey, M., Lee, M. R., Farokhnia, M., Bouhlal, S., Oldmeadow, C. & Leggio, L., Jun 2017, In: Alcoholism: Clinical and Experimental Research. 41, 6, p. 1220-1227 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

The effects of pioglitazone adjuvant therapy on negative symptoms of patients with chronic schizophrenia: A double-blind and placebo-controlled trial

Iranpour, N., Zandifar, A., Farokhnia, M., Goguol, A., Yekehtaz, H., Khodaie-Ardakani, M. R., Salehi, B., Esalatmanesh, S., Zeionoddini, A., Mohammadinejad, P., Zeinoddini, A. & Akhondzadeh, S., Mar 1 2016, In: Human Psychopharmacology. 31, 2, p. 103-112 10 p.

Research output: Contribution to journal › Article › peer-review

2015

A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism

Ghaleiha, A., Rasa, S. M., Nikoo, M., Farokhnia, M., Mohammadi, M. R. & Akhondzadeh, S., Sep 30 2015, In: Psychiatry research. 229, 1-2, p. 181-187 7 p.

Research output: Contribution to journal › Article › peer-review

Celecoxib adjunctive therapy for acute bipolar mania: A randomized, double-blind, placebo-controlled trial

Arabzadeh, S., Ameli, N., Zeinoddini, A., Rezaei, F., Farokhnia, M., Mohammadinejad, P., Ghaleiha, A. & Akhondzadeh, S., Sep 1 2015, In: Bipolar Disorders. 17, 6, p. 606-614 9 p.

Research output: Contribution to journal › Article › peer-review

N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: A randomized, double-blind, placebo-controlled clinical trial of efficacy and safety

Nikoo, M., Radnia, H., Farokhnia, M., Mohammadi, M. R. & Akhondzadeh, S., Feb 2 2015, In: Clinical neuropharmacology. 38, 1, p. 11-17 7 p.

Research output: Contribution to journal › Article › peer-review

Pioglitazone adjunctive therapy for depressive episode of bipolar disorder: A randomized, double-blind, placebo-controlled trial

Zeinoddini, A., Sorayani, M., Hassanzadeh, E., Arbabi, M., Farokhnia, M., Salimi, S., Ghaleiha, A. & Akhondzadeh, S., Mar 1 2015, In: Depression and anxiety. 32, 3, p. 167-173 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Simvastatin as an adjuvant therapy to fluoxetine in patients with moderate to severe major depression: A double-blind placebo-controlled trial

Gougol, A., Zareh-Mohammadi, N., Raheb, S., Farokhnia, M., Salimi, S., Iranpour, N., Yekehtaz, H. & Akhondzadeh, S., May 5 2015, In: Journal of Psychopharmacology. 29, 5, p. 575-581 7 p.

Research output: Contribution to journal › Article › peer-review

2014

A double-blind, placebo controlled, randomized trial of riluzole as an adjunct to risperidone for treatment of negative symptoms in patients with chronic schizophrenia

Farokhnia, M., Sabzabadi, M., Pourmahmoud, H., Khodaie-Ardakani, M. R., Hosseini, S. M. R., Yekehtaz, H., Tabrizi, M., Rezaei, F., Salehi, B. & Akhondzadeh, S., Feb 2014, In: Psychopharmacology. 231, 3, p. 533-542 10 p.

Research output: Contribution to journal › Article › peer-review

Mehdi Farokhnia

Research output

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