Marjan Gharagozloo

2025

NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway

Gill, A. J., Smith, M. D., Galleguillos, D., Garton, T., Mace, J. W., Gadani, S. P., Kumar, S., Pokharel, A., Solem, K., Potluri, S., Hussein, O., Rogines, G. S., Singh, A., Clark, A., Calabresi, P. A. & Gharagozloo, M., Dec 2025, In: Journal of Neuroinflammation. 22, 1, 21.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination

Kapell, H., Fazio, L., Dyckow, J., Schwarz, S., Cruz-Herranz, A., Mayer, C., Campos, J., D’Este, E., Möbius, W., Cordano, C., Pröbstel, A. K., Gharagozloo, M., Zulji, A., Naik, V. N., Delank, A., Cerina, M., Müntefering, T., Lerma-Martin, C., Sonner, J. K. & Sin, J. H. & 22 others, Disse, P., Rychlik, N., Sabeur, K., Chavali, M., Srivastava, R., Heidenreich, M., Fitzgerald, K. C., Seebohm, G., Stadelmann, C., Hemmer, B., Platten, M., Jentsch, T. J., Engelhardt, M., Budde, T., Nave, K. A., Calabresi, P. A., Friese, M. A., Green, A. J., Acuna, C., Rowitch, D. H., Meuth, S. G. & Schirmer, L., Apr 3 2023, In: Journal of Clinical Investigation. 133, 7, e164223.

Research output: Contribution to journal › Article › peer-review

Open Access

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives

Gharagozloo, M., Galleguillos, D., Jank, L., Sotirchos, E. S., Smith, M. D., Garton, T., Kumar, S., Hussein, O., Potluri, S., Taylor, M., Siu, C., Mace, J. W., Dawson, T., Dawson, V. L., Lee, S. & Calabresi, P. A., Jul 2023, In: Neurotherapeutics. 20, 4, p. 1229-1240 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Animal models to investigate the effects of inflammation on remyelination in multiple sclerosis

Gharagozloo, M., Mace, J. W. & Calabresi, P. A., Nov 3 2022, In: Frontiers in Molecular Neuroscience. 15, 995477.

Research output: Contribution to journal › Short survey › peer-review

Open Access

Breaking the barriers to remyelination in multiple sclerosis

Gharagozloo, M., Bannon, R. & Calabresi, P. A., Apr 2022, In: Current Opinion in Pharmacology. 63, 102194.

Research output: Contribution to journal › Review article › peer-review

Open Access

Menstruation: a possible independent health promoter, aging and COVID-19

Bolourian, A., Shen, J., Gharagozloo, M. & Mojtahedi, Z., 2022, In: Caspian Journal of Internal Medicine. 13, p. 155-160 6 p.

Research output: Contribution to journal › Review article › peer-review

Reactive Astrocytes Derived From Human Induced Pluripotent Stem Cells Suppress Oligodendrocyte Precursor Cell Differentiation

Smith, M. D., Chamling, X., Gill, A. J., Martinez, H., Li, W., Fitzgerald, K. C., Sotirchos, E. S., Moroziewicz, D., Bauer, L., Paull, D., Gharagozloo, M., Bhargava, P., Zack, D. J., Fossati, V. & Calabresi, P. A., May 6 2022, In: Frontiers in Molecular Neuroscience. 15, 874299.

Research output: Contribution to journal › Article › peer-review

Open Access

Retinal pathology in spontaneous opticospinal experimental autoimmune encephalitis mice

Jin, J., Shneyderman, M., Smith, M. D., Gharagozloo, M., Sotirchos, E. S. & Calabresi, P. A., Jun 15 2022, In: Journal of Neuroimmunology. 367, 577859.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

Absinta, M., Maric, D., Gharagozloo, M., Garton, T., Smith, M. D., Jin, J., Fitzgerald, K. C., Song, A., Liu, P., Lin, J. P., Wu, T., Johnson, K. R., McGavern, D. B., Schafer, D. P., Calabresi, P. A. & Reich, D. S., Sep 30 2021, In: Nature. 597, 7878, p. 709-714 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation

Gharagozloo, M., Smith, M. D., Jin, J., Garton, T., Taylor, M., Chao, A., Meyers, K., Kornberg, M. D., Zack, D. J., Ohayon, J., Calabresi, B. A., Reich, D. S., Eberhart, C. G., Pardo, C. A., Kemper, C., Whartenby, K. & Calabresi, P. A., Nov 2021, In: Acta neuropathologica. 142, 5, p. 899-915 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Machine Learning in Modeling of Mouse Behavior

Gharagozloo, M., Amrani, A., Wittingstall, K., Hamilton-Wright, A. & Gris, D., Sep 14 2021, In: Frontiers in Neuroscience. 15, 700253.

Research output: Contribution to journal › Article › peer-review

Open Access

Therapeutic Potential of a Novel Glucagon-like Peptide-1 Receptor Agonist, NLY01, in Experimental Autoimmune Encephalomyelitis

Gharagozloo, M., Smith, M. D., Sotirchos, E. S., Jin, J., Meyers, K., Taylor, M., Garton, T., Bannon, R., Lord, H. N., Dawson, T. M., Dawson, V. L., Lee, S. & Calabresi, P. A., Jul 2021, In: Neurotherapeutics. 18, 3, p. 1834-1848 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Bhargava, P., Smith, M. D., Mische, L., Harrington, E., Fitzgerald, K. C., Martin, K., Kim, S., Reyes, A. A., Gonzalez-Cardona, J., Volsko, C., Tripathi, A., Singh, S., Varanasi, K., Lord, H. N., Meyers, K., Taylor, M., Gharagozloo, M., Sotirchos, E. S., Nourbakhsh, B. & Dutta, R. & 3 others, Mowry, E. M., Waubant, E. & Calabresi, P. A., Jul 1 2020, In: Journal of Clinical Investigation. 130, 7, p. 3467-3482 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2019

Astrocytes maintain glutamate homeostasis in the cns by controlling the balance between glutamate uptake and release

Mahmoud, S., Gharagozloo, M., Simard, C. & Gris, D., Feb 2019, In: Cells. 8, 2, 184.

Research output: Contribution to journal › Review article › peer-review

Open Access

Experimental autoimmune encephalomyelitis potentiates mouse mast cell protease 4-dependent pressor responses to centrally or systemically administered big endothelin-1

Desbiens, L., Lapointe, C., Gendron, L., Gharagozloo, M., Vincent, L., Pejler, G., Gris, D. & D'Orléans-Juste, P., 2019, In: Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 437-446 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

NLRX1 enhances glutamate uptake and inhibits glutamate release by astrocytes

Mahmoud, S., Gharagozloo, M., Simard, C., Amrani, A. & Gris, D., May 2019, In: Cells. 8, 5, 400.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Decline in peripheral blood NKG2D+CD3+CD56+ NKT cells in metastatic colorectal cancer patients

Gharagozloo, M., Rezaei, A., Kalantari, H., Bahador, A., Hassannejad, N., Maracy, M., Nouri, N., Sedghi, M., Ghazanfari, H. & Bayat, B., 2018, In: Bratislava Medical Journal. 119, 1, p. 6-11 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Exhaustive multi-parametric assessment of the behavioral array of daily activities of mice using cluster and factor analysis

Yamamoto, K., Gris, K. V., Sotelo Fonseca, J. E., Gharagozloo, M., Mahmoud, S., Simard, C., Houle-Martel, D., Cloutier, T., Gris, P. & Gris, D., Aug 30 2018, In: Frontiers in Behavioral Neuroscience. 12, 187.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring the role of physical activity and exercise for managing vascular comorbidities in people with multiple sclerosis: A scoping review

Ewanchuk, B. W., Gharagozloo, M., Peelen, E. & Pilutti, L. A., Nov 2018, In: Multiple Sclerosis and Related Disorders. 26, p. 19-32 14 p.

Research output: Contribution to journal › Review article › peer-review

NLR-dependent regulation of inflammation in multiple sclerosis- Dependent regulation of inflammation in multiple sclerosis

Gharagozloo, M., Gris, K. V., Mahvelati, T., Amrani, A., Lukens, J. R. & Gris, D., Jan 18 2018, In: Frontiers in immunology. 8, 2012.

Research output: Contribution to journal › Review article › peer-review

Open Access

The dual immunoregulatory function of Nlrp12 in T cell-mediated immune response: Lessons from experimental autoimmune encephalomyelitis

Gharagozloo, M., Mahmoud, S., Simard, C., Mahvelati, T. M., Amrani, A. & Gris, D., Sep 2018, In: Cells. 7, 9, 119.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Inhibition of apoptosis and proliferation in t cells by immunosuppressive silymarine

Almasi, E., Gharagozloo, M., Eskandari, N., Almasi, A. & Sabzghabaee, A. M., Apr 2017, In: Iranian Journal of Allergy, Asthma and Immunology. 16, 2, p. 107-119 13 p.

Research output: Contribution to journal › Article › peer-review

Silymarin impacts on immune system as an immunomodulator: One key for many locks

Esmaeil, N., Anaraki, S. B., Gharagozloo, M. & Moayedi, B., Sep 2017, In: International immunopharmacology. 50, p. 194-201 8 p.

Research output: Contribution to journal › Review article › peer-review

2016

Modulatory effects of thymol and carvacrol on inflammatory transcription factors in lipopolysaccharide-treated macrophages

Gholijani, N., Gharagozloo, M., Farjadian, S. & Amirghofran, Z., Mar 3 2016, In: Journal of Immunotoxicology. 13, 2, p. 157-164 8 p.

Research output: Contribution to journal › Article › peer-review

Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis

Desbiens, L., Lapointe, C., Gharagozloo, M., Mahmoud, S., Pejler, G., Gris, D. & D'orléans-Juste, P., 2016, In: Mediators of inflammation. 2016, 9797021.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

A flow cytometric approach to study the mechanism of gene delivery to cells by gemini-lipid nanoparticles: An implication for cell membrane nanoporation

Gharagozloo, M., Rafiee, A., Chen, D. W. & Foldvari, M., Sep 29 2015, In: Journal of Nanobiotechnology. 13, 1, 62.

Research output: Contribution to journal › Article › peer-review

Open Access

Altered th17/treg ratio in recurrent miscarriage after treatment with paternal lymphocytes and vitamin d3: A doubleblind placebo-controlled study

Rafiee, M., Gharagozloo, M., Ghahiri, A., Mehrabian, F., Maracy, M. R., Kouhpayeh, S., Pieper, I. L. & Rezaei, A., Sep 1 2015, In: Iranian Journal of Immunology. 12, 4, p. 252-262 11 p.

Research output: Contribution to journal › Article › peer-review

Cadmium induces reactive oxygen species-dependent apoptosis in MCF-7 human breast cancer cell line

Khojastehfar, A., Aghaei, M., Gharagozloo, M. & Panjehpour, M., Jan 1 2015, In: Toxicology Mechanisms and Methods. 25, 1, p. 48-55 8 p.

Research output: Contribution to journal › Article › peer-review

Comparing in-vitro effects of two immunosuppressive drugs on the expression of Foxp3 from Naïve CD4+ T Cells

Shajanian, S., Gharagozloo, M., Ganjalikhani-Hakemi, M. & Rafiee, M., Jul 24 2015, In: Journal of Isfahan Medical School. 33, 329

Research output: Contribution to journal › Article › peer-review

Modulation of cytokine production and transcription factors activities in human jurkat t cells by thymol and carvacrol

Gholijani, N., Gharagozloo, M., Kalantar, F., Ramezani, A. & Amirghofran, Z., 2015, In: Advanced Pharmaceutical Bulletin. 5, p. 653-660 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Selective nuclear localization of siRNA by metallic versus semiconducting single wall carbon nanotubes in keratinocytes

Huzil, J. T., Saliaj, E., Ivanova, M. V., Gharagozloo, M., Loureiro, M. J., Lamprecht, C., Korinek, A., Chen, D. W. & Foldvari, M., Nov 2015, In: Future Science OA. 1, 3, FSO17.

Research output: Contribution to journal › Article › peer-review

Open Access

The decrease in NKG2D+ Natural Killer cells in peripheral blood of patients with metastatic colorectal cancer

Gharagozloo, M., Kalantari, H., Rezaei, A., Maracy, M. R., Salehi, M., Bahador, A., Hassannejad, N., Narimani, M., Sanei, M. H., Bayat, B. & Ghazanfari, H., 2015, In: Bratislava Medical Journal. 116, 5, p. 296-301 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis

Gharagozloo, M., Mahvelati, T. M., Imbeault, E., Gris, P., Zerif, E., Bobbala, D., Ilangumaran, S., Amrani, A. & Gris, D., Oct 31 2015, In: Journal of Neuroinflammation. 12, 1, 198.

Research output: Contribution to journal › Article › peer-review

Open Access

Therapeutic applications of nanomedicine in autoimmune diseases: From immunosuppression to tolerance induction

Gharagozloo, M., Majewski, S. & Foldvari, M., May 1 2015, In: Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 4, p. 1003-1018 16 p.

Research output: Contribution to journal › Review article › peer-review

2014

Co-administration of silymarin and deferoxamine against kidney, liver and heart iron deposition in male iron overload rat model

Navidi-Shishaone, M., Mohhebi, S., Nematbakhsh, M., Roozbehani, S., Talebi, A., Pezeshki, Z., Eshraghi-Jazi, F., Mazaheri, S., Shirdavani, S., Gharagozloo, M. & Moaeidi, B. A., Jan 2014, In: International Journal of Preventive Medicine. 5, 1, p. 110-116 7 p.

Research output: Contribution to journal › Article › peer-review

Comparison of nucleostemin gene expression in CD133+ and CD133- cell population in colon cancer cell line HT29

Zia-Jahromi, N., Hejazi, S. H., Panjepour, M., Parivar, K. & Gharagozloo, M., 2014, In: Journal of Cancer Research and Therapeutics. 10, 1, p. 68-72 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Variations in T-helper 17 and regulatory T cells during the menstrual cycle in peripheral blood of women with recurrent spontaneous abortion

Sereshki, N., Gharagozloo, M., Ostadi, V., Ghahiri, A., Roghaei, M. A., Mehrabian, F., Andalib, A., Hassanzadeh, A., Hosseini, H. & Rezaei, A., 2014, In: International Journal of Fertility and Sterility. 8, 1, p. 59-66 8 p.

Research output: Contribution to journal › Article › peer-review

2013

Antibodies to interferon beta in patients with multiple sclerosis receiving CinnoVex, rebif, and betaferon

Zare, N., Zarkesh-Esfahani, S. H., Gharagozloo, M. & Shaygannejad, V., 2013, In: Journal of Korean Medical Science. 28, 12, p. 1801-1806 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A randomized double-blind, placebo-controlled study of therapeutic effects of silymarin in β-thalassemia major patients receiving desferrioxamine

Moayedi, B., Gharagozloo, M., Esmaeil, N., Maracy, M. R., Hoorfar, H. & Jalaeikar, M., Mar 2013, In: European Journal of Haematology. 90, 3, p. 202-209 8 p.

Research output: Contribution to journal › Article › peer-review

Biased Treg/Th17 balance away from regulatory toward inflammatory phenotype in relapsed multiple sclerosis and its correlation with severity of symptoms

Jamshidian, A., Shaygannejad, V., Pourazar, A., Zarkesh-Esfahani, S. H. & Gharagozloo, M., 2013, In: Journal of Neuroimmunology. 262, 1-2, p. 106-112 7 p.

Research output: Contribution to journal › Article › peer-review

Elevated serum levels of cell death circulating biomarkers, M30 and M65, in patients with β-thalassemia major

Esmaeil, N., Moayedi, B., Gharagozloo, M. & Maracy, M. R., 2013, In: Hemoglobin. 37, 4, p. 404-410 7 p.

Research output: Contribution to journal › Article › peer-review

Immunomodulatory effects of silymarin in patients with β-thalassemia major

Gharagozloo, M., Karimi, M. & Amirghofran, Z., Jun 2013, In: International immunopharmacology. 16, 2, p. 243-247 5 p.

Research output: Contribution to journal › Article › peer-review

Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: The impact on T cell proliferation and cytokine production

Gharagozloo, M., Jafari, S., Esmaeil, N., Javid, E. N., Bagherpour, B. & Rezaei, A., Sep 2013, In: Basic and Clinical Pharmacology and Toxicology. 113, 3, p. 209-214 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Protective role of silymarin and deferoxamine against iron dextran-induced renal iron deposition in male rats

Nematbakhsh, M., Pezeshki, Z., Moaeidi, B. A., Eshraghi-Jazi, F., Talebi, A., Nasri, H., Baradaran, S., Gharagozloo, M., Safari, T. & Haghighi, M., Mar 2013, In: International Journal of Preventive Medicine. 4, 3, p. 286-292 7 p.

Research output: Contribution to journal › Article › peer-review

Silymarin Inhibits Cell Cycle Progression and mTOR Activity in Activated Human T Cells: Therapeutic Implications for Autoimmune Diseases

Gharagozloo, M., Javid, E. N., Rezaei, A. & Mousavizadeh, K., Apr 2013, In: Basic and Clinical Pharmacology and Toxicology. 112, 4, p. 251-256 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Marjan Gharagozloo

Research output

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