Linda Knutsson

2024

Compartmental anisotropy of filtered exchange imaging (FEXI) in human white matter: What is happening in FEXI?

Shin, H. G., Li, X., Heo, H. Y., Knutsson, L., Szczepankiewicz, F., Nilsson, M. & van Zijl, P. C. M., 2024, (Accepted/In press) In: Magnetic resonance in medicine.

Research output: Contribution to journal › Article › peer-review

2023

Abnormal cerebral hemodynamics and blood-brain barrier permeability detected with perfusion MRI in systemic lupus erythematosus patients

Salomonsson, T., Rumetshofer, T., Jönsen, A., Bengtsson, A. A., Zervides, K. A., Nilsson, P., Knutsson, M., Wirestam, R., Lätt, J., Knutsson, L. & Sundgren, P. C., Jan 2023, In: NeuroImage: Clinical. 38, 103390.

Research output: Contribution to journal › Article › peer-review

Open Access

A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI: On the influence of head motion at 3T

Lehmann, P. M., Seidemo, A., Andersen, M., Xu, X., Li, X., Yadav, N. N., Wirestam, R., Liebig, P., Testud, F., Sundgren, P., van Zijl, P. C. M. & Knutsson, L., May 2023, In: Magnetic resonance in medicine. 89, 5, p. 1871-1887 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Concurrent measurement of perfusion parameters related to small blood vessels and cerebrospinal fluid circulation in the human brain using dynamic dual-spin-echo perfusion MRI

Cao, D., Sun, Y., Li, Y., Su, P., Pillai, J. J., Qiao, Y., Lu, H., Van Zijl, P. C. M., Knutsson, L. & Hua, J., Oct 2023, In: NMR in biomedicine. 36, 10, e4984.

Research output: Contribution to journal › Article › peer-review

Corrigendum to “Test-retest analysis of cerebral oxygen extraction estimates in healthy volunteers: Comparison of methods based on quantitative susceptibility mapping and dynamic susceptibility contrast magnetic resonance imaging” [Heliyon 8(12) (December 2022) e12364] (Heliyon (2022) 8(12), (S2405844022036520), (10.1016/j.heliyon.2022.e12364))

Wirestam, R., Lundberg, A., Chakwizira, A., van Westen, D., Knutsson, L. & Lind, E., Nov 2023, In: Heliyon. 9, 11, e21155.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Deep learning–based Lorentzian fitting of water saturation shift referencing spectra in MRI

Mohammed Ali, S., Yadav, N. N., Wirestam, R., Singh, M., Heo, H. Y., van Zijl, P. C. & Knutsson, L., Oct 2023, In: Magnetic resonance in medicine. 90, 4, p. 1610-1624 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Diffusion MRI with pulsed and free gradient waveforms: Effects of restricted diffusion and exchange

Chakwizira, A., Westin, C. F., Brabec, J., Lasič, S., Knutsson, L., Szczepankiewicz, F. & Nilsson, M., Jan 2023, In: NMR in biomedicine. 36, 1, e4827.

Research output: Contribution to journal › Article › peer-review

Open Access

Gray matter hypoperfusion is a late pathological event in the course of Alzheimer’s disease

Ahmadi, K., Pereira, J. B., Berron, D., Vogel, J., Ingala, S., Strandberg, O. T., Janelidze, S., Barkhof, F., Pfeuffer, J., Knutsson, L., van Westen, D., Palmqvist, S., Mutsaerts, H. J. M. M. & Hansson, O., Apr 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 4, p. 565-580 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Imaging of sugar-based contrast agents using their hydroxyl proton exchange properties

Knutsson, L., Xu, X., van Zijl, P. C. M. & Chan, K. W. Y., Jun 2023, In: NMR in biomedicine. 36, 6, e4784.

Research output: Contribution to journal › Article › peer-review

Meningioma microstructure assessed by diffusion MRI: An investigation of the source of mean diffusivity and fractional anisotropy by quantitative histology

Brabec, J., Friedjungová, M., Vašata, D., Englund, E., Bengzon, J., Knutsson, L., Szczepankiewicz, F., van Westen, D., Sundgren, P. C. & Nilsson, M., Jan 2023, In: NeuroImage: Clinical. 37, 103365.

Research output: Contribution to journal › Article › peer-review

Open Access

Probing brain tissue microstructure with MRI: principles, challenges, and the role of multidimensional diffusion-relaxation encoding

Lampinen, B., Szczepankiewicz, F., Lätt, J., Knutsson, L., Mårtensson, J., Björkman-Burtscher, I. M., van Westen, D., Sundgren, P. C., Ståhlberg, F. & Nilsson, M., Nov 15 2023, In: NeuroImage. 282, 120338.

Research output: Contribution to journal › Review article › peer-review

Open Access

Tissue response curve-shape analysis of dynamic glucose-enhanced and dynamic contrast-enhanced magnetic resonance imaging in patients with brain tumor

Seidemo, A., Wirestam, R., Helms, G., Markenroth Bloch, K., Xu, X., Bengzon, J., Sundgren, P. C., van Zijl, P. C. M. & Knutsson, L., Jun 2023, In: NMR in biomedicine. 36, 6, e4863.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A Randomized Controlled Trial on the Effects of a 12-Week High- vs. Low-Intensity Exercise Intervention on Hippocampal Structure and Function in Healthy, Young Adults

Kaiser, A., Reneman, L., Solleveld, M. M., Coolen, B. F., Scherder, E. J. A., Knutsson, L., Bjørnerud, A., van Osch, M. J. P., Wijnen, J. P., Lucassen, P. J. & Schrantee, A., Jan 21 2022, In: Frontiers in Psychiatry. 12, 780095.

Research output: Contribution to journal › Article › peer-review

Open Access

Comparison of MRI methods for measuring whole-brain oxygen extraction fraction under different geometric conditions at 7T

Lundberg, A., Lind, E., Olsson, H., Helms, G., Knutsson, L. & Wirestam, R., May 1 2022, In: Journal of Neuroimaging. 32, 3, p. 442-458 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Diffusion tensor imaging in glioblastoma patients treated with volumetric modulated arc radiotherapy: a longitudinal study

Rydelius, A., Lampinen, B., Rundcrantz, A., Bengzon, J., Engelholm, S., van Westen, D., Kinhult, S., Knutsson, L., Lätt, J., Nilsson, M. & Sundgren, P. C., 2022, In: Acta Oncologica. 61, 6, p. 680-687 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Dynamic contrast-enhanced CEST MRI using a low molecular weight dextran

Han, Z., Chen, C., Xu, X., Bai, R., Staedtke, V., Huang, J., Chan, K. W. Y., Xu, J., Kamson, D. O., Wen, Z., Knutsson, L., van Zijl, P. C. M. & Liu, G., Mar 2022, In: NMR in biomedicine. 35, 3, e4649.

Research output: Contribution to journal › Article › peer-review

Open Access

Histogram analysis of tensor-valued diffusion MRI in meningiomas: Relation to consistency, histological grade and type

Brabec, J., Szczepankiewicz, F., Lennartsson, F., Englund, E., Pebdani, H., Bengzon, J., Knutsson, L., Westin, C. F., Sundgren, P. C. & Nilsson, M., Jan 2022, In: NeuroImage: Clinical. 33, 102912.

Research output: Contribution to journal › Article › peer-review

Open Access

Non-parametric deconvolution using Bézier curves for quantification of cerebral perfusion in dynamic susceptibility contrast MRI

Chakwizira, A., Ahlgren, A., Knutsson, L. & Wirestam, R., Oct 2022, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 35, 5, p. 791-804 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors

Zhou, J., Zaiss, M., Knutsson, L., Sun, P. Z., Ahn, S. S., Aime, S., Bachert, P., Blakeley, J. O., Cai, K., Chappell, M. A., Chen, M., Gochberg, D. F., Goerke, S., Heo, H. Y., Jiang, S., Jin, T., Kim, S. G., Laterra, J., Paech, D., Pagel, M. D., & 16 othersPark, J. E., Reddy, R., Sakata, A., Sartoretti-Schefer, S., Sherry, A. D., Smith, S. A., Stanisz, G. J., Sundgren, P. C., Togao, O., Vandsburger, M., Wen, Z., Wu, Y., Zhang, Y., Zhu, W., Zu, Z. & van Zijl, P. C. M., Aug 2022, In: Magnetic resonance in medicine. 88, 2, p. 546-574 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sensitivity of Diffusion MRI to White Matter Pathology: Influence of Diffusion Protocol, Magnetic Field Strength, and Processing Pipeline in Systemic Lupus Erythematosus

Kornaropoulos, E. N., Winzeck, S., Rumetshofer, T., Wikstrom, A., Knutsson, L., Correia, M. M., Sundgren, P. C. & Nilsson, M., Apr 26 2022, In: Frontiers in Neurology. 13, 837385.

Research output: Contribution to journal › Article › peer-review

Open Access

Separating Glioma Hyperintensities From White Matter by Diffusion-Weighted Imaging With Spherical Tensor Encoding

Brabec, J., Durmo, F., Szczepankiewicz, F., Brynolfsson, P., Lampinen, B., Rydelius, A., Knutsson, L., Westin, C. F., Sundgren, P. C. & Nilsson, M., Apr 21 2022, In: Frontiers in Neuroscience. 16, 842242.

Research output: Contribution to journal › Article › peer-review

Open Access

Test-retest analysis of cerebral oxygen extraction estimates in healthy volunteers: comparison of methods based on quantitative susceptibility mapping and dynamic susceptibility contrast magnetic resonance imaging

Wirestam, R., Lundberg, A., Chakwizira, A., van Westen, D., Knutsson, L. & Lind, E., Dec 2022, In: Heliyon. 8, 12, e12364.

Research output: Contribution to journal › Article › peer-review

Open Access

Towards robust glucose chemical exchange saturation transfer imaging in humans at 3 T: Arterial input function measurements and the effects of infusion time

Seidemo, A., Lehmann, P. M., Rydhög, A., Wirestam, R., Helms, G., Zhang, Y., Yadav, N. N., Sundgren, P. C., van Zijl, P. C. M. & Knutsson, L., Feb 2022, In: NMR in biomedicine. 35, 2, e4624.

Research output: Contribution to journal › Article › peer-review

Open Access

Tract-based white matter hyperintensity patterns in patients with systemic lupus erythematosus using an unsupervised machine learning approach

Rumetshofer, T., Inglese, F., de Bresser, J., Mannfolk, P., Strandberg, O., Jönsen, A., Bengtsson, A., Nilsson, M., Knutsson, L., Lätt, J., Steup-Beekman, G. M., Huizinga, T. W. J., van Buchem, M. A., Ronen, I. & Sundgren, P. C., Dec 2022, In: Scientific reports. 12, 1, 21376.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Effects of red blood cells with reduced deformability on cerebral blood flow and vascular water transport: measurements in rats using time-resolved pulsed arterial spin labelling at 9.4 T

Bibic, A., Sordia, T., Henningsson, E., Knutsson, L., Ståhlberg, F. & Wirestam, R., Dec 2021, In: European radiology experimental. 5, 1, 53.

Research output: Contribution to journal › Article › peer-review

Open Access

Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

van Zijl, P. C. M., Brindle, K., Lu, H., Barker, P. B., Edden, R., Yadav, N. & Knutsson, L., Aug 2021, In: Current Opinion in Chemical Biology. 63, p. 209-218 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

MTT and blood-brain barrier disruption within asymptomatic vascular WM lesions

Dewey, B. E., Xu, X., Knutsson, L., Jog, A., Prince, J. L., Barker, P. B., van Zijl, P. C. M., Leigh, R. & Nyquist, P., Aug 1 2021, In: American Journal of Neuroradiology. 42, 8, p. 1396-1402 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard

Herz, K., Mueller, S., Perlman, O., Zaitsev, M., Knutsson, L., Sun, P. Z., Zhou, J., van Zijl, P., Heinecke, K., Schuenke, P., Farrar, C. T., Schmidt, M., Dörfler, A., Scheffler, K. & Zaiss, M., Oct 2021, In: Magnetic resonance in medicine. 86, 4, p. 1845-1858 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Altered d-glucose in brain parenchyma and cerebrospinal fluid of early Alzheimer’s disease detected by dynamic glucose-enhanced MRI

Huang, J., van Zijl, P. C. M., Han, X., Dong, C. M., Cheng, G. W. Y., Tse, K. H., Knutsson, L., Chen, L., Lai, J. H. C., Wu, E. X., Xu, J. & Chan, K. W. Y., May 2020, In: Science Advances. 6, 20, eaba3884.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Assessment of Amide proton transfer weighted (APTw) MRI for pre-surgical prediction of final diagnosis in gliomas

Durmo, F., Rydhog, A., Testud, F., Latt, J., Schmitt, B., Rydelius, A., Englund, E., Bengzon, J., Van Zijl, P., Knutsson, L. & Sundgren, P. C., Dec 2020, In: PloS one. 15, 12 December, e0244003.

Research output: Contribution to journal › Article › peer-review

Open Access

d-glucose weighted chemical exchange saturation transfer (glucoCEST)-based dynamic glucose enhanced (DGE) MRI at 3T: early experience in healthy volunteers and brain tumor patients

Xu, X., Sehgal, A. A., Yadav, N. N., Laterra, J., Blair, L., Blakeley, J., Seidemo, A., Coughlin, J. M., Pomper, M. G., Knutsson, L. & van Zijl, P. C. M., Jul 1 2020, In: Magnetic resonance in medicine. 84, 1, p. 247-262 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Dynamic contrast-enhanced QSM for perfusion imaging: a systematic comparison of ΔR2*- and QSM-based contrast agent concentration time curves in blood and tissue

Lind, E., Knutsson, L., Ståhlberg, F. & Wirestam, R., Oct 1 2020, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 33, 5, p. 663-676 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The role of cartilage glycosaminoglycan structure in gagCEST

Einarsson, E., Peterson, P., Önnerfjord, P., Gottschalk, M., Xu, X., Knutsson, L., Dahlberg, L. E., Struglics, A. & Svensson, J., May 1 2020, In: NMR in biomedicine. 33, 5, e4259.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2019

APT-weighted MRI: Techniques, current neuro applications, and challenging issues

Zhou, J., Heo, H. Y., Knutsson, L., van Zijl, P. C. M. & Jiang, S., Aug 2019, In: Journal of Magnetic Resonance Imaging. 50, 2, p. 347-364 18 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

63 Scopus citations

Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging—a comprehensive overview

Falk Delgado, A., Van Westen, D., Nilsson, M., Knutsson, L., Sundgren, P. C., Larsson, E. M. & Falk Delgado, A., Dec 1 2019, In: Insights into Imaging. 10, 1, 84.

Research output: Contribution to journal › Review article › peer-review

Open Access

Differentiation between glioblastomas and brain metastases and regarding their primary site of malignancy using dynamic susceptibility contrast MRI at 3T

Askaner, K., Rydelius, A., Engelholm, S., Knutsson, L., Lätt, J., Abul-Kasim, K. & Sundgren, P. C., Nov 2019, In: Journal of Neuroradiology. 46, 6, p. 367-372 6 p.

Research output: Contribution to journal › Article › peer-review

Estimation of diffusion, perfusion and fractional volumes using a multi-compartment relaxation-compensated intravoxel incoherent motion (IVIM)signal model

Rydhög, A., Pasternak, O., Ståhlberg, F., Ahlgren, A., Knutsson, L. & Wirestam, R., 2019, In: European Journal of Radiology Open. 6, p. 198-205 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

In vivo magnetic resonance imaging and spectroscopy. Technological advances and opportunities for applications continue to abound

van Zijl, P. & Knutsson, L., Sep 2019, In: Journal of Magnetic Resonance. 306, p. 55-65 11 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

Xu, X., Xu, J., Knutsson, L., Liu, J., Liu, H., Li, Y., Lal, B., Laterra, J., Artemov, D., Liu, G., van Zijl, P. C. M. & Chan, K. W. Y., Jun 2019, In: Magnetic resonance in medicine. 81, 6, p. 3798-3807 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2018

Arterial Input Functions and Tissue Response Curves in Dynamic Glucose-Enhanced (DGE) Imaging: Comparison Between glucoCEST and Blood Glucose Sampling in Humans

Knutsson, L., Seidemo, A., Rydhög Scherman, A., Markenroth Bloch, K., Kalyani, R. R., Andersen, M., Sundgren, P. C., Wirestam, R., Helms, G., van Zijl, P. C. M. & Xu, X., Dec 1 2018, In: Tomography (Ann Arbor, Mich.). 4, 4, p. 164-171 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Brain Tumor Characterization Using Multibiometric Evaluation of MRI

Durmo, F., Lätt, J., Rydelius, A., Engelholm, S., Kinhult, S., Askaner, K., Englund, E., Bengzon, J., Nilsson, M., Björkman-Burtscher, I. M., Chenevert, T., Knutsson, L. & Sundgren, P. C., Mar 1 2018, In: Tomography (Ann Arbor, Mich.). 4, 1, p. 14-25 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

CEST, ASL, and magnetization transfer contrast: How similar pulse sequences detect different phenomena

Knutsson, L., Xu, J., Ahlgren, A. & van Zijl, P. C. M., Oct 2018, In: Magnetic resonance in medicine. 80, 4, p. 1320-1340 21 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease

Donahue, M. J., Achten, E., Cogswell, P. M., De Leeuw, F. E., Derdeyn, C. P., Dijkhuizen, R. M., Fan, A. P., Ghaznawi, R., Heit, J. J., Ikram, M. A., Jezzard, P., Jordan, L. C., Jouvent, E., Knutsson, L., Leigh, R., Liebeskind, D. S., Lin, W., Okell, T. W., Qureshi, A. I., Stagg, C. J., & 8 othersvan Osch, M. J. P., van Zijl, P. C. M., Watchmaker, J. M., Wintermark, M., Wu, O., Zaharchuk, G., Zhou, J. & Hendrikse, J., Sep 1 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 9, p. 1391-1417 27 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

27 Scopus citations

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

Leigh, R., Knutsson, L., Zhou, J. & van Zijl, P. C. M., Sep 1 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 9, p. 1500-1516 17 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

48 Scopus citations

Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

Ahlgren, A., Wirestam, R., Knutsson, L. & Petersen, E. T., Nov 2018, In: Magnetic resonance in medicine. 80, 5, p. 2223-2231 9 p.

Research output: Contribution to journal › Article › peer-review

Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum

van Zijl, P. C. M., Lam, W. W., Xu, J., Knutsson, L. & Stanisz, G. J., Mar 2018, In: NeuroImage. 168, p. 222-241 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

Simultaneous Preclinical Positron Emission Tomography-Magnetic Resonance Imaging Study of Lymphatic Drainage of Chelator-Free ⁶⁴Cu-Labeled Nanoparticles

Madru, R., Budassi, M., Benveniste, H., Lee, H., Smith, S. D., Schlyer, D. J., Vaska, P., Knutsson, L. & Strand, S. E., Aug 2018, In: Cancer Biotherapy and Radiopharmaceuticals. 33, 6, p. 213-220 8 p.

Research output: Contribution to journal › Article › peer-review