Kornel Schuebel

2023

Convergent antibody responses are associated with broad neutralization of hepatitis C virus

Skinner, N. E., Ogega, C. O., Frumento, N., Clark, K. E., Yegnasubramanian, S., Schuebel, K., Meyers, J., Gupta, A., Wheelan, S., Cox, A. L., Crowe, J. E., Ray, S. C. & Bailey, J. R., 2023, In: Frontiers in immunology. 14, 1135841.

Research output: Contribution to journal › Article › peer-review

Open Access

Corrigendum: Convergent antibody responses are associated with broad neutralization of hepatitis C virus (Frontiers in Immunology, (2023), 14, (1135841), 10.3389/fimmu.2023.1135841)

Skinner, N. E., Ogega, C. O., Frumento, N., Clark, K. E., Paul, H., Yegnasubramanian, S., Schuebel, K., Meyers, J., Gupta, A., Wheelan, S., Cox, A. L., Crowe, J. E., Ray, S. C. & Bailey, J. R., 2023, In: Frontiers in immunology. 14, 1201033.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

The endocannabinoid system promotes hepatocyte progenitor cell proliferation and maturation by modulating cellular energetics

Mukhopadhyay, B., Holovac, K., Schuebel, K., Mukhopadhyay, P., Cinar, R., Iyer, S., Marietta, C., Goldman, D. & Kunos, G., Dec 2023, In: Cell Death Discovery. 9, 1, 104.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers (Nature, (2021), 596, 7870, (126-132), 10.1038/s41586-021-03752-4)

Caushi, J. X., Zhang, J., Ji, Z., Vaghasia, A., Zhang, B., Hsiue, E. H. C., Mog, B. J., Hou, W., Justesen, S., Blosser, R., Tam, A., Anagnostou, V., Cottrell, T. R., Guo, H., Chan, H. Y., Singh, D., Thapa, S., Dykema, A. G., Burman, P., Choudhury, B., & 35 othersAparicio, L., Cheung, L. S., Lanis, M., Belcaid, Z., El Asmar, M., Illei, P. B., Wang, R., Meyers, J., Schuebel, K., Gupta, A., Skaist, A., Wheelan, S., Naidoo, J., Marrone, K. A., Brock, M., Ha, J., Bush, E. L., Park, B. J., Bott, M., Jones, D. R., Reuss, J. E., Velculescu, V. E., Chaft, J. E., Kinzler, K. W., Zhou, S., Vogelstein, B., Taube, J. M., Hellmann, M. D., Brahmer, J. R., Merghoub, T., Forde, P. M., Yegnasubramanian, S., Ji, H., Pardoll, D. M. & Smith, K. N., Oct 21 2021, In: Nature. 598, 7881, p. E1

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Bile acid–activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury

Guillot, A., Guerri, L., Feng, D., Kim, S. J., Ahmed, Y. A., Paloczi, J., He, Y., Schuebel, K., Dai, S., Liu, F., Pacher, P., Kisseleva, T., Qin, X., Goldman, D., Tacke, F. & Gao, B., May 2021, In: Journal of Clinical Investigation. 131, 9, e132305.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

Caushi, J. X., Zhang, J., Ji, Z., Vaghasia, A., Zhang, B., Hsiue, E. H. C., Mog, B. J., Hou, W., Justesen, S., Blosser, R., Tam, A., Anagnostou, V., Cottrell, T. R., Guo, H., Chan, H. Y., Singh, D., Thapa, S., Dykema, A. G., Burman, P., Choudhury, B., & 35 othersAparicio, L., Cheung, L. S., Lanis, M., Belcaid, Z., El Asmar, M., Illei, P. B., Wang, R., Meyers, J., Schuebel, K., Gupta, A., Skaist, A., Wheelan, S., Naidoo, J., Marrone, K. A., Brock, M., Ha, J., Bush, E. L., Park, B. J., Bott, M., Jones, D. R., Reuss, J. E., Velculescu, V. E., Chaft, J. E., Kinzler, K. W., Zhou, S., Vogelstein, B., Taube, J. M., Hellmann, M. D., Brahmer, J. R., Merghoub, T., Forde, P. M., Yegnasubramanian, S., Ji, H., Pardoll, D. M. & Smith, K. N., Aug 5 2021, In: Nature. 596, 7870, p. 126-132 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity

Ames, N. J., Barb, J. J., Schuebel, K., Mudra, S., Meeks, B. K., Tuason, R. T. S., Brooks, A. T., Kazmi, N., Yang, S., Ratteree, K., Diazgranados, N., Krumlauf, M., Wallen, G. R. & Goldman, D., Nov 1 2020, In: Gut Microbes. 11, 6, p. 1608-1631 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2019

Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling

Xin, W., Schuebel, K. E., Jair, K. W., Cimbro, R., De Biase, L. M., Goldman, D. & Bonci, A., Jan 1 2019, In: Neuropsychopharmacology. 44, 2, p. 344-355 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2017

A four-gene promoter methylation marker panel consisting of GREM1, NEURL, LAD1, and NEFH predicts survival of clear cell renal cell cancer patients

Van Vlodrop, I. J. H., Joosten, S. C., De Meyer, T., Smits, K. M., Van Neste, L., Melotte, V., Baldewijns, M. M. L. L., Schouten, L. J., Van Den Brandt, P. A., Jeschke, J., Yi, J. M., Schuebel, K. E., Ahuja, N., Herman, J. G., Aarts, M. J., Bosman, F. T., Van Criekinge, W. & Van Engeland, M., Apr 15 2017, In: Clinical Cancer Research. 23, 8, p. 2006-2018 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Local Cues Establish and Maintain Region-Specific Phenotypes of Basal Ganglia Microglia

De Biase, L. M., Schuebel, K. E., Fusfeld, Z. H., Jair, K., Hawes, I. A., Cimbro, R., Zhang, H. Y., Liu, Q. R., Shen, H., Xi, Z. X., Goldman, D. & Bonci, A., Jul 19 2017, In: Neuron. 95, 2, p. 341-356.e6

Research output: Contribution to journal › Article › peer-review

Open Access

163 Scopus citations

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder

Dubey, N., Hoffman, J. F., Schuebel, K., Yuan, Q., Martinez, P. E., Nieman, L. K., Rubinow, D. R., Schmidt, P. J. & Goldman, D., Aug 1 2017, In: Molecular psychiatry. 22, 8, p. 1172-1184 13 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

The influence of FKBP5 genotype on expression of FKBP5 and other glucocorticoid-regulated genes, dependent on trauma exposure

Yeo, S., Enoch, M. A., Gorodetsky, E., Akhtar, L., Schuebel, K., Roy, A. & Goldman, D., Feb 1 2017, In: Genes, Brain and Behavior. 16, 2, p. 223-232 10 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Timeless insights into prevention of acetaldehyde genotoxicity?

Brooks, P. J. & Schuebel, K., Feb 16 2017, In: Cell Cycle. 16, 4, p. 308-309 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

4 Scopus citations

2016

Making sense of epigenetics

Schuebel, K., Gitik, M., Domschke, K. & Goldman, D., Nov 1 2016, In: International Journal of Neuropsychopharmacology. 19, 11, pyw058.

Research output: Contribution to journal › Review article › peer-review

Open Access

36 Scopus citations

2015

Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms

Mukhopadhyay, B., Schuebel, K., Mukhopadhyay, P., Cinar, R., Godlewski, G., Xiong, K., Mackie, K., Lizak, M., Yuan, Q., Goldman, D. & Kunos, G., May 1 2015, In: Hepatology. 61, 5, p. 1615-1626 12 p.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity

Barbier, E., Tapocik, J. D., Juergens, N., Pitcairn, C., Borich, A., Schank, J. R., Sun, H., Schuebel, K., Zhou, Z., Yuan, Q., Vendruscolo, L. F., Goldman, D. & Heilig, M., Apr 15 2015, In: Journal of Neuroscience. 35, 15, p. 6153-6164 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Epigenetic silencing of neurofilament genes promotes an aggressive phenotype in breast cancer

Calmon, M. F., Jeschke, J., Zhang, W., Dhir, M., Siebenkäs, C., Herrera, A., Tsai, H. C., O’Hagan, H. M., Pappou, E. P., Hooker, C. M., Fu, T., Schuebel, K. E., Gabrielson, E., Rahal, P., Herman, J. G., Baylin, S. B. & Ahuja, N., Jan 1 2015, In: Epigenetics. 10, 7, p. 622-632 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Spectrin repeat containing nuclear envelope 1 and forkhead box protein E1 are promising markers for the detection of colorectal cancer in blood

Melotte, V., Yi, J. M., Lentjes, M. H. F. M., Smits, K. M., Van Neste, L., Niessen, H. E. C., Wouters, K. A. D., Louwagie, J., Schuebel, K. E., Herman, J. G., Baylin, S. B., Van Criekinge, W., Meijer, G. A., Ahuja, N. & Van Engeland, M., Feb 1 2015, In: Cancer Prevention Research. 8, 2, p. 157-164 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

2014

Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer

Wrangle, J., Machida, E. O., Danilova, L., Hulbert, A., Franco, N., Zhang, W., Glöckner, S. C., Tessema, M., Van Neste, L., Easwaran, H., Schuebel, K. E., Licchesi, J., Hooker, C. M., Ahuja, N., Amano, J., Belinsky, S. A., Baylin, S. B., Herman, J. G. & Brock, M. V., Apr 1 2014, In: Clinical Cancer Research. 20, 7, p. 1856-1864 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2013

Frequent inactivation of Cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines

Jeschke, J., O'Hagan, H. M., Zhang, W., Vatapalli, R., Calmon, M. F., Danilova, L., Nelkenbrecher, C., Van Neste, L., Bijsmans, I. T. G. W., Van Engeland, M., Gabrielson, E., Schuebel, K. E., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., Jun 15 2013, In: Clinical Cancer Research. 19, 12, p. 3201-3211 11 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

2012

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen

Jeschke, J., Van Neste, L., Glöckner, S. C., Dhir, M., Calmon, M. F., Deregowski, V., Van Criekinge, W., Vlassenbroeck, I., Koch, A., Chan, T. A., Cope, L., Hooker, C. M., Schuebel, K. E., Gabrielson, E., Winterpacht, A., Baylin, S. B., Herman, J. G. & Ahuja, N., 2012, In: Epigenetics. 7, 7, p. 701-709 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Detection of CpG methylation patterns by affinity capture methods

Acevedo, L. G., Sanz, A., Maixner, D., Schuebel, K., Jelinek, M. A., Goldman, D. & Fernandez, J. M., Jan 1 2012, Epigenomics: From Chromatin Biology to Therapeutics. Cambridge University Press, p. 197-209 13 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

2011

Genomic and epigenomic integration identifies a prognostic signature in colon cancer

Yi, J. M., Dhir, M., Van Neste, L., Downing, S. R., Jeschke, J., Glockner, S. C., Calmon, M. D. F., Hooker, C. M., Funes, J. M., Boshoff, C., Smits, K. M., Van Engeland, M., Weijenberg, M. P., Iacobuzio-Donahue, C. A., Herman, J. G., Schuebel, K. E., Baylin, S. B. & Ahuja, N., Mar 15 2011, In: Clinical Cancer Research. 17, 6, p. 1535-1545 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Hyperactivation of anandamide synthesis and regulation of cell-Cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

Mukhopadhyay, B., Cinar, R., Yin, S., Liu, J., Tam, J., Godlewski, G., Harvey-White, J., Mordi, I., Cravatt, B. F., Lotersztajn, S., Gao, B., Yuan, Q., Schuebel, K., Goldman, D. & Kunos, G., Apr 12 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6323-6328 6 p.

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

2010

Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus

Easwaran, H. P., Van Neste, L., Cope, L., Sen, S., Mohammad, H. P., Pageau, G. J., Lawrence, J. B., Herman, J. G., Schuebel, K. E. & Baylin, S. B., Oct 15 2010, In: Cancer Research. 70, 20, p. 8015-8024 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

A bioinformatics pipeline for cancer epigenetics

van Neste, L., Herman, J. G., Schuebel, K. E., Cope, L., Baylin, S. B., van Criekinge, W. & Ahuja, N., Dec 16 2010, In: Current Bioinformatics. 5, 3, p. 153-163 11 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Cancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells

Ohm, J. E., Mali, P., Van Neste, L., Berman, D. M., Liang, L., Pandiyan, K., Briggs, K. J., Zhang, W., Argani, P., Simons, B., Yu, W., Matsui, W., Van Criekinge, W., Rassool, F. V., Zambidis, E., Schuebel, K. E., Cope, L., Yen, J., Mohammad, H. P., Cheng, L., & 1 othersBaylin, S. B., Oct 1 2010, In: Cancer Research. 70, 19, p. 7662-7673 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma

Van Vlodrop, I. J. H., Baldewijns, M. M. L., Smits, K. M., Schouten, L. J., Van Neste, L., Van Criekinge, W., Van Poppel, H., Lerut, E., Schuebel, K. E., Ahuja, N., Herman, J. G., De Bruïne, A. P. & Van Engeland, M., Feb 2010, In: American Journal of Pathology. 176, 2, p. 575-584 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

2009

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers

Tessema, M., Yu, Y. Y., Stidley, C. A., Machida, E. O., Schuebel, K. E., Baylin, S. B. & Belinsky, S. A., 2009, In: Carcinogenesis. 30, 7, p. 1132-1138 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Methylation of TFPI2 in stool DNA: A potential novel biomarker for the detection of colorectal cancer

Glöckner, S. C., Dhir, M., Joo, M. Y., McGarvey, K. E., Van Neste, L., Louwagie, J., Chan, T. A., Kleeberger, W., De Bruïne, A. P., Smits, K. M., Khalid-de Bakker, C. A. J., Jonkers, D. M. A. E., Stockbrügger, R. W., Meijer, G. A., Oort, F. A., Iacobuzio-Donahue, C., Bierau, K., Herman, J. G., Baylin, S. B., Van Engeland, M., & 2 othersSchuebel, K. E. & Ahuja, N., Jun 1 2009, In: Cancer Research. 69, 11, p. 4691-4699 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

176 Scopus citations

2008

Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors

Joo, M. Y., Tsai, H. C., Glöckner, S. C., Lin, S., Ohm, J. E., Easwaran, H., James, C. D., Costello, J. F., Riggins, G., Eberhart, C. G., Laterra, J., Vescovi, A. L., Ahuja, N., Herman, J. G., Schuebel, K. E. & Baylin, S. B., Oct 1 2008, In: Cancer Research. 68, 19, p. 8094-8103 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

123 Scopus citations

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

Ting, A. H., Suzuki, H., Cope, L., Schuebel, K. E., Lee, B. H., Toyota, M., Imai, K., Shinomura, Y., Tokino, T. & Baylin, S. B., Apr 15 2008, In: Cancer Research. 68, 8, p. 2570-2575 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

McLendon, R., Friedman, A., Bigner, D., Van Meir, E. G., Brat, D. J., Mastrogianakis, G. M., Olson, J. J., Mikkelsen, T., Lehman, N., Aldape, K., Yung, W. K. A., Bogler, O., Weinstein, J. N., VandenBerg, S., Berger, M., Prados, M., Muzny, D., Morgan, M., Scherer, S., Sabo, A., & 211 othersNazareth, L., Lewis, L., Hall, O., Zhu, Y., Ren, Y., Alvi, O., Yao, J., Hawes, A., Jhangiani, S., Fowler, G., San Lucas, A., Kovar, C., Cree, A., Dinh, H., Santibanez, J., Joshi, V., Gonzalez-Garay, M. L., Miller, C. A., Milosavljevic, A., Donehower, L., Wheeler, D. A., Gibbs, R. A., Cibulskis, K., Sougnez, C., Fennell, T., Mahan, S., Wilkinson, J., Ziaugra, L., Onofrio, R., Bloom, T., Nicol, R., Ardlie, K., Baldwin, J., Gabriel, S., Lander, E. S., Ding, L., Fulton, R. S., McLellan, M. D., Wallis, J., Larson, D. E., Shi, X., Abbott, R., Fulton, L., Chen, K., Koboldt, D. C., Wendl, M. C., Meyer, R., Tang, Y., Lin, L., Osborne, J. R., Dunford-Shore, B. H., Miner, T. L., Delehaunty, K., Markovic, C., Swift, G., Courtney, W., Pohl, C., Abbott, S., Hawkins, A., Leong, S., Haipek, C., Schmidt, H., Wiechert, M., Vickery, T., Scott, S., Dooling, D. J., Chinwalla, A., Weinstock, G. M., Mardis, E. R., Wilson, R. K., Getz, G., Winckler, W., Verhaak, R. G. W., Lawrence, M. S., O'Kelly, M., Robinson, J., Alexe, G., Beroukhim, R., Carter, S., Chiang, D., Gould, J., Gupta, S., Korn, J., Mermel, C., Mesirov, J., Monti, S., Nguyen, H., Parkin, M., Reich, M., Stransky, N., Weir, B. A., Garraway, L., Golub, T., Meyerson, M., Chin, L., Protopopov, A., Zhang, J., Perna, I., Aronson, S., Sathiamoorthy, N., Ren, G., Yao, J., Wiedemeyer, W. R., Kim, H., Sek, W. K., Xiao, Y., Kohane, I. S., Seidman, J., Park, P. J., Kucherlapati, R., Laird, P. W., Cope, L., Herman, J. G., Weisenberger, D. J., Pan, F., Van Den Berg, D., Van Neste, L., Joo, M. Y., Schuebel, K. E., Baylin, S. B., Absher, D. M., Li, J. Z., Southwick, A., Brady, S., Aggarwal, A., Chung, T., Sherlock, G., Brooks, J. D., Myers, R. M., Spellman, P. T., Purdom, E., Jakkula, L. R., Lapuk, A. V., Marr, H., Dorton, S., Yoon, G. C., Han, J., Ray, A., Wang, V., Durinck, S., Robinson, M., Wang, N. J., Vranizan, K., Peng, V., Van Name, E., Fontenay, G. V., Ngai, J., Conboy, J. G., Parvin, B., Feiler, H. S., Speed, T. P., Gray, J. W., Brennan, C., Socci, N. D., Olshen, A., Taylor, B. S., Lash, A., Schultz, N., Reva, B., Antipin, Y., Stukalov, A., Gross, B., Cerami, E., Wei, Q. W., Qin, L. X., Seshan, V. E., Villafania, L., Cavatore, M., Borsu, L., Viale, A., Gerald, W., Sander, C., Ladanyi, M., Perou, C. M., Hayes, D. N., Topal, M. D., Hoadley, K. A., Qi, Y., Balu, S., Shi, Y., Wu, J., Penny, R., Bittner, M., Shelton, T., Lenkiewicz, E., Morris, S., Beasley, D., Sanders, S., Kahn, A., Sfeir, R., Chen, J., Nassau, D., Feng, L., Hickey, E., Barker, A., Gerhard, D. S., Vockley, J., Compton, C., Vaught, J., Fielding, P., Ferguson, M. L., Schaefer, C., Zhang, J., Madhavan, S., Buetow, K. H., Collins, F., Good, P., Guyer, M., Ozenberger, B., Peterson, J. & Thomson, E., Oct 23 2008, In: Nature. 455, 7216, p. 1061-1068 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5077 Scopus citations

Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis

Chan, T. A., Glockner, S., Joo, M. Y., Chen, W., Van Neste, L., Cope, L., Herman, J. G., Velculescu, V., Schuebel, K. E., Ahuja, N. & Baylin, S. B., May 2008, In: PLoS medicine. 5, 5, p. 823-837 15 p., e114.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Defining a chromatin pattern that characterizes DNA-hypermethylated genes in colon cancer cells

McGarvey, K. M., Van Neste, L., Cope, L., Ohm, J. E., Herman, J. G., Van Criekinge, W., Schuebel, K. E. & Baylin, S. B., Jul 15 2008, In: Cancer Research. 68, 14, p. 5753-5759 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Epigenetic inactivation of the canonical Wnt antagonist SRY-box containing gene 17 in colorectal cancer

Zhang, W., Glöckner, S. C., Guo, M., Machida, E. O., Wang, D. H., Easwaran, H., Van Neste, L., Herman, J. G., Schuebel, K. E., Watkins, D. N., Ahuja, N. & Baylin, S. B., Apr 15 2008, In: Cancer Research. 68, 8, p. 2764-2772 9 p.

Research output: Contribution to journal › Article › peer-review

143 Scopus citations

Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia

Dhir, M., Montgomery, E. A., Glöckner, S. C., Schuebel, K. E., Hooker, C. M., Herman, J. G., Baylin, S. B., Gearhart, S. L. & Ahuja, N., Oct 2008, In: Journal of Gastrointestinal Surgery. 12, 10, p. 1745-1753 9 p.

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

2007

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

Ohm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., Berman, D. M., Jenuwein, T., Pruitt, K., Sharkis, S. J., Watkins, D. N., Herman, J. G. & Baylin, S. B., Feb 2007, In: Nature genetics. 39, 2, p. 237-242 6 p.

Research output: Contribution to journal › Article › peer-review

812 Scopus citations

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer

Schuebel, K. E., Chen, W., Cope, L., Glöckner, S. C., Suzuki, H., Yi, J. M., Chan, T. A., Van Neste, L., Van Criekinge, W., Van Den Bosch, S., Van Engeland, M., Ting, A. H., Jair, K., Yu, W., Toyota, M., Imai, K., Ahuja, N., Herman, J. G. & Baylin, S. B., Sep 2007, In: PLoS genetics. 3, 9, p. 1709-1723 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

289 Scopus citations

Genomic biology: The epigenomic era opens

Baylin, S. B. & Schuebel, K. E., Aug 2 2007, In: Nature. 448, 7153, p. 548-549 2 p.

Research output: Contribution to journal › Short survey › peer-review

Open Access

32 Scopus citations

Molecular genetic analyses of human endogenous retroviral elements belonging to the HERV-P family in primates, human tissues, and cancer cells

Yi, J. M., Schuebel, K. & Kim, H. S., Jan 2007, In: Genomics. 89, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2006

CIMPle origin for promoter hypermethylation in colorectal cancer?

Schuebel, K., Chen, W. & Baylin, S. B., Jul 2006, In: Nature genetics. 38, 7, p. 738-740 3 p.

Research output: Contribution to journal › Short survey › peer-review

22 Scopus citations

De novo CpG island methylation in human cancer cells

Jair, K. W., Bachman, K. E., Suzuki, H., Ting, A. H., Rhee, I., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Jan 15 2006, In: Cancer Research. 66, 2, p. 682-692 11 p.

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation

Ting, A. H., Jair, K. W., Schuebel, K. E. & Baylin, S. B., Jan 15 2006, In: Cancer Research. 66, 2, p. 729-735 7 p.

Research output: Contribution to journal › Article › peer-review

64 Scopus citations

2005

In living color: DNA methyltransferase caught in the act

Schuebel, K. & Baylin, S., Oct 2005, In: Nature Methods. 2, 10, p. 736-738 3 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Regulation of neuroendocrine differentiation in gastrointestinal carcinoid tumor cells by notch signaling

Nakakura, E. K., Sriuranpong, V. R., Kunnimalaiyaan, M., Hsiao, E. C., Schuebel, K. E., Borges, M. W., Jin, N., Collins, B. J., Nelkin, B. D., Chen, H. & Ball, D. W., Jul 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, 7, p. 4350-4356 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

Ting, A. H., Schuebel, K. E., Herman, J. G. & Baylin, S. B., Aug 2005, In: Nature genetics. 37, 8, p. 906-910 5 p.

Research output: Contribution to journal › Article › peer-review

230 Scopus citations

2004

CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Jun 2004, In: Nature genetics. 36, 6, p. 582-584 3 p.

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

Suzuki, H., Watkins, D. N., Jair, K. W., Schuebel, K. E., Markowitz, S. D., Chen, W. D., Pretlow, T. P., Yang, B., Akiyama, Y., Van Engeland, M., Toyota, M., Tokino, T., Hinoda, Y., Imai, K., Herman, J. G. & Baylin, S. B., Apr 2004, In: Nature genetics. 36, 4, p. 417-422 6 p.

Research output: Contribution to journal › Article › peer-review

873 Scopus citations

Mammalian DNA methyltransferase 1: Inspiration for new directions

Ting, A. H., Jair, K. W., Suzuki, H., Yen, R. W. C., Baylin, S. B. & Schuebel, K. E., Aug 2004, In: Cell Cycle. 3, 8, p. 1022-1024 3 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

26 Scopus citations

Kornel Schuebel

Research output

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