Research output per year
Research output per year
- 1 - 50 out of 62 results
Search results
-
2023
Direct and biologically significant interactions of human herpesvirus 8 interferon regulatory factor 1 with STAT3 and Janus kinase TYK2
Yang, Z., Xiang, Q. & Nicholas, J., Nov 2023, In: PLoS pathogens. 19, 11, e1011806.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis
Choi, C. Y., Vo, M. T., Nicholas, J. & Choi, Y. B., Feb 2022, In: Cell death and differentiation. 29, 2, p. 451-464 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
STAT and Janus kinase targeting by human herpesvirus 8 interferon regulatory factor in the suppression of type-I interferon signaling
Xiang, Q., Yang, Z. & Nicholas, J., Jul 2022, In: PLoS pathogens. 18, 7, e1010676.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Genetic analyses of contributions of viral interleukin-6 interactions and signaling to human herpesvirus 8 productive replication
Li, Q., Xiang, Q., Chen, D. & Nicholas, J., Oct 2020, In: Journal of virology. 94, 19, e00909-20.Research output: Contribution to journal › Article › peer-review
Open Access -
Kaposi’s sarcoma-associated herpesvirus drives a super-enhancer-mediated survival gene expression program in primary effusion lymphoma
Manzano, M., Günther, T., Ju, H., Nicholas, J., Bartom, E. T., Grundhoff, A. & Gottwein, E., Jul 1 2020, In: mBio. 11, 4, p. 1-23 23 p., e01457-20.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
USP7-dependent regulation of TRAF activation and signaling by a viral interferon regulatory factor homologue
Xiang, Q., Ju, H. & Nicholas, J., Jan 1 2020, In: Journal of virology. 94, 2, e01553-19.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2019
Activation of NIX-mediated mitophagy by an interferon regulatory factor homologue of human herpesvirus
Vo, M. T., Smith, B. J., Nicholas, J. & Choi, Y. B., Dec 1 2019, In: Nature communications. 10, 1, 3203.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Insulin-like growth factor 2 receptor expression is promoted by human herpesvirus 8-encoded interleukin-6 and contributes to viral latency and productive replication
Li, Q., Chen, D., Xiang, Q. & Nicholas, J., Mar 1 2019, In: Journal of virology. 93, 5, e02026-18.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2018
Human herpesvirus 8 interferon regulatory factors 1 and 3 mediate replication and latency activities via interactions with USP7 deubiquitinase
Xiang, Q., Ju, H., Li, Q., Mei, S. C., Chen, D., Choi, Y. B. & Nicholas, J., Apr 1 2018, In: Journal of virology. 92, 7, e02003-17.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
2017
Human herpesvirus 8 interleukin-6 interacts with calnexin cycle components and promotes protein folding
Chen, D., Xiang, Q. & Nicholas, J., Nov 1 2017, In: Journal of virology. 91, 22, e00965-17.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2015
Promotion of endoplasmic reticulum-associated degradation of procathepsin D by human herpesvirus 8-encoded viral interleukin-6
Chen, D. & Nicholas, J., 2015, In: Journal of virology. 89, 15, p. 7979-7990 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2014
Human herpesvirus 8 viral interleukin-6 signaling through gp130 promotes virus replication in primary effusion lymphoma and endothelial cells
Cousins, E., Gao, Y., Sandford, G. & Nicholas, J., 2014, In: Journal of virology. 88, 20, p. 12167-12172 6 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2013
Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability
Cousins, E. & Nicholas, J., 2013, In: Journal of virology. 87, 19, p. 10816-10827 12 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2012
Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry
Choi, Y. B., Sandford, G. & Nicholas, J., Jun 2012, In: PLoS pathogens. 8, 6, e1002748.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1
Chen, D., Cousins, E., Sandford, G. & Nicholas, J., Feb 2012, In: Journal of virology. 86, 3, p. 1577-1588 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2010
Bim nuclear translocation and inactivation by viral interferon regulatory factor
Choi, Y. B. & Nicholas, J., Aug 2010, In: PLoS pathogens. 6, 8, p. 13-14 2 p., e1001031.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Induction of angiogenic chemokine CCL2 by human herpesvirus 8 chemokine receptor
Choi, Y. B. & Nicholas, J., Feb 20 2010, In: Virology. 397, 2, p. 369-378 10 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2009
Determinants of secretion and intracellular localization of human herpesvirus 8 interleukin-6
Chen, D., Choi, Y. B., Sandford, G. & Nicholas, J., Jul 2009, In: Journal of virology. 83, 13, p. 6874-6882 9 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Intracellular signaling mechanisms and activities of human herpesvirus 8 interleukin-6
Chen, D., Sandford, G. & Nicholas, J., Jan 2009, In: Journal of virology. 83, 2, p. 722-733 12 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Role of ORF74-encoded viral G protein-coupled receptor in human herpesvirus 8 lytic replication
Sandford, G., Choi, Y. B. & Nicholas, J., Dec 2009, In: Journal of virology. 83, 24, p. 13009-13014 6 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2008
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines
Young, B. C. & Nicholas, J., Jul 2008, In: Journal of virology. 82, 13, p. 6501-6513 13 p.Research output: Contribution to journal › Article › peer-review
Open Access45 Scopus citations -
2007
Human herpesvirus 8-encoded proteins with potential roles in virus-associated neoplasia
Nicholas, J., 2007, In: Frontiers in Bioscience. 12, 1, p. 265-281 17 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2006
Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding
Verzijl, D., Pardo, L., Van Dijk, M., Gruijthuijsen, Y. K., Jongejan, A., Timmerman, H., Nicholas, J., Schwarz, M., Murphy, P. M., Leurs, R. & Smit, M. J., Nov 17 2006, In: Journal of Biological Chemistry. 281, 46, p. 35327-35335 9 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Signal transduction by human herpesvirus 8 viral interleukin-6 (vIL-6) is modulated by the nonsignaling gp80 subunit of the IL-6 receptor complex and is distinct from signaling induced by human IL-6
Hu, F. & Nicholas, J., Nov 2006, In: Journal of virology. 80, 21, p. 10874-10878 5 p.Research output: Contribution to journal › Article › peer-review
34 Scopus citations -
Structural requirements for gp80 independence of human herpesvirus 8 interleukin-6 (vIL-6) and evidence for gp80 stabilization of gp130 signaling complexes induced by vIL-6
Chen, D. & Nicholas, J., Oct 2006, In: Journal of virology. 80, 19, p. 9811-9821 11 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2004
Gα Protein Selectivity Determinant Specified by a Viral Chemokine Receptor-Conserved Region in the C Tail of the Human Herpesvirus 8 G Protein-Coupled Receptor
Liu, C., Sandford, G., Fei, G. & Nicholas, J., Mar 2004, In: Journal of virology. 78, 5, p. 2460-2471 12 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Molecular Mechanisms for Viral Mimicry of a Human Cytokine: Activation of gp130 by HHV-8 Interleukin-6
Boulanger, M. J., Chow, D. C., Brevnova, E., Martick, M., Sandford, G., Nicholas, J. & Garcia, K. C., Jan 9 2004, In: Journal of molecular biology. 335, 2, p. 641-654 14 p.Research output: Contribution to journal › Article › peer-review
58 Scopus citations -
2002
Identification of amino acid residues of gp130 signal transducer and gp80 α receptor subunit that are involved in ligand binding and signaling by human herpesvirus 8-encoded interleukin-6
Li, H. & Nicholas, J., 2002, In: Journal of virology. 76, 11, p. 5627-5636 10 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2001
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling
Li, H., Wang, H. & Nicholas, J., 2001, In: Journal of virology. 75, 7, p. 3325-3334 10 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Human herpesvirus 8 (HHV-8)-encoded cytokines induce expression of and autocrine signaling by vascular endothelial growth factor (VEGF) in HHV-8-infected primary-effusion lymphoma cell lines and mediate VEGF-independent antiapoptotic effects
Liu, C., Okruzhnov, Y., Li, H. & Nicholas, J., 2001, In: Journal of virology. 75, 22, p. 10933-10940 8 p.Research output: Contribution to journal › Article › peer-review
Open Access87 Scopus citations -
1999
Heterogeneity of viral IL-6 expression in HHV-8-associated diseases
Cannon, J. S., Nicholas, J., Orenstein, J. M., Mann, R. B., Murray, P. G., Browning, P. J., DiGiuseppe, J. A., Cesarman, E., Hayward, G. S. & Ambinder, R. F., 1999, In: Journal of Infectious Diseases. 180, 3, p. 824-828 5 p.Research output: Contribution to journal › Article › peer-review
Open Access104 Scopus citations -
High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations
Zong, J., Ciufo, D. M., Alcendor, D. J., Wan, X., Nicholas, J., Browning, P. J., Rady, P. L., Tyring, S. K., Orenstein, J. M., Rabkin, C. S., Su, I. J., Powell, K. F., Croxson, M., Foreman, K. E., Nickoloff, B. J., Alkan, S. & Hayward, G. S., 1999, In: Journal of virology. 73, 5, p. 4156-4170 15 p.Research output: Contribution to journal › Article › peer-review
Open Access235 Scopus citations -
Human herpesvirus 8-encoded thymidine kinase and phoshpotransferase homologues confer sensitivity to ganciclovir
Cannon, J. S., Hamzeh, F., Moore, S., Nicholas, J. & Ambinder, R. F., 1999, In: Journal of virology. 73, 6, p. 4786-4793 8 p.Research output: Contribution to journal › Article › peer-review
Open Access77 Scopus citations -
Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6
Wan, X., Wang, H. & Nicholas, J., 1999, In: Journal of virology. 73, 10, p. 8268-8278 11 p.Research output: Contribution to journal › Article › peer-review
Open Access82 Scopus citations -
1998
Novel organizational features, captured cellular genes, and strain variability within the genome of KSHV/HHV8.
Nicholas, J., Zong, J. C., Alcendor, D. J., Ciufo, D. M., Poole, L. J., Sarisky, R. T., Chiou, C. J., Zhang, X., Wan, X., Guo, H. G., Reitz, M. S. & Hayward, G. S., 1998, In: Journal of the National Cancer Institute. Monographs. 23, p. 79-88 10 p.Research output: Contribution to journal › Article › peer-review
122 Scopus citations -
1997
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak
Cheng, E. H. Y., Nicholas, J., Bellows, D. S., Hayward, G. S., Guo, H. G., Reitz, M. S. & Hardwick, J. M., Jan 21 1997, In: Proceedings of the National Academy of Sciences of the United States of America. 94, 2, p. 690-694 5 p.Research output: Contribution to journal › Article › peer-review
Open Access378 Scopus citations -
A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins
Nicholas, J., Ruvolo, V., Zong, J., Ciufo, D., Guo, H. G., Reitz, M. S. & Hayward, G. S., Mar 1997, In: Journal of virology. 71, 3, p. 1963-1974 12 p.Research output: Contribution to journal › Article › peer-review
Open Access156 Scopus citations -
Characterization of a chemokine receptor-related gene in human herpesvirus 8 and its expression in Kaposi's sarcoma
Guo, H. G., Browning, P., Nicholas, J., Hayward, G. S., Tschachler, E., Jiang, Y. W., Sadowska, M., Raffeld, M., Colombini, S., Gallo, R. C. & Reitz, M. S., Feb 17 1997, In: Virology. 228, 2, p. 371-378 8 p.Research output: Contribution to journal › Article › peer-review
Open Access102 Scopus citations -
Identification and analysis of a lytic-phase origin of DNA replication in human herpesvirus 7
Van Loon, N., Dykes, C., Deng, H., Dominguez, G., Nicholas, J. & Dewhurst, S., 1997, In: Journal of virology. 71, 4, p. 3279-3284 6 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Identification of envelope glycoproteins h and b homologues of human herpesvirus 7
Secchiero, P., Berneman, Z. N., Sun, D., Nicholas, J. & Reitz, M. S., Jan 1 1997, In: Intervirology. 40, 1, p. 22-32 11 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6
Nicholas, J., Ruvolo, V. R., Burns, W. H., Sandford, G., Wan, X., Ciufo, D., Hendrickson, S. B., Guo, H. G., Hayward, G. S. & Reitz, M. S., 1997, In: Nature medicine. 3, 3, p. 287-292 6 p.Research output: Contribution to journal › Article › peer-review
326 Scopus citations -
Strain variability among Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genomes: Evidence that a large cohort of United States AIDS patients may have been infected by a single common isolate
Zong, J. C., Metroka, C., Reitz, M. S., Nicholas, J. & Hayward, G. S., 1997, In: Journal of virology. 71, 3, p. 2505-2511 7 p.Research output: Contribution to journal › Article › peer-review
Open Access99 Scopus citations -
1996
Cloning, restriction endonuclease mapping and partial sequence analysis of the genome of human herpesvirus 7 strain JI
Ruvolo, V. R., Berneman, Z., Secchiero, P. & Nicholas, J., Aug 1996, In: Journal of General Virology. 77, 8, p. 1901-1912 12 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Determination and analysis of the complete nucleotide sequence of human herpesvirus 7
Nicholas, J., Sep 1996, In: Journal of virology. 70, 9, p. 5975-5989 15 p.Research output: Contribution to journal › Article › peer-review
245 Scopus citations -
1995
Human herpesvirus 6 (strain U1102) encodes homologues of the conserved herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding protein
Lawrence, G. L., Nicholas, J. & Barrell, B. G., 1995, In: Journal of General Virology. 76, 1, p. 147-152 6 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Identification of human telomeric repeat motifs at the genome termini of human herpesvirus 7: Structural analysis and heterogeneity
Secchiero, P., Nicholas, J., Deng, H., Xiaopeng, T., Van Loon, N., Ruvolo, V. R., Berneman, Z. N., Reitz, M. S. & Dewhurst, S., Dec 1995, In: Journal of virology. 69, 12, p. 8041-8045 5 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
The DNA Sequence of Human Herpesvirus-6: Structure, Coding Content, and Genome Evolution
Gompels, U. A., Nicholas, J., Lawrence, G., Jones, M., Thomson, B. J., Martin, M. E. D., Efstathiou, S., Craxton, M. & Macaulay, H. A., May 10 1995, In: Virology. 209, 1, p. 29-51 23 p., 71228.Research output: Contribution to journal › Article › peer-review
Open Access491 Scopus citations -
1994
Nucleotide Sequence Analysis of a 21-kbp Region of the Genome of Human Herpesvirus-6 Containing Homologues of Human Cytomegalovirus Major Immediate-Early and Replication Genes
Nicholas, J., Nov 1 1994, In: Virology. 204, 2, p. 738-750 13 p., 71589.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene homologs and transactivating functions
Nicholas, J. & Martin, M. E. D., Feb 1994, In: Journal of virology. 68, 2, p. 597-610 14 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
1993
Identification and expression of the human herpesvirus 6 glycoprotein H and interaction with an accessory 40K glycoprotein
Liu, D. X., Gompels, U. A., Nicholas, J. & Lelliott, C., 1993, In: Journal of General Virology. 74, 9, p. 1847-1857 11 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations