John Isaacs

2021

Mipsagargin: The beginning—not the end—of thapsigargin prodrug-based cancer therapeutics

Isaacs, J. T., Brennen, W. N., Christensen, S. B. & Denmeade, S. R., Dec 1 2021, In: Molecules. 26, 24, 7469.

Research output: Contribution to journal › Review article › peer-review

Open Access

2019

Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer

Akinboye, E. S., Brennen, W. N., Denmeade, S. R. & Isaacs, J. T., Jan 2019, In: Asian Journal of Urology. 6, 1, p. 99-108 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

9 Scopus citations

2018

Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise

Krueger, T. E. G., Thorek, D. L. J., Denmeade, S. R., Isaacs, J. T. & Brennen, W. N., Sep 2018, In: Stem Cells Translational Medicine. 7, 9, p. 651-663 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

78 Scopus citations

Mesenchymal stem cells and the embryonic reawakening theory of BPH

Brennen, W. N. & Isaacs, J. T., Nov 1 2018, In: Nature Reviews Urology. 15, 11, p. 703-715 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

11 Scopus citations

The what, when, and why of human prostate cancer xenografts

Brennen, W. N. & Isaacs, J. T., Jun 15 2018, In: Prostate. 78, 9, p. 646-654 9 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

2015

Targeting thapsigargin towards tumors

Doan, N. T. Q., Paulsen, E. S., Sehgal, P., Møller, J. V., Nissen, P., Denmeade, S. R., Isaacs, J. T., Dionne, C. A. & Christensen, S. B., May 2015, In: Steroids. 97, p. 2-7 6 p.

Research output: Contribution to journal › Review article › peer-review

81 Scopus citations

2014

Enhancement of the t-cell armamentarium as a cell-based therapyfor prostate cancer

Brennen, W. N., Drake, C. G. & Isaacs, J. T., Jul 1 2014, In: Cancer Research. 74, 13, p. 3390-3395 6 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2 Scopus citations

2013

Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment

Brennen, W. N., Denmeade, S. R. & Isaacs, J. T., Oct 2013, In: Endocrine-related cancer. 20, 5, p. R269-R290

Research output: Contribution to journal › Review article › peer-review

Open Access

49 Scopus citations

2012

Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy

Brennen, W. N., Isaacs, J. T. & Denmeade, S. R., Feb 2012, In: Molecular cancer therapeutics. 11, 2, p. 257-266 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

142 Scopus citations

2010

Bipolar androgen therapy: The rationale for rapid cycling of supraphysiologic androgen/ablation in men with castration resistant prostate cancer

Denmeade, S. R. & Isaacs, J. T., Oct 1 2010, In: Prostate. 70, 14, p. 1600-1607 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

51 Scopus citations

The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancer

Isaacs, J. T., Oct 2010, In: Expert Opinion on Investigational Drugs. 19, 10, p. 1235-1243 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

33 Scopus citations

2009

A trojan horse in drug development: Targeting of thapsigargins towards prostate cancer cells

Christensen, S. B., Mondrup Skytte, D., Denmeade, S. R., Dionne, C., Møller, J. V., Nissen, P. & Isaacs, J. T., 2009, In: Anti-Cancer Agents in Medicinal Chemistry. 9, 3, p. 276-294 19 p.

Research output: Contribution to journal › Review article › peer-review

76 Scopus citations

DNA licensing as a novel androgen receptor mediated therapeutic target for prostate cancer

D'Antonio, J. M., Vander Griend, D. J. & Isaacs, J. T., Jun 2009, In: Endocrine-related cancer. 16, 2, p. 325-332 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

34 Scopus citations

2008

Prostate stem cells and benign prostatic hyperplasia

Isaacs, J. T., Jun 15 2008, In: Prostate. 68, 9, p. 1025-1034 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

65 Scopus citations

The current state of preclinical prostate cancer animal models

Pienta, K. J., Abate-Shen, C., Agus, D. B., Attar, R. M., Chung, L. W. K., Greenberg, N. M., Hahn, W. C., Isaacs, J. T., Navone, N. M., Peehl, D. M., Simons, J. W., Solit, D. B., Soule, H. R., VanDyke, T. A., Weber, M. J., Wu, L. & Vessella, R. L., May 1 2008, In: Prostate. 68, 6, p. 629-639 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

96 Scopus citations

2007

Does PSA play a role as a promoting agent during the initiation and/or progression of prostate cancer?

Williams, S. A., Singh, P., Isaacs, J. T. & Denmeade, S. R., Feb 15 2007, In: Prostate. 67, 3, p. 312-329 18 p.

Research output: Contribution to journal › Review article › peer-review

82 Scopus citations

Stabilizing androgen receptor in mitosis inhibits prostate cancer proliferation

Vander Griend, D. J., Litvinov, I. V. & Isaacs, J. T., Mar 15 2007, In: Cell Cycle. 6, 6, p. 647-651 5 p.

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

2006

Combinatorial androgen receptor targeted therapy for prostate cancer

Singh, P., Uzgare, A., Litvinov, I., Denmeade, S. R. & Isaacs, J. T., Sep 2006, In: Endocrine-related cancer. 13, 3, p. 653-666 14 p.

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

2005

The SERCA pump as a therapeutic target: Making a "smart bomb" for prostate cancer

Denmeade, S. R. & Isaacs, J. T., Jan 2005, In: Cancer Biology and Therapy. 4, 1, p. 21-29 9 p.

Research output: Contribution to journal › Review article › peer-review

183 Scopus citations

2004

Development of Prostate Cancer Treatment: The Good News

Denmeade, S. R. & Isaacs, J. T., Feb 15 2004, In: Prostate. 58, 3, p. 211-224 14 p.

Research output: Contribution to journal › Review article › peer-review

73 Scopus citations

In vitro culturing and characteristics of transit amplifying epithelial cells from human prostate tissue

Uzgare, A. R., Xu, Y. & Isaacs, J. T., Jan 2004, In: Journal of cellular biochemistry. 91, 1, p. 196-205 10 p.

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

The role of prostate-specific antigen in the clinical evaluation of prostatic disease

Denmeade, S. R. & Isaacs, J. T., Mar 2004, In: BJU International. 93, SUPPL. 1, p. 10-15 6 p.

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

2003

Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling?

Litvinov, I. V., De Marzo, A. M. & Isaacs, J. T., Jul 1 2003, In: Journal of Clinical Endocrinology and Metabolism. 88, 7, p. 2972-2982 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

175 Scopus citations

2002

A history of prostate cancer treatment

Denmeade, S. R. & Isaacs, J. T., May 2002, In: Nature Reviews Cancer. 2, 5, p. 389-396 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

343 Scopus citations

Mechanisms involved in the progression of androgen-independent prostate cancers: It is not only the cancer cell's fault

Arnold, J. T. & Isaacs, J. T., 2002, In: Endocrine-related cancer. 9, 1, p. 61-73 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

180 Scopus citations

2001

Apoptotic pathways in prostate cancer

Denmeade, S. R., Tombal, B. & Isaacs, J. T., 2001, In: Advances in Cell Aging and Gerontology. 6, C, p. 23-54 32 p.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

1997

Molecular advances in prostate cancer

Dong, J. T., Isaacs, W. B. & Isaacs, J. T., Jan 1 1997, In: Current opinion in oncology. 9, 1, p. 101-107 7 p.

Research output: Contribution to journal › Review article › peer-review

74 Scopus citations

Molecular markers for prostate cancer metastasis: Developing diagnostic methods for predicting the aggressiveness of prostate cancer

Isaacs, J. T., 1997, In: American Journal of Pathology. 150, 5, p. 1511-1521 11 p.

Research output: Contribution to journal › Review article › peer-review

90 Scopus citations

1996

Programmed cell death (apoptosis) and cancer chemotherapy

Denmeade, S. R. & Isaacs, J. T., 1996, In: Cancer Control. 3, 4, p. 303-309 7 p.

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Recent advances in the development of animal and cell culture models for prostate cancer research: A minireview

Bosland, M. C., Chung, L. W. K., Greenberg, N. M., Ho, S. M., Isaacs, J. T., Lane, K., Peehl, D. M., Thompson, T. C., Van Steenbrugge, G. J. & Van Weerden, W. M., Jul 1996, In: Urologic oncology. 2, 4, p. 99-128 30 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Scopus citations

1995

The genetics of programmed (apoptotic) cell death

Lin, X. S., Denmeade, S. R. & Isaacs, J. T., 1995, In: Cancer Surveys. 25, p. 173-194 22 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

1994

Advances and controversies in the study of programmed cell death/apoptosis in the development of and therapy for cancer

Isaacs, J. T., Jan 1 1994, In: Current opinion in oncology. 6, 1, p. 82-89 8 p.

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Proliferation-independent programmed cell death as a therapeutic target for prostate cancer

Furuya, Y. & Isaacs, J. T., 1994, In: Cancer Bulletin. 46, 2, p. 173-179 7 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

1993

5Alpha-reductase inhibitors and the treatment of benign prostatic hyperplasia

Isaacs, J. T., Oct 13 1993, In: Drugs of Today. 29, 5, p. 335-342 8 p.

Research output: Contribution to journal › Review article › peer-review

11 Scopus citations

1992

Androgen regulation of programmed death of normal and malignant prostatic cells

Isaacs, J. T., Lundmo, P. I., Berges, R., Martikainen, P., Kyprianou, N. & English, H. F., 1992, In: Journal of andrology. 13, 6, p. 457-464 8 p.

Research output: Contribution to journal › Review article › peer-review

139 Scopus citations

Comparative aspects of multistep prostatic carcinogenesis in humans and rodents.

Isaacs, J. T., Isaacs, W. B. & Schalken, J., 1992, In: Progress in clinical and biological research. 376, p. 261-288 28 p.

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

1991

Genetic factors and metastatic potential of prostatic cancer

Ichikawa, T., Ichikawa, Y. & Isaacs, J. T., Dec 1 1991, In: Cancer Surveys. 11, p. 35-42 8 p.

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Programmed cell death as a new target for prostatic cancer therapy

Kyprianou, N., Martikainen, P., Davis, L., English, H. F. & Isaacs, J. T., Dec 1 1991, In: Cancer Surveys. 11, p. 265-277 13 p.

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

1990

Development of hormone refractory tumors: adaption versus clonal selection.

Schulze, H. & Isaacs, J. T., 1990, In: Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer. 118, p. 153-162 10 p.

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Overview of hormonal therapy for prostate cancer.

Carter, H. B. & Isaacs, J. T., 1990, In: Progress in clinical and biological research. 350, p. 129-140 12 p.

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

1989

Biological basis for chemohormonal therapy for prostatic cancer.

Isaacs, J. T. & Kyprianou, N., 1989, In: Cancer treatment and research. 46, p. 177-193 17 p.

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

1988

Experimental and theoretical basis for hormonal treatment of prostatic cancer.

Carter, H. B. & Isaacs, J. T., Nov 1988, In: Seminars in urology. 6, 4, p. 262-268 7 p.

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

NEUERE ASPEKTE ZUR PATHOGENESE UND THERAPIE DES PROSTATAKARZINOMS

Translated title of the contribution: Pathogenesis and therapy of prostatic cancer. Some new aspectsSchulze, H., Isaacs, J. T. & Senge, T., 1988, In: Urologe - Ausgabe A. 27, 2, p. 105-110 6 p.

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

1987