Jim Sylvester – Research output — Johns Hopkins University

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124 Article
13 Conference contribution
3 Editorial
2 Review article
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2021
Acetazolamide prevents hypoxia-induced reactive oxygen species generation and calcium release in pulmonary arterial smooth muscle
Shimoda, L. A., Suresh, K., Undem, C., Jiang, H., Yun, X., Sylvester, J. T. & Swenson, E. R., 2021, In: Pulmonary Circulation. 11, 4
Research output: Contribution to journal › Article › peer-review

Open Access
2013
Activation of hypoxia-inducible factor-1 in pulmonary arterial smooth muscle cells by endothelin-1
Pisarcik, S., Maylor, J., Lu, W., Yun, X., Undem, C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., 2013, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 304, 8, p. L549-L561
Research output: Contribution to journal › Article › peer-review

Open Access
51 Scopus citations
2012
Ca ²⁺ responses of pulmonary arterial myocytes to acute hypoxia require release from ryanodine and inositol trisphosphate receptors in sarcoplasmic reticulum
Wang, J., Shimoda, L. A. & Sylvester, J. T., Jul 15 2012, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 2, p. L161-L168
Research output: Contribution to journal › Article › peer-review

Open Access
15 Scopus citations
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
Abud, E. M., Maylor, J., Undem, C., Punjabi, A., Zaiman, A. L., Myers, A. C., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jan 24 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 4, p. 1239-1244 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
61 Scopus citations
Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1
Leggett, K., Maylor, J., Undem, C., Lai, N., Lu, W., Schweitzer, K., King, L. S., Myers, A. C., Sylvester, J. T., Sidhaye, V. & Shimoda, L. A., Aug 15 2012, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 303, 4, p. L343-L353
Research output: Contribution to journal › Article › peer-review
38 Scopus citations
Hypoxic pulmonary vasoconstriction
Sylvester, J. T., Shimoda, L. A., Aaronson, P. I. & Ward, J. P. T., Jan 2012, In: Physiological reviews. 92, 1, p. 367-520 154 p.
Research output: Contribution to journal › Article › peer-review
382 Scopus citations
In memoriam Dr Solbert Permutt, 1925-2012.
Mitzner, W. & Sylvester, J. T., Oct 2012, In: European Respiratory Journal. 40, 4, p. 811-813 3 p.
Research output: Contribution to journal › Article › peer-review
Kinase-dependent activation of voltage-gated Ca ²⁺ channels by ET-1 in pulmonary arterial myocytes during chronic hypoxia
Luke, T., Maylor, J., Undem, C., Sylvester, J. T. & Shimoda, L. A., May 15 2012, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 302, 10, p. L1128-L1139
Research output: Contribution to journal › Article › peer-review
14 Scopus citations
2011
Enhancement of myofilament calcium sensitivity by acute hypoxia in rat distal pulmonary arteries
Weigand, L., Shimoda, L. A. & Sylvester, J. T., Sep 2011, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 3, p. L380-L387
Research output: Contribution to journal › Article › peer-review

Open Access
10 Scopus citations
2009
Knockdown of stromal interaction molecule 1 attenuates store-operated Ca²⁺ entry and Ca²⁺ responses to acute hypoxia in pulmonary arterial smooth muscle
Lu, W., Wang, J., Peng, G., Shimoda, L. A. & Sylvester, J. T., Jul 2009, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 297, 1, p. L17-L25
Research output: Contribution to journal › Article › peer-review

Open Access
62 Scopus citations
2008
Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca²⁺ responses to hypoxia
Lu, W., Wang, J., Shimoda, L. A. & Sylvester, J. T., Jul 2008, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 1, p. L104-L113
Research output: Contribution to journal › Article › peer-review

Open Access
97 Scopus citations
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K ⁺ channel expression in pulmonary arterial myocytes
Whitman, E. M., Pisarcik, S., Luke, T., Fallon, M., Wang, J., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Feb 2008, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 2, p. L309-L318
Research output: Contribution to journal › Article › peer-review
81 Scopus citations
2007
Ca²⁺ signaling in hypoxic pulmonary vasoconstriction: Effects of myosin light chain and Rho kinase antagonists
Wang, J., Weigand, L., Foxson, J., Shimoda, L. A. & Sylvester, J. T., Sep 2007, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 293, 3, p. L674-L685
Research output: Contribution to journal › Article › peer-review
55 Scopus citations
Inhibition of hypoxia-induced calcium responses in pulmonary arterial smooth muscle by acetazolamide is independent of carbonic anhydrase inhibition
Shimoda, L. A., Luke, T., Sylvester, J. T., Shih, H. W., Jain, A. & Swenson, E. R., Apr 2007, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 292, 4, p. L1002-L1012
Research output: Contribution to journal › Article › peer-review
51 Scopus citations
2006
Hypoxia inducible factor 1 mediates hypoxia-induced TRPC expression and elevated intracellular Ca ²⁺ in pulmonary arterial smooth muscle cells
Wang, J., Weigand, L., Lu, W., Sylvester, J. T., Semenza, G. L. & Shimoda, L. A., Jun 2006, In: Circulation research. 98, 12, p. 1528-1537 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
262 Scopus citations
Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats
Weigand, L., Sylvester, J. T. & Shimoda, L. A., Feb 2006, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 2, p. L284-L290
Research output: Contribution to journal › Article › peer-review
75 Scopus citations
2005
Acute hypoxia increases intracellular [Ca²⁺] in pulmonary arterial smooth muscle by enhancing capacitative Ca²⁺ entry
Wang, J., Shimoda, L. A., Weigand, L., Wang, W., Sun, D. & Sylvester, J. T., Jun 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 6 32-6, p. L1059-L1069
Research output: Contribution to journal › Article › peer-review
122 Scopus citations
Chronic hypoxia inhibits K_v channel gene expression in rat distal pulmonary artery
Wang, J., Weigand, L., Wang, W., Sylvester, J. T. & Shimoda, L. A., Jun 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 288, 6 32-6, p. L1049-L1058
Research output: Contribution to journal › Article › peer-review
76 Scopus citations
Decreased exhaled nitric oxide in pulmonary arterial hypertension: Response to Bosentan therapy
Girgis, R. E., Champion, H. C., Diette, G. B., Johns, R. A., Permutt, S. & Sylvester, J. T., Aug 1 2005, In: American journal of respiratory and critical care medicine. 172, 3, p. 352-357 6 p.
Research output: Contribution to journal › Article › peer-review
99 Scopus citations
Effects of tidal volume and respiratory frequency on lung lymph flow
Pearse, D. B., Searcy, R. M., Mitzner, W., Permutt, S. & Sylvester, J. T., Aug 2005, In: Journal of applied physiology. 99, 2, p. 556-563 8 p.
Research output: Contribution to journal › Article › peer-review
20 Scopus citations
Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca²⁺ and nonselective cation channels
Weigand, L., Foxson, J., Wang, J., Shimoda, L. A. & Sylvester, J. T., Jul 2005, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 289, 1 33-1, p. L5-L13
Research output: Contribution to journal › Article › peer-review
91 Scopus citations
2004
Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle
Wang, J., Shimoda, L. A. & Sylvester, J. T., Apr 2004, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 4 30-4, p. L848-L858
Research output: Contribution to journal › Article › peer-review
167 Scopus citations
2003
Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries
Liu, J. Q., Sham, J. S. K., Shimoda, L. A., Kuppusamy, P. & Sylvester, J. T., Aug 1 2003, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 285, 2 29-2, p. L322-L333
Research output: Contribution to journal › Article › peer-review
98 Scopus citations
2002
Acute and chronic hypoxic pulmonary vasoconstriction: A central role for endothelin-1?
Shimoda, L. A., Sham, J. S. K., Liu, Q. & Sylvester, J. T., Aug 22 2002, In: Respiratory Physiology and Neurobiology. 132, 1, p. 93-106 14 p.
Research output: Contribution to journal › Article › peer-review
39 Scopus citations
An uncommon mimic of an acute asthma exacerbation
Zaas, D., Brock, M., Yang, S. & Sylvester, J. T., 2002, In: CHEST. 121, 5, p. 1707-1709 3 p.
Research output: Contribution to journal › Article › peer-review
12 Scopus citations
2001
Inhibition of voltage-gated K⁺ currents by endothelin-1 in human pulmonary arterial myocytes
Shimoda, L. A., Sylvester, J. T., Booth, G. M., Shimoda, T. H., Sonya, M., Undem, B. J. & Sham, J. S. K., 2001, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 5 25-5, p. L1115-L1122
Research output: Contribution to journal › Article › peer-review
54 Scopus citations
Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
Shimoda, L. A., Manalo, D. J., Sham, J. S. K., Semenza, G. L. & Sylvester, J. T., 2001, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 281, 1 25-1, p. L202-L208
Research output: Contribution to journal › Article › peer-review
166 Scopus citations
2000
Airway nitric oxide diffusion in asthma: Role in pulmonary function and bronchial responsiveness
Silkoff, P. E., Sylvester, J. T., Zamel, N. & Permutt, S., Jan 1 2000, In: American journal of respiratory and critical care medicine. 161, 4 I, p. 1218-1228 11 p.
Research output: Contribution to journal › Article › peer-review
217 Scopus citations
Altered pulmonary vasoreactivity in the chronically hypoxic lung
Shimoda, L. A., Sham, J. S. K. & Sylvester, J. T., 2000, In: Physiological Research. 49, 5, p. 549-560 12 p.
Research output: Contribution to journal › Article › peer-review
79 Scopus citations
Effects of hypoxia in porcine pulmonary arterial myocytes: Roles of K(v) channel and endothelin-1
Sham, J. S. K., Crenshaw, B. R., Deng, L. H., Shimoda, L. A. & Sylvester, J. T., 2000, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 2 23-2, p. L262-L272
Research output: Contribution to journal › Article › peer-review
68 Scopus citations
Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries
Leach, R. M., Sheehan, D. W., Chacko, V. P. & Sylvester, J. T., Feb 2000, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 278, 2 22-2, p. L294-L304
Research output: Contribution to journal › Article › peer-review
47 Scopus citations
L-type Ca²⁺ channels, resting [Ca²⁺](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes
Shimoda, L. A., Sham, J. S. K., Shimoda, T. H. & Sylvester, J. T., 2000, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 279, 5 23-5, p. L884-L894
Research output: Contribution to journal › Article › peer-review
121 Scopus citations
Mobilization of intracellular Ca²⁺ by endothelin-1 in rat intrapulmonary arterial smooth muscle cells
Shimoda, L. A., Sylvester, J. T. & Sham, J. S. K., Jan 2000, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 278, 1 22-1, p. L157-L164
Research output: Contribution to journal › Article › peer-review
55 Scopus citations
1999
Chronic hypoxia alters effects of endothelin and angiotensin on K⁺ currents in pulmonary arterial myocytes
Shimoda, L. A., Sylvester, J. T. & Sham, J. S. K., Sep 1999, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 277, 3 21-3, p. L431-L439
Research output: Contribution to journal › Article › peer-review
59 Scopus citations
Development of intrinsic tone in isolated pulmonary arterioles
Liu, Q. & Sylvester, J. T., May 1999, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 276, 5 20-5, p. L805-L813
Research output: Contribution to journal › Article › peer-review
8 Scopus citations
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R., Beaty, T., Sham, J. S. K., Wiener, C. M., Sylvester, J. T. & Semenza, G. L., Mar 1999, In: Journal of Clinical Investigation. 103, 5, p. 691-696 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
520 Scopus citations
1998
Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles
Leach, R. M., Sheehan, D. W., Chacko, V. P. & Sylvester, J. T., 1998, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 275, 6 19-6, p. L1051-L1060
Research output: Contribution to journal › Article › peer-review
24 Scopus citations
Effects of hypoxia on energy state and pH in resting pulmonary and femoral arterial smooth muscles -
Sylvester, J. T., 1998, In: American Journal of Physiology. 275, 6 PART 1, p. L1051-L1060
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
Inhibition of voltage-gated K⁺ current in rat intrapulmonary arterial myocytes by endothelin-1
Shimoda, L. A., Sylvester, J. T. & Sham, J. S. K., May 1998, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 274, 5 18-5, p. L842-L853
Research output: Contribution to journal › Article › peer-review
119 Scopus citations
Protective effects of intravascular pressure and nitric oxide in ischemic lung injury
Becker, P. M., Buchanan, W. & Sylvester, J. T., Mar 1998, In: Journal of applied physiology. 84, 3, p. 803-808 6 p.
Research output: Contribution to journal › Article › peer-review
19 Scopus citations
1997
Assessment of protein permeability in normal human systemic circulation
Shanholtz, C., White, P., Permutt, S., Sylvester, J. T. & Brower, R., 1997, In: American Journal of Physiology - Heart and Circulatory Physiology. 273, 3 42-3, p. H1049-H1057
Research output: Contribution to journal › Article › peer-review
Differential effects of hypoxia and 4-aminopyridine (4-AP) in intracellular [Ca²⁺] and cell-length in porcine distal and proximal pulmonary and femoral arterial smooth muscle cells (ASMCs)
Sham, J. S. K., Crenshaw, B. R. & Sylvester, J. T., Dec 1 1997, In: FASEB Journal. 11, 3, p. A342
Research output: Contribution to journal › Article › peer-review
Endothelin-1 (ET-1) causes inhibition of delayed rectifier K⁺ (K_DR) current and constriction in human pulmonary artery (PA)
Shimoda, L. A., Booth, G. M., Undem, B. J., Sylvester, J. T. & Sham, J. S. K., Dec 1 1997, In: FASEB Journal. 11, 3, p. A344
Research output: Contribution to journal › Article › peer-review
Nitric oxide (NO) stimulates Ca²⁺-activated K⁺ (K_Ca) channels and causes relaxation via cGMP-dependent pathways in human and rat pulmonary arteries
Deng, L. H., Crenshaw, B. R., Booth, G. M., Shimoda, L. A., Undem, B. J., Sylvester, J. T. & Sham, J. S. K., Dec 1 1997, In: FASEB Journal. 11, 3, p. A342
Research output: Contribution to journal › Article › peer-review
1996
Mobilization of intracellular Ca²⁺ by endothelin-1 in rat intrapulmonary arterial smooth muscle cells
Shimoda, L. A., Sylvester, J. T. & Sham, J. S. K., Dec 1 1996, In: FASEB Journal. 10, 3, p. A307
Research output: Contribution to journal › Article › peer-review
Vascular injury in isolated sheep lungs: Role of ischemia, extracorporeal perfusion, and oxygen
Pearse, D. B. & Sylvester, J. T., 1996, In: American journal of respiratory and critical care medicine. 153, 1, p. 196-202 7 p.
Research output: Contribution to journal › Article › peer-review
17 Scopus citations
1995
Mechanisms of hypoxic vasodilation in ferret pulmonary arteries
Wiener, C. M., Banta, M. R., Dowless, M. S., Flavahan, N. A. & Sylvester, J. T., Oct 13 1995, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 269, 3 13-3, p. L351-L357
Research output: Contribution to journal › Article › peer-review
19 Scopus citations
1994
A comparative study of EPR spin trapping and cytochrome c reduction techniques for the measurement of superoxide anions
Sanders, S. P., Harrison, S. J., Kuppusamy, P., Sylvester, J. T. & Zweier, J. L., Jun 1994, In: Free Radical Biology and Medicine. 16, 6, p. 753-761 9 p.
Research output: Contribution to journal › Article › peer-review
46 Scopus citations
Effect of hypoxia on lung fluid balance in ferrets
White, P., Sylvester, J. T., Humphrey, R. L., Permutt, T., Permutt, S. & Brower, R. G., May 1994, In: American journal of respiratory and critical care medicine. 149, 5, p. 1112-1117 6 p.
Research output: Contribution to journal › Article › peer-review
3 Scopus citations
1993
Developmental differences in catalase activity and hypoxic-hyperoxic effects on fluid balance in isolated lamb lungs
Bonuccelli, C. M., Permutt, S. & Sylvester, J. T., May 1993, In: Pediatric research. 33, 5, p. 519-526 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
4 Scopus citations