Jennifer Durham

2023

A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma

Heumann, T., Judkins, C., Li, K., Lim, S. J., Hoare, J., Parkinson, R., Cao, H., Zhang, T., Gai, J., Celiker, B., Zhu, Q., McPhaul, T., Durham, J., Purtell, K., Klein, R., Laheru, D., De Jesus-Acosta, A., Le, D. T., Narang, A., Anders, R., & 9 othersBurkhart, R., Burns, W., Soares, K., Wolfgang, C., Thompson, E., Jaffee, E., Wang, H., He, J. & Zheng, L., Dec 2023, In: Nature communications. 14, 1, 3650.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A randomized, phase II trial of oral azacitidine (CC-486) in patients with resected pancreatic adenocarcinoma at high risk for recurrence

Heumann, T. R., Baretti, M., Sugar, E. A., Durham, J. N., Linden, S., Lopez-Vidal, T. Y., Leatherman, J., Cope, L., Sharma, A., Weekes, C. D., O’Dwyer, P. J., Reiss, K. A., Monga, D. K., Ahuja, N. & Azad, N. S., Dec 2022, In: Clinical Epigenetics. 14, 1, 166.

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy

Li, K., Tandurella, J. A., Gai, J., Zhu, Q., Lim, S. J., Thomas, D. L., Xia, T., Mo, G., Mitchell, J. T., Montagne, J., Lyman, M., Danilova, L. V., Zimmerman, J. W., Kinny-Köster, B., Zhang, T., Chen, L., Blair, A. B., Heumann, T., Parkinson, R., Durham, J. N., & 11 othersNarang, A. K., Anders, R. A., Wolfgang, C. L., Laheru, D. A., He, J., Osipov, A., Thompson, E. D., Wang, H., Fertig, E. J., Jaffee, E. M. & Zheng, L., Nov 14 2022, In: Cancer cell. 40, 11, p. 1374-1391.e7

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Neoadjuvant cabozantinib and nivolumab convert locally advanced hepatocellular carcinoma into resectable disease with enhanced antitumor immunity

Ho, W. J., Zhu, Q., Durham, J., Popovic, A., Xavier, S., Leatherman, J., Mohan, A., Mo, G., Zhang, S., Gross, N., Charmsaz, S., Lin, D., Quong, D., Wilt, B., Kamel, I., Weiss, M. J., Philosophe, B., Burkhart, R., Burns, W. R., Shubert, C., & 11 othersEjaz, A., He, J., Deshpande, A., Danilova, L., Stein-O’Brien, G., Sugar, E. A., Laheru, D. A., Anders, R. A., Fertig, E. J., Jaffee, E. M. & Yarchoan, M., Sep 2021, In: Nature Cancer. 2, 9, p. 891-903 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity

Chow, A., Schad, S., Green, M. D., Hellmann, M. D., Allaj, V., Ceglia, N., Zago, G., Shah, N. S., Sharma, S. K., Mattar, M., Chan, J., Rizvi, H., Zhong, H., Liu, C., Bykov, Y., Zamarin, D., Shi, H., Budhu, S., Wohlhieter, C., Uddin, F., & 21 othersGupta, A., Khodos, I., Waninger, J. J., Qin, A., Markowitz, G. J., Mittal, V., Balachandran, V., Durham, J. N., Le, D. T., Zou, W., Shah, S. P., McPherson, A., Panageas, K., Lewis, J. S., Perry, J. S. A., de Stanchina, E., Sen, T., Poirier, J. T., Wolchok, J. D., Rudin, C. M. & Merghoub, T., Jul 12 2021, In: Cancer cell. 39, 7, p. 973-988.e9

Research output: Contribution to journal › Article › peer-review

Open Access

Vaccine-induced intratumoral lymphoid aggregates correlate with survival following treatment with a neoadjuvant and adjuvant vaccine in patients with resectable pancreatic adenocarcinoma

Zheng, L., Ding, D., Edil, B. H., Judkins, C., Durham, J. N., Thomas, D. L., Bever, K. M., Mo, G., Solt, S. E., Hoare, J. A., Bhattacharya, R., Zhu, Q., Osipov, A., Onner, B., Purtell, K. A., Cai, H., Parkinson, R., Hacker-Prietz, A., Herman, J. M., Le, D. T., & 17 othersAzad, N. S., de Jesus-Acosta, A. M. C., Blair, A. B., Kim, V., Soares, K. C., Manos, L., Cameron, J. L., Makary, M. A., Weiss, M. J., Schulick, R. D., He, J., Wolfgang, C. L., Thompson, E. D., Anders, R. A., Sugar, E., Jaffee, E. M. & Laheru, D. A., Mar 1 2021, In: Clinical Cancer Research. 27, 5, p. 1278-1286 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2020

An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma

Bever, K. M., Borazanci, E. H., Thompson, E. A., Durham, J. N., Pinero, K., Jameson, G. S., Vrana, A., Liu, M., Wilt, C., Wu, A. A., Fu, W., Wang, H., Yin, Y., Leal, J. P., de Jesus-Acosta, A., Zheng, L., Laheru, D. A., von Hoff, D. D., Jaffee, E. M., Powell, J. D., & 1 othersLe, D. T., May 26 2020, In: Oncotarget. 11, 21, p. 1929-1941 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer

Yarchoan, M., Huang, C. Y., Zhu, Q., Ferguson, A. K., Durham, J. N., Anders, R. A., Thompson, E. D., Rozich, N. S., Thomas, D. L., Nauroth, J. M., Rodriguez, C., Osipov, A., De Jesus-Acosta, A., Le, D. T., Murphy, A. G., Laheru, D., Donehower, R. C., Jaffee, E. M., Zheng, L. & Azad, N. S., Feb 1 2020, In: Cancer medicine. 9, 4, p. 1485-1494 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

A Phase II Study of Allogeneic GM-CSF–Transfected Pancreatic Tumor Vaccine (GVAX) with Ipilimumab as Maintenance Treatment for Metastatic Pancreatic Cancer

Wu, A. A., Bever, K. M., Ho, W. J., Fertig, E. J., Niu, N., Zheng, L., Parkinson, R. M., Durham, J. N., Onners, B., Ferguson, A. K., Wilt, C., Ko, A. H., Wang-Gillam, A., Laheru, D. A., Anders, R. A., Thompson, E. D., Sugar, E. A., Jaffee, E. M. & Le, D. T., Oct 1 2020, In: Clinical Cancer Research. 26, 19, p. 5129-5139 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer

Tsujikawa, T., Crocenzi, T., Durham, J. N., Sugar, E. A., Wu, A. A., Onners, B., Nauroth, J. M., Anders, R. A., Fertig, E. J., Laheru, D. A., Reiss, K., Vonderheide, R. H., Ko, A. H., Tempero, M. A., Fisher, G. A., Considine, M., Danilova, L., Brockstedt, D. G., Coussens, L. M., Jaffee, E. M., & 1 othersLe, D. T., Jul 15 2020, In: Clinical Cancer Research. 26, 14, p. 3578-3588 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Integrated immunological analysis of a successful conversion of locally advanced hepatocellular carcinoma to resectability with neoadjuvant therapy

Ho, W. J., Sharma, G., Zhu, Q., Stein-O'brien, G., Durham, J., Anders, R., Popovic, A., Mo, G., Kamel, I., Weiss, M., Jaffee, E., Fertig, E. J. & Yarchoan, M., Nov 20 2020, In: Journal for immunotherapy of cancer. 8, 2, e000932.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

T-cell infiltration and adaptive treg resistance in response to androgen deprivation with or without vaccination in localized prostate cancer

Obradovic, A. Z., Dallos, M. C., Zahurak, M. L., Partin, A. W., Schaeffer, E. M., Ross, A. E., Allaf, M. E., Nirschl, T. R., Liu, D., Chapman, C. G., O'Neal, T., Cao, H., Durham, J. N., Guner, G., Baena-Del Valle, J. A., Ertunc, O., de Marzo, A. M., Antonarakis, E. S. & Drake, C. G., Jul 2020, In: Clinical Cancer Research. 26, 13, p. 3182-3192 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2019

A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors

Gaillard, S. L., Zahurak, M., Sharma, A., Durham, J. N., Reiss, K. A., Sartorius-Mergenthaler, S., Downs, M., Anders, N. M., Ahuja, N., Rudek, M. A. & Azad, N., Aug 15 2019, In: Cancer. 125, 16, p. 2837-2845 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (Journal for Immuno Therapy of Cancer (2019) 7 (40) DOI: 10.1186/s40425-018-0492-x)

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L., & 21 othersCope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Mar 6 2019, In: Journal for immunotherapy of cancer. 7, 1, 7.

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response

Mandal, R., Samstein, R. M., Lee, K. W., Havel, J. J., Wang, H., Krishna, C., Sabio, E. Y., Makarov, V., Kuo, F., Blecua, P., Ramaswamy, A. T., Durham, J. N., Bartlett, B., Ma, X., Srivastava, R., Middha, S., Zehir, A., Hechtman, J. F., Morris, L. G., Weinhold, N., & 4 othersRiaz, N., Le, D. T., Diaz, L. A. & Chan, T. A., 2019, In: Science. 364, 6439, p. 485-491 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

154 Scopus citations

Immunopathologic stratification of colorectal cancer for checkpoint blockade immunotherapy

Llosa, N. J., Luber, B., Siegel, N., Awan, A. H., Oke, T., Zhu, Q., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Jaffee, E. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., Pardoll, D. M., Wang, H., Housseau, F. & Anders, R. A., 2019, In: Cancer Immunology Research. 7, 10, p. 1574-1579 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Intratumoral adaptive immunosuppression and type 17 immunity in mismatch repair proficient colorectal tumors

Llosa, N. J., Luber, B., Tam, A. J., Smith, K. N., Siegel, N., Awan, A. H., Fan, H., Oke, T., Zhang, J., Domingue, J., Engle, E. L., Roberts, C. A., Bartlett, B. R., Aulakh, L. K., Thompson, E. D., Taube, J. M., Durham, J. N., Sears, C. L., Le, D. T., Diaz, L. A., & 4 othersPardoll, D. M., Wang, H., Anders, R. A. & Housseau, F., Sep 1 2019, In: Clinical Cancer Research. 25, 17, p. 5250-5259 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Lesion-level response dynamics to programmed cell death protein (PD-1) blockade

Osorio, J. C., Arbour, K. C., Le, D. T., Durham, J. N., Plodkowski, A. J., Halpenny, D. F., Ginsberg, M. S., Sawan, P., Crompton, J. G., Yu, H. A., Namakydoust, A., Nabet, B. Y., Chaft, J. E., Riely, G. J., Rizvi, H., Diaz, L. A. & Hellmann, M. D., 2019, In: Journal of Clinical Oncology. 37, 36, p. 3546-3555 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Noninvasive detection of microsatellite instabilit and high tumor mutation burden in cancer patients treated with PD-1 blockade

Georgiadis, A., Durham, J. N., Keefer, L. A., Bartlett, B. R., Zielonka, M., Murphy, D., White, J. R., Lu, S., Verner, E. L., Ruan, F., Riley, D., Anders, R. A., Gedvilaite, E., Angiuoli, S., Jones, S., Velculescu, V. E., Le, D. T., Diaz, L. A. & Sausen, M., Dec 1 2019, In: Clinical Cancer Research. 25, 23, p. 7024-7034 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Smith, K. N., Llosa, N. J., Cottrell, T. R., Siegel, N., Fan, H., Suri, P., Chan, H. Y., Guo, H., Oke, T., Awan, A. H., Verde, F., Danilova, L., Anagnostou, V., Tam, A. J., Luber, B. S., Bartlett, B. R., Aulakh, L. K., Sidhom, J. W., Zhu, Q., Sears, C. L., & 21 othersCope, L., Sharfman, W. H., Thompson, E. D., Riemer, J., Marrone, K. A., Naidoo, J., Velculescu, V. E., Forde, P. M., Vogelstein, B., Kinzler, K. W., Papadopoulos, N., Durham, J. N., Wang, H., Le, D. T., Justesen, S., Taube, J. M., Diaz, L. A., Brahmer, J. R., Pardoll, D. M., Anders, R. A. & Housseau, F., Feb 11 2019, In: Journal for immunotherapy of cancer. 7, 1, 40.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2018

T cell receptor repertoire features associated with survival in immunotherapy-treated pancreatic ductal adenocarcinoma

Hopkins, A. C., Yarchoan, M., Durham, J. N., Yusko, E. C., Rytlewski, J. A., Robins, H. S., Laheru, D. A., Le, D. T., Lutz, E. R. & Jaffee, E. M., Jul 12 2018, In: JCI Insight. 3, 13

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

2017

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

Le, D. T., Durham, J. N., Smith, K. N., Wang, H., Bartlett, B. R., Aulakh, L. K., Lu, S., Kemberling, H., Wilt, C., Luber, B. S., Wong, F., Azad, N. S., Rucki, A. A., Laheru, D., Donehower, R., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Greten, T. F., & 26 othersDuffy, A. G., Ciombor, K. K., Eyring, A. D., Lam, B. H., Joe, A., Kang, S. P., Holdhoff, M., Danilova, L., Cope, L., Meyer, C., Zhou, S., Goldberg, R. M., Armstrong, D. K., Bever, K. M., Fader, A. N., Taube, J., Housseau, F., Spetzler, D., Xiao, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Eshleman, J. R., Vogelstein, B., Anders, R. A. & Diaz, L. A., Jul 28 2017, In: Science. 357, 6349, p. 409-413 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2392 Scopus citations

2015

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

De Remigis, A., De Gruijl, T. D., Uram, J. N., Tzou, S. C., Iwama, S., Talor, M. V., Armstrong, T. D., Santegoets, S. J. A. M., Slovin, S. F., Zheng, L., Laheru, D. A., Jaffee, E. M., Gerritsen, W. R., Van Den Eertwegh, A. J. M., Le, D. T. & Caturegli, P., Jan 1 2015, In: International Journal of Cancer. 136, 1, p. 127-137 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

PD-1 blockade in tumors with mismatch-repair deficiency

Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., Biedrzycki, B., Donehower, R. C., Zaheer, A., Fisher, G. A., Crocenzi, T. S., Lee, J. J., Duffy, S. M., Goldberg, R. M., De La Chapelle, A., Koshiji, M., & 15 othersBhaijee, F., Huebner, T., Hruban, R. H., Wood, L. D., Cuka, N., Pardoll, D. M., Papadopoulos, N., Kinzler, K. W., Zhou, S., Cornish, T. C., Taube, J. M., Anders, R. A., Eshleman, J. R., Vogelstein, B. & Diaz, L. A., Jun 25 2015, In: New England Journal of Medicine. 372, 26, p. 2509-2520 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4570 Scopus citations

Safety and survival with GVAX pancreas prime and Listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer

Le, D. T., Wang-Gillam, A., Picozzi, V., Greten, T. F., Crocenzi, T., Springett, G., Morse, M., Zeh, H., Cohen, D., Fine, R. L., Onners, B., Uram, J. N., Laheru, D. A., Lutz, E. R., Solt, S., Murphy, A. L., Skoble, J., Lemmens, E., Grous, J., Dubensky, T., & 2 othersBrockstedt, D. G. & Jaffee, E. M., Apr 20 2015, In: Journal of Clinical Oncology. 33, 12, p. 1325-1333 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

323 Scopus citations

2014

A feasibility study of cyclophosphamide, trastuzumab, and an allogeneic GM-CSF-secreting breast tumor vaccine for HER2+ metastatic breast cancer

Chen, G., Gupta, R., Petrik, S., Laiko, M., Leatherman, J. M., Asquith, J. M., Daphtary, M. M., Garrett-Mayer, E., Davidson, N. E., Hirt, K., Berg, M., Uram, J. N., Dauses, T., Fetting, J. H., Duus, E. M., Atay-Rosenthal, S., Ye, X., Wolff, A. C., Stearns, V., Jaffee, E. M., & 1 othersEmens, L., Oct 1 2014, In: Cancer Immunology Research. 2, 10, p. 949-961 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

A Safety and Feasibility Study of an Allogeneic Colon Cancer Cell Vaccine Administered with a Granulocyte–Macrophage Colony Stimulating Factor–Producing Bystander Cell Line in Patients with Metastatic Colorectal Cancer

Zheng, L., Edil, B. H., Soares, K. C., El-Shami, K., Uram, J. N., Judkins, C., Zhang, Z., Onners, B., Laheru, D., Pardoll, D., Jaffee, E. M. & Schulick, R. D., Oct 8 2014, In: Annals of surgical oncology. 21, 12, p. 3931-3937 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access