jeff Rothstein

2024

Nuclear pore dysfunction and disease: a complex opportunity

Fare, C. M. & Rothstein, J. D., 2024, In: Nucleus. 15, 1, 2314297.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review

Shefner, J. M., Bedlack, R., Andrews, J. A., Berry, J. D., Bowser, R., Brown, R., Glass, J. D., Maragakis, N. J., Miller, T. M., Rothstein, J. D. & Cudkowicz, M. E., Dec 12 2022, In: JAMA Neurology. 79, 12, p. 1312-1318 7 p.

Research output: Contribution to journal › Review article › peer-review

Nuclear pore complexes — a doorway to neural injury in neurodegeneration

Coyne, A. N. & Rothstein, J. D., Jun 2022, In: Nature Reviews Neurology. 18, 6, p. 348-362 15 p.

Research output: Contribution to journal › Review article › peer-review

Nuclear Pore Dysfunction in Neurodegeneration

Spead, O., Zaepfel, B. L. & Rothstein, J. D., Jul 2022, In: Neurotherapeutics. 19, 4, p. 1050-1060 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2021

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W. T., Cohen-Salmon, M. & Cunningham, C. & 61 others, Deneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J. E., Goldman, S. A., Götz, M., Gutiérrez, A., Haydon, P. G., Heiland, D. H., Hol, E. M., Holt, M. G., Iino, M., Kastanenka, K. V., Kettenmann, H., Khakh, B. S., Koizumi, S., Lee, C. J., Liddelow, S. A., MacVicar, B. A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A. V., Murai, K. K., Norris, C. M., Okada, S., Oliet, S. H. R., Oliveira, J. F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B. G., Pfrieger, F. W., Poskanzer, K. E., Quintana, F. J., Ransohoff, R. M., Riquelme-Perez, M., Robel, S., Rose, C. R., Rothstein, J. D., Rouach, N., Rowitch, D. H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R. A., Vitorica, J., Wanner, I. B., Wood, L. B., Wu, J., Zheng, B., Zimmer, E. R., Zorec, R., Sofroniew, M. V. & Verkhratsky, A., Mar 2021, In: Nature neuroscience. 24, 3, p. 312-325 14 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

28 Scopus citations

RNA Is a Double-Edged Sword in ALS Pathogenesis

Zaepfel, B. L. & Rothstein, J. D., Jul 19 2021, In: Frontiers in Cellular Neuroscience. 15, 708181.

Research output: Contribution to journal › Review article › peer-review

Open Access

2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C. & Schürer, S. C. & 87 others, Vasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J. E., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L. M., Gray, J. W., Korkola, J. E., Mills, G. B., LaBarge, M., Feiler, H. S., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 24 2018, In: Cell Systems. 6, 1, p. 13-24 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

127 Scopus citations

2017

Oligodendroglia: Metabolic supporters of neurons

Philips, T. & Rothstein, J. D., Sep 1 2017, In: Journal of Clinical Investigation. 127, 9, p. 3271-3280 10 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

91 Scopus citations

2016

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

Haeusler, A. R., Donnelly, C. J. & Rothstein, J. D., Jun 1 2016, In: Nature Reviews Neuroscience. 17, 6, p. 383-395 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

109 Scopus citations

2015

ALSUntangled: Introducing the table of evidence

ALSUntangled Group, Mar 1 2015, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 142-145 4 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

7 Scopus citations

2014

Advances in treating amyotrophic lateral sclerosis: Insights from pathophysiological studies

Vucic, S., Rothstein, J. D. & Kiernan, M. C., Aug 2014, In: Trends in neurosciences. 37, 8, p. 433-442 10 p.

Research output: Contribution to journal › Review article › peer-review

140 Scopus citations

Glial cells in amyotrophic lateral sclerosis

Philips, T. & Rothstein, J. D., Dec 1 2014, In: Experimental Neurology. 262, Part B, p. 111-120 10 p.

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; An observational myopathology study

Al-Sarraj, S., King, A., Cleveland, M., Pradat, P. F., Corse, A., Rothstein, J. D., Leigh, P. N., Abila, B., Bates, S., Wurthner, J. & Meininger, V., Jan 27 2014, In: Acta Neuropathologica Communications. 2, 1, 165.

Research output: Contribution to journal › Review article › peer-review

Open Access

17 Scopus citations

2013

ALS untangled no. 20: The Deanna protocol

Fournier, C., Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S. & Rowland, L. P. & 69 others, Pioro, E., Kinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Maragakis, N., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J., Pastula, D., Levitsky, G., Ogino, M., Rosenfeld, J., Carmi, E., Oster, C., Barkhaus, P. & Valor, E., May 2013, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, 4, p. 319-323 5 p.

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Oligodendroglia: Metabolic supporters of axons

Morrison, B. M., Lee, Y. & Rothstein, J. D., Dec 2013, In: Trends in Cell Biology. 23, 12, p. 644-651 8 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

138 Scopus citations

The blood-brain barrier: An engineering perspective

Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E. & Searson, P. C., Aug 30 2013, In: Frontiers in Neuroengineering. JUL

Research output: Contribution to journal › Review article › peer-review

Open Access

244 Scopus citations

2012

ALS untangled no. 17: "When ALS Is Lyme"

Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S., Rowland, L. P. & Pioro, E. & 61 others, Kinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Marigakis, N., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J. & Pastula, D., Sep 2012, In: Amyotrophic Lateral Sclerosis. 13, 5, p. 487-491 5 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

5 Scopus citations

2009

Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

Rothstein, J. D., Jan 1 2009, In: Annals of neurology. 65, SUPPL. 1, p. S3-S9

Research output: Contribution to journal › Review article › peer-review

527 Scopus citations

2006

Mechanisms of Disease: Astrocytes in neurodegenerative disease

Maragakis, N. J. & Rothstein, J. D., Dec 2006, In: Nature Clinical Practice Neurology. 2, 12, p. 679-689 11 p.

Research output: Contribution to journal › Review article › peer-review

595 Scopus citations

2004

Glutamate transporters: Animal models to neurologic disease

Maragakis, N. J. & Rothstein, J. D., Apr 2004, In: Neurobiology of Disease. 15, 3, p. 461-473 13 p.

Research output: Contribution to journal › Review article › peer-review

281 Scopus citations

Preclinical studies: How much can we rely on?

Rothstein, J. D., Sep 2004, In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5, SUPPL. 1, p. 22-25 4 p.

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

2003

Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice

Maragakis, N. J., Jackson, M., Ganel, R. & Rothstein, J. D., Feb 27 2003, In: Neuroscience Letters. 338, 2, p. 107-110 4 p.

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

2002

Amyotrophic lateral sclerosis: Evaluation and treatment of respiratory impairment

Lechtzin, N., Rothstein, J., Clawson, L., Diette, G. B. & Wiener, C. M., 2002, In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, 1, p. 5-13 9 p.

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Models of amyotrophic lateral sclerosis.

Jackson, M., Ganel, R. & Rothstein, J. D., Nov 2002, In: Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. Chapter 9, p. Unit 9.13

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Therapeutic developments in the treatment of amyotrophic lateral sclerosis

Jackson, M., Lladó, J. & Rothstein, J. D., Oct 1 2002, In: Expert Opinion on Investigational Drugs. 11, 10, p. 1343-1364 22 p.

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

2001

Glutamate transporters in neurologic disease

Maragakis, N. J. & Rothstein, J. D., 2001, In: Archives of neurology. 58, 3, p. 365-370 6 p.

Research output: Contribution to journal › Review article › peer-review

251 Scopus citations

1996

Excitotoxicity hypothesis

Rothstein, J. D., Oct 1996, In: Neurology. 47, 4 SUPPL., p. S19-S26

Research output: Contribution to journal › Review article › peer-review

170 Scopus citations

1995

Amyotrophic lateral sclerosis. An autoimmune disease?

Drachman, D. B., Fishman, P. S., Rothstein, J. D., Motomura, M., Lang, B., Vincent, A. & Mellits, E. D., 1995, In: Advances in neurology. 68, p. 59-65 7 p.

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

Rothstein, J. D., 1995, In: Advances in neurology. 68, p. 7-20; discussion 21-27

Research output: Contribution to journal › Review article › peer-review

168 Scopus citations

1989

Neurologic manifestations of hepatic disease

Rothstein, J. D. & Herlong, H. F., 1989, In: Neurologic clinics. 7, 3, p. 563-578 16 p.

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

jeff Rothstein

Research output

Search results