jeff Rothstein

Research output

Research output per year 1979 1997 1998 2001 2002 2003 2004 2006 2007 2011 2012 2013 2014 2016 2017 2020 2021 2022 2024

• 295 Article
• 29 Review article
• 13 Comment/debate
• 8 Short survey
• 17 More
  • 6 Chapter
  • 6 Letter
  • 4 Editorial
  • 1 Conference contribution

Research output per year

Research output per year

Search results

• 2022

  Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review

  Shefner, J. M., Bedlack, R., Andrews, J. A., Berry, J. D., Bowser, R., Brown, R., Glass, J. D., Maragakis, N. J., Miller, T. M., Rothstein, J. D. & Cudkowicz, M. E., Dec 12 2022, In: JAMA Neurology. 79, 12, p. 1312-1318 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Health Care Outcome Assessment 61%
  • Clinical Trials 60%
  • Biomarkers 60%
  • Drug Approval 40%

• Nuclear pore complexes — a doorway to neural injury in neurodegeneration

  Coyne, A. N. & Rothstein, J. D., Jun 2022, In: Nature Reviews Neurology. 18, 6, p. 348-362 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Nuclear Pore 100%
  • Nuclear Pore Complex Proteins 78%
  • Neurodegenerative Diseases 64%
  • Cell Nucleus Active Transport 50%
  • Wounds and Injuries 36%

• Nuclear Pore Dysfunction in Neurodegeneration

  Spead, O., Zaepfel, B. L. & Rothstein, J. D., Jul 2022, In: Neurotherapeutics. 19, 4, p. 1050-1060 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Nuclear Pore 100%
  • Cell Nucleus Active Transport 14%
  • Huntington Disease 13%
  • Amyotrophic Lateral Sclerosis 13%
  • Neurodegenerative Diseases 10%
• 2021

  Reactive astrocyte nomenclature, definitions, and future directions

  Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., Allen, N. J., Araque, A., Barbeito, L., Barzilai, A., Bergles, D. E., Bonvento, G., Butt, A. M., Chen, W. T., Cohen-Salmon, M., Cunningham, C., & 61 othersDeneen, B., De Strooper, B., Díaz-Castro, B., Farina, C., Freeman, M., Gallo, V., Goldman, J. E., Goldman, S. A., Götz, M., Gutiérrez, A., Haydon, P. G., Heiland, D. H., Hol, E. M., Holt, M. G., Iino, M., Kastanenka, K. V., Kettenmann, H., Khakh, B. S., Koizumi, S., Lee, C. J., Liddelow, S. A., MacVicar, B. A., Magistretti, P., Messing, A., Mishra, A., Molofsky, A. V., Murai, K. K., Norris, C. M., Okada, S., Oliet, S. H. R., Oliveira, J. F., Panatier, A., Parpura, V., Pekna, M., Pekny, M., Pellerin, L., Perea, G., Pérez-Nievas, B. G., Pfrieger, F. W., Poskanzer, K. E., Quintana, F. J., Ransohoff, R. M., Riquelme-Perez, M., Robel, S., Rose, C. R., Rothstein, J. D., Rouach, N., Rowitch, D. H., Semyanov, A., Sirko, S., Sontheimer, H., Swanson, R. A., Vitorica, J., Wanner, I. B., Wood, L. B., Wu, J., Zheng, B., Zimmer, E. R., Zorec, R., Sofroniew, M. V. & Verkhratsky, A., Mar 2021, In: Nature neuroscience. 24, 3, p. 312-325 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Terminology 100%
  • Astrocytes 91%
  • Direction compound 71%
  • Central Nervous System Infections 13%
  • Central Nervous System Diseases 12%
  28 Scopus citations

• RNA Is a Double-Edged Sword in ALS Pathogenesis

  Zaepfel, B. L. & Rothstein, J. D., Jul 19 2021, In: Frontiers in Cellular Neuroscience. 15, 708181.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • RNA 64%
  • RNA-Binding Proteins 21%
  • Motor Neurons 18%
  • Frontotemporal Dementia With Motor Neuron Disease 14%
• 2018

  The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

  Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., Kuleshov, M. V., Ma'ayan, A., Stathias, V., Terryn, R., Cooper, D., Forlin, M., Koleti, A., Vidovic, D., Chung, C., Schürer, S. C., & 87 othersVasiliauskas, J., Pilarczyk, M., Shamsaei, B., Fazel, M., Ren, Y., Niu, W., Clark, N. A., White, S., Mahi, N., Zhang, L., Kouril, M., Reichard, J. F., Sivaganesan, S., Medvedovic, M., Meller, J., Koch, R. J., Birtwistle, M. R., Iyengar, R., Sobie, E. A., Azeloglu, E. U., Kaye, J., Osterloh, J., Haston, K., Kalra, J., Finkbiener, S., Li, J., Milani, P., Adam, M., Escalante-Chong, R., Sachs, K., Lenail, A., Ramamoorthy, D., Fraenkel, E., Daigle, G., Hussain, U., Coye, A., Rothstein, J., Sareen, D., Ornelas, L., Banuelos, M., Mandefro, B., Ho, R., Svendsen, C. N., Lim, R. G., Stocksdale, J., Casale, M. S., Thompson, T. G., Wu, J., Thompson, L. M., Dardov, V., Venkatraman, V., Matlock, A., Van Eyk, J., Jaffe, J. D., Papanastasiou, M., Subramanian, A., Golub, T. R., Erickson, S. D., Fallahi-Sichani, M., Hafner, M., Gray, N. S., Lin, J. R., Mills, C. E., Muhlich, J. L., Niepel, M., Shamu, C. E., Williams, E. H., Wrobel, D., Sorger, P. K., Heiser, L. M., Gray, J. W., Korkola, J. E., Mills, G. B., LaBarge, M., Feiler, H. S., Dane, M. A., Bucher, E., Nederlof, M., Sudar, D., Gross, S., Kilburn, D. F., Smith, R., Devlin, K., Margolis, R., Derr, L., Lee, A. & Pillai, A., Jan 24 2018, In: Cell Systems. 6, 1, p. 13-24 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Cataloging 100%
  • Libraries 57%
  • Heart Diseases 21%
  • Catalogs 16%
  • Molecular Imaging 15%
  127 Scopus citations
• 2017

  Oligodendroglia: Metabolic supporters of neurons

  Philips, T. & Rothstein, J. D., Sep 1 2017, In: Journal of Clinical Investigation. 127, 9, p. 3271-3280 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Oligodendroglia 100%
  • Neurons 55%
  • Oligodendrocyte Precursor Cells 24%
  • Energy Transfer 23%
  • Pyruvic Acid 19%
  91 Scopus citations
• 2016

  The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

  Haeusler, A. R., Donnelly, C. J. & Rothstein, J. D., Jun 1 2016, In: Nature Reviews Neuroscience. 17, 6, p. 383-395 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Chromosomes, Human, Pair 9 100%
  • Open Reading Frames 72%
  • Neurodegenerative Diseases 65%
  • Nucleotides 60%
  • Frontotemporal Dementia With Motor Neuron Disease 29%
  109 Scopus citations
• 2015

  ALSUntangled: Introducing the table of evidence

  ALSUntangled Group, Mar 1 2015, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16, 1-2, p. 142-145 4 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  7 Scopus citations
• 2014

  Advances in treating amyotrophic lateral sclerosis: Insights from pathophysiological studies

  Vucic, S., Rothstein, J. D. & Kiernan, M. C., Aug 2014, In: Trends in neurosciences. 37, 8, p. 433-442 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Amyotrophic lateral sclerosis 1 49%
  • RNA 25%
  • Chromosomes, Human, Pair 9 24%
  • Genes 22%
  140 Scopus citations

• Glial cells in amyotrophic lateral sclerosis

  Philips, T. & Rothstein, J. D., Dec 1 2014, In: Experimental Neurology. 262, Part B, p. 111-120 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Neuroglia 82%
  • Oligodendroglia 68%
  • Microglia 63%
  • Astrocytes 57%
  115 Scopus citations

• Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; An observational myopathology study

  Al-Sarraj, S., King, A., Cleveland, M., Pradat, P. F., Corse, A., Rothstein, J. D., Leigh, P. N., Abila, B., Bates, S., Wurthner, J. & Meininger, V., Jan 27 2014, In: Acta Neuropathologica Communications. 2, 1, 165.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Amyotrophic Lateral Sclerosis 100%
  • Skeletal Muscle 73%
  • Observational Studies 72%
  • Inflammation 54%
  • Muscles 40%
  17 Scopus citations
• 2013

  ALS untangled no. 20: The Deanna protocol

  Fournier, C., Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S., Rowland, L. P., & 69 othersPioro, E., Kinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Maragakis, N., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J., Pastula, D., Levitsky, G., Ogino, M., Rosenfeld, J., Carmi, E., Oster, C., Barkhaus, P. & Valor, E., May 2013, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, 4, p. 319-323 5 p.

  Research output: Contribution to journal › Review article › peer-review
  12 Scopus citations

• Oligodendroglia: Metabolic supporters of axons

  Morrison, B. M., Lee, Y. & Rothstein, J. D., Dec 2013, In: Trends in Cell Biology. 23, 12, p. 644-651 8 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Oligodendroglia 100%
  • Axons 79%
  • Nervous System 36%
  • Energy Transfer 19%
  • Neurons 18%
  138 Scopus citations

• The blood-brain barrier: An engineering perspective

  Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E. & Searson, P. C., Aug 30 2013, In: Frontiers in Neuroengineering. JUL

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Blood-Brain Barrier 100%
  • Neurology 44%
  • Central Nervous System Diseases 41%
  • Brain 23%
  • Permeability 16%
  244 Scopus citations
• 2012

  ALS untangled no. 17: "When ALS Is Lyme"

  Bedlack, R., Hardiman, O., Heiman-Patterson, T., Gutmann, L., Bromberg, M., Ostrow, L., Carter, G., Kabashi, E., Bertorini, T., Mozaffar, T., Andersen, P., Dietz, J., Gamez, J., Dimachkie, M., Wang, Y., Wicks, P., Heywood, J., Novella, S., Rowland, L. P., Pioro, E., & 61 othersKinsley, L., Mitchell, K., Glass, J., Sathornsumetee, S., Kwiecinski, H., Baker, J., Atassi, N., Forshew, D., Ravits, J., Conwit, R., Jackson, C., Sherman, A., Dalton, K., Tindall, K., Gonzalez, G., Robertson, J., Phillips, L., Benatar, M., Sorenson, E., Shoesmith, C., Nash, S., Marigakis, N., Moore, D., Caress, J., Boylan, K., Armon, C., Grosso, M., Gerecke, B., Wymer, J., Oskarsson, B., Bowser, R., Drory, V., Shefner, J., Lechtzin, N., Leitner, M., Miller, R., Mitsumoto, H., Levine, T., Russell, J., Sharma, K., Saperstein, D., McClusky, L., MacGowan, D., Licht, J., Verma, A., Strong, M., Lomen-Hoerth, C., Tandan, R., Rivner, M., Kolb, S., Polak, M., Rudnicki, S., Kittrell, P., Quereshi, M., Sachs, G., Pattee, G., Weiss, M., Kissel, J., Goldstein, J., Rothstein, J. & Pastula, D., Sep 2012, In: Amyotrophic Lateral Sclerosis. 13, 5, p. 487-491 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  5 Scopus citations
• 2009

  Current hypotheses for the underlying biology of amyotrophic lateral sclerosis

  Rothstein, J. D., Jan 1 2009, In: Annals of neurology. 65, SUPPL. 1, p. S3-S9

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Motor Neurons 67%
  • Mutation 52%
  • Pathology 44%
  • Superoxide Dismutase-1 29%
  527 Scopus citations
• 2006

  Mechanisms of Disease: Astrocytes in neurodegenerative disease

  Maragakis, N. J. & Rothstein, J. D., Dec 2006, In: Nature Clinical Practice Neurology. 2, 12, p. 679-689 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Astrocytes 100%
  • Neurodegenerative Diseases 94%
  • Pathology 27%
  • Huntington Disease 24%
  • Amyotrophic Lateral Sclerosis 23%
  595 Scopus citations
• 2004

  Glutamate transporters: Animal models to neurologic disease

  Maragakis, N. J. & Rothstein, J. D., Apr 2004, In: Neurobiology of Disease. 15, 3, p. 461-473 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amino Acid Transport System X-AG 100%
  • Nervous System Diseases 70%
  • Animal Models 54%
  • Central Nervous System 22%
  • Excitatory Amino Acids 19%
  281 Scopus citations

• Preclinical studies: How much can we rely on?

  Rothstein, J. D., Sep 2004, In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 5, SUPPL. 1, p. 22-25 4 p.

  Research output: Contribution to journal › Review article › peer-review
  8 Scopus citations
• 2003

  Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice

  Maragakis, N. J., Jackson, M., Ganel, R. & Rothstein, J. D., Feb 27 2003, In: Neuroscience Letters. 338, 2, p. 107-110 4 p.

  Research output: Contribution to journal › Review article › peer-review

  • Topiramate 100%
  • Nerve Degeneration 96%
  • Motor Neurons 74%
  • Transgenic Mice 68%
  • Spinal Cord 62%
  41 Scopus citations
• 2002

  Amyotrophic lateral sclerosis: Evaluation and treatment of respiratory impairment

  Lechtzin, N., Rothstein, J., Clawson, L., Diette, G. B. & Wiener, C. M., 2002, In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 3, 1, p. 5-13 9 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Noninvasive Ventilation 47%
  • Tracheostomy 42%
  • Muscle Weakness 39%
  • Artificial Respiration 35%
  54 Scopus citations

• Models of amyotrophic lateral sclerosis.

  Jackson, M., Ganel, R. & Rothstein, J. D., Nov 2002, In: Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]. Chapter 9, p. Unit 9.13

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Spinal Cord 50%
  • Superoxide Dismutase-1 39%
  • Motor Neurons 30%
  • Nervous System Diseases 29%
  14 Scopus citations

• Therapeutic developments in the treatment of amyotrophic lateral sclerosis

  Jackson, M., Lladó, J. & Rothstein, J. D., Oct 1 2002, In: Expert Opinion on Investigational Drugs. 11, 10, p. 1343-1364 22 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Motor Neurons 45%
  • Amyotrophic Lateral Sclerosis 3 43%
  • Glutamic Acid 40%
  • Cell Culture Techniques 35%
  24 Scopus citations
• 2001

  Glutamate transporters in neurologic disease

  Maragakis, N. J. & Rothstein, J. D., 2001, In: Archives of neurology. 58, 3, p. 365-370 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Amino Acid Transport System X-AG 100%
  • Plasticity 83%
  • Amino Acids 82%
  • Nervous System Diseases 70%
  • Excess 69%
  251 Scopus citations
• 1996

  Excitotoxicity hypothesis

  Rothstein, J. D., Oct 1996, In: Neurology. 47, 4 SUPPL., p. S19-S26

  Research output: Contribution to journal › Review article › peer-review
  170 Scopus citations
• 1995

  Amyotrophic lateral sclerosis. An autoimmune disease?

  Drachman, D. B., Fishman, P. S., Rothstein, J. D., Motomura, M., Lang, B., Vincent, A. & Mellits, E. D., 1995, In: Advances in neurology. 68, p. 59-65 7 p.

  Research output: Contribution to journal › Review article › peer-review
  22 Scopus citations

• Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

  Rothstein, J. D., 1995, In: Advances in neurology. 68, p. 7-20; discussion 21-27

  Research output: Contribution to journal › Review article › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Glutamic Acid 81%
  • Riluzole 55%
  • Motor Neurons 54%
  • Excitatory Amino Acid Agents 31%
  168 Scopus citations
• 1989

  Neurologic manifestations of hepatic disease

  Rothstein, J. D. & Herlong, H. F., 1989, In: Neurologic clinics. 7, 3, p. 563-578 16 p.

  Research output: Contribution to journal › Review article › peer-review

  • Neurologic Manifestations 100%
  • Liver 51%
  • Hepatolenticular Degeneration 42%
  • Hepatic Encephalopathy 39%
  • Metabolic Brain Diseases 25%
  24 Scopus citations