Jason Villano

Research output

Research output per year 2008 2008 2012 2014 2017 2021 2022 2023 2023

• 28 Article
• 5 Chapter
• 5 Review article
• 2 Editorial
• 2 More
  • 1 Book
  • 1 Comment/debate

Research output per year

Research output per year

Search results

• 2023

  Behavioral Evaluation of Laboratory-housed Ferrets (Mustela Putorius Furo) in Different Enclosure Sizes

  Jimenez, I. A., Craney, M. C., Painter, M. C., Burch-Strong, K. E., Plunkard, J. C. M., Villano, J. S. & Hopper, L. M., 2023, In: Journal of the American Association for Laboratory Animal Science. 62, 5, p. 382-394 13 p.

  Research output: Contribution to journal › Article › peer-review

  • ferrets 100%
  • cage size 61%
  • cages 54%
  • aggression 14%
  • social support 12%

• COVID-19 and Contributions from Animal-based Research

  Villano, J. S., Feb 2023, In: Comparative medicine. 1, 4, p. 4-5 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Growth hormone–releasing hormone receptor antagonist MIA-602 attenuates cardiopulmonary injury induced by BSL-2 rVSV-SARS-CoV-2 in hACE2 mice

  Condor Capcha, J. M., Kamiar, A., Robleto, E., Saad, A. G., Cui, T., Wong, A., Villano, J., Zhong, W., Pekosz, A., Medina, E., Cai, R., Sha, W., Ranek, M. J., Webster, K. A., Schally, A. V., Jackson, R. M. & Shehadeh, L. A., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 48, e2308342120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GHRH(1-29)NH2, (PhAc-Ada)(0)-Tyr(1), Arg(2), Fpa(5,6), Ala(8), Har(9), Tyr(Me)(10), His(11), Orn(12,) Abu(15), His(20), Orn(21), Nle(27), Arg(28), Har(29)- 100%
  • SARS Virus 70%
  • Somatotropin Receptors 66%
  • Hormone Antagonists 64%
  • Pneumonia 23%

• SARS-CoV-2 Enters Human Leydig Cells and Affects Testosterone Production In Vitro

  Li, L., Sottas, C. M., Chen, H. Y., Li, Y., Cui, H., Villano, J. S., Mankowski, J. L., Cannon, P. M. & Papadopoulos, V., Apr 2023, In: Cells. 12, 8, 1198.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Leydig Cells 92%
  • Testosterone 90%
  • In Vitro Techniques 33%

• SARS-CoV-2 Variant Pathogenesis Following Primary Infection and Reinfection in Syrian Hamsters

  Plunkard, J., Mulka, K., Zhou, R., Tarwater, P., Zhong, W., Lowman, M., Wong, A., Pekosz, A. & Villano, J., Mar 2023, In: mBio. 14, 2

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Mesocricetus 94%
  • Cricetinae 52%
  • Pathology 49%

• Supramolecular filaments for concurrent ACE2 docking and enzymatic activity silencing enable coronavirus capture and infection prevention

  Anderson, C. F., Wang, Q., Stern, D., Leonard, E. K., Sun, B., Fergie, K. J., Choi, C. Y., Spangler, J. B., Villano, J., Pekosz, A., Brayton, C. F., Jia, H. & Cui, H., Feb 1 2023, In: Matter. 6, 2, p. 583-604 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Enzymes 100%
  • Filament 86%
  • Enzyme Activity 71%
  • Complexation 66%
  • Biological Role 54%
• 2022

  ¹²⁴I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection

  Ruiz-Bedoya, C. A., Mota, F., Ordonez, A. A., Foss, C. A., Singh, A. K., Praharaj, M., Mahmud, F. J., Ghayoor, A., Flavahan, K., De Jesus, P., Bahr, M., Dhakal, S., Zhou, R., Solis, C. V., Mulka, K. R., Bishai, W. R., Pekosz, A., Mankowski, J. L., Villano, J., Klein, S. L., & 1 othersJain, S. K., Feb 2022, In: Molecular Imaging and Biology. 24, 1, p. 135-143 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • N,N-diethyl-2-(2-(4-methoxyphenyl)-5,7-dimethyl-pyrazolo(1,5-a)pyrimidin-3-yl)-acetamide 100%
  • Severe Acute Respiratory Syndrome 62%
  • Cricetinae 49%
  • Positron-Emission Tomography 45%
  • Coronavirus 27%

• A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants

  Jiang, L., Driedonks, T. A. P., Jong, W. S. P., Dhakal, S., Bart van den Berg van Saparoea, H., Sitaras, I., Zhou, R., Caputo, C., Littlefield, K., Lowman, M., Chen, M., Lima, G., Gololobova, O., Smith, B., Mahairaki, V., Riley Richardson, M., Mulka, K. R., Lane, A. P., Klein, S. L., Pekosz, A., & 5 othersBrayton, C., Mankowski, J. L., Luirink, J., Villano, J. S. & Witwer, K. W., Mar 2022, In: Journal of Extracellular Vesicles. 11, 3, e12192.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Extracellular Vesicles 91%
  • Neutralizing Antibodies 77%
  • Vaccines 58%

• Evaluation of Various IVC Systems According to Mouse Reproductive Performance and Husbandry and Environmental Parameters

  Stover, M. G. & Villano, J. S., Jan 2022, In: Journal of the American Association for Laboratory Animal Science. 61, 1, p. 31-41 11 p.

  Research output: Contribution to journal › Article › peer-review

  • reproductive performance 100%
  • cages 86%
  • mice 64%
  • pups 55%
  • litter size 28%

• Progression and Resolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Golden Syrian Hamsters

  Johns Hopkins COVID-19 Hamster Study Group, Feb 2022, In: American Journal of Pathology. 192, 2, p. 195-207 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 90%
  • Coronavirus 87%
  • Mesocricetus 84%
  • Lung 29%
  • SARS Virus 20%
• 2021

  COVID-19 and Animal-Based Research

  Villano, J. S., Oct 2021, In: Comparative medicine. 71, 5, p. 331-332 2 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Hamsters as a Model of Severe Acute Respiratory Syndrome Coronavirus-2

  Braxton, A. M., Creisher, P. S., Ruiz-Bedoya, C. A., Mulka, K. R., Dhakal, S., Ordonez, A. A., Beck, S. E., Jain, S. K. & Villano, J. S., Oct 2021, In: Comparative medicine. 71, 5, p. 1-13 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Severe acute respiratory syndrome coronavirus 100%
  • Severe Acute Respiratory Syndrome 74%
  • Coronavirus 72%
  • Interstitial 60%
  • Cricetinae 58%

• Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model

  Johns Hopkins COVID-19 Hamster Study Group, Aug 1 2021, In: mBio. 12, 4, e00974-21.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Severe Acute Respiratory Syndrome 100%
  • Coronavirus 97%
  • Mesocricetus 94%
  • Sex Characteristics 72%
  • Antibody Formation 69%

• The Role of Animal Research in Pandemic Responses

  Brockhurst, J. K. & Villano, J. S., Oct 2021, In: Comparative medicine. 71, 5, p. 359-368 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • animal research 100%
  • pandemic 96%
  • Pandemics 79%
  • infectious diseases 50%
  • Ebolavirus 39%

• Weight gain, glucose tolerance, and the gut microbiome of male c57bl/6j mice housed on corncob or paper bedding and fed normal or high-fat diet

  Islam, M. R., Schultz, K. A., Varghese, M., Abrishami, S. H., Villano, J. S. & Singer, K., Jul 2021, In: Journal of the American Association for Laboratory Animal Science. 60, 4, p. 407-421 15 p.

  Research output: Contribution to journal › Article › peer-review

  • glucose tolerance 100%
  • corn cobs 89%
  • high fat diet 79%
  • microbiome 71%
  • digestive system 59%
• 2020

  Acepromazine and Chlorpromazine as Pharmaceutical-grade Alternatives to Chlorprothixene for Pupillary Light Reflex Imaging in Mice

  Eckley, S. S., Villano, J. S., Kuo, N. S. & Wong, K. Y., Mar 2020, In: Journal of the American Association for Laboratory Animal Science. 59, 2, p. 197-203 7 p.

  Research output: Contribution to journal › Article › peer-review

  • acepromazine 100%
  • sedatives 80%
  • chlorpromazine 79%
  • reflexes 64%
  • image analysis 51%
  1 Scopus citations
• 2019

  Outbreak of murine infection with Clostridium difficile associated with the administration of a pre- and perinatal methyl donor diet

  Mau, T., Eckley, S. S., Bergin, I. L., Saund, K., Villano, J. S., Vendrov, K. C., Snitkin, E. S., Young, V. B. & Yung, R., Mar 1 2019, In: mSphere. 4, 2, e00138-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clostridium Infections 100%
  • Clostridium difficile 79%
  • Disease Outbreaks 70%
  • Diet 54%
  • Anti-Bacterial Agents 26%
  1 Scopus citations

• Variation in bacterial contamination of microisolation cage tops according to rodent species and housing system

  Esvelt, M. A., Steiner, L., Childs-Thor, C., Dysko, R. C., Villano, J. S. & Freeman, Z. T., 2019, In: Journal of the American Association for Laboratory Animal Science. 58, 4, p. 450-455 6 p.

  Research output: Contribution to journal › Article › peer-review

  • bacterial contamination 100%
  • cages 71%
  • rodents 68%
  • ventilation systems 41%
  • mice 28%
• 2018

  Assessment of mouse handling techniques during cage changing

  Doerning, C. M., Thurston, S. E., Villano, J. S., Kaska, C. L., Vozheiko, T. D., Soleimanpour, S. A. & Lofgren, J. L., 2018, In: Journal of the American Association for Laboratory Animal Science. 58, 6, p. 767-773 7 p.

  Research output: Contribution to journal › Article › peer-review

  • cages 100%
  • gloves 84%
  • mice 65%
  • ergonomics 43%
  • hands 41%

• Safety Considerations When Working with Humanized Animals

  Villano, J. S., Vleck, S. E., Felt, S. A., Myers, D. D. & Lester, P. A., Dec 31 2018, In: ILAR journal. 59, 2, p. 150-160 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Safety 100%
  • Occupational Health 94%
  • Animal Models 92%
  • Animals 86%
  • Animal Housing 76%
• 2017

  Clinical assessment of urinary tract damage during sustained-release estrogen supplementation in mice

  Collins, D. E., Mulka, K. R., Hoenerhoff, M. J., Taichman, R. S. & Villano, J. S., Feb 2017, In: Comparative medicine. 67, 1, p. 11-21 11 p.

  Research output: Contribution to journal › Article › peer-review

  • urinary tract 100%
  • Estradiol 82%
  • Estrogen 76%
  • Urinary Tract 71%
  • estrogens 64%
  3 Scopus citations

• Personal protective equipment in animal research

  Villano, J. S., Follo, J. M., Chappell, M. G. & Collins, M. T., Jun 2017, In: Comparative medicine. 67, 3, p. 203-214 12 p.

  Research output: Contribution to journal › Review article › peer-review

  • Personal Protective Equipment 100%
  • animal research 95%
  • Protective 59%
  • animal care 40%
  • Occupational Health 31%
  5 Scopus citations

• Response to Protocol Review Scenario: FCR and defining the review process

  Jen, K. & Villano, J., Mar 22 2017, In: Lab Animal. 46, 4, p. 88-89 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Special issue: Infectious disease research: Animal models and risk management

  Villano, J. S. & Ogden, B. E., Jun 2017, In: Comparative medicine. 67, 3, p. 189-191 3 p.

  Research output: Contribution to journal › Review article › peer-review
  1 Scopus citations

• Viral vector biosafety in laboratory animal research

  Collins, D. E., Reuter, J. D., Rush, H. G. & Villano, J. S., Jun 2017, In: Comparative medicine. 67, 3, p. 215-221 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Containment of Biohazards 100%
  • animal research 95%
  • biosafety 93%
  • Laboratory Animals 82%
  • laboratory animals 66%
  13 Scopus citations
• 2016

  ACLAM position statement on rodent surgery

  Foley, P., Hitt, N., Leblanc, M., McCrackin, M., Sexton, S. & Villano, J., Nov 2016, In: Journal of the American Association for Laboratory Animal Science. 55, 6, p. 822-823 2 p.

  Research output: Contribution to journal › Article › peer-review

  • surgery 100%
  • Institutional Animal Care and Use Committee 83%
  • rodents 83%
  • stress response 80%
  • veterinarians 54%
  4 Scopus citations

• Distribution and prevalence of malaria parasites among long-tailed macaques (Macaca fascicularis) in regional populations across Southeast Asia

  Zhang, X., Kadir, K. A., Quintanilla-Zariñan, L. F., Villano, J., Houghton, P., Du, H., Singh, B. & Smith, D. G., Sep 2 2016, In: Malaria journal. 15, 1, 450.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Southeastern Asia 100%
  • Macaca fascicularis 97%
  • Macaca 88%
  • South East Asia 82%
  • malaria 81%
  18 Scopus citations
• 2015

  Diagnostic Exercise: Metastatic Calcification in Guinea Pigs

  Villano, J. S., Fann, M. K., Suckow, C. E. & Cooper, T. K., Jul 11 2015, In: Veterinary pathology. 52, 4, p. 757-759 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • calcification 100%
  • histopathology 91%
  • myocardium 89%
  • necropsy 82%
  • exercise 78%
• 2014

  A genetic comparison of two alleged subspecies of Philippine cynomolgus macaques

  Smith, D. G., Ng, J., George, D., Trask, J. S., Houghton, P., Singh, B., Villano, J. & Kanthaswamy, S., Sep 2014, In: American journal of physical anthropology. 155, 1, p. 136-148 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Philippines 100%
  • Macaca 86%
  • Mitochondrial DNA 54%
  • Indonesia 45%
  • Malaysia 44%
  19 Scopus citations

• Bacterial infections in Myd88-deficient mice

  Villano, J. S., Rong, F. & Cooper, T. K., Apr 2014, In: Comparative medicine. 64, 2, p. 110-114 5 p.

  Research output: Contribution to journal › Article › peer-review

  • bacterial infections 100%
  • Drinking Water 92%
  • Bacterial Infections 84%
  • mice 51%
  • Environment 50%
  10 Scopus citations

• Laws, Regulations, Guidelines, and Principles Pertaining to Laboratory Animals in Southeast Asia

  Gettayacamin, M., Grant, R., Winoto, I. L., Sajuthi, D., Paramastri, Y. A., Khoo, J. D., Chatikavanij, P., Villano, J. & Mutalib, A. R., 2014, Laboratory Animals: Regulations and Recommendations for Global Collaborative Research. Elsevier Inc., p. 295-332 38 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Southeastern Asia 100%
  • Animal Welfare 92%
  • Laboratory Animals 91%
  • Timor-Leste 81%
  • Formal Social Control 79%
  1 Scopus citations
• 2013

  Mandibular fracture and necrotizing sialometaplasia in a rabbit

  Villano, J. S. & Cooper, T. K., Feb 2013, In: Comparative medicine. 63, 1, p. 67-70 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Necrotizing Sialometaplasia 100%
  • mandible (bone) 74%
  • Mandible 55%
  • White 47%
  • Rabbits 39%
  3 Scopus citations
• 2012

  A multifaceted career

  Villano, J., Dec 2012, In: Lab Animal. 42, 1, 1 p.

  Research output: Contribution to journal › Article › peer-review

• Complications of elastase-induced arterial saccular aneurysm in rabbits: Case reports and literature review

  Villano, J. S., Boehm, C. A., Carney, E. L. & Cooper, T. K., Dec 2012, In: Comparative medicine. 62, 6, p. 480-486 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemodynamic 100%
  • aneurysm 98%
  • Shear Stress 81%
  • Pancreatic Elastase 80%
  • Aneurysm 60%
  4 Scopus citations

• Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates

  Lai, C. M., Estcourt, M. J., Himbeck, R. P., Lee, S. Y., Yew-San Yeo, I., Luu, C., Loh, B. K., Lee, M. W., Barathi, A., Villano, J., Ang, C. L., Van Der Most, R. G., Constable, I. J., Dismuke, D., Samulski, R. J., Degli-Esposti, M. A. & Rakoczy, E. P., Oct 2012, In: Gene Therapy. 19, 10, p. 999-1009 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Primates 100%
  • Eye 66%
  • Safety 62%
  • Genetic Therapy 49%
  • Injections 46%
  34 Scopus citations

• The laboratory rat, second edition

  Sharp, P. & Villano, J., Jan 1 2012, CRC Press. 359 p.

  Research output: Book/Report › Book

  • Animal Husbandry 100%
  • Occupational Health 70%
  • Biomedical Research 63%
  • Animal Technicians 54%
  • Animal Care Committees 47%
  19 Scopus citations
• 2009

  Morphometries and pelage characterization of longtailed macaques (Macaca fascicularis) from Pulau Bintan, Indonesia; Singapore; and Southern Vietnam

  Villano, J. S., Ogden, B. E., Yong, P. P., Lood, N. M. & Sharp, P. E., Nov 2009, In: Journal of the American Association for Laboratory Animal Science. 48, 6, p. 727-733 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Macaca fascicularis 96%
  • morphometry 92%
  • Macaca 90%
  • Indonesia 74%
  • genetic polymorphism 40%
  7 Scopus citations
• 2008

  Animal handling and surgical procedures: Blood collection from laboratory animals

  Villano, J., Jan 1 2008, Using Animal Models in Biomedical Research: A Primer for the Investigator. World Scientific Publishing Co., p. 95-99 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Animal welfare considerations: Postoperative care and pain management

  Villano, J., Jan 1 2008, Using Animal Models in Biomedical Research: A Primer for the Investigator. World Scientific Publishing Co., p. 199-204 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Cerebellar abscess in a cynomolgus macaque (Macaca fascicularis)

  Villano, J. S., Ogden, B., Goh, A., Hui, L. S. & Chow, P. K. H., Feb 2008, In: Journal of medical primatology. 37, SUPPL.1, p. 82-87 6 p.

  Research output: Contribution to journal › Article › peer-review

  • abscess 100%
  • Macaca fascicularis 96%
  • Clinical Pathology 95%
  • Macaca 88%
  • Abscess 73%
  2 Scopus citations

• Safety management of an animal facility: Zoonoses and laboratory animal allergies

  Villano, J., Jan 1 2008, Using Animal Models in Biomedical Research: A Primer for the Investigator. World Scientific Publishing Co., p. 236-239 4 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Scientific considerations and choice of species: Nonhuman primates as models in biomedical research

  Villano, J. & Ogden, B., Jan 1 2008, Using Animal Models in Biomedical Research: A Primer for the Investigator. World Scientific Publishing Co., p. 18-22 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter