James Yager

Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E. & McMullen, P. D., Apr 1 2017, In: Archives of Toxicology. 91, 4, p. 1749-1762 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis

Maertens, A., Bouhifd, M., Zhao, L., Odwin-DaCosta, S., Kleensang, A., Yager, J. D. & Hartung, T., Jan 1 2017, In: Archives of Toxicology. 91, 1, p. 217-230 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Plasma selenium protein P isoform 1 (SEPP1): A predictor of selenium status in Nepalese children detected by plasma proteomics

Schulze, K. J., Cole, R. N., Chaerkady, R., Wu, L. S. F., Nonyane, B. A. S., Lee, S. E., Yager, J. D., Groopman, J. D., Christian, P. & West, K. P., 2017, In: International Journal for Vitamin and Nutrition Research. 87, 5-6, p. 287-296 10 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children

Lee, S. E., Stewart, C. P., Schulze, K. J., Cole, R. N., Wu, L. S. F., Yager, J. D., Groopman, J. D., Khatry, S. K., Adhikari, R. K., Christian, P. & West, K. P., Mar 2017, In: Journal of Nutrition. 147, 3, p. 304-313 10 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2016

Biological Systems of Vitamin K: A Plasma Nutriproteomics Study of Subclinical Vitamin K Deficiency in 500 Nepalese Children

Lee, S. E., Schulze, K. J., Cole, R. N., Wu, L. S. F., Yager, J. D., Groopman, J., Christian, P. & West, K. P., Apr 1 2016, In: OMICS A Journal of Integrative Biology. 20, 4, p. 214-223 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

General intelligence is associated with subclinical inflammation in Nepalese children: A population-based plasma proteomics study

Lee, S. E., West, K. P., Cole, R. N., Schulze, K. J., Wu, L. S. F., Yager, J. D., Groopman, J. & Christian, P., Aug 1 2016, In: Brain, Behavior, and Immunity. 56, p. 253-263 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function

Kleensang, A., Vantangoli, M. M., Odwin-Dacosta, S., Andersen, M. E., Boekelheide, K., Bouhifd, M., Fornace, A. J., Li, H. H., Livi, C. B., Madnick, S., Maertens, A., Rosenberg, M., Yager, J. D., Zhaog, L. & Hartung, T., Jul 26 2016, In: Scientific reports. 6, 28994.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

2015

A plasma α-tocopherome can be identified from proteins associated with vitamin e status in school-aged children of Nepal

West, K. P., Cole, R. N., Shrestha, S., Schulze, K. J., Lee, S. E., Betz, J., Nonyane, B. A. S., Wu, L. S. F., Yager, J. D., Groopman, J. D. & Christian, P., 2015, In: Journal of Nutrition. 145, 12, p. 2646-2656 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Plasma proteome biomarkers of inflammation in school aged children in Nepal

Lee, S. E., West, K. P., Cole, R. N., Schulze, K. J., Christian, P., Wu, L. S. F., Yager, J. D., Groopman, J. & Ruczinski, I., Dec 1 2015, In: PloS one. 10, 12, e0144279.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The Human Toxome Project

Bouhifd, M., Andersen, M. E., Baghdikian, C., Boekelheide, K., Crofton, K. M., Fornace, A. J., Kleensang, A., Li, H., Livi, C., Maertens, A., McMullen, P. D., Rosenberg, M., Thomas, R., Vantangoli, M., Yager, J. D., Zhao, L. & Hartung, T., 2015, In: ALTEX. 32, 2, p. 112-124 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

47 Scopus citations

2013

Massive open online courses in public health

Gooding, I., Klaas, B., Yager, J. D. & Kanchanaraksa, S., Nov 25 2013, In: Frontiers in Public Health. 1, NOV, 59.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells

Yang, L., Zahid, M., Liao, Y., Rogan, E. G., Cavalieri, E. L., Davidson, N. E., Yager, J. D., Visvanathan, K., Groopman, J. D. & Kensler, T. W., Nov 2013, In: Carcinogenesis. 34, 11, p. 2587-2592 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

Statistical inference from multiple iTRAQ experiments without using common reference standards

Herbrich, S. M., Cole, R. N., West, K. P., Schulze, K., Yager, J. D., Groopman, J. D., Christian, P., Wu, L., O'Meally, R. N., May, D. H., McIntosh, M. W. & Ruczinski, I., Feb 1 2013, In: Journal of proteome research. 12, 2, p. 594-604 11 p.

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

The plasma proteome identifies expected and novel proteins correlated with micronutrient status in undernourished nepalese children^1-3

Cole, R. N., Ruczinski, I., Schulze, K., Christian, P., Herbrich, S., Wu, L., DeVine, L. R., O'Meally, R. N., Shrestha, S., Boronina, T. N., Yager, J. D., Groopman, J. & West, K. P., 2013, In: Journal of Nutrition. 143, 10, p. 1540-1548 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

2012

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing - t4 report*.

Basketter, D. A., Clewell, H., Kimber, I., Rossi, A., Blaauboer, B., Burrier, R., Daneshian, M., Eskes, C., Goldberg, A., Hasiwa, N., Hoffmann, S., Jaworska, J., Knudsen, T. B., Landsiedel, R., Leist, M., Locke, P., Maxwell, G., McKim, J., McVey, E. A., Ouédraogo, G., & 15 othersPatlewicz, G., Pelkonen, O., Roggen, E., Rovida, C., Ruhdel, I., Schwarz, M., Schepky, A., Schoeters, G., Skinner, N., Trentz, K., Turner, M., Vanparys, P., Yager, J., Zurlo, J. & Hartung, T., 2012, In: ALTEX. 29, 1, p. 3-91 89 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal

Scholl, P. F., Cole, R. N., Ruczinski, I., Gucek, M., Diez, R., Rennie, A., Nathasingh, C., Schulze, K., Christian, P., Yager, J. D., Groopman, J. D. & West, K. P., May 2012, In: Placenta. 33, 5, p. 424-432 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

Blaauboer, B. J., Boekelheide, K., Clewell, H. J., Daneshian, M., Dingemans, M. M. L., Goldberg, A., Heneweer, M., Jaworska, J., Kramer, N. I., Leist, M., Seibert, H., Testai, E., Vandebriel, R. J., Yager, J. D. & Zurlo, J., 2012, In: ALTEX. 29, 4, p. 411-425 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

77 Scopus citations

2011

Critical evaluation of the use of dogs in biomedical research and testing in Europe

Hasiwa, N., Bailey, J., Clausing, P., Daneshian, M., Eileraas, M., Farkas, S., Gyertyań, I., Hubrecht, R., Kobel, W., Krummenacher, G., Leist, M., Lohi, H., Miklośi, A., Ohl, F., Olejniczak, K., Schmitt, G., Sinnett-Smith, P., Smith, D., Wagner, K., Yager, J. D., & 2 othersZurlo, J. & Hartung, T., 2011, In: ALTEX. 28, 4, p. 326-340 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

The impact of local environmental health capacity on foodborne illness morbidity in maryland

Zablotsky Kufel, J. S., Resnick, B. A., Fox, M. A., McGready, J., Yager, J. P. & Burke, T. A., Aug 1 2011, In: American journal of public health. 101, 8, p. 1495-1500 6 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2010

Manganese superoxide dismutase: Effect of the ala16val polymorphism on protein, activity, and mRNA levels in human breast cancer cell lines and stably transfected mouse embryonic fibroblasts

McAtee, B. L. & Yager, J. D., Feb 2010, In: Molecular and Cellular Biochemistry. 335, 1-2, p. 107-118 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2009

Effects of cadmium on estrogen receptor mediated signaling and estrogen induced DNA synthesis in T47D human breast cancer cells

Zang, Y., Odwin-DaCosta, S. & Yager, J. D., Jan 30 2009, In: Toxicology Letters. 184, 2, p. 134-138 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Johns Hopkins Bloomberg School of Public Health OpenCourseWare

Kanchanaraksa, S., Gooding, I., Klaas, B. & Yager, J. D., Feb 2009, In: Open Learning. 24, 1, p. 39-46 8 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2008

Catechol-O-methyltransferase: Effects of the val108met polymorphism on protein turnover in human cells

Doyle, A. E. & Yager, J. D., Jan 2008, In: Biochimica et Biophysica Acta - General Subjects. 1780, 1, p. 27-33 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N⁷-guanine in human urine

Bransfield, L. A., Rennie, A., Visvanathan, K., Odwin, S. A., Kensler, T. W., Yager, J. D., Friesen, M. & Groopman, J. D., Aug 2008, In: Chemical research in toxicology. 21, 8, p. 1622-1630 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2007

Serum estrogen, but not testosterone, levels differ between black and white men in a nationally representative sample of Americans

Rohrmann, S., Nelson, W. G., Rifai, N., Brown, T. R., Dobs, A., Kanarek, N., Yager, J. D. & Platz, E. A., Jul 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 7, p. 2519-2525 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

122 Scopus citations

2005

Functional and structural comparisons of cysteine residues in the Val108 wild type and Met108 variant of human soluble catechol O-methyltransferase

Li, Y., Yang, X., Chang, M., Yager, J. D., Van Breemen, R. B. & Bolton, J. L., Apr 15 2005, In: Chemico-Biological Interactions. 152, 2-3, p. 151-163 13 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2004

Binding of MCF-7 cell mitochondrial proteins and recombinant human estrogen receptors α and β to human mitochondrial DNA estrogen response elements

Chen, J. Q., Eshete, M., Alworth, W. L. & Yager, J. D., 2004, In: Journal of cellular biochemistry. 93, 2, p. 358-373 16 p.

Research output: Contribution to journal › Article › peer-review

119 Scopus citations

Catechol-O-methyltransferase low activity genotype (COMT ^LL) is associated with low levels of COMT protein in human hepatocytes

Doyle, A. E. S., Goodman, J. E., Silber, P. M. & Yager, J. D., Oct 28 2004, In: Cancer Letters. 214, 2, p. 189-195 7 p.

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Equine Catechol Estrogen 4-Hydroxyequilenin Is a More Potent Inhibitor of the Variant Form of Catechol-O-Methyltransferase

Li, Y., Yao, J., Chang, M., Nikolic, D., Yu, L., Yager, J. D., Mesecar, A. D., Van Breemen, R. B. & Bolton, J. L., Apr 2004, In: Chemical research in toxicology. 17, 4, p. 512-520 9 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Estrogen's effects on mitochondrial gene expression: Mechanisms and potential contributions to estrogen carcinogenesis

Chen, J. Q. & Yager, J. D., 2004, In: Annals of the New York Academy of Sciences. 1028, p. 258-272 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

67 Scopus citations

Mitochondrial localization of ERα and ERβ in human MCF7 cells

Chen, J. Q., Delannoy, M., Cooke, C. & Yager, J. D., Jun 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 286, 6 49-6, p. E1011-E1022

Research output: Contribution to journal › Article › peer-review

233 Scopus citations

2003

Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase

Yao, J., Li, Y., Chang, M., Wu, H., Yang, X., Goodman, J. E., Liu, X., Liu, H., Mesecar, A. D., Van Breemen, R. B., Yager, J. D. & Bolton, J. L., May 1 2003, In: Chemical research in toxicology. 16, 5, p. 668-675 8 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

2002

Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation

Goodman, J. E., Jensen, L. T., He, P. & Yager, J. D., Oct 2002, In: Pharmacogenetics. 12, 7, p. 517-528 12 p.

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Copper redox-dependent activation of 2-tert-butyl(1,4)hydroquinone: formation of reactive oxygen species and induction of oxidative DNA damage in isolated DNA and cultured rat hepatocytes

Li, Y., Seacat, A., Kuppusamy, P., Zweier, J. L., Yager, J. D. & Trush, M. A., Jul 25 2002, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 518, 2, p. 123-133 11 p.

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

2001

COMT genotype, micronutrients in the folate metabolic pathway and breast cancer risk

Goodman, J. E., Lavigne, J. A., Wu, K., Helzlsouer, K. J., Strickland, P. T., Selhub, J. & Yager, J. D., 2001, In: Carcinogenesis. 22, 10, p. 1661-1665 5 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

The effects of catechol-O-methyltransferase inhibition on estrogen metabolite and oxidative DNA damage levels in estradiol-treated MCF-7 cells

Lavigne, J. A., Goodman, J. E., Fonong, T., Odwin, S., He, P., Yager, J. D. & Roberts, D. W., Oct 15 2001, In: Cancer Research. 61, 20, p. 7488-7494 7 p.

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

2000

Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk

Goodman, J. E., Lavigne, J. A., Hengstler, J. G., Tanner, B., Helzlsouer, K. J. & Yager, J. D., 2000, In: Cancer Epidemiology Biomarkers and Prevention. 9, 12, p. 1373-1376 4 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Inhibition of TGF-β-induced apoptosis by ethinyl estradiol in cultured, precision cut rat liver slices and hepatocytes

Chen, J., Gokhale, M., Schofield, B., Odwin, S. & Yager, J. D., 2000, In: Carcinogenesis. 21, 6, p. 1205-1211 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

1999

Increased mitochondrial superoxide production in rat liver mitochondria, rat hepatocytes, and HepG2 cells following ethinyl estradiol treatment

Chen, J., Li, Y., Lavigne, J. A., Trush, M. A. & Yager, J. D., 1999, In: Toxicological Sciences. 51, 2, p. 224-235 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Serum concentrations of organochlorine compounds and the subsequent development of breast cancer

Helzlsouer, K. J., Alberg, A. J., Huang, H. Y., Hoffman, S. C., Strickland, P. T., Brock, J. W., Burse, V. W., Needham, L. L., Bell, D. A., Lavigne, J. A., Yager, J. D. & Comstock, G. W., Jun 1999, In: Cancer Epidemiology Biomarkers and Prevention. 8, 6, p. 525-532 8 p.

Research output: Contribution to journal › Article › peer-review