Jaiprasath Sachithanandham

2025

A Surrogate Enzyme-Linked Immunosorbent Assay to Select High-Titer Human Convalescent Plasma for Treating Immunocompromised Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Dolange, V., Slamanig, S., Abdeljawad, A., Lai, T. Y., Lemus, N., Singh, G., Carreño, J. M., Abbad, A., Srivastava, K., Simon, V., Sachithanandham, J., Pekosz, A., Sullivan, D., Krammer, F., Sun, W., Palese, P. & González-Domínguez, I., Apr 15 2025, In: Journal of Infectious Diseases. 231, 4, p. e723-e733

Research output: Contribution to journal › Article › peer-review

A third COVID-19 vaccine dose in kidney transplant recipients induces antibody response to vaccine and Omicron variants but shows limited Ig subclass switching

Lee, J. M., Sachithanandham, J., Lee, J. S., Shapiro, J. R., Li, M., Sitaris, I., Peralta, S. R., Wouters, C., Cox, A. L., Segev, D. L., Durand, C. M., Robien, M., Tobian, A. A. R., Karaba, A. H., Blankson, J. N., Werbel, W. A., Pekosz, A. & Klein, S. L., Mar 2025, In: Microbiology Spectrum. 13, 3

Research output: Contribution to journal › Article › peer-review

Direct-Acting Antivirals Quickly Eradicate Hepatitis C Virus from the Liver in People with Human Immunodeficiency Virus but Do Not Fully Reverse Immune Activation

Sachithanandham, J., Leep-Lazar, J., Quinn, J., Bowden, K., Balasubramaniam, P., Ward, K., Ribeiro, R. M., Sulkowski, M. S. & Balagopal, A., May 15 2025, In: Journal of Infectious Diseases. 231, 5, p. 1299-1308 10 p.

Research output: Contribution to journal › Article › peer-review

2024

A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Gordy, J. T., Hui, Y., Schill, C., Wang, T., Chen, F., Fessler, K., Meza, J., Li, Y., Taylor, A. D., Bates, R. E., Karakousis, P. C., Pekosz, A., Sachithanandham, J., Li, M., Karanika, S. & Markham, R. B., 2024, In: Frontiers in immunology. 15, 1292059.

Research output: Contribution to journal › Article › peer-review

Open Access

COVID-19 Diarrhea is Inflammatory, Caused by Direct Viral Effects Plus Major Role of Virus-induced Cytokines

Donowitz, M., Tse, C. M., Sarker, R., Lin, R., Dokladny, K., Rawat, M., Horwitz, I., Ye, C. Y., McNamara, G., In, J., Kell, A., Guo, C., JuiTsai, S., Vong, T., Karaba, A., Singh, V., Sachithanandham, J., Pekosz, A., Cox, A. & Bradfute, S. & 3 others, Zachos, N. C., Gould, S. & Kovbasnjuk, O., Jan 2024, In: CMGH. 18, 5, 101383.

Research output: Contribution to journal › Article › peer-review

Open Access

Outpatient COVID-19 convalescent plasma recipient antibody thresholds correlated to reduced hospitalizations within a randomized trial

Park, H. S., Yin, A., Barranta, C., Lee, J. S., Caputo, C. A., Sachithanandham, J., Li, M., Yoon, S., Sitaras, I., Jedlicka, A., Eby, Y., Ram, M., Fernandez, R. E., Baker, O. R., Shenoy, A. G., Mosnaim, G. S., Fukuta, Y., Patel, B., Heath, S. L. & Levine, A. C. & 61 others, Meisenberg, B. R., Spivak, E. S., Anjan, S., Huaman, M. A., Blair, J. E., Currier, J. S., Paxton, J. H., Gerber, J. M., Petrini, J. R., Broderick, P. B., Rausch, W., Cordisco, M. E., Hammel, J., Greenblatt, B., Cluzet, V. C., Cruser, D., Oei, K., Abinante, M., Hammitt, L. L., Sutcliffe, C. G., Forthal, D. N., Zand, M. S., Cachay, E. R., Raval, J. S., Kassaye, S. G., Marshall, C. E., Yarava, A., Lane, K., McBee, N. A., Gawad, A. L., Karlen, N., Singh, A., Ford, D. E., Jabs, D. A., Appel, L. J., Shade, D. M., Lau, B., Ehrhardt, S., Baksh, S. N., Shapiro, J. R., Ou, J., Na, Y. B., Knoll, M. D., Ornelas-Gatdula, E., Arroyo-Curras, N., Gniadek, T. J., Caturegli, P., Wu, J., Ndahiro, N., Betenbaugh, M. J., Ziman, A., Hanley, D. F., Casadevall, A., Shoham, S., Bloch, E. M., Gebo, K. A., Tobian, A. A. R., Laeyendecker, O., Pekosz, A., Klein, S. L. & Sullivan, D. J., 2024, In: JCI Insight. 9, 8, e178460.

Research output: Contribution to journal › Article › peer-review

Open Access

Reduced control of SARS-CoV-2 infection associates with lower mucosal antibody responses in pregnancy

Clair, L. A. S., Eldesouki, R. E., Sachithanandham, J., Yin, A., Fall, A., Morris, C. P., Norton, J. M., Abdullah, O., Dhakal, S., Barranta, C., Golding, H., Bersoff-Matcha, S. J., Pilgrim-Grayson, C., Berhane, L., Cox, A. L., Burd, I., Pekosz, A., Mostafa, H. H., Klein, E. Y. & Klein, S. L., Mar 2024, In: mSphere. 9, 3

Research output: Contribution to journal › Article › peer-review

Open Access

Respiratory virus disease and outcomes at a large academic medical center in the United States: a retrospective observational study of the early 2023/2024 respiratory viral season

Mostafa, H. H., Fall, A., Norton, J. M., Sachithanandham, J., Yunker, M., Abdullah, O., Hanlon, A., Gluck, L., Morris, C. P., Pekosz, A. & Klein, E. Y., Oct 2024, In: Microbiology Spectrum. 12, 10, 01116-24.

Research output: Contribution to journal › Article › peer-review

Open Access

SARS-CoV-2 Variants from Long-Term, Persistently Infected Immunocompromised Patients Have Altered Syncytia Formation, Temperature-Dependent Replication, and Serum Neutralizing Antibody Escape

Wouters, C., Sachithanandham, J., Akin, E., Pieterse, L., Fall, A., Truong, T. T., Bard, J. D., Yee, R., Sullivan, D. J., Mostafa, H. H. & Pekosz, A., Sep 2024, In: Viruses. 16, 9, 1436.

Research output: Contribution to journal › Article › peer-review

2023

Omicron Subvariants: Clinical, Laboratory, and Cell Culture Characterization

Morris, C. P., Eldesouki, R. E., Sachithanandham, J., Fall, A., Norton, J. M., Abdullah, O., Gallagher, N., Li, M., Pekosz, A., Klein, E. Y. & Mostafa, H. H., Apr 1 2023, In: Clinical Infectious Diseases. 76, 7, p. 1276-1284 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SARS-CoV-2 seroprevalence among blood donors in Uganda: 2019–2022

Bloch, E. M., Kyeyune, D., White, J. L., Ddungu, H., Ashokkumar, S., Habtehyimer, F., Baker, O., Kasirye, R., Patel, E. U., Grabowski, M. K., Musisi, E., Moses, K., Hume, H. A., Lubega, I., Shrestha, R., Motevalli, M., Fernandez, R. E., Reynolds, S. J., Redd, A. D. & Wambongo Musana, H. & 17 others, Dhabangi, A., Ouma, J., Eroju, P., de Lange, T., Fowler, M. G., Musoke, P., Stramer, S. L., Whitby, D., Zimmerman, P. A., McCullough, J., Sachithanandham, J., Pekosz, A., Goodrich, R., Quinn, T. C., Ness, P. M., Laeyendecker, O. & Tobian, A. A. R., Jul 2023, In: Transfusion. 63, 7, p. 1354-1365 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Second-Phase Hepatitis C Plasma Viral Kinetics Directly Reflects Reduced Intrahepatic Burden of Hepatitis C Virus

Sachithanandham, J., Balagopal, A., Leep-Lazar, J., Quinn, J., Bowden, K., Ward, K., Ribeiro, R. M. & Sulkowski, M. S., Aug 1 2023, In: Journal of Infectious Diseases. 228, 3, p. 311-320 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization

McConnell, S. A., Sachithanandham, J., Mudrak, N. J., Zhu, X., Farhang, P. A., Cordero, R. J. B., Wear, M. P., Shapiro, J. R., Park, H. S., Klein, S. L., Tobian, A. A. R., Bloch, E. M., Sullivan, D. J., Pekosz, A. & Casadevall, A., Jul 20 2023, In: Cell Chemical Biology. 30, 7, p. 726-738.e4

Research output: Contribution to journal › Article › peer-review

Open Access

Three doses of COVID-19 mRNA vaccine induce class-switched antibody responses in inflammatory arthritis patients on immunomodulatory therapies

Lee, J. M., Figueroa, A., Sachithanandham, J., Li, M., Connolly, C. M., Shapiro, J. R., Chen, Y., Jones, M., Dhara, V. G., Towns, M., Lee, J. S., Peralta, S. R., Milstone, A. M., Betenbaugh, M., Debes, A. K., Blankson, J., Sitaras, I., Yoon, S., Thompson, E. A. & Bingham, C. O. & 3 others, Klein, S. L., Pekosz, A. & Bailey, J. R., 2023, In: Frontiers in immunology. 14, 1266370.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection

Park, H. S., Shapiro, J. R., Sitaras, I., Woldemeskel, B. A., Garliss, C. C., Dziedzic, A., Sachithanandham, J., Jedlicka, A. E., Caputo, C. A., Rousseau, K. E., Thakar, M., Suwanmanee, S., Hauk, P., Aliyu, L., Majewska, N. I., Koley, S., Patel, B., Broderick, P., Mosnaim, G. & Heath, S. L. & 18 others, Spivak, E. S., Shenoy, A., Bloch, E. M., Gniadek, T. J., Shoham, S., Casadevall, A., Hanley, D., Cox, A. L., Laeyendecker, O., Betenbaugh, M. J., Cramer, S. M., Mostafa, H. H., Pekosz, A., Blankson, J. N., Klein, S. L., Tobian, A. A. R., Sullivan, D. & Gebo, K. A., Mar 8 2022, In: JCI Insight. 7, 5, e155944.

Research output: Contribution to journal › Article › peer-review

Open Access

Evaluation of Four Point of Care (POC) Antigen Assays for the Detection of the SARS-CoV-2 Variant Omicron

Hardick, J., Gallagher, N., Sachithanandham, J., Fall, A., Siddiqui, Z., Pekosz, A., Manabe, Y. C. & Mostafa, H. H., Jun 2022, In: Microbiology Spectrum. 10, 3

Research output: Contribution to journal › Article › peer-review

Open Access

Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated with Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals

Huai Luo, C., Paul Morris, C., Sachithanandham, J., Amadi, A., Gaston, D. C., Li, M., Swanson, N. J., Schwartz, M., Klein, E. Y., Pekosz, A. & Mostafa, H. H., Jul 1 2022, In: Clinical Infectious Diseases. 75, 1, p. E715-E725

Research output: Contribution to journal › Article › peer-review

Open Access

Large Scale SARS-CoV-2 Molecular Testing and Genomic Surveillance Reveal Prolonged Infections, Protracted RNA shedding, and Viral Reinfections

Morris, C. P., Luo, C. H., Sachithanandham, J., Li, M., Schwartz, M., Gaston, D. C., Gniazdowski, V., Giraldo-Castillo, N., Amadi, A., Norton, J. M., Wright, W. F., Klein, E. Y., Pekosz, A. & Mostafa, H. H., Apr 11 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 809407.

Research output: Contribution to journal › Article › peer-review

Open Access

The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads

Fall, A., Eldesouki, R. E., Sachithanandham, J., Morris, C. P., Norton, J. M., Gaston, D. C., Forman, M., Abdullah, O., Gallagher, N., Li, M., Swanson, N. J., Pekosz, A., Klein, E. Y. & Mostafa, H. H., May 2022, In: EBioMedicine. 79, 104008.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

The Natural History of Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Composite but Incomplete Picture

Sachithanandham, J., Thio, C. L. & Balagopal, A., Nov 1 2021, In: Clinical Infectious Diseases. 73, 9, p. E2943-E2945

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

2019

Characteristics of treatment-naïve HBV-infected individuals with HIV-1 coinfection: A cross-sectional study from South India

Demosthenes, J., Sachithanandham, J., Fletcher, G., Zachariah, U., Varghese, G., John Daniel, H., Jeyaseelan, L., Abraham, P. & Kannangai, R., Apr 1 2019, In: Indian Journal of Medical Microbiology. 37, 2, p. 219-224 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Performance of a modified in-house HIV-1 avidity assay among a cohort of newly diagnosed HIV-1 infected individuals and the effect of ART on the maturation of HIV-1 specific antibodies

Alex, D., Williams, T. I. R., Sachithanandham, J., Prasannakumar, S., Demosthenes, J. P., Ramalingam, V. V., Victor, P. J., Rupali, P., Fletcher, G. J. & Kannangai, R., 2019, In: Current HIV research. 17, 2, p. 134-145 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

BK virus characterisation among HIV-1-Infected individuals and its association with immunosuppression

Jagannath, S., Sachithanandham, J., Ramalingam, V. V., Demosthenes, J. P., Abraham, A. M., Zachariah, A., Varghese, G. M. & Kannangai, R., Apr 1 2018, In: Indian Journal of Medical Microbiology. 36, 2, p. 172-177 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

No recovery of replication-competent HIV-1 from human liver macrophages

Kandathil, A. J., Sugawara, S., Goyal, A., Durand, C. M., Quinn, J., Sachithanandham, J., Cameron, A. M., Bailey, J. R., Perelson, A. S. & Balagopal, A., Oct 1 2018, In: Journal of Clinical Investigation. 128, 10, p. 4501-4509 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2017

Presence of human hepegivirus-1 in a cohort of people who inject drugs

Kandathil, A. J., Breitwieser, F. P., Sachithanandham, J., Robinson, M., Mehta, S. H., Timp, W., Salzberg, S. L., Thomas, D. L. & Balagopal, A., Jul 4 2017, In: Annals of internal medicine. 167, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2016

Expression of cytokine-mRNA in peripheral blood mononuclear cell of human immunodeficiency virus-1 subtype C infected individuals with opportunistic viral infections from India (South)

Sachithanandham, J., Ramalingam, V. V., Raja, J., Abraham, O. C., Pulimood, S. A. & Kannangai, R., Jan 1 2016, In: Indian Journal of Medical Microbiology. 34, 1, p. 76-81 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The performance of reverse transcriptase assay for the estimation of the plasma viral load in HIV-1 and HIV-2 infections

Padaki, P. A., Sachithanandham, J., Isaac, R., Ramalingam, V. V., Abraham, O. C., Pulimood, S. A. & Kannangai, R., 2016, In: Infectious Diseases. 48, 6, p. 467-471 5 p.

Research output: Contribution to journal › Article › peer-review

2015

Emergence of HIV-1 drug-resistant variants in women following antiretroviral prophylaxis for the prevention of mother to child transmission

Mani, M., Ramalingam, V. V., Lionel, J., Christina, S. A., Sachithanandham, J., Peedicayil, A. & Kannangai, R., Apr 1 2015, In: Indian Journal of Medical Microbiology. 33, 2, p. 225-230 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Frequency of Epstein - Barr virus infection as detected by messenger RNA for EBNA 1 in histologically proven gastric adenocarcinoma in patients presenting to a tertiary care center in South India

Rymbai, M., Ramalingam, V., Samarasan, I., Chandran, B., Mathew, G., Jerobin, J., Abraham, A., Sachithanandham, J. & Kannangai, R., Jul 1 2015, In: Indian Journal of Medical Microbiology. 33, 3, p. 369-373 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Frequency of Transmitted Drug Resistance Mutations Among Treatment-Naïve HIV-1-Infected Individuals at a Tertiary Care Centre in South India

Kannangai, R., David, S., Sundaresan, V. C., Sachithanandham, J., Mani, M., Abraham, O. C., Pulimood, S. A., Rupali, P. & Sridharan, G., Oct 30 2015, In: Molecular Diagnosis and Therapy. 19, 5, p. 273-275 3 p.

Research output: Contribution to journal › Article › peer-review

2014

Performance of LigAmp Assay for Sensitive Detection of Drug-Resistant Hepatitis B Virus Minor Variants in Comparison with Standard Nucleotide Sequencing

Ismail, A. M., Sachithanandham, J., Eapen, C. E., Kannangai, R. & Abraham, P., Nov 27 2014, In: Molecular Diagnosis and Therapy. 18, 6, p. 655-663 9 p.

Research output: Contribution to journal › Article › peer-review

Significance of Epstein-Barr virus (HHV-4) and CMV (HHV-5) infection among subtype-C human immunodeficiency virus-infected individuals

Sachithanandham, J., Kannangai, R., Pulimood, S. A., Desai, A., Abraham, A. M., Abraham, O. C., Ravi, V., Samuel, P. & Sridharan, G., 2014, In: Indian Journal of Medical Microbiology. 32, 3, p. 261-269 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Association of neurotropic viruses in HIV-infected individuals who died of secondary complications of tuberculosis, cryptococcosis, or toxoplasmosis in south India

Kannangai, R., Sachithanandham, J., Mahadevan, A., Abraham, A. M., Sridharan, G., Desai, A., Ravi, V. & Shankar, S. K., Mar 2013, In: Journal of clinical microbiology. 51, 3, p. 1022-1025 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Human herpes virus-8 infections among subjects with human immunodeficiency virus infection and normal healthy individuals in India

Sachithanandham, J., Kannangai, R., Abraham, A. M., Fletcher, G. J., Abraham, O. C., Daniel, D. & Pulimood, S. A., Jul 2013, In: Intervirology. 56, 4, p. 253-257 5 p.

Research output: Contribution to journal › Article › peer-review

2012

Comparison of HIV-1 RNA level estimated with plasma and DBS samples: A pilot study from India (South)

David, S., Sachithanandham, J., Jerobin, J., Parasuram, S. & Kannangai, R., 2012, In: Indian Journal of Medical Microbiology. 30, 4, p. 403-406 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Daily quality control in CD3⁺ and CD4⁺ T cell estimation by the FACSCount system at a tertiary care center in South India

Ramalingam, V. V., Mani, M., Sundaresan, V. C., Karunaiya, R. J., Sachithanandham, J. & Kannangai, R., Oct 2012, In: Clinical and Vaccine Immunology. 19, 10, p. 1693-1696 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

Evaluation of a dry format reagent for CD4+ and CD8+ T-cell enumeration with FACSCount and Guava polymerase chain reaction

Sachithanandham, J., Solomon, K., Prasannakumar, S., Nithyandham, G. & Kannangai, R., 2011, In: Indian Journal of Medical Microbiology. 29, 4, p. 401-405 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2010

Immune responses to Epstein-Barr virus in individuals with systemic and organ specific autoimmune disorders

Kannangai, R., Sachithanandham, J., Kandathil, A. J., Ebenezer, D. L., Danda, D., Vasuki, Z., Thomas, N., Vasan, S. K. & Sridharan, G., Apr 1 2010, In: Indian Journal of Medical Microbiology. 28, 2, p. 120-123 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2009

Detection of opportunistic DNA viral infections by multiplex PCR among HIV infected individuals receiving care at a tertiary care hospital in South India

Sachithanandham, J., Ramamurthy, M., Kannangai, R., Daniel, H. D., Abraham, O. C., Rupali, P., Pulimood, S. A., Abraham, A. M. & Sridharan, G., Jul 1 2009, In: Indian Journal of Medical Microbiology. 27, 3, p. 210-216 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2008

Experience with a fourth generation human immunodeficiency virus serological assay at a tertiary care centre in south India

Kannangai, R., Moorthy, M., Kandathil, A., Sachithanandham, J., Thirupavai, V., Nithyanandam, G. & Sridharan, G., Apr 1 2008, In: Indian Journal of Medical Microbiology. 26, 2, p. 200-202 3 p.

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Jaiprasath Sachithanandham

Research output

Search results