Jacques Grosset

2024

Risk-stratified treatment for drug-susceptible pulmonary tuberculosis

AIDS Clinical Trial Group & Tuberculosis Trials Consortium, Dec 2024, In: Nature communications. 15, 1, 9400.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial

study team, Apr 18 2020, In: The Lancet. 395, 10232, p. 1259-1267 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

High-dose rifamycins enable shorter oral treatment in a murine model of mycobacterium ulcerans disease

Omansen, T. F., Almeida, D., Converse, P. J., Li, S. Y., Lee, J., Stienstra, Y., van der Werf, T., Grosset, J. H. & Nuermberger, E. L., Feb 2019, In: Antimicrobial agents and chemotherapy. 63, 2, e01478-18.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Oxazolidinones can replace clarithromycin in combination with rifampin in a mouse model of Buruli ulcer

Almeida, D. V., Omansen, T. F., Li, S. Y., Lee, J., Grosset, J. H., Converse, P. J. & Nuermberger, E. L., Mar 2019, In: Antimicrobial agents and chemotherapy. 63, 3, e02171-18.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Treatment-shortening effect of a novel regimen combining clofazimine and high-dose rifapentine in pathologically distinct mouse models of tuberculosis

Saini, V., Ammerman, N. C., Chang, Y. S., Tasneen, R., Chaisson, R. E., Jain, S., Nuermberger, E. & Grosset, J. H., Jun 2019, In: Antimicrobial agents and chemotherapy. 63, 6, e00388-19.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2018

C-reactive protein as a screening test for HIVassociated pulmonary tuberculosis prior to antiretroviral therapy in South Africa

Shapiro, A. E., Hong, T., Govere, S., Thulare, H., Moosa, M. Y., Dorasamy, A., Wallish, C. L., Celum, C. L., Grosset, J. & Drain, P. K., 2018, In: AIDS. 32, 13, p. 1811-1820 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Impact of clofazimine dosing on treatment shortening of the first-line regimen in a mouse model of tuberculosis

Ammerman, N. C., Swanson, R. V., Bautista, E. M., Almeida, D. V., Saini, V., Omansen, T. F., Guo, H., Chang, Y. S., Li, S. Y., Tapley, A., Tasneen, R., Tyagi, S., Betoudji, F., Moodley, C., Ngcobo, B., Pillay, L., Bester, L. A., Singh, S. D., Chaisson, R. E. & Nuermberger, E. & 1 others, Grosset, J. H., Jul 2018, In: Antimicrobial agents and chemotherapy. 62, 7, e00636-18.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Shorter-course treatment for Mycobacterium ulcerans disease with high-dose rifamycins and clofazimine in a mouse model of Buruli ulcer

Converse, P. J., Almeida, D. V., Tasneen, R., Saini, V., Tyagi, S., Ammerman, N. C., Li, S. Y., Anders, N. M., Rudek, M. A., Grosset, J. H. & Nuermberger, E. L., Aug 2018, In: PLoS neglected tropical diseases. 12, 8, e0006728.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2017

Clofazimine has delayed antimicrobial activity against Mycobacterium tuberculosis both in vitro and in vivo

Ammerman, N. C., Swanson, R. V., Tapley, A., Moodley, C., Ngcobo, B., Adamson, J., Dorasamy, A., Moodley, S., Mgaga, Z., Bester, L. A., Singh, S. D., Almeida, D. V. & Grosset, J. H., Feb 2017, In: Journal of Antimicrobial Chemotherapy. 72, 2, p. 455-461 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2016

Clofazimine contributes sustained antimicrobial activity after treatment cessation in a mouse model of tuberculosis chemotherapy

Swanson, R. V., Ammerman, N. C., Ngcobo, B., Adamson, J., Moodley, C., Dorasamy, A., Moodley, S., Mgaga, Z., Bester, L. A., Singh, S. D., Almeida, D. V. & Grosset, J. H., May 2016, In: Antimicrobial agents and chemotherapy. 60, 5, p. 2864-2869 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

Desjardins, C. A., Cohen, K. A., Munsamy, V., Abeel, T., Maharaj, K., Walker, B. J., Shea, T. P., Almeida, D. V., Manson, A. L., Salazar, A., Padayatchi, N., O'Donnell, M. R., Mlisana, K. P., Wortman, J., Birren, B. W., Grosset, J., Earl, A. M. & Pym, A. S., May 1 2016, In: Nature genetics. 48, 5, p. 544-551 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Mutations in pepQ confer low-level resistance to bedaquiline and clofazimine in Mycobacterium tuberculosis

Almeida, D., Ioerger, T., Tyagi, S., Li, S. Y., Mdluli, K., Andries, K., Grosset, J., Sacchettini, J. & Nuermberger, E., Aug 2016, In: Antimicrobial agents and chemotherapy. 60, 8, p. 4590-4599 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2015

Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations

Andréjak, C., Almeida, D. V., Tyagi, S., Converse, P. J., Ammerman, N. C. & Grosset, J. H., Apr 1 2015, In: Antimicrobial agents and chemotherapy. 59, 4, p. 2129-2135 7 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis

Tyagi, S., Ammerman, N. C., Li, S. Y., Adamson, J., Converse, P. J., Swanson, R. V., Almeida, D. V. & Grosset, J. H., Jan 20 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 3, p. 869-874 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

88 Scopus citations

Efficacy of rifampin plus clofazimine in a murine model of Mycobacterium ulcerans disease

Converse, P. J., Tyagi, S., Xing, Y., Li, S. Y., Kishi, Y., Adamson, J., Nuermberger, E. L. & Grosset, J. H., Jun 4 2015, In: PLoS neglected tropical diseases. 9, 6, e0003823.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal

Cohen, K. A., Abeel, T., Manson McGuire, A., Desjardins, C. A., Munsamy, V., Shea, T. P., Walker, B. J., Bantubani, N., Almeida, D. V., Alvarado, L., Chapman, S. B., Mvelase, N. R., Duffy, E. Y., Fitzgerald, M. G., Govender, P., Gujja, S., Hamilton, S., Howarth, C., Larimer, J. D. & Maharaj, K. & 13 others, Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M., Sep 2015, In: PLoS medicine. 12, 9, e1001880.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa

Cohen, K. A., Abeel, T., McGuire, A. M., Desjardins, C. A., Munsamy, V., Shea, T. P., Walker, B. J., Bantubani, N., Almeida, D. V., Alvarado, L., Chapman, S., Mvelase, N. R., Duffy, E. Y., Fitzgerald, M. G., Govender, P., Gujja, S., Hamilton, S., Howarth, C., Larimer, J. D. & Maharaj, K. & 13 others, Pearson, M. D., Priest, M. E., Zeng, Q., Padayatchi, N., Grosset, J., Young, S. K., Wortman, J., Mlisana, K. P., O'Donnell, M. R., Birren, B. W., Bishai, W. R., Pym, A. S. & Earl, A. M., 2015, (Accepted/In press) In: International Journal of Mycobacteriology.

Research output: Contribution to journal › Article › peer-review

Flu-like and Other Systemic Drug Reactions among Persons Receiving Weekly Rifapentine Plus Isoniazid or Daily Isoniazid for Treatment of Latent Tuberculosis Infection in the PREVENT Tuberculosis Study

Sterling, T. R., Moro, R. N., Borisov, A. S., Phillips, E., Shepherd, G., Adkinson, N. F., Weis, S., Ho, C., Villarino, M. E., Adkinson, N. F., Grosset, J., Hackman, J., Hamilton, R. G., Villarino, M. E., Shang, N., Gordin, F., Khan, A., Hamilton, C. D., Menzies, D. & Kerrigan, A. & 11 others, Horsburgh, C. R., Chaisson, R. E., McSherry, G., Arevalo, B., Vernon, A., Kleinbaum, D. G., Heilig, C., Fryer, K., Sanchez, I., Lam, S. K. & Scott, N., Aug 15 2015, In: Clinical Infectious Diseases. 61, 4, p. 527-535 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis

Swanson, R. V., Adamson, J., Moodley, C., Ngcobo, B., Ammerman, N. C., Dorasamy, A., Moodley, S., Mgaga, Z., Tapley, A., Bester, L. A., Singh, S., Grosset, J. H. & Almeida, D. V., Jun 1 2015, In: Antimicrobial agents and chemotherapy. 59, 6, p. 3042-3051 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Targeting DnaN for tuberculosis therapy using novel griselimycins

Kling, A., Lukat, P., Almeida, D. V., Bauer, A., Fontaine, E., Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S. C., König, C., Ammerman, N. C., Barrio, M. B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P. & Heinz, D. W. & 12 others, Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Tyagi, S., Fraisse, L., Grosset, J. H., Lagrange, S. & Müller, R., Jun 5 2015, In: Science. 348, 6239, p. 1106-1112 7 p.

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

2014

Accelerated Detection of Mycolactone Production and Response to Antibiotic Treatment in a Mouse Model of Mycobacterium ulcerans Disease

Converse, P. J., Xing, Y., Kim, K. H., Tyagi, S., Li, S. Y., Almeida, D. V., Nuermberger, E. L., Grosset, J. H. & Kishi, Y., Jan 2014, In: PLoS neglected tropical diseases. 8, 1, p. 52 1 p., e2618.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2013

Assessment of clofazimine activity in a second-line regimen for tuberculosis in mice

Grosset, J. H., Tyagi, S., Almeida, D. V., Converse, P. J., Li, S. Y., Ammerman, N. C., Bishai, W. R., Enarson, D. & Trébucq, A., Sep 1 2013, In: American journal of respiratory and critical care medicine. 188, 5, p. 608-612 5 p.

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

Almeida, D. V., Converse, P. J., Li, S. Y., Tyagi, S., Nuermberger, E. L. & Grosset, J. H., Feb 2013, In: PLoS neglected tropical diseases. 7, 2, e2085.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Contribution of moxifloxacin or levofloxacin in second-line regimens with or without continuation of pyrazinamide in murine tuberculosis

Ahmad, Z., Tyagi, S., Minkowski, A., Peloquin, C. A., Grosset, J. H. & Nuermberger, E. L., Jul 1 2013, In: American journal of respiratory and critical care medicine. 188, 1, p. 97-102 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Improving existing tools for Mycobacterium xenopi treatment: Assessment of drug combinations and characterization of mouse models of infection and chemotherapy

Andréjak, C., Almeida, D. V., Tyagi, S., Converse, P., Ammerman, N. & Grosset, J. H., Mar 2013, In: Journal of Antimicrobial Chemotherapy. 68, 3, p. 659-665 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Microbiological, Histological, Immunological, and Toxin Response to Antibiotic Treatment in the Mouse Model of Mycobacterium ulcerans Disease

Sarfo, F. S., Converse, P. J., Almeida, D. V., Zhang, J., Robinson, C., Wansbrough-Jones, M. & Grosset, J. H., 2013, In: PLoS neglected tropical diseases. 7, 3, e2101.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Rapid, Serial, Non-invasive Assessment of Drug Efficacy in Mice with Autoluminescent Mycobacterium ulcerans Infection

Zhang, T., Li, S. Y., Converse, P. J., Grosset, J. H. & Nuermberger, E. L., 2013, In: PLoS neglected tropical diseases. 7, 12, e2598.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2012

Activity of 5-chloro-pyrazinamide in mice infected with Mycobacterium tuberculosis or Mycobacterium bovis

Ahmad, Z., Tyagi, S., Minkowski, A., Almeida, D., Nuermberger, E. L., Peck, K. M., Welch, J. T., Baughn, A. S., Jacobs, W. R. & Grosset, J. H., Nov 2012, In: Indian Journal of Medical Research. 136, 5, p. 808-814 7 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Dose-ranging comparison of rifampin and rifapentine in two pathologically distinct murine models of tuberculosis

Rosenthal, I. M., Tasneen, R., Peloquin, C. A., Zhang, M., Almeida, D., Mdluli, K. E., Karakousis, P. C., Grosset, J. H. & Nuermberger, E. L., Aug 2012, In: Antimicrobial agents and chemotherapy. 56, 8, p. 4331-4340 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide

Grosset, J., Almeida, D., Converse, P. J., Tyagi, S., Li, S. Y., Ammerman, N. C., Pym, A. S., Wallengren, K., Hafner, R., Lalloo, U., Swindells, S. & Bishai, W. R., Sep 11 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 15001-15005 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs

Dutta, N. K., Illei, P. B., Peloquin, C. A., Pinn, M. L., Mdluli, K. E., Nuermberger, E. L., Grosset, J. H. & Karakousis, P. C., Jul 2012, In: Antimicrobial agents and chemotherapy. 56, 7, p. 3726-3731 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2011

Activities of rifampin, rifapentine and clarithromycin alone and in combination against Mycobacterium ulcerans disease in mice

Almeida, D., Converse, P. J., Ahmad, Z., Dooley, K. E., Nuermberger, E. L. & Grosset, J. H., 2011, In: PLoS neglected tropical diseases. 5, 1, e933.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Activity of the fluoroquinolone DC-159a in the initial and continuation phases of treatment of murine tuberculosis

Ahmad, Z., Minkowski, A., Peloquin, C. A., Williams, K. N., Mdluli, K. E., Grosset, J. H. & Nuermberger, E. L., Apr 2011, In: Antimicrobial agents and chemotherapy. 55, 4, p. 1781-1783 3 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

BCG-mediated protection against Mycobacterium ulcerans infection in the mouse

Converse, P. J., Almeida, D. V., Nuermberger, E. L. & Grosset, J. H., Mar 2011, In: PLoS neglected tropical diseases. 5, 3, e985.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections

Ahmad, Z., Fraig, M. M., Bisson, G. P., Nuermberger, E. L., Grosset, J. H. & Karakousis, P. C., Apr 2011, In: Antimicrobial agents and chemotherapy. 55, 4, p. 1527-1532 6 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models

Ahmad, Z., Fraig, M. M., Pinn, M. L., Tyagi, S., Nuermberger, E. L., Grosset, J. H. & Karakousis, P. C., Jul 2011, In: Journal of Antimicrobial Chemotherapy. 66, 7, p. 1560-1566 7 p., dkr188.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

New drugs for tuberculosis treatment

Sánchez, F., López Colomés, J. L., Villarino, E. & Grosset, J., Mar 2011, In: Enfermedades Infecciosas y Microbiologia Clinica. 29, SUPPL. 1, p. 47-56 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

PA-824 exhibits time-dependent activity in a murine model of tuberculosis

Ahmad, Z., Peloquin, C. A., Singh, R. P., Derendorf, H., Tyagi, S., Ginsberg, A., Grosset, J. H. & Nuermberger, E. L., Jan 2011, In: Antimicrobial agents and chemotherapy. 55, 1, p. 239-245 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Scopus citations

Treatment of tuberculosis with rifamycin-containing regimens in immune-deficient mice

Zhang, M., Li, S. Y., Rosenthal, I. M., Almeida, D. V., Ahmad, Z., Converse, P. J., Peloquin, C. A., Nuermberger, E. L. & Grosset, J. H., May 1 2011, In: American journal of respiratory and critical care medicine. 183, 9, p. 1254-1261 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Using bioluminescence to monitor treatment response in real time in mice with mycobacterium ulcerans infection

Zhang, T., Li, S. Y., Converse, P. J., Almeida, D. V., Grosset, J. H. & Nuermberger, E. L., Jan 2011, In: Antimicrobial agents and chemotherapy. 55, 1, p. 56-61 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

2010

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig

Ahmad, Z., Nuermberger, E. L., Tasneen, R., Pinn, M. L., Williams, K. N., Peloquin, C. A., Grosset, J. H. & Karakousis, P. C., Jan 31 2010, In: Journal of Antimicrobial Chemotherapy. 65, 4, p. 729-734 6 p., dkq007.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Methionine Aminopeptidases from Mycobacterium tuberculosis as Novel Antimycobacterial Targets

Olaleye, O., Raghunand, T. R., Bhat, S., He, J., Tyagi, S., Lamichhane, G., Gu, P., Zhou, J., Zhang, Y., Grosset, J., Bishai, W. R. & Liu, J. O., Jan 29 2010, In: Chemistry and Biology. 17, 1, p. 86-97 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection

Alffenaar, J. W. C., Nienhuis, W. A., De Velde, F., Zuur, A. T., Wessels, A. M. A., Almeida, D., Grosset, J., Adjei, O., Uges, D. R. A. & Van Der Werf, T. S., Sep 2010, In: Antimicrobial agents and chemotherapy. 54, 9, p. 3878-3883 6 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains

Zhang, T., Bishai, W. R., Grosset, J. H. & Nuermberger, E. L., Jul 2010, In: Antimicrobial agents and chemotherapy. 54, 7, p. 2806-2813 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

The Impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models

Converse, P. J., Eisenach, K. D., Theus, S. A., Nuermberger, E. L., Tyagi, S., Ly, L. H., Geiman, D. E., Guo, H., Nolan, S. T., Akar, N. C., Klinkenberg, L. G., Gupta, R., Lun, S., Karakousis, P. C., Lamichhane, G., McMurray, D. N., Grosset, J. H. & Bishai, W. R., 2010, In: PloS one. 5, 4, e10292.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters

Ahmad, Z., Pinn, M. L., Nuermberger, E. L., Peloquin, C. A., Grosset, J. H. & Karakousis, P. C., Aug 6 2010, In: Journal of Antimicrobial Chemotherapy. 65, 10, p. 2172-2175 4 p., dkq277.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2009

Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis

Williams, K. N., Brickner, S. J., Stover, C. K., Zhu, T., Ogden, A., Tasneen, R., Tyagi, S., Grosset, J. H. & Nuermberger, E. L., Aug 15 2009, In: American journal of respiratory and critical care medicine. 180, 4, p. 371-376 6 p.

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Benzothiazinones Kill Mycobacterium tuberculosis by blocking Arabinan synthesis

Makarov, V., Manina, G., Mikusova, K., Möllmann, U., Ryabova, O., Saint-Joanis, B., Dhar, N., Pasca, M. R., Buroni, S., Lucarelli, A. P., Milano, A., De Rossi, E., Belanova, M., Bobovska, A., Dianiskova, P., Kordulakova, J., Sala, C., Fullam, E., Schneider, P. & McKinney, J. D. & 17 others, Brodin, P., Christophe, T., Waddell, S., Butcher, P., Albrethsen, J., Rosenkrands, I., Brosch, R., Nandi, V., Bharath, S., Gaonkar, S., Shandil, R. K., Balasubramanian, V., Balganesh, T., Tyagi, S., Grosset, J., Riccardi, G. & Cole, S. T., May 8 2009, In: Science. 324, 5928, p. 801-804 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

502 Scopus citations

Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, mycobacterium tuberculosis in the guinea pig

Ahmad, Z., Klinkenberg, L. G., Pinn, M. L., Fraig, M. M., Peloquin, C. A., Bishai, W. R., Nuermberger, E. L., Grosset, J. H. & Karakousis, P. C., Oct 1 2009, In: Journal of Infectious Diseases. 200, 7, p. 1136-1143 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

80 Scopus citations

Paradoxical effect of isoniazid on the activity of rifampin-pyrazinamide combination in a mouse model of tuberculosis

Almeida, D., Nuermberger, E., Tasneen, R., Rosenthal, I., Tyagi, S., Williams, K., Peloquin, C. & Grosset, J., Oct 2009, In: Antimicrobial agents and chemotherapy. 53, 10, p. 4178-4184 7 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Jacques Grosset

Research output

Search results