Ivo Francischetti

2023

A bispecific inhibitor of complement and coagulation blocks activation in complementopathy models via a novel mechanism

Andersen, J. F., Lei, H., Strayer, E. C., Kanai, T., Pham, V., Pan, X. Z., Alvarenga, P. H., Gerber, G. F., Asojo, O. A., Francischetti, I. M. B., Brodsky, R. A., Valenzuela, J. G. & Ribeiro, J. M. C., Jun 22 2023, In: Blood. 141, 25, p. 3109-3121 13 p.

Research output: Contribution to journal › Article › peer-review

2022

Functional aspects of evolution in a cluster of salivary protein genes from mosquitoes

Alvarenga, P. H., Dias, D. R., Xu, X., Francischetti, I. M. B., Gittis, A. G., Arp, G., Garboczi, D. N., Ribeiro, J. M. C. & Andersen, J. F., Jul 2022, In: Insect Biochemistry and Molecular Biology. 146, 103785.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood–brain barrier damage, and inflammation

Leinweber, J., Mizurini, D. M., Francischetti, I. M. B., Fleischer, M., Hermann, D. M., Kleinschnitz, C. & Langhauser, F., Mar 2021, In: Brain, Behavior, and Immunity. 93, p. 288-298 11 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Neutrophil and Eosinophil Extracellular Traps in Hodgkin Lymphoma

Francischetti, I. M. B., Alejo, J. C., Sivanandham, R., Davies-Hill, T., Fetsch, P., Pandrea, I., Jaffe, E. S. & Pittaluga, S., Sep 1 2021, In: HemaSphere. 5, 9, e633.

Research output: Contribution to journal › Article › peer-review

Open Access

Pax-5 negative B-cell Lymphoma

Almiski, M., Ng, D. P., Moltzan, C., Francischetti, I. M. & Sellen, L. D., Sep 2021, In: Human Pathology: Case Reports. 25, 200474.

Research output: Contribution to journal › Article › peer-review

Open Access

Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection

Francischetti, I. M. B., Toomer, K., Zhang, Y., Jani, J., Siddiqui, Z., Brotman, D. J., Hooper, J. E. & Kickler, T. S., Sep 2021, In: EClinicalMedicine. 39, 101069.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Agaphelin modulates the activation of human bronchial epithelial cells induced by lipopolysaccharide and IL-4

Favarin, D. C., Pereira, A. B. M., Francischetti, I. M. B., da Silva, M. V., Rodrigues, V., da Silva, P. R., Valenzuela, J. G., Teixeira, D. N. S., Oliveira, C. J. F. & Rogério, A. D. P., May 2020, In: Immunobiology. 225, 3, 151937.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and hairy cell leukemia: clinical, pathologic and molecular features

Obiorah, I. E., Francischetti, I. M. B., Wang, H. W., Ahn, I. E., Wang, W., Raffeld, M., Kreitman, R. J., Wiestner, A. & Calvo, K. R., 2020, In: Leukemia and Lymphoma. 61, 13, p. 3177-3187 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes

Rodrigues, D. A. S., Prestes, E. B., Gama, A. M. S., de Souza Silva, L., Pinheiro, A. A. S., Ribeiro, J. M. C., Campos, R. M. P., Pimentel-Coelho, P. M., de Souza, H. S., Dicko, A., Duffy, P. E., Fried, M., Francischetti, I. M. B., Saraiva, E. M., Paula-Neto, H. A. & Bozza, M. T., Aug 2020, In: PLoS pathogens. 16, 8, e1008230.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Development of ¹³¹I-ixolaris as a theranostic agent: metastatic melanoma preclinical studies

Barboza, T., Gomes, T., da Costa Medeiros, P., Ramos, I. P., Francischetti, I., Monteiro, R. Q., Gutfilen, B. & de Souza, S. A. L., Aug 1 2020, In: Clinical and Experimental Metastasis. 37, 4, p. 489-497 9 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2019

NMR structure determination of Ixolaris and factor X(a) interaction reveals a noncanonical mechanism of Kunitz inhibition

De Paula, V. S., Sgourakis, N. G., Francischetti, I. M. B., Almeida, F. C. L., Monteiro, R. Q. & Valente, A. P., Aug 22 2019, In: Blood. 134, 8, p. 699-708 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2018

Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis

Assumpção, T. C., Mizurini, D. M., Ma, D., Monteiro, R. Q., Ahlstedt, S., Reyes, M., Kotsyfakis, M., Mather, T. N., Andersen, J. F., Lukszo, J., Ribeiro, J. M. C. & Francischetti, I. M. B., Dec 1 2018, In: Scientific reports. 8, 1, 4806.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2017

¹H, ¹⁵N and ¹³C resonance assignments of Ixolaris, a tissue factor pathway inhibitor from the tick salivary gland

De Paula, V. S., Silva, F. H. S., Francischetti, I. M. B., Monteiro, R. Q. & Valente, A. P., Oct 1 2017, In: Biomolecular NMR Assignments. 11, 2, p. 293-296 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

An insight into the sialome of Hyalomma excavatum

Ribeiro, J. M. C., Slovák, M. & Francischetti, I. M. B., Feb 1 2017, In: Ticks and Tick-borne Diseases. 8, 2, p. 201-207 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Incidental primary mediastinal choriocarcinoma diagnosed by endobronchial ultrasound-guided fine needle aspiration in a patient presenting with transient ischemic attack and stroke

Francischetti, I. M. B., Cajigas, A., Suhrland, M., Farinhas, J. M. & Khader, S., Aug 2017, In: Diagnostic cytopathology. 45, 8, p. 738-743 6 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy

Schechter, M. E., Andrade, B. B., He, T., Richter, G. H., Tosh, K. W., Policicchio, B. B., Singh, A., Raehtz, K. D., Sheikh, V., Ma, D., Brocca-Cofano, E., Apetrei, C., Tracy, R., Ribeiro, R. M., Sher, A., Francischetti, I. M. B., Pandrea, I. & Sereti, I., Aug 30 2017, In: Science translational medicine. 9, 405, aam5441.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Laboratory and clinical predictors of 30-day survival for patients on Extracorporeal Membrane Oxygenation (ECMO): 8-Year experience at Albert Einstein College of Medicine, Montefiore Medical Center

Francischetti, I. M. B., Szymanski, J., Rodriguez, D., Heo, M. & Wolgast, L. R., Aug 1 2017, In: Journal of Critical Care. 40, p. 136-144 9 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Recombinant expression of Ixolaris, a Kunitz-type inhibitor from the tick salivary gland, for NMR studies

De Paula, V. S., Silva, F. H. S., Francischetti, I. M. B., Monteiro, R. Q. & Valente, A. P., Nov 2017, In: Protein Expression and Purification. 139, p. 49-56 8 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2016

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus

Assumpção, T. C., Ma, D., Mizurini, D. M., Kini, R. M., Ribeiro, J. M. C., Kotsyfakis, M., Monteiro, R. Q. & Francischetti, I. M. B., Jan 8 2016, In: PLoS neglected tropical diseases. 10, 1, e0004298.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Molecular Diversity between Salivary Proteins from New World and Old World Sand Flies with Emphasis on Bichromomyia olmeca, the Sand Fly Vector of Leishmania mexicana in Mesoamerica

Abdeladhim, M., V. Coutinho-Abreu, I., Townsend, S., Pasos-Pinto, S., Sanchez, L., Rasouli, M., B. Guimaraes-Costa, A., Aslan, H., Francischetti, I. M. B., Oliveira, F., Becker, I., Kamhawi, S., Ribeiro, J. M. C., Jochim, R. C. & Valenzuela, J. G., Jul 13 2016, In: PLoS neglected tropical diseases. 10, 7, e0004771.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2015

^99mTc-ixolaris targets glioblastoma-associated tissue factor: In vitro and pre-clinical applications

Barboza, T., Gomes, T., Mizurini, D. M., Monteiro, R. Q., König, S., Francischetti, I. M. B., Signoretti, P. V. P., Ramos, I. P., Gutfilen, B. & Souza, S. A. L., Aug 1 2015, In: Thrombosis research. 136, 2, p. 432-439 8 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

A deep insight into the sialotranscriptome of the chagas disease vector, Panstrongylus megistus (hemiptera: Heteroptera)

Ribeiro, J. M. C., Schwarz, A. & Francischetti, I. M. B., May 1 2015, In: Journal of medical entomology. 52, 3, p. 351-358 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

An insight into the sialome of the horse fly, Tabanus bromius

Ribeiro, J. M. C., Kazimirova, M., Takac, P., Andersen, J. F. & Francischetti, I. M. B., Oct 1 2015, In: Insect Biochemistry and Molecular Biology. 65, p. 83-90 8 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Salivary thromboxane A2-binding proteins from triatomine vectors of chagas disease inhibit platelet-mediated neutrophil extracellular traps (NETs) formation and arterial thrombosis

Mizurini, D. M., Aslan, J. S., Gomes, T., Ma, D., Francischetti, I. M. B. & Monteiro, R. Q., Jun 25 2015, In: PLoS neglected tropical diseases. 9, 6, e0003869.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Sexual differences in the sialomes of the zebra tick, Rhipicephalus pulchellus

Tan, A. W. L., Francischetti, I. M. B., Slovak, M., Kini, R. M. & Ribeiro, J. M. C., Mar 8 2015, In: Journal of Proteomics. 117, p. 120-144 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

The structure of hookworm platelet inhibitor (HPI), a CAP superfamily member from Ancylostoma caninum

Ma, D., Francischetti, I. M. B., Ribeiro, J. M. C. & Andersen, J. F., Jun 1 2015, In: Acta Crystallographica Section F:Structural Biology Communications. 71, p. 643-649 7 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

2014

Evidence for a lectin specific for sulfated glycans in the salivary gland of the malaria vector, anopheles gambiae

Francischetti, I. M. B., Ma, D., Andersen, J. F. & Ribeiro, J. M. C., Sep 1 2014, In: PloS one. 9, 9, e107295.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Examination of the ligand-binding and enzymatic properties of a bilin-binding protein from the poisonous caterpillar lonomia obliqua

Veiga, A. B. G., Ribeiro, J. M. C., Francischetti, I. M. B., Xu, E., Guimarães, J. A. & Andersen, J. F., Jun 27 2014, In: PloS one. 9, 6, e95424.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis

Waisberg, M., Molina-Cruz, A., Mizurini, D. M., Gera, N., Sousa, B. C., Ma, D., Leal, A. C., Gomes, T., Kotsyfakis, M., Ribeiro, J. M. C., Lukszo, J., Reiter, K., Porcella, S. F., Oliveira, C. J., Monteiro, R. Q., Barillas-Mury, C., Pierce, S. K. & Francischetti, I. M. B., Sep 1 2014, In: PLoS pathogens. 10, 9

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Purification of a serine protease and evidence for a protein C activator from the saliva of the tick, Ixodes scapularis

Pichu, S., Ribeiro, J. M. C., Mather, T. N. & Francischetti, I. M. B., 2014, In: Toxicon. 77, p. 32-39 8 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Tempol, an intracellular antioxidant, inhibits tissue factor expression, attenuates dendritic cell function, and is partially protective in a murine model of cerebral malaria

Francischetti, I. M. B., Gordon, E., Bizzarro, B., Gera, N., Andrade, B. B., Oliveira, F., Ma, D., Assumpção, T. C. F., Ribeiro, J. M. C., Pena, M., Qi, C. F., Diouf, A., Moretz, S. E., Long, C. A., Ackerman, H. C., Pierce, S. K., Sá-Nunes, A. & Waisberg, M., Feb 28 2014, In: PloS one. 9, 2, e87140.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2013

Aegyptin inhibits collagen-induced coagulation activation in vitro and thromboembolism in vivo

Mizurini, D. M., Francischetti, I. M. B. & Monteiro, R. Q., Jun 28 2013, In: Biochemical and Biophysical Research Communications. 436, 2, p. 235-239 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

Ma, D., Mizurini, D. M., Assumpção, T. C. F., Li, Y., Qi, Y., Kotsyfakis, M., Ribeiro, J. M. C., Monteiro, R. Q. & Francischetti, I. M. B., 2013, In: Blood. 122, 25, p. 4094-4106 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

Novel family of insect salivary inhibitors blocks contact pathway activation by binding to polyphosphate, heparin, and dextran sulfate

Alvarenga, P. H., Xu, X., Oliveira, F., Chagas, A. C., Nascimento, C. R., Francischetti, I. M. B., Juliano, M. A., Juliano, L., Scharfstein, J., Valenzuela, J. G., Ribeiro, J. M. C. & Andersen, J. F., Dec 2013, In: Arteriosclerosis, thrombosis, and vascular biology. 33, 12, p. 2759-2770 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Proteome of Rhipicephalus sanguineus tick saliva induced by the secretagogues pilocarpine and dopamine

Oliveira, C. J., Anatriello, E., de Miranda-Santos, I. K., Francischetti, I. M., Sá-Nunes, A., Ferreira, B. R. & Ribeiro, J. M. C., Dec 2013, In: Ticks and Tick-borne Diseases. 4, 6, p. 469-477 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

The "Vampirome": Transcriptome and proteome analysis of the principal and accessory submaxillary glands of the vampire bat Desmodus rotundus, a vector of human rabies

Francischetti, I. M. B., Assumpção, T. C. F., Ma, D., Li, Y., Vicente, E. C., Uieda, W. & Ribeiro, J. M. C., Apr 6 2013, In: Journal of Proteomics. 82, p. 288-319 32 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2012

An Insight into the Sialotranscriptome of the Cat Flea, Ctenocephalides felis

Ribeiro, J. M. C., Assumpção, T. C. F., Ma, D., Alvarenga, P. H., Pham, V. M., Andersen, J. F., Francischetti, I. M. B. & Macaluso, K. R., Sep 25 2012, In: PloS one. 7, 9, e44612.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America

Assumpção, T. C. F., Eaton, D. P., Pham, V. M., Francischetti, I. M. B., Aoki, V., Hans-Filho, G., Rivitti, E. A., Valenzuela, J. G., Diaz, L. A. & Ribeiro, J. M. C., Jun 1 2012, In: American Journal of Tropical Medicine and Hygiene. 86, 6, p. 1005-1014 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

An insight into the sialotranscriptome of Triatoma rubida (Hemiptera: Heteroptera)

Ribeiro, J. M. C., Assumçãpo, T. C. F., Pham, V. M., Francischetti, I. M. B. & Reisenman, C. E., May 2012, In: Journal of medical entomology. 49, 3, p. 563-572 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria

Francischetti, I. M. B., Oliveira, C. J., Ostera, G. R., Yager, S. B., Debierre-Grockiego, F., Carregaro, V., Jaramillo-Gutierrez, G., Hume, J. C. C., Jiang, L., Moretz, S. E., Lin, C. K., Ribeiro, J. M. C., Long, C. A., Vickers, B. K., Schwarz, R. T., Seydel, K. B., Iacobelli, M., Ackerman, H. C., Srinivasan, P., Gomes, R. B., & 5 othersWang, X., Monteiro, R. Q., Kotsyfakis, M., Sá-Nunes, A. & Waisberg, M., Mar 2012, In: Arteriosclerosis, thrombosis, and vascular biology. 32, 3, p. 786-798 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Disintegrins from hematophagous sources

Assumpcao, T. C. F., Ribeiro, J. M. C. & Francischetti, I. M. B., May 2012, In: Toxins. 4, 5, p. 296-322 27 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Evolutionarily Conserved Interaction between the Phosphoproteins and X Proteins of Bornaviruses from Different Vertebrate Species

Fujino, K., Horie, M., Honda, T., Nakamura, S., Matsumoto, Y., Francischetti, I. M. B. & Tomonaga, K., Dec 7 2012, In: PloS one. 7, 12, e51161.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Inhibition of tissue factor by ixolaris reduces primary tumor growth and experimental metastasis in a murine model of melanoma

De Oliveira, A. D. S., Lima, L. G., Mariano-Oliveira, A., MacHado, D. E., Nasciutti, L. E., Andersen, J. F., Petersen, L. C., Francischetti, I. M. B. & Monteiro, R. Q., Sep 2012, In: Thrombosis research. 130, 3, p. e163-e170

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Lufaxin, a novel factor Xa inhibitor from the salivary gland of the sand fly lutzomyia longipalpis blocks protease-activated receptor 2 activation and inhibits inflammation and thrombosis in vivo

Collin, N., Assumpção, T. C. F., Mizurini, D. M., Gilmore, D. C., Dutra-Oliveira, A., Kotsyfakis, M., Sá-Nunes, A., Teixeira, C., Ribeiro, J. M. C., Monteiro, R. Q., Valenzuela, J. G. & Francischetti, I. M. B., Sep 2012, In: Arteriosclerosis, thrombosis, and vascular biology. 32, 9, p. 2185-2196 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Scopus citations

Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P

Waisberg, M., Cerqueira, G. C., Yager, S. B., Francischetti, I. M. B., Lu, J., Gera, N., Srinivasan, P., Miura, K., Rada, B., Lukszo, J., Barbian, K. D., Leto, T. L., Porcella, S. F., Narum, D. L., El-Sayed, N., Miller, L. H. & Pierce, S. K., Apr 3 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 14, p. 5429-5434 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Simukunin from the salivary glands of the black fly simulium vittatum inhibits enzymes that regulate clotting and inflammatory responses

Tsujimoto, H., Kotsyfakis, M., Francischetti, I. M. B., Eum, J. H., Strand, M. R. & Champagne, D. E., Feb 23 2012, In: PloS one. 7, 2, e29964.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Structure of protein having inhibitory disintegrin and leukotriene scavenging functions contained in single domain

Xu, E., Francischetti, I. M. B., Lai, R., Ribeiro, J. M. C. & Andersen, J. F., Mar 30 2012, In: Journal of Biological Chemistry. 287, 14, p. 10967-10976 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

The sialotranscriptome of Antricola delacruzi female ticks is compatible with non-hematophagous behavior and an alternative source of food

Ribeiro, J. M. C., Labruna, M. B., Mans, B. J., Maruyama, S. R., Francischetti, I. M. B., Barizon, G. C. & de Miranda Santos, I. K. F., May 2012, In: Insect Biochemistry and Molecular Biology. 42, 5, p. 332-342 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

The tick-derived inhibitor Ixolaris prevents tissue factor signaling on tumor cells

Carneiro-Lobo, T. C., Schaffner, F., Disse, J., Ostergaard, H., Francischetti, I. M. B., Monteiro, R. Q. & Ruf, W., Sep 2012, In: Journal of Thrombosis and Haemostasis. 10, 9, p. 1849-1858 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

29 Scopus citations

Triplatin, a platelet aggregation inhibitor from the salivary gland of the triatomine vector of chagas disease, binds to TXA₂ but does not interact with glycoprotein PVI

Ma, D., Assumpção, T. C. F., Li, Y., Andersen, J. F., Ribeiro, J. M. C. & Francischetti, I. M. B., Jan 2012, In: Thrombosis and Haemostasis. 107, 1, p. 111-123 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Ivo Francischetti

Research output

Search results