Research output per year
Research output per year
- 25 results
Search results
-
2025
miR-217-5p NanomiRs Inhibit Glioblastoma Growth and Enhance Effects of Ionizing Radiation via EZH2 Inhibition and Epigenetic Reprogramming
Korleski, J., Sudhir, S., Rui, Y., Caputo, C. A., Sall, S., Johnson, A. L., Khela, H. S., Madhvacharyula, T., Rasamsetty, A., Li, Y., Lal, B., Zhou, W., Smith-Connor, K., Tzeng, S., Green, J., Laterra, J. & Lopez-Bertoni, H., Jan 2025, In: Cancers. 17, 1, 80.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Preclinical Efficacy of LP-184, a Tumor Site Activated Synthetic Lethal Therapeutic, in Glioblastoma
Lal, B., Kulkarni, A., McDermott, J., Rais, R., Alt, J., Wu, Y., Lopez-Bertoni, H., Sall, S., Kathad, U., Zhou, J., Slusher, B. S., Bhatia, K. & Laterra, J., Oct 15 2023, In: Clinical Cancer Research. 29, 20, p. 4209-4218 10 p.Research output: Contribution to journal › Article › peer-review
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2022
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
Lopez-Bertoni, H., Johnson, A., Rui, Y., Lal, B., Sall, S., Malloy, M., Coulter, J. B., Lugo-Fagundo, M., Shudir, S., Khela, H., Caputo, C., Green, J. J. & Laterra, J., Dec 2022, In: Signal Transduction and Targeted Therapy. 7, 1, 37.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting UDP-α-D-glucose 6-dehydrogenase alters the CNS tumor immune microenvironment and inhibits glioblastoma growth
Zhan, D., Yalcin, F., Ma, D., Fu, Y., Wei, S., Lal, B., Li, Y., Dzaye, O., Laterra, J., Ying, M., Lopez-Bertoni, H. & Xia, S., May 2022, In: Genes and Diseases. 9, 3, p. 717-730 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The endosomal pH regulator NHE9 is a driver of stemness in glioblastoma
Ko, M., Makena, M. R., Schiapparelli, P., Suarez-Meade, P., Mekile, A. X., Lal, B., Lopez-Bertoni, H., Kozielski, K. L., Green, J. J., Laterra, J., Quinones-Hinojosa, A. & Rao, R., Mar 1 2022, In: PNAS Nexus. 1, 1, pgac013.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Monoallelic IDH1 R132H mutation mediates glioma cell response to anticancer therapies via induction of senescence
Zhan, D., Ma, D., Wei, S., Lal, B., Fu, Y., Eberhart, C., Laterra, J., Ying, M., Li, Y., Meeker, A., Lopez-Bertoni, H. & Xia, S., Nov 2021, In: Molecular Cancer Research. 19, 11, p. 1878-1888 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1
Ma, D., Zhan, D., Fu, Y., Wei, S., Lal, B., Wang, J., Li, Y., Lopez-Bertoni, H., Yalcin, F., Dzaye, O., Eberhart, C. G., Laterra, J., Wilson, M. A., Ying, M. & Xia, S., Oct 1 2021, In: Cancer Letters. 517, p. 35-45 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Opinion: miRNAs – The new wave of molecular cancer therapeutics
Lopez-Bertoni, H. & Laterra, J., Jun 2021, In: Translational Oncology. 14, 6, 101064.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
A Sox2:miR-486-5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks
Lopez-Bertoni, H., Kotchetkov, I. S., Mihelson, N., Lal, B., Rui, Y., Ames, H., Lugo-Fagundo, M., Guerrero-Cazares, H., Quinones-Hinojosa, A., Green, J. J. & Laterra, J., Apr 15 2020, In: Cancer Research. 80, 8, p. 1644-1655 12 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2019
Extracellular matrix protein tenascin C increases phagocytosis mediated by CD47 Loss of function in glioblastoma
Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R. S., Gao, P., Lopez-Bertoni, H., Ying, M., Li, J. J., Laterra, J., Wilson, M. A. & Xia, S., 2019, In: Cancer Research. 79, 10, p. 2697-2708 12 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
TET1 regulates DNA repair in human glial cells
Kuhns, K. J., Lopez-Bertoni, H., Coulter, J. B. & Bressler, J. P., Oct 1 2019, In: Toxicology and Applied Pharmacology. 380, 114646.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2018
Bioreducible Polymeric Nanoparticles Containing Multiplexed Cancer Stem Cell Regulating miRNAs Inhibit Glioblastoma Growth and Prolong Survival
Lopez-Bertoni, H., Kozielski, K. L., Rui, Y., Lal, B., Vaughan, H., Wilson, D. R., Mihelson, N., Eberhart, C. G., Laterra, J. & Green, J. J., Jul 11 2018, In: Nano Letters. 18, 7, p. 4086-4094 9 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Crizotinib and erlotinib inhibits growth of c-Met+/EGFRvIII+ primary human glioblastoma xenografts
Goodwin, C. R., Rath, P., Oyinlade, O., Lopez, H., Mughal, S., Xia, S., Li, Y., Kaur, H., Zhou, X., Ahmed, A. K., Ho, S., Olivi, A. & Lal, B., Aug 2018, In: Clinical Neurology and Neurosurgery. 171, p. 26-33 8 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2017
TET1 deficiency attenuates the DNA damage response and promotes resistance to DNA damaging agents
Coulter, J. B., Lopez-Bertoni, H., Kuhns, K. J., Lee, R. S., Laterra, J. & Bressler, J. P., Oct 3 2017, In: Epigenetics. 12, 10, p. 854-864 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
2016
Analysis of SOX2-regulated transcriptome in glioma stem cells
Acanda De La Rocha, A. M., López-Bertoni, H., Guruceaga, E., González-Huarriz, M., Martínez-Vélez, N., Xipell, E., Fueyo, J., Gomez-Manzano, C. & Alonso, M. M., Sep 2016, In: PloS one. 11, 9Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells
Lopez-Bertoni, H., Lal, B., Michelson, N., Guerrero-Cázares, H., Quinõnes-Hinojosa, A., Li, Y. & Laterra, J., Sep 15 2016, In: Oncogene. 35, 37, p. 4903-4913 11 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2015
DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2
Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. & Li, Y., Jul 23 2015, In: Oncogene. 34, 30, p. 3994-4004 11 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
The cancer stem cell phenotype: You can't win until you learn how to lose it
Lopez-Bertoni, H. & Laterra, J., Jul 3 2015, In: Molecular and Cellular Oncology. 2, 3, e989760.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
2014
The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1
Pang, X., Zhang, J., Lopez, H., Wang, Y., Li, W., O'Neill, K. L., Evans, J. J. D., George, N. M., Long, J., Chen, Y. & Luo, X., Jun 20 2014, In: Journal of Biological Chemistry. 289, 25, p. 17802-17811 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2012
Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study
Rajule, R., Bryant, V. C., Lopez, H., Luo, X. & Natarajan, A., Apr 1 2012, In: Bioorganic and Medicinal Chemistry. 20, 7, p. 2227-2234 8 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells
Menezes, M. R., Waisertreiger, I. S. R., Lopez-Bertoni, H., Luo, X. & Pavlov, Y. I., Feb 27 2012, In: PloS one. 7, 2, e32313.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2011
2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study
Chen, Q., Bryant, V. C., Lopez, H., Kelly, D. L., Luo, X. & Natarajan, A., Apr 1 2011, In: Bioorganic and Medicinal Chemistry Letters. 21, 7, p. 1929-1932 4 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Active Bax and Bak are functional holins
Pang, X., Moussa, S. H., Targy, N. M., Bose, J. L., George, N. M., Gries, C., Lopez, H., Zhang, L., Bayles, K. W., Young, R. & Luo, X., Nov 1 2011, In: Genes and Development. 25, 21, p. 2278-2290 13 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways
Zhang, L., Lopez, H., George, N. M., Liu, X., Pang, X. & Luo, X., May 2011, In: Cell death and differentiation. 18, 5, p. 864-873 10 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
2010
Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage
Lopez, H., Zhang, L., George, N. M., Liu, X., Pang, X., Evans, J. J. D., Targy, N. M. & Luo, X., May 14 2010, In: Journal of Biological Chemistry. 285, 20, p. 15016-15026 11 p.Research output: Contribution to journal › Article › peer-review
Open Access44 Scopus citations