Heeseong Jang

Research output

Research output per year 2008 2012 2013 2014 2015 2020 2021 2022 2023

• 36 Article
• 4 Review article
• 1 Editorial

Research output per year

Research output per year

Search results

• 2023

  Epoxyeicosatrienoic acid administration or soluble epoxide hydrolase inhibition attenuates renal fibrogenesis in obstructive nephropathy

  Noh, M. R., Jang, H. S., Salem, F. E., Ferrer, F. A., Kim, J. & Padanilam, B. J., Feb 2023, In: American Journal of Physiology - Renal Physiology. 324, 2, p. F138-F151

  Research output: Contribution to journal › Article › peer-review

  • Epoxide Hydrolases 100%
  • Ureteral Obstruction 92%
  • Acids 54%
  • Kidney 38%
  • Macrophages 30%

• Human milk oligosaccharides reduce necrotizing enterocolitis-induced neuroinflammation and cognitive impairment in mice

  Sodhi, C. P., Ahmad, R., Fulton, W. B., Lopez, C. M., Eke, B. O., Scheese, D., Duess, J. W., Steinway, S. N., Raouf, Z., Moore, H., Tsuboi, K., Sampah, M. E., Jang, H. S., Buck, R. H., Hill, D. R., Niemiro, G. M., Prindle, T., Wang, S., Wang, M., Jia, H., & 3 othersCatazaro, J., Lu, P. & Hackam, D. J., Jul 2023, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 325, 1, p. G23-G41

  Research output: Contribution to journal › Article › peer-review

  • Necrotizing Enterocolitis 100%
  • Oligosaccharides 90%
  • Human Milk 89%
  • Cognitive Dysfunction 66%
  • Brain Injuries 61%
• 2022

  2-Mercaptoethanol protects against DNA double-strand breaks after kidney ischemia and reperfusion injury through GPX4 upregulation

  Moon, D., Padanilam, B. J., Jang, H. S. & Kim, J., Oct 2022, In: Pharmacological Reports. 74, 5, p. 1041-1053 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Phospholipid Hydroperoxide Glutathione Peroxidase 100%
  • Mercaptoethanol 80%
  • Double-Stranded DNA Breaks 70%
  • Reperfusion Injury 59%
  • Ataxia Telangiectasia 52%

• Hepatic and proximal tubule angiotensinogen play distinct roles in kidney dysfunction, glomerular and tubular injury, and fibrosis progression

  Jang, H. S., Noh, M. R., Plumb, T., Lee, K., He, J. C., Ferrer, F. A. & Padanilam, B. J., Oct 1 2022, In: American Journal of Physiology - Renal Physiology. 323, 4, p. F435-F446

  Research output: Contribution to journal › Article › peer-review

  • Angiotensinogen 100%
  • Fibrosis 57%
  • Chronic Renal Insufficiency 55%
  • Kidney 41%
  • Liver 39%

• Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury

  Tang, W., Panja, S., Jogdeo, C. M., Tang, S., Ding, L., Yu, A., Foster, K. W., Dsouza, D. L., Chhonker, Y. S., Jensen-Smith, H., Jang, H. S., Boesen, E. I., Murry, D. J., Padanilam, B. & Oupický, D., Jun 2022, In: Biomaterials. 285, 121562.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chitosan 100%
  • Cell death 70%
  • Nanoparticles 70%
  • Acute Kidney Injury 67%
  • Acids 64%

• Preferential siRNA delivery to injured kidneys for combination treatment of acute kidney injury

  Tang, W., Chen, Y., Jang, H. S., Hang, Y., Jogdeo, C. M., Li, J., Ding, L., Zhang, C., Yu, A., Yu, F., Foster, K. W., Padanilam, B. J. & Oupický, D., Jan 2022, In: Journal of Controlled Release. 341, p. 300-313 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chemokine Receptor CXCR4 Antagonist 100%
  • Acute Kidney Injury 54%
  • Small Interfering RNA 47%
  • Cisplatin 30%
  • Kidney 30%
• 2021

  IDH2 gene deficiency accelerates unilateral ureteral obstruction-induced kidney inflammation through oxidative stress and activation of macrophages

  Kim, J. I., Noh, M. R., Yoon, G. E., Jang, H. S., Kong, M. J. & Park, K. M., Mar 2021, In: Korean Journal of Physiology and Pharmacology. 25, 2, p. 139-146 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • mouse isocitrate dehydrogenase 2 100%
  • Isocitrate Dehydrogenase 62%
  • Ureteral Obstruction 58%
  • Macrophage Activation 52%
  • Oxidative Stress 33%

• Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy

  Jang, H. S., Noh, M. R., Ha, L., Kim, J. & Padanilam, B. J., Oct 2021, In: American Journal of Physiology - Renal Physiology. 321, 4, p. F431-F442

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclophilin D 100%
  • Ureteral Obstruction 34%
  • Kidney 33%
  • Fibrosis 26%
  • Proximal Kidney Tubule 11%
• 2020

  Nephron progenitor maintenance is controlled through fibroblast growth factors and sprouty1 interaction

  Huh, S. H., Ha, L. & Jang, H. S., Nov 2020, In: Journal of the American Society of Nephrology. 31, 11, p. 2559-2572 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fibroblast Growth Factors 100%
  • Nephrons 94%
  • Maintenance 58%
  • Stem Cells 51%
  • Hereditary renal agenesis 18%

• Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

  Jang, H. S., Noh, M. R., Jung, E. M., Kim, W. Y., Southekal, S., Guda, C., Foster, K. W., Oupicky, D., Ferrer, F. A. & Padanilam, B. J., Feb 2020, In: Kidney international. 97, 2, p. 327-339 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cyclophilin D 100%
  • Acute Kidney Injury 59%
  • Peroxisome Proliferator-Activated Receptors 56%
  • Cisplatin 56%
  • Fatty Acids 53%
• 2019

  Determinants of preferential renal accumulation of synthetic polymers in acute kidney injury

  Chen, Y., Tang, W., Yu, F., Xie, Y., Jaramillo, L., Jang, H. S., Li, J., Padanilam, B. J. & Oupický, D., Sep 10 2019, In: International Journal of Pharmaceutics. 568, 118555.

  Research output: Contribution to journal › Article › peer-review

  • Acute Kidney Injury 100%
  • Radical Polimerization 95%
  • Polymers 93%
  • Kidney 56%
  • Drug 55%
• 2018

  Downregulation of exocyst Sec10 accelerates kidney tubule cell recovery through enhanced cell migration

  Noh, M. R., Jang, H. S., Song, D. K., Lee, S. R., Lipschutz, J. H., Park, K. M. & Kim, J. I., Feb 5 2018, In: Biochemical and Biophysical Research Communications. 496, 2, p. 309-315 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Diacylglycerol Kinase Inhibitor 100%
  • Kidney Tubules 70%
  • Cell Movement 39%
  • Reperfusion Injury 37%
  • Wound Healing 34%
• 2017

  Hepatic ischemia/reperfusion injury disrupts the homeostasis of kidney primary cilia via oxidative stress

  Han, S. J., Jang, H. S., Seu, S. Y., Cho, H. J., Hwang, Y. J., Kim, J. I. & Park, K. M., Jul 2017, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 7, p. 1817-1828 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cilia 100%
  • Reperfusion Injury 83%
  • Oxidative Stress 62%
  • Homeostasis 62%
  • Kidney 46%

• Mitochondrial NADP+-dependent isocitrate dehydrogenase deficiency exacerbates mitochondrial and cell damage after kidney ischemia-reperfusion injury

  Han, S. J., Jang, H. S., Noh, M. R., Kim, J., Kong, M. J., Kim, J. I., Park, J. W. & Park, K. M., Apr 2017, In: Journal of the American Society of Nephrology. 28, 4, p. 1200-1215 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • isocitrate dehydrogenase (NADP+) 100%
  • Reperfusion Injury 57%
  • Reperfusion 52%
  • Ischemia 45%
  • Gene Deletion 32%
• 2016

  Smooth muscle-generated methylglyoxal impairs endothelial cell-mediated vasodilatation of cerebral microvessels in type 1 diabetic rats

  Alomar, F., Singh, J., Jang, H. S., Rozanzki, G. J., Shao, C. H., Padanilam, B. J., Mayhan, W. G. & Bidasee, K. R., 2016, In: British Journal of Pharmacology. 173, 23, p. 3307-3326 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Pyruvaldehyde 100%
  • Microvessels 70%
  • Vasodilation 68%
  • Smooth Muscle 62%
  • Endothelial Cells 52%

• Unilateral nephrectomy elongates primary cilia in the remaining kidney via reactive oxygen species

  Han, S. J., Jang, H. S., Kim, J. I., Lipschutz, J. H. & Park, K. M., Feb 29 2016, In: Scientific reports. 6, 22281.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cilia 100%
  • Nephrectomy 85%
  • Reactive Oxygen Species 68%
  • Kidney 46%
  • Porphyrins 32%
• 2015

  Methionine sulfoxide reductase A deficiency exacerbates progression of kidney fibrosis induced by unilateral ureteral obstruction

  Kim, J. I., Noh, M. R., Kim, K. Y., Jang, H. S., Kim, H. Y. & Park, K. M., Dec 1 2015, In: Free Radical Biology and Medicine. 89, p. 201-208 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Methionine Sulfoxide Reductases 100%
  • Ureteral Obstruction 74%
  • Methionine 58%
  • Sulfoxide 56%
  • Fibrosis 42%

• Simultaneous deletion of bax and bak is required to prevent apoptosis and interstitial fibrosis in obstructive nephropathy

  Jang, H. S. & Padanilam, B. J., Sep 15 2015, In: American Journal of Physiology - Renal Physiology. 309, 6, p. F540-F550

  Research output: Contribution to journal › Article › peer-review

  • Fibrosis 100%
  • Apoptosis 82%
  • Ureteral Obstruction 74%
  • Kidney 72%
  • Cell Death 29%
• 2014

  Angiotensin II Removes Kidney Resistance Conferred by Ischemic Preconditioning

  Jang, H. S., Kim, J. I., Kim, J., Park, J. W. & Park, K. M., 2014, In: BioMed research international. 2014, 602149.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Angiotensin II 100%
  • Ischemic Preconditioning 99%
  • Resistance 49%
  • Kidney 42%
  • Losartan 35%

• Recruitment and subsequent proliferation of bone marrow-derived cells in the postischemic kidney are important to the progression of fibrosis

  Jang, H. S., Kim, J. I., Han, S. J. & Park, K. M., Jun 15 2014, In: American Journal of Physiology - Renal Physiology. 306, 12, p. F1451-F1461

  Research output: Contribution to journal › Article › peer-review

  • Bone Marrow Cells 100%
  • Fibrosis 78%
  • Green Fluorescent Proteins 64%
  • Reperfusion Injury 58%
  • Kidney 56%

• Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis

  Jang, H. S., Kim, J. I., Noh, M., Rhee, M. H. & Park, K. M., Sep 2014, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 9, p. 1733-1741 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GTP-Binding Protein Regulators 100%
  • Ureteral Obstruction 53%
  • Fibrosis 49%
  • Kidney 35%
  • Angiotensin II 24%
• 2013

  Activation of ERK accelerates repair of renal tubular epithelial cells, whereas it inhibits progression of fibrosis following ischemia/reperfusion injury

  Jang, H. S., Han, S. J., Kim, J. I., Lee, S., Lipschutz, J. H. & Park, K. M., 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 1998-2008 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Extracellular Signal-Regulated MAP Kinases 100%
  • Reperfusion Injury 89%
  • U 0126 82%
  • Ischemia 69%
  • Fibrosis 68%

• Bone marrow-derived cells play a major role in kidney fibrosis via proliferation and differentiation in the infiltrated site

  Jang, H. S., Kim, J. I., Jung, K. J., Kim, J., Han, K. H. & Park, K. M., Jun 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 6, p. 817-825 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bone Marrow Cells 100%
  • Fibrosis 78%
  • Ureteral Obstruction 58%
  • Kidney 56%
  • Fibroblasts 22%

• Defect in Runx2 gene accelerates ureteral obstruction-induced kidney fibrosis via increased TGF-β signaling pathway

  Kim, J. I., Jang, H. S., Jeong, J. H., Noh, M. R., Choi, J. Y. & Park, K. M., Oct 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 10, p. 1520-1527 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ureteral Obstruction 100%
  • Transforming Growth Factors 81%
  • Fibrosis 57%
  • Kidney 41%
  • Genes 31%

• Gender-specific role of HDAC11 in kidney ischemia- and reperfusion-induced PAI-1 expression and injury

  Kim, J. I., Jung, K. J., Jang, H. S. & Park, K. M., Jul 1 2013, In: American Journal of Physiology - Renal Physiology. 305, 1, p. F61-F70

  Research output: Contribution to journal › Article › peer-review

  • Plasminogen Activator Inhibitor 1 100%
  • Reperfusion 77%
  • Ischemia 67%
  • Kidney 47%
  • Wounds and Injuries 43%

• Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction

  Jung, K. J., Jang, H. S., Kim, J. I., Han, S. J., Park, J. W. & Park, K. M., 2013, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1832, 12, p. 1989-1997 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hydrogen Sulfide 100%
  • Ureteral Obstruction 99%
  • Homocysteine 83%
  • Cystathionine 79%
  • sodium bisulfide 57%

• Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys

  Kim, J. I., Kim, J., Jang, H. S., Noh, M. R., Lipschutz, J. H. & Park, K. M., 2013, In: American Journal of Physiology - Renal Physiology. 304, 10, p. 1283-1294 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Cilia 100%
  • Oxidative Stress 62%
  • Ischemia 50%
  • Kidney 46%
  • Wounds and Injuries 41%
• 2012

  Bone marrow derived cells and reactive oxygen species in hypertrophy of contralateral kidney of transient unilateral renal ischemia-induced mouse

  Jang, H. S., Kim, J. I., Kim, J., Na, Y. K., Park, J. W. & Park, K. M., Jul 2012, In: Free Radical Research. 46, 7, p. 903-911 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Bone Marrow Cells 100%
  • Reactive Oxygen Metabolite 99%
  • Hypertrophy 96%
  • Reactive Oxygen Species 84%
  • Ischemia 79%

• Orchiectomy attenuates kidney fibrosis after ureteral obstruction by reduction of oxidative stress in mice

  Cho, M. H., Jung, K. J., Jang, H. S., Kim, J. I. & Park, K. M., Jan 2012, In: American Journal of Nephrology. 35, 1, p. 7-16 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ureteral Obstruction 100%
  • Orchiectomy 92%
  • Fibrosis 57%
  • Oxidative Stress 56%
  • Kidney 41%

• Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice; A role for the Akt signal pathway

  Jang, H. S., Kim, J., Kim, K. Y., Kim, J. I., Cho, M. H. & Park, K. M., Oct 2012, In: Nephrology Dialysis Transplantation. 27, 10, p. 3762-3770 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Reperfusion Injury 100%
  • Reperfusion 90%
  • Signal Transduction 80%
  • Ischemia 77%
  • Kidney 55%
• 2011

  Evaluation of kidney repair capacity using 99mTc-DMSA in ischemia/reperfusion injury models

  Kwak, W., Jang, H. S., Belay, T., Kim, J., Ha, Y. S., Lee, S. W., Ahn, B. C., Lee, J., Park, K. M. & Yoo, J., Mar 4 2011, In: Biochemical and Biophysical Research Communications. 406, 1, p. 7-12 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Technetium Tc 99m Dimercaptosuccinic Acid 100%
  • Reperfusion Injury 62%
  • Reperfusion 40%
  • Ischemia 34%
  • Kidney 34%

• Protective role of cytosolic NADP ⁺-dependent isocitrate dehydrogenase, IDH1, in ischemic pre-conditioned kidney in mice

  Kim, J., Kim, J. I., Jang, H. S., Park, J. W. & Park, K. M., Jul 2011, In: Free Radical Research. 45, 7, p. 759-766 8 p.

  Research output: Contribution to journal › Article › peer-review

  • isocitrate dehydrogenase (NADP+) 100%
  • Glutathione 53%
  • Protective 49%
  • Ischemia 45%
  • Ischemic Preconditioning 43%
• 2010

  Endotoxin-induced renal tolerance against ischemia and reperfusion injury is removed by iNOS, but not eNOS, gene-deletion

  Kim, J. I., Jang, H. S. & Park, K. M., Sep 2010, In: BMB Reports. 43, 9, p. 629-634 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipopolysaccharide 100%
  • Gene Deletion 99%
  • Endotoxins 90%
  • Reperfusion Injury 88%
  • Lipopolysaccharides 78%

• Reactive oxygen species generated by renal ischemia and reperfusion trigger protection against subsequent renal ischemia and reperfusion injury in mice

  Kim, J., Jang, H. S. & Park, K. M., Jan 2010, In: American Journal of Physiology - Renal Physiology. 298, 1, p. F158-F166

  Research output: Contribution to journal › Article › peer-review

  • Reperfusion Injury 100%
  • Reperfusion 90%
  • Reactive Oxygen Species 82%
  • Ischemia 77%
  • Kidney 55%
• 2009

  Role of cytosolic NADP⁺-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney

  Kim, J., Ki, Y. K., Jang, H. S., Yoshida, T., Tsuchiya, K., Nitta, K., Park, J. W., Bonventre, J. V. & Park, K. M., Mar 2009, In: American Journal of Physiology - Renal Physiology. 296, 3, p. F622-F633

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • isocitrate dehydrogenase (NADP+) 100%
  • NADP 64%
  • Reperfusion Injury 57%
  • Kidney 32%
  • Glutathione Disulfide 27%
• 2008

  Infiltrated macrophages contribute to recovery after ischemic injury but not to ischemic preconditioning in kidneys

  Jang, H. S., Kim, J., Park, Y. K. & Park, K. M., Feb 2008, In: Transplantation. 85, 3, p. 447-455 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Ischemic Preconditioning 100%
  • Clodronic Acid 56%
  • Macrophages 55%
  • Kidney 42%
  • Wounds and Injuries 38%