Hanseok Ko

2023

Advanced human iPSC-based preclinical model for Parkinson's disease with optogenetic alpha-synuclein aggregation

Kim, M. S., Ra, E. A., Kweon, S. H., Seo, B. A., Ko, H. S., Oh, Y. & Lee, G., Jul 6 2023, In: Cell stem cell. 30, 7, p. 973-986.e11

Research output: Contribution to journal › Article › peer-review

Open Access

2022

c-Abl Regulates the Pathological Deposition of TDP-43 via Tyrosine 43 Phosphorylation

Lee, S., Ryu, H. G., Kweon, S. H., Kim, H., Park, H., Lee, K. H., Jang, S. M., Na, C. H., Kim, S. & Ko, H. S., Dec 2022, In: Cells. 11, 24, 3972.

Research output: Contribution to journal › Article › peer-review

Open Access

Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy

Kuo, S. H., Tasset, I., Cheng, M. M., Diaz, A., Pan, M. K., Lieberman, O. J., Hutten, S. J., Alcalay, R. N., Kim, S., Ximénez-Embún, P., Fan, L., Kim, D., Ko, H. S., Yacoubian, T., Kanter, E., Liu, L., Tang, G., Muñoz, J., Sardi, S. P., Li, A., & 3 othersGan, L., Cuervo, A. M. & Sulzer, D., Feb 2022, In: Science Advances. 8, 6, eabm6393.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Alpha-synuclein preformed fibrils induce cellular senescence in parkinson’s disease models

Verma, D. K., Seo, B. A., Ghosh, A., Ma, S. X., Hernandez-Quijada, K., Andersen, J. K., Ko, H. S. & Kim, Y. H., Jul 2021, In: Cells. 10, 7, 1694.

Research output: Contribution to journal › Article › peer-review

Open Access

A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease

Kwon, S. H., Kim, S., Park, A. Y., Lee, S., Gadhe, C. G., Seo, B. A., Park, J. S., Jo, S., Oh, Y., Kweon, S. H., Ma, S. X., Kim, W. R., Kim, M., Kim, H., Kim, J. E., Lee, S., Lee, J. & Ko, H. S., Oct 28 2021, In: Journal of medicinal chemistry. 64, 20, p. 15091-15110 20 p.

Research output: Contribution to journal › Article › peer-review

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Park, J. S., Kam, T. I., Lee, S., Park, H., Oh, Y., Kwon, S. H., Song, J. J., Kim, D., Kim, H., Jhaldiyal, A., Na, D. H., Lee, K. C., Park, E. J., Pomper, M. G., Pletnikova, O., Troncoso, J. C., Ko, H. S., Dawson, V. L., Dawson, T. M. & Lee, S., Dec 2021, In: Acta Neuropathologica Communications. 9, 1, 78.

Research output: Contribution to journal › Article › peer-review

Open Access

Complement and Coagulation Cascades are Potentially Involved in Dopaminergic Neurodegeneration in α-Synuclein-Based Mouse Models of Parkinson's Disease

Ma, S. X., Seo, B. A., Kim, D., Xiong, Y., Kwon, S. H., Brahmachari, S., Kim, S., Kam, T. I., Nirujogi, R. S., Kwon, S. H., Dawson, V. L., Dawson, T. M., Pandey, A., Na, C. H. & Ko, H. S., Jul 2 2021, In: Journal of proteome research. 20, 7, p. 3428-3443 16 p.

Research output: Contribution to journal › Article › peer-review

Graphene Quantum Dots Alleviate Impaired Functions in Niemann-Pick Disease Type C in Vivo

Kang, I., Yoo, J. M., Kim, D., Kim, J., Cho, M. K., Lee, S. E., Kim, D. J., Lee, B. C., Lee, J. Y., Kim, J. J., Shin, N., Choi, S. W., Lee, Y. H., Ko, H. S., Shin, S., Hong, B. H. & Kang, K. S., Mar 10 2021, In: Nano Letters. 21, 5, p. 2339-2346 8 p.

Research output: Contribution to journal › Article › peer-review

PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease

Jo, A., Lee, Y., Kam, T-I., Kang, S. U., Neifert, S., Karuppagounder, S., Khang, R., Kang, H., Park, H., Chou, S. C., Oh, S., Jiang, H., Swing, D. A., Ham, S., Pirooznia, S., Umanah, G., Mao, X., Kumar, M., Ko, H. S., Kang, H. C., & 15 othersLee, B. D., Lee, Y. I., Andrabi, S. A., Park, C. H., Lee, J. Y., Kim, H., Kim, H., Kim, H., Cho, J. W., Paek, S. H., Na, C. H., Tessarollo, L., Dawson, V. L., Dawson, T. M. & Shin, J. H., Jul 28 2021, In: Science translational medicine. 13, 604, eaax8891.

Research output: Contribution to journal › Article › peer-review

Open Access

TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease

Seo, B. A., Kim, D., Hwang, H., Kim, M. S., Ma, S. X., Kwon, S. H., Kweon, S. H., Wang, H., Yoo, J. M., Choi, S., Kwon, S. H., Kang, S. U., Kam, T. I., Kim, K., Karuppagounder, S. S., Kang, B. G., Lee, S., Park, H., Kim, S., Yan, W., & 10 othersLi, Y. S., Kuo, S. H., Redding-Ochoa, J., Pletnikova, O., Troncoso, J. C., Lee, G., Mao, X., Dawson, V. L., Dawson, T. M. & Ko, H. S., Dec 1 2021, In: Neuron. 109, 23, p. 3758-3774.e11

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion

Ham, S., Yun, S. P., Kim, H., Kim, D., Seo, B. A., Kim, H., Shin, J. Y., Dar, M. A., Lee, G. H., Lee, Y. I., Kim, D., Kim, S., Kweon, H. S., Shin, J. H., Ko, H. S. & Lee, Y., Nov 11 2020, In: Science translational medicine. 12, 569, eaax0091.

Research output: Contribution to journal › Article › peer-review

Open Access

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

Kumar, M., Acevedo-Cintrón, J., Jhaldiyal, A., Wang, H., Andrabi, S. A., Eacker, S., Karuppagounder, S. S., Brahmachari, S., Chen, R., Kim, H., Ko, H. S., Dawson, V. L. & Dawson, T. M., Sep 8 2020, In: Stem Cell Reports. 15, 3, p. 629-645 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2019

Cell-based screen using amyloid mimic β23 expression identifies peucedanocoumarin iii as a novel inhibitor of α-synuclein and huntingtin aggregates

Ham, S., Kim, H., Hwang, S., Kang, H., Yun, S. P., Kim, S., Kim, D., Kwon, H. S., Lee, Y. S., Cho, M., Shin, H. M., Choi, H., Chung, K. Y., Ko, H. S., Lee, G. H. & Lee, Y., 2019, In: Molecules and cells. 42, 6, p. 480-494 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations

Li, H., Ham, A., Ma, T. C., Kuo, S. H., Kanter, E., Kim, D., Ko, H. S., Quan, Y., Sardi, S. P., Li, A., Arancio, O., Kang, U. J., Sulzer, D. & Tang, G., Jan 2 2019, In: Autophagy. 15, 1, p. 113-130 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S. S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T. I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S., & 2 othersDawson, V. L. & Dawson, T. M., Aug 1 2019, In: Brain. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Parkinson's disease gene therapy: Will focused ultrasound and nanovectors be the next frontier?

Price, R. J., Fisher, D. G., Suk, J. S., Hanes, J., Ko, H. S. & Kordower, J. H., Sep 1 2019, In: Movement Disorders. 34, 9, p. 1279-1282 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T. I., Panicker, N., Karuppagounder, S. S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C. A., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V. L., Dawson, T. M. & Ko, H. S., Aug 21 2019, In: Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journal › Article › peer-review

Open Access

238 Scopus citations

2018

A novel extended form of alpha-synuclein 3′UTR in the human brain

Je, G., Guhathakurta, S., Yun, S. P., Ko, H. S. & Kim, Y. S., May 25 2018, In: Molecular Brain. 11, 1, 29.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T. I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S. S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. U., & 13 othersLee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V. L., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In: Nature medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

246 Scopus citations

D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model

Kim, D., Hwang, H., Choi, S., Kwon, S. H., Lee, S., Park, J. H., Kim, S. M. & Ko, H. S., Apr 27 2018, In: Acta Neuropathologica Communications. 6, 1, p. 32 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G. E., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S. S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V. L., Dawson, T. M. & Ko, H. S., Jan 23 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease

Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., Park, M. J., Lee, M. J., Choi, S., Kwon, S. H., Lee, S., Kwon, S. H., Kim, S., Park, Y. J., Kinoshita, M., Lee, Y. H., Shin, S., Paik, S. R., Lee, S. J., Lee, S., & 2 othersHong, B. H. & Ko, H. S., Sep 1 2018, In: Nature Nanotechnology. 13, 9, p. 812-818 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

120 Scopus citations

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T. I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S. S., Umanah, G. E., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. S., & 2 othersDawson, T. M. & Dawson, V. L., Nov 2 2018, In: Science. 362, 6414, eaat8407.

Research output: Contribution to journal › Article › peer-review

Open Access

127 Scopus citations

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S. S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S. U., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V. L., Feb 13 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model

Lee, S., Kim, S., Park, Y. J., Yun, S. P., Kwon, S. H., Kim, D., Kim, D. Y., Shin, J. S., Cho, D. J., Lee, G. Y., Ju, H. S., Yun, H. J., Park, J. H., Kim, W. R., Jung, E. A., Lee, S. & Ko, H. S., Jul 1 2018, In: Human molecular genetics. 27, 13, p. 2344-2356 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Yun, S. P., Kim, D., Kim, S., Kim, S., Karuppagounder, S. S., Kwon, S. H., Lee, S., Kam, T. I., Lee, S., Ham, S., Park, J. H., Dawson, V. L., Dawson, T. M., Lee, Y. & Ko, H. S., Jan 8 2018, In: Molecular neurodegeneration. 13, 1, 1.

Research output: Contribution to journal › Article › peer-review

Open Access

24 Scopus citations

2017

Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology

Xiong, Y., Neifert, S., Karuppagounder, S. S., Stankowski, J. N., Lee, B. D., Grima, J. C., Chen, G., Ko, H. S., Lee, Y., Swing, D., Tessarollo, L., Dawson, T. M. & Dawson, V. L., 2017, In: eNeuro. 4, 2, e0004.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S. U., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T-I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V. L., Shin, J. H., & 1 othersDawson, T. M., Jan 24 2017, In: Cell Reports. 18, 4, p. 918-932 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2

PilYun, S., Kim, H., Ham, S., Kwon, S. H., Lee, G. H., Shin, J. H., Lee, S. H., Ko, H. S. & Lee, Y., 2017, In: Cell Death and Disease. 8, 4, e2741.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2016

Activation of tyrosine kinase c-Abl contributes to α-synuclein-induced neurodegeneration

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S. S., Kumar, M., Mao, X., Shin, J. H., Lee, Y., Pletnikova, O., Troncoso, J. C., Dawson, V. L., Dawson, T. M. & Ko, H. S., Aug 1 2016, In: Journal of Clinical Investigation. 126, 8, p. 2970-2988 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H. D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C. P., Lokman, H., Lee, Y., Kim, D., Ko, H. S., Kim, S. O., Park, J. H., Cho, N. J., Hyde, T. M., Kleinman, J. E., Shin, J. H., Weinberger, D. R., & 3 othersTan, E. K., Je, H. S. & Ng, H. H., Aug 4 2016, In: Cell stem cell. 19, 2, p. 248-257 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

285 Scopus citations

Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3

Mao, X., Ou, M. T., Karuppagounder, S. S., Kam, T. I., Yin, X., Xiong, Y., Ge, P., Umanah, G. E., Brahmachari, S., Shin, J. H., Kang, H. C., Zhang, J., Xu, J., Chen, R., Park, H., Andrabi, S. A., Kang, S. U., Gonçalves, R. A., Liang, Y., Zhang, S., & 12 othersQi, C., Lam, S., Keiler, J. A., Tyson, J., Kim, D., Panicker, N., Yun, S. P., Workman, C. J., Vignali, D. A. A., Dawson, V. L., Ko, H. S. & Dawson, T. M., Sep 30 2016, In: Science. 353, 6307, aah3374.

Research output: Contribution to journal › Article › peer-review

Open Access

275 Scopus citations

2015

Lysosomal enzyme Glucocerebrosidase protects against Aβ_1-42 oligomer-induced neurotoxicity

Choi, S., Kim, D., Kam, T. I., Yun, S., Kim, S., Park, H., Hwang, H., Pletnikova, O., Troncoso, J. C., Dawson, V. L., Dawson, T. M. & Ko, H. S., Dec 1 2015, In: PloS one. 10, 12, e0143854.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

2014

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

Karuppagounder, S. S., Brahmachari, S., Lee, Y., Dawson, V. L., Dawson, T. M. & Ko, H. S., May 2 2014, In: Scientific reports. 4, 4874.

Research output: Contribution to journal › Article › peer-review

Open Access

132 Scopus citations

2013

Parthanatos mediates AIMP2-activated age-dependent dopaminergic neuronal loss

Lee, Y., Karuppagounder, S., Shin, J. H., Lee, Y. I., Ko, H. S., Swing, D., Jiang, H., Kang, S. U., Lee, B. D., Kang, H. C., Kim, D., Tessarollo, L., Dawson, V. L. & Dawson, T. M., Oct 2013, In: Nature neuroscience. 16, 10, p. 1392-1400 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

117 Scopus citations

Sulfhydration mediates neuroprotective actions of parkin

Vandiver, M. S., Paul, B. D., Xu, R., Karuppagounder, S., Rao, F., Snowman, A. M., Seok Ko, H., Il Lee, Y., Dawson, V. L., Dawson, T. M., Sen, N. & Snyder, S. H., 2013, In: Nature communications. 4, 1626.

Research output: Contribution to journal › Article › peer-review

Open Access

166 Scopus citations

2011

Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage

Kang, H. C., Lee, Y. I., Shin, J. H., Andrabi, S. A., Chi, Z., Gagné, J. P., Lee, Y., Ko, H. S., Lee, B. D., Poirier, G. G., Dawson, V. L. & Dawson, T. M., Aug 23 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14103-14108 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

143 Scopus citations

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in parkinson's disease

Shin, J. H., Ko, H. S., Kang, H., Lee, Y., Lee, Y. I., Pletinkova, O., Troconso, J. C., Dawson, V. L. & Dawson, T. M., Mar 4 2011, In: Cell. 144, 5, p. 689-702 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

588 Scopus citations

2010

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Lee, B. D., Shin, J. H., Vankampen, J., Petrucelli, L., West, A. B., Ko, H. S., Lee, Y. I., Maguire-Zeiss, K. A., Bowers, W. J., Federoff, H. J., Dawson, V. L. & Dawson, T. M., Sep 2010, In: Nature medicine. 16, 9, p. 998-1000 3 p.

Research output: Contribution to journal › Article › peer-review

264 Scopus citations

Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

Ko, H. S., Lee, Y., Shin, J. H., Karuppagounder, S. S., Gadad, B. S., Koleske, A. J., Pletnikova, O., Troncoso, J. C., Dawson, V. L. & Dawson, T. M., Sep 21 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 38, p. 16691-16696 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

170 Scopus citations

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., De Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., Magrané, J., Moore, D. J., Dawson, V. L., Grailhe, R., Dawson, T. M., Li, C., Tieu, K. & Przedborski, S., 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 1, p. 378-383 6 p.

Research output: Contribution to journal › Article › peer-review

1065 Scopus citations

2009

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Ko, H. S., Bailey, R., Smith, W. W., Liu, Z., Shin, J. H., Lee, Y. I., Zhang, Y. J., Jiang, H., Ross, C. A., Moore, D. J., Patterson, C., Petrucelli, L., Dawson, T. M. & Dawson, V. L., Feb 24 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 8, p. 2897-2902 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease

Tsang, A. H. K., Lee, Y. I. L., Ko, H. S., Savitt, J. M., Pletnikova, O., Troncoso, J. C., Dawson, V. L., Dawson, T. M. & Chung, K. K. K., Mar 24 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 12, p. 4900-4905 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

2008

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

Tan, J. M. M., Wong, E. S. P., Kirkpatrick, D. S., Pletnikova, O., Ko, H. S., Tay, S. P., Ho, M. W. L., Troncoso, J., Gygi, S. P., Lee, M. K., Dawson, V. L., Dawson, T. M. & Lim, K. L., Feb 1 2008, In: Human molecular genetics. 17, 3, p. 431-439 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

286 Scopus citations

Role of tuberin in neuronal degeneration

Habib, S. L., Michel, D., Masliah, E., Thomas, B., Ko, H. S., Dawson, T. M., Abboud, H., Clark, R. A. & Imam, S. Z., Jun 2008, In: Neurochemical Research. 33, 6, p. 1113-1116 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2007

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

Andres-Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T. M., Thomas, B., Han, S. K., Sasaki, M., Ischiropoulos, H., Przedborski, S., Dawson, T. M. & Dawson, V. L., Sep 11 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 37, p. 14807-14812 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

356 Scopus citations

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

Wong, E. S. P., Tan, J. M. M., Wang, C., Zhang, Z., Tay, S. P., Zaiden, N., Han, S. K., Dawson, V. L., Dawson, T. M. & Lim, K. L., Apr 20 2007, In: Journal of Biological Chemistry. 282, 16, p. 12310-12318 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

2006

Identification of far upstream element-binding protein-1 as an authentic Parkin substrate

Han, S. K., Seong, W. K., Sriram, S. R., Dawson, V. L. & Dawson, T. M., Jun 16 2006, In: Journal of Biological Chemistry. 281, 24, p. 16193-16196 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

2005

Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death

Ko, H. S., Von Coelln, R., Sriram, S. R., Kim, S. W., Chung, K. K. K., Pletnikova, O., Troncoso, J., Johnson, B., Saffary, R., Goh, E. L., Song, H., Park, B. J., Kim, M. J., Kim, S., Dawson, V. L. & Dawson, T. M., Aug 31 2005, In: Journal of Neuroscience. 25, 35, p. 7968-7978 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

191 Scopus citations

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

Wang, C., Ko, H. S., Thomas, B., Tsang, F., Chew, K. C. M., Tay, S. P., Ho, M. W. L., Lim, T. M., Soong, T. W., Pletnikova, O., Troncoso, J., Dawson, V. L., Dawson, T. M. & Lim, K. L., Dec 15 2005, In: Human molecular genetics. 14, 24, p. 3885-3897 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

172 Scopus citations

Hanseok Ko

Research output

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