Hanna Jaaro-Peled

2023

The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder

Namkung, H., Yukitake, H., Fukudome, D., Lee, B. J., Tian, M., Ursini, G., Saito, A., Lam, S., Kannan, S., Srivastava, R., Niwa, M., Sharma, K., Zandi, P., Jaaro-Peled, H., Ishizuka, K., Chatterjee, N., Huganir, R. L. & Sawa, A., Jan 18 2023, In: Neuron. 111, 2, p. 220-235.e9

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition

Bhattarai, J. P., Etyemez, S., Jaaro-Peled, H., Janke, E., Leon Tolosa, U. D., Kamiya, A., Gottfried, J. A., Sawa, A. & Ma, M., Sep 2022, In: Seminars in Cell and Developmental Biology. 129, p. 31-39 9 p.

Research output: Contribution to journal › Review article › peer-review

Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit

Jaaro-Peled, H., Kumar, S., Hughes, D., Sumitomo, A., Kim, S. H., Zoubovsky, S., Hirota-Tsuyada, Y., Zala, D., Bruyere, J., Katz, B. M., Huang, B., Flores, R., Narayan, S., Hou, Z., Economides, A. N., Hikida, T., Wetsel, W. C., Deisseroth, K., Mori, S., Brandon, N. J., & 7 othersTanaka, M., Ishizuka, K., Houslay, M. D., Saudou, F., Dzirasa, K., Sawa, A. & Tomoda, T., Mar 2022, In: Molecular psychiatry. 27, 3, p. 1805-1815 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sex-specific involvement of the Notch–JAG pathway in social recognition

Jaaro-Peled, H., Landek-Salgado, M. A., Cascella, N. G., Nucifora, F. C., Coughlin, J. M., Nestadt, G., Sedlak, T. W., Lavoie, J., De Silva, S., Lee, S., Tajinda, K., Hiyama, H., Ishizuka, K., Yang, K. & Sawa, A., Dec 2022, In: Translational psychiatry. 12, 1, 99.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Neurodevelopmental Factors in Schizophrenia

Jaaro-Peled, H. & Sawa, A., Jun 2020, In: Psychiatric Clinics of North America. 43, 2, p. 263-274 12 p.

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Parvalbumin interneuron dysfunction in a thalamo-prefrontal cortical circuit in disc1 locus impairment mice

Delevich, K., Jaaro-Peled, H., Penzo, M., Sawa, A. & Li, B., 2020, In: eNeuro. 7, 2, ENEURO.0496-19.2020.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2019

[¹¹C](R)-Rolipram positron emission tomography detects DISC1 inhibition of phosphodiesterase type 4 in live Disc1 locus-impaired mice

Ooms, M., Tsujikawa, T., Lohith, T. G., Mabins, S. N., Zoghbi, S. S., Sumitomo, A., Jaaro-Peled, H., Kimura, Y., Telu, S., Pike, V. W., Tomoda, T., Innis, R. B., Sawa, A. & Fujita, M., Jul 1 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 7, p. 1306-1313 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Aripiprazole and haloperidol protect neurite lesions via reducing excessive D2R-DISC1 complex formation

Zheng, P., Hu, M., Xie, Y., Yu, Y., Jaaro-Peled, H. & Huang, X. F., Jun 8 2019, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 92, p. 59-69 11 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood

Yang, K., Kondo, M. A., Jaaro-Peled, H., Cash-Padgett, T., Kano, S. I., Ishizuka, K., Pevsner, J., Tomoda, T., Sawa, A. & Niwa, M., Aug 2019, In: Schizophrenia Research. 210, p. 149-156 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1

Jaaro-Peled, H., Altimus, C., LeGates, T., Cash-Padgett, T., Zoubovsky, S., Hikida, T., Ishizuka, K., Hattar, S., Mongrain, V. & Sawa, A., Nov 1 2016, In: Neuroscience Research. 112, p. 63-69 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

DISC1 a key molecular lead in psychiatry and neurodevelopment: No-More Disrupted-in-Schizophrenia 1

Niwa, M., Cash-Padgett, T., Kubo, K. I., Saito, A., Ishii, K., Sumitomo, A., Taniguchi, Y., Ishizuka, K., Jaaro-Peled, H., Tomoda, T., Nakajima, K., Sawa, A. & Kamiya, A., Nov 1 2016, In: Molecular psychiatry. 21, 11, p. 1488-1489 2 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

47 Scopus citations

Increased stereotypy in conditional Cxcr4 knockout mice

Cash-Padgett, T., Sawa, A. & Jaaro-Peled, H., Apr 1 2016, In: Neuroscience Research. 105, p. 75-79 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Role for neonatal D-serine signaling: Prevention of physiological and behavioral deficits in adult Pick1 knockout mice

Nomura, J., Jaaro-Peled, H., Lewis, E., Nuñez-Abades, P., Huppe-Gourgues, F., Cash-Padgett, T., Emiliani, F., Kondo, M. A., Furuya, A., Landek-Salgado, M. A., Ayhan, Y., Kamiya, A., Takumi, T., Huganir, R., Pletnikov, M., O'Donnell, P. & Sawa, A., Mar 1 2016, In: Molecular psychiatry. 21, 3, p. 386-393 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Utility and validity of DISC1 mouse models in biological psychiatry

Tomoda, T., Sumitomo, A., Jaaro-Peled, H. & Sawa, A., 2016, In: Neuroscience. 321, p. 99-107 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

42 Scopus citations

2015

Adolescent cannabis exposure interacts with mutant DISC1 to produce impaired adult emotional memory

Ballinger, M. D., Saito, A., Abazyan, B., Taniguchi, Y., Huang, C. H., Ito, K., Zhu, X., Segal, H., Jaaro-Peled, H., Sawa, A., Mackie, K., Pletnikov, M. V. & Kamiya, A., Oct 1 2015, In: Neurobiology of Disease. 82, p. 176-184 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

DISC1 regulates trafficking and processing of APP and Aβ generation

Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T. W., Korth, C., Brandon, N. J., Kamiya, A., Subramaniam, S., Tomoda, T. & Sawa, A., Jul 24 2015, In: Molecular psychiatry. 20, 7, p. 874-879 6 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex

Seshadri, S., Faust, T., Ishizuka, K., Delevich, K., Chung, Y., Kim, S. H., Cowles, M., Niwa, M., Jaaro-Peled, H., Tomoda, T., Lai, C., Anton, E. S., Li, B. & Sawa, A., Dec 11 2015, In: Nature communications. 6, 10118.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1)

Zoubovsky, S., Oh, E. C., Cash-Padgett, T., Johnson, A. W., Hou, Z., Mori, S., Gallagher, M., Katsanis, N., Sawa, A. & Jaaro-Peled, H., Sep 1 2015, In: Neuroscience Research. 98, p. 45-49 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2013

Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids

Niwa, M., Jaaro-Peled, H., Tankou, S., Seshadri, S., Hikida, T., Matsumoto, Y., Cascella, N. G., Kano, S. I., Ozaki, N., Nabeshima, T. & Sawa, A., Jan 18 2013, In: Science. 339, 6117, p. 335-339 5 p.

Research output: Contribution to journal › Article › peer-review

210 Scopus citations

Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness

Johnson, A. W., Jaaro-Peled, H., Shahani, N., Sedlak, T. W., Zoubovsky, S., Burruss, D., Emiliani, F., Sawa, A. & Gallagher, M., Jul 23 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12462-12467 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Scopus citations

DISC1 mouse models as a tool to decipher gene-environment interactions in psychiatric disorders

Cash-Padgett, T. & Jaaro-Peled, H., Sep 3 2013, In: Frontiers in Behavioral Neuroscience. SEP, 113.

Research output: Contribution to journal › Review article › peer-review

Open Access

36 Scopus citations

Subcortical dopaminergic deficits in a DISC1 mutant model: A study in direct reference to human molecular brain imaging

Jaaro-Peled, H., Niwa, M., Foss, C. A., Murai, R., Reyes, S. D. L., Kamiya, A., Mateo, Y., O'Donnell, P., Cascella, N. G., Nabeshima, T., Guilarte, T. R., Pomper, M. G. & Sawa, A., Apr 2013, In: Human molecular genetics. 22, 8, p. 1574-1580 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Unique pharmacological actions of atypical neuroleptic quetiapine: Possible role in cell cycle/fate control

Kondo, M. A., Tajinda, K., Colantuoni, C., Hiyama, H., Seshadri, S., Huang, B., Pou, S., Furukori, K., Hookway, C., Jaaro-Peled, H., Kano, S. I., Matsuoka, N., Harada, K., Ni, K., Pevsner, J. & Sawa, A., 2013, In: Translational psychiatry. 3, e243.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2012

Better understanding of mechanisms of schizophrenia and bipolar disorder: From human gene expression profiles to mouse models

Lin, C. Y., Sawa, A. & Jaaro-Peled, H., Jan 2012, In: Neurobiology of Disease. 45, 1, p. 48-56 9 p.

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Pharmacokinetics of oral D-serine in D-amino acid oxidase knockout mice

Rais, R., Thomas, A. G., Wozniak, K., Wu, Y., Jaaro-Peled, H., Sawa, A., Strick, C. A., Engle, S. J., Brandon, N. J., Rojas, C., Slusher, B. S. & Tsukamoto, T., Nov 2012, In: Drug Metabolism and Disposition. 40, 11, p. 2067-2073 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2011

DISC1 mouse models

Ayhan, Y., Jaaro-Peled, H., Sawa, A. & Pletnikov, M. V., 2011, Animal Models of Schizophrenia and Related Disorders. O'Donnell, P. (ed.). p. 211-229 19 p. (Neuromethods; vol. 59).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

2010

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood

Ibi, D., Nagai, T., Koike, H., Kitahara, Y., Mizoguchi, H., Niwa, M., Jaaro-Peled, H., Nitta, A., Yoneda, Y., Nabeshima, T., Sawa, A. & Yamada, K., Jan 5 2010, In: Behavioural Brain Research. 206, 1, p. 32-37 6 p.

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Enhanced dopamine function in DISC1-L100P mutant mice: Implications for schizophrenia

Lipina, T. V., Niwa, M., Jaaro-Peled, H., Fletcher, P. J., Seeman, P., Sawa, A. & Roder, J. C., Oct 2010, In: Genes, Brain and Behavior. 9, 7, p. 777-789 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

Niwa, M., Kamiya, A., Murai, R., Kubo, K. I., Gruber, A. J., Tomita, K., Lu, L., Tomisato, S., Jaaro-Peled, H., Seshadri, S., Hiyama, H., Huang, B., Kohda, K., Noda, Y., O'Donnell, P., Nakajima, K., Sawa, A. & Nabeshima, T., Feb 25 2010, In: Neuron. 65, 4, p. 480-489 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

223 Scopus citations

Review of pathological hallmarks of schizophrenia: Comparison of genetic models with patients and nongenetic models

Jaaro-Peled, H., Ayhan, Y., Pletnikov, M. & Sawa, A., Mar 2010, In: Schizophrenia bulletin. 36, 2, p. 301-313 13 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

106 Scopus citations

2009

Gene models of schizophrenia: DISC1 mouse models

Jaaro-Peled, H., 2009, In: Progress in brain research. 179, C, p. 75-86 12 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1-ErbB4 and DISC1

Jaaro-Peled, H., Hayashi-Takagi, A., Seshadri, S., Kamiya, A., Brandon, N. J. & Sawa, A., Sep 2009, In: Trends in neurosciences. 32, 9, p. 485-495 11 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

259 Scopus citations

2008

How has DISC1 enabled drug discovery?

Wang, Q., Jaaro-Peled, H., Sawa, A. & Brandon, N. J., Feb 2008, In: Molecular and Cellular Neuroscience. 37, 2, p. 187-195 9 p.

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

2007

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

Hikida, T., Jaaro-Peled, H., Seshadri, S., Oishi, K., Hookway, C., Kong, S., Wu, D., Xue, R., Andradé, M., Tankou, S., Mori, S., Gallagher, M., Ishizuka, K., Pletnikov, M., Kida, S. & Sawa, A., Sep 4 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 36, p. 14501-14506 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

338 Scopus citations

2006

Building complex brains - Missing pieces in an evolutionary puzzle

Jaaro, H. & Fainzilber, M., Aug 1 2006, In: Brain, behavior and evolution. 68, 3, p. 191-195 5 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

2005

A genome wide screening approach for membrane-targeted proteins

Jaaro, H., Levy, Z. & Fainzilber, M., Mar 2005, In: Molecular and Cellular Proteomics. 4, 3, p. 328-333 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2002

Rabies virus glycoprotein (RVG) is a trimeric ligand for the N-terminal cysteine-rich domain of the mammalian p75 neurotrophin receptor

Langevin, C., Jaaro, H., Bressanelli, S., Fainzilber, M. & Tuffereau, C., Oct 4 2002, In: Journal of Biological Chemistry. 277, 40, p. 37655-37662 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

2001

Evolving better brains: A need for neurotrophins?

Jaaro, H., Beck, G., Conticello, S. G. & Fainzilber, M., Feb 1 2001, In: Trends in neurosciences. 24, 2, p. 79-85 7 p.

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

1999

CPG16, a novel protein serine/threonine kinase downstream of cAMP- dependent protein kinase

Silverman, M. A., Benard, O., Jaaro, H., Rattner, A., Citri, Y. & Seger, R., Jan 29 1999, In: Journal of Biological Chemistry. 274, 5, p. 2631-2636 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access