Hamilton Smith

Research output

Research output per year 1964 1973 1976 1980 1985 1988 1997 1998 1999 2000 2002 2009 2011 2013 2015 2019 2022

• 134 Article
• 10 Review article
• 6 Comment/debate
• 4 Letter
• 5 More
  • 3 Short survey
  • 1 Chapter
  • 1 Foreword/postscript

Research output per year

Research output per year

Search results

• 2022

  Fundamental behaviors emerge from simulations of a living minimal cell

  Thornburg, Z. R., Bianchi, D. M., Brier, T. A., Gilbert, B. R., Earnest, T. M., Melo, M. C. R., Safronova, N., Sáenz, J. P., Cook, A. T., Wise, K. S., Hutchison, C. A., Smith, H. O., Glass, J. I. & Luthey-Schulten, Z., Jan 20 2022, In: Cell. 185, 2, p. 345-360.e28

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Reaction Half Life 100%
  • Nucleoside 96%
  • Pharmacological Metabolism 80%
  • Simulation 65%
  • Energy 49%
• 2020

  Gross chromosomal rearrangements in kluyveromyces marxianus revealed by illumina and oxford nanopore sequencing

  Ding, L., Macdonald, H. D., Smith, H. O., Hutchison, C. A., Merryman, C., Michael, T. P., Abramson, B. W., Kannan, K., Liang, J., Gill, J., Gibson, D. G. & Glass, J. I., Oct 1 2020, In: International journal of molecular sciences. 21, 19, p. 1-10 10 p., 7112.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Nanopore Sequencing 100%
  • Kluyveromyces 87%
  • Nanopores 87%
  • sequencing 80%
  • DNA Sequencing 73%
• 2019

  Direct Transfer of a Mycoplasma mycoides Genome to Yeast Is Enhanced by Removal of the Mycoides Glycerol Uptake Factor Gene glpF

  Karas, B. J., Moreau, N. G., Deerinck, T. J., Gibson, D. G., Venter, J. C., Smith, H. O. & Glass, J. I., Feb 15 2019, In: ACS Synthetic Biology. 8, 2, p. 239-244 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mycoplasma mycoides 100%
  • Glycerol 68%
  • Yeast 66%
  • Genomics 57%
  • Genes 53%

• Essential metabolism for a minimal cell

  Breuer, M., Earnest, T. M., Merryman, C., Wise, K. S., Sun, L., Lynott, M. R., Hutchison, C. A., Smith, H. O., Lapek, J. D., Gonzalez, D. J., Crécy-Lagard, V. D., Haas, D., Hanson, A. D., Labhsetwar, P., Glass, J. I. & Luthey-Schulten, Z., 2019, In: eLife. 8, p. 1-75 75 p., e36842.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metabolic 100%
  • Pharmacological Metabolism 95%
  • Enzymatic Reaction 61%
  • Genome 50%
  • Genes 49%

• Kinetic Modeling of the Genetic Information Processes in a Minimal Cell

  Thornburg, Z. R., Melo, M. C. R., Bianchi, D., Brier, T. A., Crotty, C., Breuer, M., Smith, H. O., Hutchison, C. A., Glass, J. I. & Luthey-Schulten, Z., Nov 28 2019, In: Frontiers in Molecular Biosciences. 6, 130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Phenomena 100%
  • Pharmacological Metabolism 56%
  • Kinetics 53%
  • Nutrient 39%
  • Genome 37%

• Polar effects of transposon insertion into a minimal bacterial genome

  Hutchison, C. A., Merryman, C., Sun, L., Assad-Garcia, N., Richter, R. A., Smith, H. O. & Glass, J. I., Oct 1 2019, In: Journal of bacteriology. 201, 19, e00185-19.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Genomes 100%
  • Puromycin 88%
  • Essential Genes 31%
  • Genes 30%
  • Antitoxins 12%
• 2018

  Synthetic cells and minimal life

  Gibson, D. G., Hutchison, C. A., Smith, H. O. & Venter, J. C., Dec 7 2018, Handbook of Astrobiology. CRC Press, p. 75-90 16 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Tuning Gene Activity by Inducible and Targeted Regulation of Gene Expression in Minimal Bacterial Cells

  Mariscal, A. M., Kakizawa, S., Hsu, J. Y., Tanaka, K., González-González, L., Broto, A., Querol, E., Lluch-Senar, M., Piñero-Lambea, C., Sun, L., Weyman, P. D., Wise, K. S., Merryman, C., Tse, G., Moore, A. J., Hutchison, C. A., Smith, H. O., Tomita, M., Venter, J. C., Glass, J. I., & 2 othersPiñol, J. & Suzuki, Y., Jun 15 2018, In: ACS Synthetic Biology. 7, 6, p. 1538-1552 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Kasugamycin 100%
  • kasugamycin 65%
  • Mycoplasma 64%
  • Clustered Regularly Interspaced Short Palindromic Repeats 59%
  • Gene expression 56%
• 2017

  Minimal cells-real and imagined

  Glass, J. I., Merryman, C., Wise, K. S., Hutchison, C. A. & Smith, H. O., Dec 2017, In: Cold Spring Harbor Perspectives in Biology. 9, 12, a023861.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Protein 100%
  • Gene Components 55%
  • Genome 54%
  • Bacteria 54%
  • Essential Genes 45%
• 2016

  Design and synthesis of a minimal bacterial genome

  Hutchison, C. A., Chuang, R. Y., Noskov, V. N., Assad-Garcia, N., Deerinck, T. J., Ellisman, M. H., Gill, J., Kannan, K., Karas, B. J., Ma, L., Pelletier, J. F., Qi, Z. Q., Richter, R. A., Strychalski, E. A., Sun, L., Suzuki, Y., Tsvetanova, B., Wise, K. S., Smith, H. O., Glass, J. I., & 3 othersMerryman, C., Gibson, D. G. & Venter, J. C., Mar 25 2016, In: Science. 351, 6280, aad6253.

  Research output: Contribution to journal › Article › peer-review

  • Bacterial Genomes 100%
  • Genome 50%
  • Essential Genes 42%
  • Mutagenesis 36%
  • Mycoplasma mycoides 33%

• One step engineering of the small-subunit ribosomal RNA using CRISPR/Cas9

  Kannan, K., Tsvetanova, B., Chuang, R. Y., Noskov, V. N., Assad-Garcia, N., Ma, L., Hutchison, C. A., Smith, H. O., Glass, J. I., Merryman, C., Venter, J. C. & Gibson, D. G., Aug 4 2016, In: Scientific reports. 6, 30714.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mycoplasma mycoides 100%
  • Ribosomal RNA 94%
  • Clustered Regularly Interspaced Short Palindromic Repeats 85%
  • 16S Ribosomal RNA 57%
  • Genome 50%
• 2015

  Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

  Suzuki, Y., Assad-Garcia, N., Kostylev, M., Noskov, V. N., Wise, K. S., Karas, B. J., Stam, J., Montague, M. G., Hanly, T. J., Enriquez, N. J., Ramon, A., Goldgof, G. M., Richter, R. A., Vashee, S., Chuang, R. Y., Winzeler, E. A., Hutchison, C. A., Gibson, D. G., Smith, H. O., Glass, J. I., & 1 othersVenter, J. C., Mar 1 2015, In: Genome research. 25, 3, p. 435-444 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Genomes 100%
  • Cluster Analysis 66%
  • Yeasts 60%
  • Genome 50%
  • Mycoplasma 18%
  20 Scopus citations

• Designed surface residue substitutions in [NiFe] hydrogenase that improve electron transfer characteristics

  Yonemoto, I. T., Smith, H. O. & Weyman, P. D., Jan 16 2015, In: International journal of molecular sciences. 16, 1, p. 2020-2033 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nickel-iron hydrogenase 100%
  • Ferredoxins 73%
  • Ferredoxin 69%
  • electron transfer 56%
  • Electrons 55%

• Designer diatom episomes delivered by bacterial conjugation

  Karas, B. J., Diner, R. E., Lefebvre, S. C., McQuaid, J., Phillips, A. P. R., Noddings, C. M., Brunson, J. K., Valas, R. E., Deerinck, T. J., Jablanovic, J., Gillard, J. T. F., Beeri, K., Ellisman, M. H., Glass, J. I., Hutchison, C. A., Smith, H. O., Venter, J. C., Allen, A. E., Dupont, C. L. & Weyman, P. D., Apr 21 2015, In: Nature communications. 6, 6925.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Genetic Conjugation 100%
  • Diatoms 91%
  • algae 70%
  • conjugation 69%
  • Biochemistry 53%

• The sequence of the human genome

  Venter, J. C., Smith, H. O. & Adams, M. D., Sep 1 2015, In: Clinical chemistry. 61, 9, p. 1207-1208 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Where Next for Microbiome Research?

  Waldor, M. K., Tyson, G., Borenstein, E., Ochman, H., Moeller, A., Finlay, B. B., Kong, H. H., Gordon, J. I., Nelson, K. E., Dabbagh, K. & Smith, H., 2015, In: PLoS biology. 13, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RNA Sequencing 100%
  • DNA Sequencing 74%
  • Microbiota 59%
  • microbiome 58%
  • Metabolic 48%
• 2014

  A broad survey reveals substitution tolerance of residues ligating FeS clusters in [NiFe] hydrogenase

  Yonemoto, I. T., Clarkson, B. R., Smith, H. O. & Weyman, P. D., Jun 17 2014, In: BMC Biochemistry. 15, 1, 10.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • nickel-iron hydrogenase 100%
  • Hydrogenase 61%
  • Molecular Cluster 36%
  • Substitution Reaction 35%
  • Enzymes 30%

• Rescue of mutant fitness defects using in vitro reconstituted designer transposons in Mycoplasma mycoides

  Karas, B. J., Wise, K. S., Sun, L., Craig Venter, J., Glass, J. I., Hutchison, C. A., Smith, H. O. & Suzuki, Y., 2014, In: Frontiers in Microbiology. 5, JUL, 00369.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mycoplasma mycoides 100%
  • Transposases 39%
  • Mycoplasma 34%
  • In Vitro Techniques 24%
  • Genes 22%

• Transferring whole genomes from bacteria to yeast spheroplasts using entire bacterial cells to reduce DNA shearing

  Karas, B. J., Jablanovic, J., Irvine, E., Sun, L., Ma, L., Weyman, P. D., Gibson, D. G., Glass, J. I., Venter, J. C., Hutchison, C. A., Smith, H. O. & Suzuki, Y., Apr 2014, In: Nature protocols. 9, 4, p. 743-750 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Spheroplasts 100%
  • Yeasts 52%
  • Genome 44%
  • Bacteria 44%
  • Purification 44%
• 2013

  Assembly of eukaryotic algal chromosomes in yeast

  Karas, B. J., Molparia, B., Jablanovic, J., Hermann, W. J., Lin, Y. C., Dupont, C. L., Tagwerker, C., Yonemoto, I. T., Noskov, V. N., Chuang, R. Y., Allen, A. E., Glass, J. I., Hutchison, C. A., Smith, H. O., Venter, J. C. & Weyman, P. D., Dec 10 2013, In: Journal of Biological Engineering. 7, 1, 30.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Yeast 100%
  • Chromosomes 96%
  • chromosome 86%
  • yeast 82%
  • Yeasts 67%

• Direct transfer of whole genomes from bacteria to yeast

  Karas, B. J., Jablanovic, J., Sun, L., Ma, L., Goldgof, G. M., Stam, J., Ramon, A., Manary, M. J., Winzeler, E. A., Venter, J. C., Weyman, P. D., Gibson, D. G., Glass, J. I., Hutchison, C. A., Smith, H. O. & Suzuki, Y., May 2013, In: Nature Methods. 10, 5, p. 410-412 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Yeasts 100%
  • Donor 84%
  • Genome 84%
  • Bacteria 83%
  • Bacterial Genomes 41%

• Dual organism design cycle reveals small subunit substitutions that improve [NiFe] hydrogenase hydrogen evolution

  Yonemoto, I. T., Matteri, C. W., Nguyen, T. A., Smith, H. O. & Weyman, P. D., Jul 2 2013, In: Journal of Biological Engineering. 7, 1, 17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nickel-iron hydrogenase 100%
  • Hydrogenase 66%
  • Hydrogen 64%
  • Substitution reactions 55%
  • substitution 49%

• Foreword

  Smith, H. O., Dec 1 2013, Victor McKusick and the History of Medical Genetics. Springer New York, p. v-vi

  Research output: Chapter in Book/Report/Conference proceeding › Foreword/postscript
• 2012

  Assembly of large, high G+C bacterial DNA fragments in yeast

  Noskov, V. N., Karas, B. J., Young, L., Chuang, R. Y., Gibson, D. G., Lin, Y. C., Stam, J., Yonemoto, I. T., Suzuki, Y., Andrews-Pfannkoch, C., Glass, J. I., Smith, H. O., Hutchison, C. A., Venter, J. C. & Weyman, P. D., Jul 20 2012, In: ACS Synthetic Biology. 1, 7, p. 267-273 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Bacterial DNA 100%
  • Yeast 91%
  • DNA 79%
  • Yeasts 62%
  • Toxic 58%

• Cloning the acholeplasma laidlawii pg-8a genome in saccharomyces cerevisiae as a yeast centromeric plasmid

  Karas, B. J., Tagwerker, C., Yonemoto, I. T., Hutchison, C. A. & Smith, H. O., Jan 20 2012, In: ACS Synthetic Biology. 1, 1, p. 22-28 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Acholeplasma laidlawii 100%
  • Cloning 74%
  • Yeast 66%
  • Genomics 58%
  • Saccharomyces cerevisiae 51%

• Sequence analysis of a complete 1.66 Mb Prochlorococcus marinus MED4 genome cloned in yeast

  Tagwerker, C., Dupont, C. L., Karas, B. J., Ma, L., Chuang, R. Y., Benders, G. A., Ramon, A., Novotny, M., Montague, M. G., Venepally, P., Brami, D., Schwartz, A., Andrews-Pfannkoch, C., Gibson, D. G., Glass, J. I., Smith, H. O., Venter, J. C. & Hutchison, C. A., Nov 2012, In: Nucleic acids research. 40, 20, p. 10375-10383 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Prochlorococcus 100%
  • Sequence Analysis 49%
  • Yeasts 43%
  • Genome 36%
  • Saccharomyces cerevisiae 21%
  36 Scopus citations
• 2011

  [NiFe] Hydrogenase from Alteromonas macleodii with unusual stability in the presence of oxygen and high temperature

  Vargas, W. A., Weyman, P. D., Tong, Y., Smith, H. O. & Xu, Q., Mar 2011, In: Applied and environmental microbiology. 77, 6, p. 1990-1998 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Alteromonas 100%
  • nickel-iron hydrogenase 99%
  • Alteromonas macleodii 99%
  • Hydrogenase 85%
  • ferredoxin hydrogenase 73%

• Genetic analysis of the Alteromonas macleodii [NiFe]-hydrogenase

  Weyman, P. D., Smith, H. O. & Xu, Q., Sep 2011, In: FEMS microbiology letters. 322, 2, p. 180-187 8 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  • Alteromonas 100%
  • nickel-iron hydrogenase 99%
  • Hydrogenase 85%
  • Ecotype 58%
  • Mediterranean Sea 19%

• Heterologous expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] hydrogenases in Escherichia coli

  Weyman, P. D., Vargas, W. A., Chuang, R. Y., Chang, Y., Smith, H. O. & Xu, Q., May 2011, In: Microbiology. 157, 5, p. 1363-1374 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alteromonas 82%
  • nickel-iron hydrogenase 81%
  • Hydrogenase 63%
  • Ecotype 43%
  • Escherichia coli 32%

• Heterologous expression of alteromonas macleodii and thiocapsa roseopersicina [NiFe] hydrogenases in synechococcus elongatus

  Weyman, P. D., Vargas, W. A., Tong, Y., Yu, J., Maness, P. C., Smith, H. O. & Xu, Q., 2011, In: PloS one. 6, 5, e20126.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Alteromonas 82%
  • nickel-iron hydrogenase 81%
  • Alteromonas macleodii 81%
  • Thiocapsa roseopersicina 79%
  • Synechococcus 72%

• Single-step linker-based combinatorial assembly of promoter and gene cassettes for pathway engineering

  Ramon, A. & Smith, H. O., Mar 2011, In: Biotechnology Letters. 33, 3, p. 549-555 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Genes 100%
  • Acetate 73%
  • Escherichia coli 66%
  • Acetates 51%
  • Libraries 46%
• 2010

  Chemical synthesis of the mouse mitochondrial genome

  Gibson, D. G., Smith, H. O., Hutchison, C. A., Venter, J. C. & Merryman, C., Nov 2010, In: Nature Methods. 7, 11, p. 901-903 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Mitochondrial Genome 100%
  • Oligonucleotide 69%
  • Length 47%
  • Oligonucleotides 41%
  • Genetic Recombination 38%

• Cloning whole bacterial genomes in yeast

  Benders, G. A., Noskov, V. N., Denisova, E. A., Lartigue, C., Gibson, D. G., Assad-Garcia, N., Chuang, R. Y., Carrera, W., Moodie, M., Algire, M. A., Phan, Q., Alperovich, N., Vashee, S., Merryman, C., Venter, J. C., Smith, H. O., Glass, J. I. & Hutchison, C. A., Mar 6 2010, In: Nucleic acids research. 38, 8, p. 2558-2569 12 p., gkq119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Genomes 100%
  • Organism Cloning 68%
  • Yeasts 60%
  • Genome 50%
  • Mycoplasma genitalium 28%

• Creation of a bacterial cell controlled by a chemically synthesized genome

  Gibson, D. G., Glass, J. I., Lartigue, C., Noskov, V. N., Chuang, R. Y., Algire, M. A., Benders, G. A., Montague, M. G., Ma, L., Moodie, M. M., Merryman, C., Vashee, S., Krishnakumar, R., Assad-Garcia, N., Andrews-Pfannkoch, C., Denisova, E. A., Young, L., Qi, Z. N., Segall-Shapiro, T. H., Calvey, C. H., & 4 othersParmar, P. P., Hutchison, C. A., Smith, H. O. & Venter, J. C., Jul 2 2010, In: Science. 329, 5987, p. 52-56 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Mycoplasma mycoides 100%
  • Genome 75%
  • Sequence Deletion 31%
  • Gene Deletion 30%
  • Base Pairing 28%
  1500 Scopus citations
• 2009

  A systems biology tour de force for a near-minimal bacterium

  Glass, J. I., Hutchison, C. A., Smith, H. O. & Venter, J. C., Jan 20 2009, In: Molecular systems biology. 5, 330.

  Research output: Contribution to journal › Short survey › peer-review

  Open Access

  • Systems Biology 100%
  • Open access 99%
  • Bacteria 94%
  • systems biology 94%
  • Licensure 83%

• Creating bacterial strains from genomes that have been cloned and engineered in yeast

  Laitigue, C., Vashee, S., Algire, M. A., Chuang, R. Y., Benders, G. A., Ma, L., Noskov, V. N., Denisova, E. A., Gibson, D. G., Assad-Garcia, N., Alperovich, N., Thomas, D. W., Merryman, C., Hutchison, C. A., Smith, H. O., Venter, J. C. & Glass, J. I., 2009, In: Science. 325, 5948, p. 1693-1696 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Genomes 100%
  • Mycoplasma mycoides 80%
  • Yeasts 60%
  • Genome 30%
  • Mycoplasma capricolum 28%

• Discovery of [NiFe] hydrogenase genes in metagenomic DNA: Cloning and heterologous expression in Thiocapsa roseopersicina

  Maróti, G., Tong, Y., Yooseph, S., Baden-Tillson, H., Smith, H. O., Kovács, K. L., Frazier, M., Venter, J. C. & Xu, Q., Sep 2009, In: Applied and environmental microbiology. 75, 18, p. 5821-5830 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Alteromonas 82%
  • nickel-iron hydrogenase 81%
  • Thiocapsa roseopersicina 79%
  • ferredoxin hydrogenase 60%
  • cloning 57%

• Enzymatic assembly of DNA molecules up to several hundred kilobases

  Gibson, D. G., Young, L., Chuang, R. Y., Venter, J. C., Hutchison, C. A. & Smith, H. O., 2009, In: Nature Methods. 6, 5, p. 343-345 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Single-Stranded DNA 100%
  • Phosphodiesterase I 75%
  • DNA Ligases 70%
  • Synthetic Genes 66%
  • DNA-Directed DNA Polymerase 52%

• The evolution of RecD outside of the RecBCD complex

  Montague, M., Barnes, C., Smith, H. O., Chuang, R. Y. & Vashee, S., Oct 2009, In: Journal of Molecular Evolution. 69, 4, p. 360-371 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Deinococcus 100%
  • Deinococcus radiodurans 91%
  • gene 63%
  • Double-Stranded DNA Breaks 48%
  • DNA repair 45%
  14 Scopus citations
• 2008

  Complete chemical synthesis, assembly, and cloning of a Mycoplasma genitalium genome

  Gibson, D. G., Benders, G. A., Andrews-Pfannkoch, C., Denisova, E. A., Baden-Tillson, H., Zaveri, J., Stockwell, T. B., Brownley, A., Thomas, D. W., Algire, M. A., Merryman, C., Young, L., Noskov, V. N., Glass, J. I., Venter, J. C., Hutchison, C. A. & Smith, H. O., Feb 29 2008, In: Science. 319, 5867, p. 1215-1220 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Mycoplasma genitalium 100%
  • Organism Cloning 60%
  • Genome 44%
  • Clone Cells 22%
  • Genetic Recombination 17%

• One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome

  Gibson, D. G., Benders, G. A., Axelrod, K. C., Zaveri, J., Algire, M. A., Moodie, M., Montague, M. G., Venter, J. C., Smith, H. O. & Hutchison, C. A., Dec 23 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 51, p. 20404-20409 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mycoplasma genitalium 100%
  • Genetic Recombination 62%
  • Yeasts 52%
  • Genome 44%
  • DNA 36%
  306 Scopus citations
• 2007

  Genome transplantation in bacteria: Changing one species to another

  Lartigue, C., Glass, J. I., Alperovich, N., Pieper, R., Parmar, P. P., Hutchison, C. A., Smith, H. O. & Venter, J. C., Aug 3 2007, In: Science. 317, 5838, p. 632-638 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mycoplasma mycoides 100%
  • Transplantation 56%
  • Genome 50%
  • Bacteria 50%
  • Mycoplasma capricolum 35%

• The Sorcerer II Global Ocean Sampling expedition: Northwest Atlantic through eastern tropical Pacific

  Rusch, D. B., Halpern, A. L., Sutton, G., Heidelberg, K. B., Williamson, S., Yooseph, S., Wu, D., Eisen, J. A., Hoffman, J. M., Remington, K., Beeson, K., Tran, B., Smith, H., Baden-Tillson, H., Stewart, C., Thorpe, J., Freeman, J., Andrews-Pfannkoch, C., Venter, J. E., Li, K., & 20 othersKravitz, S., Heidelberg, J. F., Utterback, T., Rogers, Y. H., Falcón, L. I., Souza, V., Bonilla-Rosso, G., Eguiarte, L. E., Karl, D. M., Sathyendranath, S., Platt, T., Bermingham, E., Gallardo, V., Tamayo-Castillo, G., Ferrari, M. R., Strausberg, R. L., Nealson, K., Friedman, R., Frazier, M. & Venter, J. C., Mar 2007, In: PLoS biology. 5, 3, p. 398-431 34 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Expeditions 100%
  • Northwest Atlantic 97%
  • Ribotyping 92%
  • Oceans and Seas 75%
  • ribotypes 71%
• 2006

  Essential genes of a minimal bacterium

  Glass, J. I., Assad-Garcia, N., Alperovich, N., Yooseph, S., Lewis, M. R., Maruf, M., Hutchison, C. A., Smith, H. O. & Venter, J. C., Jan 10 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 2, p. 425-430 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Essential Genes 100%
  • Mycoplasma genitalium 80%
  • Bacteria 59%
  • Proteins 32%
  • Genes 28%
• 2005

  Cell-free cloning using φ29 DNA polymerase

  Hutchison, C. A., Smith, H. O., Pfannkoch, C. & Venter, J. C., Nov 29 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 48, p. 17332-17336 5 p.

  Research output: Contribution to journal › Article › peer-review

  • DNA-Directed DNA Polymerase 100%
  • Organism Cloning 81%
  • DNA 49%
  • Environmental DNA 25%
  • Synthetic Genes 20%
• 2004

  Environmental Genome Shotgun Sequencing of the Sargasso Sea

  Venter, J. C., Remington, K., Heidelberg, J. F., Halpern, A. L., Rusch, D., Eisen, J. A., Wu, D., Paulsen, I., Nelson, K. E., Nelson, W., Fouts, D. E., Levy, S., Knap, A. H., Lomas, M. W., Nealson, K., White, O., Peterson, J., Hoffman, J., Parsons, R., Baden-Tillson, H., & 3 othersPfannkoch, C., Rogers, Y. H. & Smith, H. O., Apr 2 2004, In: Science. 304, 5667, p. 66-74 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Oceans and Seas 100%
  • Firearms 99%
  • Bermuda 81%
  • Genome 59%
  • Seawater 56%
• 2003

  Generating a synthetic genome by whole genome assembly: φX174 bacteriophage from synthetic oligonucleotides

  Smith, H. O., Hutchison, C. A., Pfannkoch, C. & Venter, J. C., Dec 23 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 26, p. 15440-15445 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Oligonucleotides 100%
  • Bacteriophages 95%
  • Genome 65%
  • Ligation 28%
  • DNA 26%

• The independence of our genome assemblies

  Adams, M. D., Sutton, G. G., Smith, H. O., Myers, E. W. & Craig Venter, J., Mar 18 2003, In: Proceedings of the National Academy of Sciences of the United States of America. 100, 6, p. 3025-3026 2 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
• 2002

  A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome

  Mural, R. J., Adams, M. D., Myers, E. W., Smith, H. O., Gabor Miklos, G. L., Wides, R., Halpern, A., Li, P. W., Sutton, G. G., Nadeau, J., Salzberg, S. L., Holt, R. A., Kodira, C. D., Lu, F., Chen, L., Deng, Z., Evangelista, C. C., Gan, W., Heiman, T. J., Li, J., & 157 othersLi, Z., Merkulov, G. V., Milshina, N. V., Naik, A. K., Qi, R., Chris Shue, B., Wang, A., Wang, J., Wang, X., Yan, X., Ye, J., Yooseph, S., Zhao, Q., Zheng, L., Zhu, S. C., Biddick, K., Bolanos, R., Delcher, A. L., Dew, I. M., Fasulo, D., Flanigan, M. J., Huson, D. H., Kravitz, S. A., Miller, J. R., Mobarry, C. M., Reinert, K., Remington, K. A., Zhang, Q., Zheng, X. H., Nusskern, D. R., Lai, Z., Lei, Y., Zhong, W., Yao, A., Guan, P., Ji, R. R., Gu, Z., Wang, Z. Y., Zhong, F., Xiao, C., Chiang, C. C., Yandell, M., Wortman, J. R., Amanatides, P. G., Hladun, S. L., Pratts, E. C., Johnson, J. E., Dodson, K. L., Woodford, K. J., Evans, C. A., Gropman, B., Rusch, D. B., Venter, E., Wang, M., Smith, T. J., Houck, J. T., Tompkins, D. E., Haynes, C., Jacob, D., Chin, S. H., Allen, D. R., Dahlke, C. E., Sanders, R., Li, K., Liu, X., Levitsky, A. A., Majoros, W. H., Chen, Q., Xia, A. C., Lopez, J. R., Donnelly, M. T., Newman, M. H., Glodek, A., Kraft, C. L., Nodell, M., Ali, F., An, H. J., Baldwin-Pitts, D., Beeson, K. Y., Cai, S., Carnes, M., Carver, A., Caulk, P. M., Center, A., Chen, Y. H., Cheng, M. L., Coyne, M. D., Crowder, M., Danaher, S., Davenport, L. B., Desilets, R., Dietz, S. M., Doup, L., Dullaghan, P., Ferriera, S., Fosler, C. R., Gire, H. C., Gluecksmann, A., Gocayne, J. D., Gray, J., Hart, B., Haynes, J., Hoover, J., Howland, T., Ibegwam, C., Jalali, M., Johns, D., Kline, L., Ma, D. S., MacCawley, S., Magoon, A., Mann, F., May, D., McIntosh, T. C., Mehta, S., Moy, L., Moy, M. C., Murphy, B. J., Murphy, S. D., Nelson, K. A., Nuri, Z., Parker, K. A., Prudhomme, A. C., Puri, V. N., Qureshi, H., Raley, J. C., Reardon, M. S., Regier, M. A., Rogers, Y. H. C., Romblad, D. L., Schutz, J., Scott, J. L., Scott, R., Sitter, C. D., Smallwood, M., Sprague, A. C., Stewart, E., Strong, R. V., Suh, E., Sylvester, K., Thomas, R., Ni Tint, N., Tsonis, C., Wang, G., Wang, G., Williams, M. S., Williams, S. M., Windsor, S. M., Wolfe, K., Wu, M. M., Zaveri, J., Chaturvedi, K., Gabrielian, A. E., Ke, Z., Sun, J., Subramanian, G. & Craig Venter, J., May 31 2002, In: Science. 296, 5573, p. 1661-1671 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosomes, Human, Pair 16 100%
  • Firearms 83%
  • Human Genome 76%
  • Genome 49%
  • Genes 19%
  275 Scopus citations

• A preliminary comparison of the mouse and human genomes

  Mural, R. J., Myers, E. W., Smith, H., Gabor Miklos, G. L., Wides, R., Halpern, A., Li, P. W., Sutton, G., Nadeau, J. H., Salzberg, S. L., Holt, R., Evans, C. A., Lu, F., Biddick, K., Bonazzi, V., Delcher, A., Zheng, X. H., Yandell, M., Rusch, D., Majoros, W., & 4 othersHoover, J., Wang, J., Venter, J. C. & Adams, M. D., Dec 1 2002, In: International Congress Series. 1246, C, p. 169-181 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Human Genome 100%
  • Genome 64%
  • Synteny 10%
  • Data Accuracy 7%
  • Accidental Falls 5%
  1 Scopus citations