Research output per year
Research output per year
- 1 - 50 out of 70 results
Search results
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2023
Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos
Nkoula, S. N., Velez-Aguilera, G., Ossareh-Nazari, B., Hove, L. V., Ayuso, C., Legros, V., Chevreux, G., Thomas, L., Seydoux, G., Askjaer, P. & Pintard, L., Jul 2023, In: Science Advances. 9, 29, eadf7826.Research output: Contribution to journal › Article › peer-review
Open Access -
Nucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly
Thomas, L., Taleb Ismail, B., Askjaer, P. & Seydoux, G., Jul 3 2023, In: EMBO Journal. 42, 13, e112987.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Improving the specificity of nucleic acid detection with endonuclease-actuated degradation
Zou, R. S., Gavrilov, M., Liu, Y., Rasoloson, D., Conte, M., Hardick, J., Shen, L., Chen, S., Pekosz, A., Seydoux, G., Manabe, Y. C. & Ha, T., Dec 2022, In: Communications biology. 5, 1, 290.Research output: Contribution to journal › Article › peer-review
Open Access -
Nuage condensates: Accelerators or circuit breakers for sRNA silencing pathways?
Ouyang, J. P. T. & Seydoux, G., Jan 2022, In: RNA. 28, 1, p. 58-66 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos
Cassani, M. & Seydoux, G., Nov 2022, In: Development (Cambridge). 149, 21, dev200920.Research output: Contribution to journal › Article › peer-review
Open Access -
The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates
Ouyang, J. P. T., Zhang, W. L. & Seydoux, G., Jul 2022, In: Nature cell biology. 24, 7, p. 1129-1140 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Protein-based condensation mechanisms drive the assembly of RNA-rich P granules
Schmidt, H., Putnam, A., Rasoloson, D. & Seydoux, G., Jun 2021, In: eLife. 10, e63698.Research output: Contribution to journal › Article › peer-review
Open Access -
Regulation of biomolecular condensates by interfacial protein clusters
Folkmann, A. W., Putnam, A., Lee, C. F. & Seydoux, G., Sep 10 2021, In: Science. 373, 6560, eabg7071.Research output: Contribution to journal › Article › peer-review
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2020
Puromycin reactivity does not accurately localize translation at the subcellular level
Enam, S. U., Zinshteyn, B., Goldman, D. H., Cassani, M., Livingston, N. M., Seydoux, G. & Green, R., Aug 2020, In: eLife. 9, p. 1-34 34 p., e60303.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins
Lee, C. Y. S., Putnam, A., Lu, T., He, S. X., Ouyang, J. P. T. & Seydoux, G., Jan 2020, In: eLife. 9, e52896.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
2019
A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos
Putnam, A., Cassani, M., Smith, J. & Seydoux, G., Mar 1 2019, In: Nature Structural and Molecular Biology. 26, 3, p. 220-226 7 p.Research output: Contribution to journal › Article › peer-review
Open Access57 Scopus citations -
Dynamics of mRNA entry into stress granules
Lee, C. Y. & Seydoux, G., Feb 1 2019, In: Nature cell biology. 21, 2, p. 116-117 2 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
P Granules Protect RNA Interference Genes from Silencing by piRNAs
Ouyang, J. P. T., Folkmann, A., Bernard, L., Lee, C. Y., Seroussi, U., Charlesworth, A. G., Claycomb, J. M. & Seydoux, G., Sep 23 2019, In: Developmental Cell. 50, 6, p. 716-728.e6Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Rapid Tagging of Human Proteins with Fluorescent Reporters by Genome Engineering using Double-Stranded DNA Donors
Paix, A., Rasoloson, D., Folkmann, A. & Seydoux, G., Dec 1 2019, In: Current protocols in molecular biology. 129, 1, e102.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms
Folkmann, A. & Seydoux, G., Mar 2019, In: Development (Cambridge). 146, 6, dev171116.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2017
MIP-MAP: High-throughput mapping of Caenorhabditis elegans temperature-sensitive mutants via molecular inversion probes
Mok, C. A., Au, V., Thompson, O. A., Edgley, M. L., Gevirtzman, L., Yochem, J., Lowry, J., Memar, N., Wallenfang, M. R., Rasoloson, D., Bowerman, B., Schnabel, R., Seydoux, G., Moerman, D. G. & Waterston, R. H., Oct 2017, In: Genetics. 207, 2, p. 447-463 17 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B
Lee, C. Y. S., Lu, T. & Seydoux, G., Nov 7 2017, In: eLife. 6, e30201.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans
Paix, A., Folkmann, A. & Seydoux, G., May 15 2017, In: Methods. 121-122, p. 86-93 8 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Scopus citations -
Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks
Paix, A., Folkmann, A., Goldman, D. H., Kulaga, H., Grzelak, M. J., Rasoloson, D., Paidemarry, S., Green, R., Reed, R. R. & Seydoux, G., Dec 12 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. E10745-E10754Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2016
Cas9-assisted recombineering in C. elegans: Genome editing using in vivo assembly of linear DNAs
Paix, A., Schmidt, H. & Seydoux, G., Sep 6 2016, In: Nucleic acids research. 44, 15, p. e128Research output: Contribution to journal › Article › peer-review
Open Access48 Scopus citations -
Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3
Smith, J., Calidas, D., Schmidt, H., Lu, T., Rasoloson, D. & Seydoux, G., Dec 3 2016, In: eLife. 5, DECEMBER2016, e21337.Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
2015
High efficiency, homology-directed genome editing in Caenorhabditis elegans using CRISPR-Cas9ribonucleoprotein complexes
Paix, A., Folkmann, A., Rasoloson, D. & Seydoux, G., Sep 1 2015, In: Genetics. 201, 1, p. 47-54 8 p.Research output: Contribution to journal › Article › peer-review
Open Access225 Scopus citations -
2014
Identification of suppressors of mbk-2/DYRK by whole-genome sequencing
Wang, Y., Wang, J. T., Rasoloson, D., Stitzel, M. L., O'Connell, K. F., Smith, H. E. & Seydoux, G., Feb 2014, In: G3: Genes, Genomes, Genetics. 4, 2, p. 231-241 11 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution
Chen, B. C., Legant, W. R., Wang, K., Shao, L., Milkie, D. E., Davidson, M. W., Janetopoulos, C., Wu, X. S., Hammer, J. A., Liu, Z., English, B. P., Mimori-Kiyosue, Y., Romero, D. P., Ritter, A. T., Lippincott-Schwartz, J., Fritz-Laylin, L., Mullins, R. D., Mitchell, D. M., Bembenek, J. N., Reymann, A. C., & 7 others, Oct 24 2014, In: Science. 346, 6208, 1257998.Research output: Contribution to journal › Article › peer-review
Open Access890 Scopus citations -
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans
Wang, J. T., Smith, J., Chen, B. C., Schmidt, H., Rasoloson, D., Paix, A., Lambrus, B. G., Calidas, D., Betzig, E. & Seydoux, G., 2014, In: eLife. 3, e04591.Research output: Contribution to journal › Article › peer-review
Open Access201 Scopus citations -
Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 sites in Caenorhabditis elegans
Paix, A., Wang, Y., Smith, H. E., Lee, C. Y. S., Calidas, D., Lu, T., Smith, J., Schmidt, H., Krause, M. W. & Seydoux, G., Dec 1 2014, In: Genetics. 198, 4, p. 1347-1356 10 p.Research output: Contribution to journal › Article › peer-review
Open Access154 Scopus citations -
2012
The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells
Voronina, E., Paix, A. & Seydoux, G., Oct 15 2012, In: Development (Cambridge). 139, 20, p. 3732-3740 9 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
2011
Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes
Motegi, F., Zonies, S., Hao, Y., Cuenca, A. A., Griffin, E. & Seydoux, G., Nov 2011, In: Nature cell biology. 13, 11, p. 1361-1367 7 p.Research output: Contribution to journal › Article › peer-review
104 Scopus citations -
Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle
Griffin, E. E., Odde, D. J. & Seydoux, G., Sep 16 2011, In: Cell. 146, 6, p. 955-968 14 p.Research output: Contribution to journal › Article › peer-review
Open Access87 Scopus citations -
2010
Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans
Gallo, C. M., Wang, J. T., Motegi, F. & Seydoux, G., Dec 17 2010, In: Science. 330, 6011, p. 1685-1689 5 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2
Zonies, S., Motegi, F., Hao, Y. & Seydoux, G., May 15 2010, In: Development. 137, 10, p. 1669-1677 9 p.Research output: Contribution to journal › Article › peer-review
84 Scopus citations -
The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules
Voronina, E. & Seydoux, G., May 1 2010, In: Development. 137, 9, p. 1441-1450 10 p.Research output: Contribution to journal › Article › peer-review
50 Scopus citations -
The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells
Merritt, C. & Seydoux, G., Jun 1 2010, In: Development. 137, 11, p. 1787-1798 12 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
2009
Regulation of MBK-2/DYRK by CDK-1 and the Pseudophosphatases EGG-4 and EGG-5 during the Oocyte-to-Embryo Transition
Cheng, K. C. C., Klancer, R., Singson, A. & Seydoux, G., Oct 30 2009, In: Cell. 139, 3, p. 560-572 13 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
2008
3′ UTRs Are the Primary Regulators of Gene Expression in the C. elegans Germline
Merritt, C., Rasoloson, D., Ko, D. & Seydoux, G., Oct 14 2008, In: Current Biology. 18, 19, p. 1476-1482 7 p.Research output: Contribution to journal › Article › peer-review
Open Access245 Scopus citations -
Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: Genetic evidence for distinct mechanisms targeting initiation and elongation
Ghosh, D. & Seydoux, G., Jan 2008, In: Genetics. 178, 1, p. 235-243 9 p.Research output: Contribution to journal › Article › peer-review
Open Access43 Scopus citations -
Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos
Gallo, C. M., Munro, E., Rasoloson, D., Merritt, C. & Seydoux, G., Nov 1 2008, In: Developmental biology. 323, 1, p. 76-87 12 p.Research output: Contribution to journal › Article › peer-review
Open Access96 Scopus citations -
2007
Conserved regulation of MAP kinase expression by PUF RNA-binding proteins
Lee, M. H., Hook, B., Pan, G., Kershner, A. M., Merritt, C., Seydoux, G., Thomson, J. A., Wickens, M. & Kimble, J., Dec 2007, In: PLoS genetics. 3, 12, p. 2540-2550 11 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
Regulation of MBK-2/Dyrk Kinase by Dynamic Cortical Anchoring during the Oocyte-to-Zygote Transition
Stitzel, M. L., Cheng, K. C. C. & Seydoux, G., Sep 18 2007, In: Current Biology. 17, 18, p. 1545-1554 10 p.Research output: Contribution to journal › Article › peer-review
Open Access47 Scopus citations -
2006
Stabilization of cell polarity by the C. elegans RING protein PAR-2
Hao, Y., Boyd, L. & Seydoux, G., Feb 2006, In: Developmental Cell. 10, 2, p. 199-208 10 p.Research output: Contribution to journal › Article › peer-review
Open Access99 Scopus citations -
The 2006 Genetics Society of America Medal. Victor Ambros.
Seydoux, G., Feb 2006, In: Genetics. 172, 2, p. 721-722 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The C. elegans DYRK kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation
Stitzel, M. L., Pellettieri, J. & Seydoux, G., Jan 10 2006, In: Current Biology. 16, 1, p. 56-62 7 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline
D'Agostino, I., Merritt, C., Chen, P. L., Seydoux, G. & Subramaniam, K., Apr 1 2006, In: Developmental biology. 292, 1, p. 244-252 9 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Scopus citations -
2003
Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans
Pellettieri, J., Reinke, V., Kim, S. K. & Seydoux, G., Sep 1 2003, In: Developmental Cell. 5, 3, p. 451-462 12 p.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
Dedifferentiation of primary spermatocytes into germ cell tumors in C. elegans Lacking the pumilio-like protein PUF-8
Subramaniam, K. & Seydoux, G., Jan 21 2003, In: Current Biology. 13, 2, p. 134-139 6 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation
DeRenzo, C., Reese, K. J. & Seydoux, G., Aug 7 2003, In: Nature. 424, 6949, p. 685-689 5 p.Research output: Contribution to journal › Article › peer-review
Open Access133 Scopus citations -
2002
cdk-7 is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos
Wallenfang, M. R. & Seydoux, G., Apr 16 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 8, p. 5527-5532 6 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
Hilar lymph nodes in N2 disease: Survival analysis of patients with non-small cell lung cancers and regional lymph node metastasis
Wallenfang, M. R. & Seydoux, G., 2002, In: Surgery Today. 32, 4, p. 300-304 5 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2001
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans
Tenenhaus, C., Subramaniam, K., Dunn, M. A. & Seydoux, G., Apr 15 2001, In: Genes and Development. 15, 8, p. 1031-1040 10 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Spindle dynamics and the role of γ-tubulin in early Caenorhabditis elegans embryos
Strome, S., Powers, J., Dunn, M., Reese, K., Malone, C. J., White, J., Seydoux, G. & Saxton, W., 2001, In: Molecular biology of the cell. 12, 6, p. 1751-1764 14 p.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations