Fredrick Wigley

Research output

Research output per year 1969 2009 2016 2018 2024

• 262 Article
• 30 Review article
• 17 Chapter
• 16 Letter
• 21 More
  • 8 Comment/debate
  • 5 Editorial
  • 4 Foreword/postscript
  • 2 Book
  • 1 Conference contribution
  • 1 Short survey

Research output per year

Research output per year

Search results

• 2024

  Anti-Gephyrin Antibodies: A Novel Specificity in Patients With Systemic Sclerosis and Lower Bowel Dysfunction

  McMahan, Z. H., Kulkarni, S., Andrade, F., Perin, J., Zhang, C., Hooper, J. E., Wigley, F. M., Rosen, A., Pasricha, P. J. & Casciola-Rosen, L., Jan 2024, In: Arthritis and Rheumatology. 76, 1, p. 92-99 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 70%
  • Anti-Idiotypic Antibodies 51%
  • Enteric Nervous System 40%
  • Autoantibodies 34%
  • Constipation 31%

• Distinct Scleroderma Autoantibody Profiles Stratify Patients for Cancer Risk at Scleroderma Onset and During the Disease Course

  Kim, J. S., Woods, A., Gutierrez-Alamillo, L., Laffoon, M., Wigley, F. M., Hummers, L. K., Rosen, A., Zeger, S., Domsic, R. T., Casciola-Rosen, L. & Shah, A. A., Jan 2024, In: Arthritis and Rheumatology. 76, 1, p. 68-77 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoantibodies 100%
  • Odds Ratio 46%
  • Confidence Intervals 43%
  • Neoplasms 34%
  • Logistic Models 11%

• Myositis mimics in scleroderma: A case series of neuromuscular diseases that can co-exist in scleroderma

  Joyce, E., Wigley, F. M., Hummers, L. K. & Paik, J. J., Feb 2024, In: Journal of Scleroderma and Related Disorders. 9, 1, p. NP12-NP15

  Research output: Contribution to journal › Article › peer-review

  • Neuromuscular Diseases 100%
  • Myositis 97%
  • Systemic Scleroderma 60%
  • Muscular Diseases 28%
  • Muscles 15%

• Treatment of Systemic Sclerosis–associated Interstitial Lung Disease: Evidence-based Recommendations An Official American Thoracic Society Clinical Practice Guideline

  Raghu, G., Ghazipura, M., Montesi, S. B., Silver, R. M., Hossain, T., Macrea, M., Herman, D., Barnes, H., Adegunsoye, A., Azuma, A., Burlile, D., Chung, L., Gardner, G. C., Highland, K. B., Hudson, M., Kaner, R. J., Kemper, K. A., Knight, S. L., Kolb, M., Scholand, M. B., & 4 othersSteen, V., Thomson, C. C., Volkmann, E. R. & Wigley, F. M., Jan 15 2024, In: American journal of respiratory and critical care medicine. 209, 2, p. 137-152 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Interstitial Lung Diseases 96%
  • Practice Guidelines 82%
  • Thorax 60%
  • nintedanib 46%
• 2023

  Cumulative disease damage and anti-PM/Scl antibodies are associated with a heavy burden of calcinosis in systemic sclerosis

  Richardson, C., Perin, J., Zeger, S., Wigley, F. M., Hummers, L. K., Casciola-Rosen, L., Rosen, A. & Shah, A. A., Nov 1 2023, In: Rheumatology (United Kingdom). 62, 11, p. 3636-3643 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Calcinosis 100%
  • Systemic Scleroderma 91%
  • Antibodies 44%
  • Autoantibodies 15%
  • Odds Ratio 14%

• Slow Colonic Transit in Systemic Sclerosis: An Objective Assessment of Risk Factors and Clinical Phenotype

  Cheah, J. X., Perin, J., Volkmann, E. R., Hummers, L. K., Pasricha, P. J., Wigley, F. M. & McMahan, Z. H., Feb 2023, In: Arthritis Care and Research. 75, 2, p. 289-298 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Odds Ratio 56%
  • Phenotype 52%
  • Confidence Intervals 52%
  • Telangiectasis 24%

• Stress Echocardiographic Prediction of Emerging Pulmonary Vascular Disease in Systemic Sclerosis

  Lu, J., Jani, V., Mercurio, V., Hsu, S., Hummers, L. K., Wigley, F., Hassoun, P. M., Mathai, S. C., Shah, A. A. & Mukherjee, M., Feb 2023, In: Journal of the American Society of Echocardiography. 36, 2, p. 259-261 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2022

  Diastolic Dysfunction in Systemic Sclerosis: Risk Factors and Impact on Mortality

  Hinze, A. M., Perin, J., Woods, A., Hummers, L. K., Wigley, F. M., Mukherjee, M. & Shah, A. A., May 2022, In: Arthritis and Rheumatology. 74, 5, p. 849-859 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Confidence Intervals 52%
  • Odds Ratio 50%
  • Mortality 44%
  • Coronary Artery Disease 16%

• Relationship Between Gastrointestinal Transit, Medsger Gastrointestinal Severity, and University of California–Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Symptoms in Patients With Systemic Sclerosis

  McMahan, Z. H., Tucker, A. E., Perin, J., Volkmann, E. R., Kulkarni, S., Ziessman, H. A., Pasricha, P. J. & Wigley, F. M., Mar 2022, In: Arthritis Care and Research. 74, 3, p. 442-450 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Gastrointestinal Transit 100%
  • Systemic Scleroderma 79%
  • Gastrointestinal Tract 60%
  • Clinical Trials 45%
  • Radionuclide Imaging 19%

• Troponin elevation independently associates with mortality in systemic sclerosis

  Paik, J. J., Choi, D. Y., Mukherjee, M., Hsu, S., Wigley, F., Shah, A. A. & Hummers, L. K., 2022, In: Clinical and experimental rheumatology. 40, 10, p. 1933-1940 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Troponin 100%
  • Systemic Scleroderma 95%
  • Mortality 42%
  • Diffuse Scleroderma 10%
  • Vital Capacity 8%
• 2021

  Assessment of right ventricular reserve utilizing exercise provocation in systemic sclerosis

  Mukherjee, M., Mercurio, V., Hsu, S., Mayer, S. A., Mathai, S. C., Hummers, L. K., Kass, D. A., Hassoun, P. M., Wigley, F. M., Tedford, R. J. & Shah, A. A., Jul 2021, In: International Journal of Cardiovascular Imaging. 37, 7, p. 2137-2147 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Exercise 56%
  • Blood Pressure 20%
  • Echocardiography 18%
  • Ventricular Pressure 11%
  1 Scopus citations

• Essential hypertension worsens left ventricular contractility in systemic sclerosis

  Mercurio, V., Hinze, A. M., Hummers, L. K., Wigley, F. M., Shah, A. A. & Mukherjee, M., Aug 1 2021, In: Journal of Rheumatology. 48, 8, p. 1299-1306 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Essential Hypertension 91%
  • Hypertension 56%
  • Sclerosis 11%
  • Ventricular Remodeling 6%

• Exercise right ventricular ejection fraction predicts right ventricular contractile reserve

  Ireland, C. G., Damico, R. L., Kolb, T. M., Mathai, S. C., Mukherjee, M., Zimmerman, S. L., Shah, A. A., Wigley, F. M., Houston, B. A., Hassoun, P. M., Kass, D. A., Tedford, R. J. & Hsu, S., Jun 2021, In: Journal of Heart and Lung Transplantation. 40, 6, p. 504-512 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Right Ventricular Dysfunction 100%
  • Stroke Volume 95%
  • Exercise 68%
  • Dilatation 37%
  • Cardiac Catheterization 31%

• Linaclotide for the treatment of refractory lower bowel manifestations of systemic sclerosis

  Dein, E. J., Wigley, F. M. & McMahan, Z. H., Dec 2021, In: BMC Gastroenterology. 21, 1, 174.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • linaclotide 100%
  • Systemic Scleroderma 63%
  • Gastrointestinal Diseases 9%
  • Therapeutics 9%
  • Guanylyl Cyclase C Agonists 9%

• PM-Scl and Th/To in systemic sclerosis: a comparison of different autoantibody assays

  Mecoli, C. A., Gutierrez-Alamillo, L., Yang, Q., Sampedro, M., Woods, A., Hummers, L. K., Wigley, F., Shah, A. A. & Casciola-Rosen, L., Jul 2021, In: Clinical rheumatology. 40, 7, p. 2763-2769 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Immunoprecipitation 85%
  • Autoantibodies 80%
  • Statistics 33%
  • Antibodies 24%
• 2020

  ACE inhibitors in SSc patients display a risk factor for scleroderma renal crisis - A EUSTAR analysis

  Bütikofer, L., Varisco, P. A., Distler, O., Kowal-Bielecka, O., Allanore, Y., Riemekasten, G., Villiger, P. M., Adler, S., Avouac, J., Walker, U. A., Guiducci, S., Riemekasten, G., Airò, P., Hachulla, E., Valentini, G., Carreira, P. E., Cozzi, F., Gurman, A. B., Braun-Moscovici, Y., Damjanov, N., & 158 othersAnanieva, L. P., Scorza, R., Jimenez, S., Busquets, J., Li, M., Müller-Ladner, U., Maurer, B., Tyndall, A., Lapadula, G., Iannone, F., Becvar, R., Sierakowsky, S., Bielecka, O. K., Cutolo, M., Sulli, A., Cuomo, G., Vettori, S., Rednic, S., Nicoara, I., Vlachoyiannopoulos, P., Montecucco, C., Caporali, R., Novak, S., Czirják, L., Varju, C., Chizzolini, C., Kucharz, E. J., Kotulska, A., Kopec-Medrek, M., Widuchowska, M., Rozman, B., Mallia, C., Coleiro, B., Gabrielli, A., Farge, D., Hij, A., Hesselstrand, R., Scheja, A., Wollheim, F., Martinovic, D., Govoni, M., Monaco, A. L., Hunzelmann, N., Pellerito, R., Bambara, L. M., Caramaschi, P., Black, C., Denton, C., Henes, J., Santamaria, V. O., Heitmann, S., Krasowska, D., Seidel, M., Oleszowsky, M., Burkhardt, H., Himsel, A., Salvador, M. J., Stamenkovic, B., Stankovic, A., Tikly, M., Starovoytova, M. N., Engelhart, M., Strauss, G., Nielsen, H., Damgaard, K., Szücs, G., Mendoza, A. Z., De La Puente Buijdos, C., Sifuentes Giraldo, W. A., Midtvedt, Ø., Garen, T., Launay, D., Valesini, G., Riccieri, V., Ionescu, R. M., Opris, D., Groseanu, L., Wigley, F. M., Mihai, C. M., Cornateanu, R. S., Ionitescu, R., Gherghe, A. M., Gorga, M., Dobrota, R., Bojinca, M., Schett, G., Distler, J. H. W., Meroni, P., Zeni, S., Mouthon, L., De Keyser, F., Smith, V., Cantatore, F. P., Corrado, A., Ullman, S., Iversen, L., Pozzi, M. R., Eyerich, K., Hein, R., Knott, E., Szechinski, J., Wiland, P., Szmyrka-Kaczmarek, M., Sokolik, R., Morgiel, E., Krummel-Lorenz, B., Saar, P., Aringer, M., Günther, C., Anic, B., Baresic, M., Mayer, M., Radominski, S. C., De Souza Müller, C., Azevedo, V. F., Agachi, S., Groppa, L., Chiaburu, L., Russu, E., Zenone, T., Stebbings, S., Highton, J., Stamp, L., Chapman, P., Baron, M., O'Donnell, J., Solanki, K., Doube, A., Veale, D., O'Rourke, M., Loyo, E., Rosato, E., Pisarri, S., Tanaseanu, C. M., Popescu, M., Dumitrascu, A., Tiglea, I., Chirieac, R., Ancuta, C., Furst, D. E., Kafaja, S., De La Peña Lefebvre, P. G., Rubio, S. R., Exposito, M. V., Sibilia, J., Chatelus, E., Gottenberg, J. E., Chifflot, H., Litinsky, I., Venalis, A., Butrimiene, I., Venalis, P., Rugiene, R., Karpec, D., Kerzberg, E., Montoya, F., Cosentino, V. & Castellvi, I., Mar 24 2020, In: Arthritis Research and Therapy. 22, 1, 59.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Angiotensin-Converting Enzyme Inhibitors 100%
  • Kidney 54%
  • Hypertension 26%
  • Antihypertensive Agents 18%
  • Glucocorticoids 18%
  7 Scopus citations

• Clinical and Molecular Phenotyping in Scleromyxedema Pretreatment and Posttreatment With Intravenous Immunoglobulin

  Mecoli, C. A., Talbot, C. C., Fava, A., Cheadle, C., Boin, F., Wigley, F. M. & Hummers, L. K., Jun 1 2020, In: Arthritis Care and Research. 72, 6, p. 761-767 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Scleromyxedema 100%
  • Intravenous Immunoglobulins 67%
  • Passive Immunization 40%
  • Skin 33%
  • Transforming Growth Factors 14%
  5 Scopus citations

• Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma

  Tiniakou, E., Fava, A., McMahan, Z. H., Guhr, T., O'Meally, R. N., Shah, A. A., Wigley, F. M., Cole, R. N., Boin, F. & Darrah, E., Aug 1 2020, In: Arthritis and Rheumatology. 72, 8, p. 1375-1384 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Type I DNA Topoisomerase 100%
  • Epitopes 65%
  • Peptides 48%
  • Interstitial Lung Diseases 36%
  • Antibodies 30%
  1 Scopus citations

• HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

  Gourh, P., Safran, S. A., Alexander, T., Boyden, S. E., Morgan, N. D., Shah, A. A., Mayes, M. D., Doumatey, A., Bentley, A. R., Shriner, D., Domsic, R. T., Medsger, T. A., Ramos, P. S., Silver, R. M., Steen, V. D., Varga, J., Hsu, V., Saketkoo, L. A., Schiopu, E., Khanna, D., & 24 othersGordon, J. K., Kron, B., Criswell, L. A., Gladue, H., Derk, C. T., Bernstein, E. J., Bridges, S. L., Shanmugam, V. K., Kolstad, K. D., Chung, L., Kafaja, S., Jan, R., Trojanowski, M., Goldberg, A., Korman, B. D., Steinbach, P. J., Chandrasekharappa, S. C., Mullikin, J. C., Adeyemo, A., Rotimi, C., Wigley, F. M., Kastner, D. L., Boin, F. & Remmers, E. F., Jan 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 1, p. 552-562 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Molecular Mimicry 100%
  • Systemic Scleroderma 81%
  • African Americans 67%
  • Autoantibodies 65%
  • Alleles 28%
  9 Scopus citations

• Longitudinal assessment of interstitial lung disease in single lung transplant recipients with scleroderma

  Hinze, A. M., Lin, C. T., Hussien, A. F., Perin, J., Venado, A., Golden, J. A., Boin, F., Brown, R. H., Wise, R. A. & Wigley, F. M., Apr 1 2020, In: Rheumatology (United Kingdom). 59, 4, p. 790-798 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interstitial Lung Diseases 100%
  • Transplant Recipients 84%
  • Lung 48%
  • Allografts 36%
  • Fibrosis 15%
  1 Scopus citations

• The scleroderma patient-centered intervention network self-management program: Protocol for a randomized feasibility trial

  SPIN Investigators, Apr 2020, In: JMIR Research Protocols. 9, 4, e16799.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Self-Management 100%
  • Systemic Scleroderma 31%
  • Self Efficacy 27%
  • Disease Management 21%
  • Randomized Controlled Trials 11%

• The Utility of Plasma Vascular Biomarkers in Systemic Sclerosis: A Prospective Longitudinal Analysis

  Mecoli, C. A., Shah, A. A., Boin, F., Wigley, F. M. & Hummers, L. K., Aug 1 2020, In: Arthritis and Rheumatology. 72, 8, p. 1341-1349 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Pulmonary Hypertension 87%
  • Biomarkers 57%
  • Blood Vessels 51%
  • Confidence Intervals 29%
  1 Scopus citations

• Vascular biomarkers and digital ulcerations in systemic sclerosis: results from a randomized controlled trial of oral treprostinil (DISTOL-1)

  Mecoli, C. A., Perin, J., Van Eyk, J. E., Zhu, J., Fu, Q., Allmon, A. G., Rao, Y., Zeger, S., Wigley, F. M., Hummers, L. K. & Shah, A. A., Apr 1 2020, In: Clinical rheumatology. 39, 4, p. 1199-1205 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • treprostinil 100%
  • Systemic Scleroderma 68%
  • Randomized Controlled Trials 40%
  • Ulcer 39%
  • Biomarkers 39%
  1 Scopus citations
• 2019

  Epigenetic activation and memory at a TGFB2 enhancer in systemic sclerosis

  Shin, J. Y., Beckett, J. D., Bagirzadeh, R., Creamer, T. J., Shah, A. A., McMahan, Z., Paik, J. J., Sampedro, M. M., MacFarlane, E. G., Beer, M. A., Warren, D., Wigley, F. M. & Dietz, H. C., 2019, In: Science translational medicine. 11, 497, eaaw0790.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Epigenomics 76%
  • Memory 64%
  • Fibrosis 39%
  • Skin 28%
  14 Scopus citations

• Morphea and systemic sclerosis are associated with an increased risk for melanoma and nonmelanoma skin cancer

  Boozalis, E., Shah, A. A., Wigley, F., Kang, S. & Kwatra, S. G., May 2019, In: Journal of the American Academy of Dermatology. 80, 5, p. 1449-1451 3 p.

  Research output: Contribution to journal › Article › peer-review
  10 Scopus citations
• 2018

  ANCA-associated vasculitis in scleroderma: A renal perspective

  Kant, S., Shah, A. A., Hummers, L. K., Wigley, F. M. & Geetha, D., Dec 1 2018, In: Clinical nephrology. 90, 6, p. 413-418 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 100%
  • Kidney 37%
  • Glomerulonephritis 22%
  • Antineutrophil Cytoplasmic Antibodies 20%
  • Immunosuppression 9%
  3 Scopus citations

• Autoantibodies and scleroderma phenotype define subgroups at high-risk and low-risk for cancer

  Igusa, T., Hummers, L. K., Visvanathan, K., Richardson, C., Wigley, F. M., Casciola-Rosen, L., Rosen, A. & Shah, A. A., Aug 1 2018, In: Annals of the rheumatic diseases. 77, 8, p. 1180-1187 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Autoantibodies 100%
  • Phenotype 65%
  • Neoplasms 34%
  • Incidence 23%
  • Early Detection of Cancer 22%
  36 Scopus citations

• Brief Report: Whole-Exome Sequencing to Identify Rare Variants and Gene Networks That Increase Susceptibility to Scleroderma in African Americans

  Gourh, P., Remmers, E. F., Boyden, S. E., Alexander, T., Morgan, N. D., Shah, A. A., Mayes, M. D., Doumatey, A., Bentley, A. R., Shriner, D., Domsic, R. T., Medsger, T. A., Steen, V. D., Ramos, P. S., Silver, R. M., Korman, B., Varga, J., Schiopu, E., Khanna, D., Hsu, V., & 22 othersGordon, J. K., Saketkoo, L. A., Gladue, H., Kron, B., Criswell, L. A., Derk, C. T., Bridges, S. L., Shanmugam, V. K., Kolstad, K. D., Chung, L., Jan, R., Bernstein, E. J., Goldberg, A., Trojanowski, M., Kafaja, S., Maksimowicz-McKinnon, K. M., Mullikin, J. C., Adeyemo, A., Rotimi, C., Boin, F., Kastner, D. L. & Wigley, F. M., Oct 2018, In: Arthritis and Rheumatology. 70, 10, p. 1654-1660 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Whole Exome Sequencing 100%
  • Gene Regulatory Networks 91%
  • African Americans 79%
  • Systemic Scleroderma 74%
  • Genes 26%
  4 Scopus citations

• Determining the Risk Factors and Clinical Features Associated With Severe Gastrointestinal Dysmotility in Systemic Sclerosis

  McMahan, Z. H., Paik, J. J., Wigley, F. M. & Hummers, L. K., Sep 2018, In: Arthritis Care and Research. 70, 9, p. 1385-1392 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Confidence Intervals 37%
  • Muscular Diseases 26%
  • Enteral Nutrition 26%
  • Odds Ratio 24%
  11 Scopus citations

• Efficacy of Mycophenolate Mofetil and Oral Cyclophosphamide on Skin Thickness: Post Hoc Analyses From Two Randomized Placebo-Controlled Trials

  Participants in the Scleroderma Lung Study I and members of the Scleroderma Lung Study II Research Group, Mar 2018, In: Arthritis Care and Research. 70, 3, p. 439-444 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mycophenolic Acid 100%
  • Cyclophosphamide 79%
  • Placebos 58%
  • Randomized Controlled Trials 57%
  • Diffuse Scleroderma 52%
  28 Scopus citations

• Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients With Breast Cancer

  Shah, D. J., Hirpara, R., Poelman, C. L., Woods, A., Hummers, L. K., Wigley, F. M., Wright, J. L., Parekh, A., Steen, V. D., Domsic, R. T. & Shah, A. A., Oct 2018, In: Arthritis Care and Research. 70, 10, p. 1517-1524 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Radiotherapy 100%
  • Breast Neoplasms 92%
  • Systemic Scleroderma 59%
  • Neoplasms 46%
  • Erythema 41%
  3 Scopus citations

• Pyridostigmine for the treatment of gastrointestinal symptoms in systemic sclerosis

  Ahuja, N. K., Mische, L., Clarke, J. OB., Wigley, F. M. & McMahan, Z. H., Aug 2018, In: Seminars in Arthritis and Rheumatism. 48, 1, p. 111-116 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Pyridostigmine Bromide 100%
  • Systemic Scleroderma 77%
  • Constipation 16%
  • Therapeutics 11%
  • Medication Adherence 5%
  9 Scopus citations

• Randomized feasibility trial of the Scleroderma patient-centered intervention network hand exercise program (SPIN-HAND): Study protocol

  SPIN Investigators, Feb 1 2018, In: Journal of Scleroderma and Related Disorders. 3, 1, p. 91-97 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hand 100%
  • Exercise 85%
  • Randomized Controlled Trials 15%
  • Pragmatic Clinical Trials 10%
  • Systemic Scleroderma 8%
  4 Scopus citations

• Rare loss of function variants in candidate genes and risk of colorectal cancer

  NHLBI GO Exome Sequencing Project, Pulmonary Arterial Hypertension (PAH), Severe Asthma Research Program (SARP), Women’s Health Initiative (WHI), Anthropometry Project Team, Blood Count/Hematology Project Team, Blood Pressure Project Team, Data Flow Working Group, Early MI Project Team, ELSI Working Group, Executive Committee, Family Study Project Team, Lipids Project Team, Lung Project Team, Personal Genomics Project Team, Phenotype and Harmonization Working Group, Population Genetics and Statistical Analysis Working Group, Publications and Presentations Working Group, Quantitative Analysis Ad Hoc Task Group, Sequencing and Genotyping Working Group, & 15 othersSteering Committee, Stroke Project Team, Structural Variation Working Group, Subclinical/Quantitative Project Team, Acute Lung Injury (ALI), Atherosclerosis Risk in Communities (ARIC), Cardiovascular Health Study (CHS), Chronic Obstructive Pulmonary Disease (COPDGene), Coronary Artery Risk Development in Young Adults (CARDIA), Cystic Fibrosis (CF), Early Pseudomonas Infection Control (EPIC), Framingham Heart Study (FHS), Jackson Heart Study (JHS), Lung Health Study (LHS) & Multi-Ethnic Study of Atherosclerosis (MESA), Oct 1 2018, In: Human genetics. 137, 10, p. 795-806 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Polyps 100%
  • Colorectal Neoplasms 78%
  • Genes 39%
  • Datasets 14%
  • Penetrance 10%
  6 Scopus citations

• Reliability and Validity of Three Versions of the Brief Fear of Negative Evaluation Scale in Patients With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study

  SPIN Investigators, Nov 2018, In: Arthritis Care and Research. 70, 11, p. 1646-1652 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Reproducibility of Results 78%
  • Fear 76%
  • Cohort Studies 59%
  • Statistical Factor Analysis 7%
  5 Scopus citations

• Right ventricular myofilament functional differences in humans with systemic sclerosis-associated versus idiopathic pulmonary arterial hypertension

  Hsu, S., Kokkonen-Simon, K. M., Kirk, J. A., Kolb, T. M., Damico, R. L., Mathai, S. C., Mukherjee, M., Shah, A. A., Wigley, F. M., Margulies, K. B., Hassoun, P. M., Halushka, M. K., Tedford, R. J. & Kass, D. A., 2018, In: Circulation. 137, 22, p. 2360-2370 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Familial Primary Pulmonary Hypertension 100%
  • Myofibrils 91%
  • Systemic Scleroderma 87%
  • Pulmonary Arterial Hypertension 65%
  • Muscle Cells 18%
  41 Scopus citations

• The scleroderma patient-centered intervention network cohort: Baseline clinical features and comparison with other large scleroderma cohorts

  SPIN Investigators, Sep 1 2018, In: Rheumatology (United Kingdom). 57, 9, p. 1623-1631 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient Reported Outcome Measures 100%
  • European Continental Ancestry Group 84%
  • Antibodies 75%
  • RNA Polymerase III 62%
  • Demography 58%
  15 Scopus citations

• Validation of the Social Appearance Anxiety Scale in Patients With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study

  and the Scleroderma Patient-Centered Intervention Network Investigators, Oct 2018, In: Arthritis Care and Research. 70, 10, p. 1557-1562 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Anxiety 62%
  • Cohort Studies 59%
  • Statistical Factor Analysis 31%
  • Body Dissatisfaction 23%
  9 Scopus citations

• Validation of the social interaction anxiety scale in scleroderma: A scleroderma patientcentered intervention network cohort study

  Gholizadeh, S., Kwakkenbos, L., Carrier, M. E., Mills, S. D., Fox, R. S., Jewett, L. R., Gottesman, K., Roesch, S., Thombs, B. D., Malcarne, V. L., Baron, M., Bartlett, S. J., Furst, D., Van Den Hoogen, F., Mayes, M. D., Mouthon, L., Nielson, W. R., Poiraudeau, S., Riggs, R., Sauve, M., & 69 othersWigley, F., Assassi, S., Boutron, I., Maia, A. C., El-Baalbaki, G., Ells, C., Van Den Ende, C., Fligelstone, K., Fortune, C., Frech, T., Godard, D., Harel, D., Hudson, M., Impens, A., Jang, Y., Johnson, S. R., Kennedy, A. T., Larche, M., Leite, C., Marra, C., Nielsen, K., Pope, J., Portales, A., Reyna, T. S. R., Schouffoer, A. A., Steele, R. J., Suarez-Almazor, M. E., Welling, J., Wong-Rieger, D., Albert, A., Arsenault, G., Bissonnette, L., Boire, G., Bruns, A., Carreira, P., Chung, L., Dagenais, P., Denton, C., Domsic, R., Dunne, J. V., Fortin, P., Gill, A., Gordon, J., Gyger, G., Herrick, A. L., Hinchcliff, M., Ikic, A., Jones, N., Fernandes, A. J. D. B., Kafaja, S., Khalidi, N., Korman, B., Liang, P., Manning, J., Masetto, A., Robinson, D., Roux, S., Smith, D., Spiera, R., Steen, V., Sutton, E., Thorne, C., Varga, J., Wilcox, P., Delisle, V. C., Fedoruk, C., Levis, B., Pepin, M. R. & Persmann, J., Feb 1 2018, In: Journal of Scleroderma and Related Disorders. 3, 1, p. 98-105 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interpersonal Relations 100%
  • Anxiety 68%
  • Cohort Studies 64%
  • Systemic Scleroderma 15%
  • Psychometrics 12%
  3 Scopus citations

• Vascular complications in systemic sclerosis: a prospective cohort study

  Mecoli, C. A., Shah, A. A., Boin, F., Wigley, F. M. & Hummers, L. K., Sep 1 2018, In: Clinical rheumatology. 37, 9, p. 2429-2437 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Pulmonary Hypertension 71%
  • Cohort Studies 59%
  • Prospective Studies 55%
  • Blood Vessels 51%
  12 Scopus citations
• 2017

  Association of Fibrosing Myopathy in Systemic Sclerosis and Higher Mortality

  Paik, J. J., Wigley, F. M., Shah, A. A., Corse, A. M., Casciola-Rosen, L., Hummers, L. K. & Mammen, A. L., Nov 2017, In: Arthritis Care and Research. 69, 11, p. 1764-1770 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • Muscular Diseases 94%
  • Myositis 53%
  • Muscles 52%
  • Mortality 44%
  11 Scopus citations

• Brief Report: Anti–RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma

  Shah, A. A., Xu, G., Rosen, A., Hummers, L. K., Wigley, F. M., Elledge, S. J. & Casciola-Rosen, L., Jun 2017, In: Arthritis and Rheumatology. 69, 6, p. 1306-1312 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Antibodies 100%
  • Autoantibodies 83%
  • Neoplasms 58%
  • Cytidine Triphosphate 47%
  • Spliceosomes 15%
  28 Scopus citations

• Clinical and serological features of systemic sclerosis in a multicenter African American cohort: Analysis of the genome research in African American scleroderma patients clinical database

  Morgan, N. D., Shah, A. A., Mayes, M. D., Domsic, R. T., Medsger, T. A., Steen, V. D., Varga, J., Carns, M., Ramos, P. S., Silver, R. M., Schiopu, E., Khanna, DI., Hsu, V., Gordon, J. K., Gladue, H., Saketkoo, L. A., Criswell, L. A., Derk, C. T., Trojanowski, M. A., Shanmugam, V. K., & 9 othersChung, L., Valenzuela, A., Jan, R., Goldberg, A., Remmers, E. F., Kastner, D. L., Wigley, F. M., Gourh, P. & Boin, F., Dec 1 2017, In: Medicine (United States). 96, 51, e8980.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Systemic Scleroderma 100%
  • African Americans 82%
  • Cohort Studies 59%
  • Genome 59%
  • Databases 52%
  33 Scopus citations

• Digital ulcers in SSc treated with oral treprostinil: A randomized, double-blind, placebo-controlled study with open-label follow-up

  Seibold, J. R., Wigley, F. M., Schiopu, E., Denton, C. P., Silver, R. M., Steen, V. D., Domsic, R., Medsger, T. A., Mayes, M. D., Chatterjee, S., Chung, L., Csuka, M. E., Khanna, D., Collier, D., Frech, T. M., Molitor, J. A., Rothfield, N., Herrick, A. L., Simms, R., Pop, J. E., & 10 othersBaron, M., Hsu, V. M., Peng, S. L., Spiera, R., Fessler, B. J., Kahaleh, B., Varga, J., Laliberte, K., Wade, M. & Rollins, K., 2017, In: Journal of Scleroderma and Related Disorders. 2, 1, p. 42-49 8 p.

  Research output: Contribution to journal › Article › peer-review

  • treprostinil 100%
  • Ulcer 54%
  • Placebos 41%
  • Raynaud Disease 15%
  • Prostaglandins I 10%
  16 Scopus citations

• Evaluation of cancer-associated myositis and scleroderma autoantibodies in breast cancer patients without rheumatic disease

  Shah, A. A., Rosen, A., Hummers, L. K., May, B. J., Kaushiva, A., Roden, R. B. S., Armstrong, D. K., Wigley, F. M., Casciola-Rosen, L. & Visvanathan, K., 2017, In: Clinical and experimental rheumatology. 35, p. S71-S74

  Research output: Contribution to journal › Article › peer-review

  • Myositis 100%
  • Rheumatic Diseases 87%
  • Autoantibodies 75%
  • Dermatomyositis 63%
  • Breast Neoplasms 52%
  11 Scopus citations

• Performance of the Patient-Reported Outcomes Measurement Information System-29 in scleroderma: A Scleroderma Patient-centered Intervention Network Cohort Study

  on behalf of the SPIN Investigators, Aug 1 2017, In: Rheumatology (United Kingdom). 56, 8, p. 1302-1311 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient Reported Outcome Measures 100%
  • Information Systems 99%
  • Cohort Studies 61%
  • Contracture 32%
  • Skin 24%
  23 Scopus citations

• Risk of Digital Vascular Events in Scleroderma Patients Who Have Both Anticentromere and Anti–Interferon-Inducible Protein 16 Antibodies

  McMahan, Z. H., Wigley, F. M. & Casciola-Rosen, L., Jun 2017, In: Arthritis Care and Research. 69, 6, p. 922-926 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Blood Vessels 100%
  • Antibodies 94%
  • Anti-Idiotypic Antibodies 79%
  • Proteins 62%
  • Gangrene 47%
  7 Scopus citations

• The Therapeutic Efficacy of Botulinum Toxin in Treating Scleroderma-Associated Raynaud's Phenomenon: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  Bello, R. J., Cooney, C. M., Melamed, E., Follmar, K., Yenokyan, G., Leatherman, G., Shah, A. A., Wigley, F. M., Hummers, L. K. & Lifchez, S. D., Aug 2017, In: Arthritis and Rheumatology. 69, 8, p. 1661-1669 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Raynaud Disease 100%
  • Botulinum Toxins 93%
  • Controlled Clinical Trials 85%
  • Hand 59%
  • Placebos 54%
  43 Scopus citations

• Update of EULAR recommendations for the treatment of systemic sclerosis

  EUSTAR Coauthors, Aug 1 2017, In: Annals of the rheumatic diseases. 76, 8, p. 1327-1339 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phosphodiesterase V Inhibitor 100%
  • Systemic Scleroderma 73%
  • Riociguat 69%
  • Rheumatic Diseases 68%
  • Endothelin Receptor Antagonist 54%
  384 Scopus citations

• What have multicentre registries across the world taught us about the disease features of systemic sclerosis?

  EULAR Scleroderma Trials and Research group (EUSTAR), Singapore Scleroderma Workgroup (SCORE) & Australian Scleroderma Interest Group (ASIG), Jan 1 2017, In: Journal of Scleroderma and Related Disorders. 2, 3, p. 169-182 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Systemic Scleroderma 100%
  • Registries 69%
  • Singapore 33%
  • Pulmonary Arterial Hypertension 22%
  • Survival 21%
  10 Scopus citations