Florin Selaru

2024

Use of Biologics for the Treatment of Inflammatory Conditions of the Pouch: A Systematic Review

Godoy-Brewer, G., Salem, G., Limketkai, B., Selaru, F. M., Grossen, A., Policarpo, T., Haq, Z. & Parian, A. M., Feb 8 2024, In: Journal of clinical gastroenterology. 58, 2, p. 183-194 12 p.

Research output: Contribution to journal › Article › peer-review

2023

A combination therapy of bortezomib, CXCR4 inhibitor, and checkpoint inhibitor is effective in cholangiocarcinoma in vivo

Li, L., Zhou, Y., Zhang, Y., Hu, H., Mao, H. Q. & Selaru, F. M., Mar 17 2023, In: iScience. 26, 3, 106095.

Research output: Contribution to journal › Article › peer-review

Open Access

Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling

Yu, H., Zhang, Z., Li, G., Feng, Y., Xian, L., Bakhsh, F., Xu, D., Xu, C., Vong, T., Wu, B., Selaru, F. M., Wan, F., Donowitz, M. & Wong, G. W., Jan 2023, In: CMGH. 15, 4, p. 1000-1015 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A nanofiber-hydrogel composite improves tissue repair in a rat model of Crohn’s disease perianal fistulas

Li, L., Yao, Z. C., Parian, A., Yang, Y. H., Chao, J., Yin, J., Salimian, K. J., Reddy, S. K., Zaheer, A., Gearhart, S. L., Mao, H. Q. & Selaru, F. M., Jan 2023, In: Science Advances. 9, 1, eade1067.

Research output: Contribution to journal › Article › peer-review

Open Access

A Novel Patient-like Swine Model of Perianal Crohn's Disease

Parian, A. M., Li, L., Duraes, L. C., Cheng, J., Hu, H., Yao, Z., Donet, J., Salem, G., Iuga, A., Salimian, K., Izzi, J., Zaheer, A., Mao, H. Q., Gearhart, S. & Selaru, F. M., Mar 1 2023, In: Diseases of the colon and rectum. 66, 3, p. 425-433 9 p.

Research output: Contribution to journal › Article › peer-review

Antibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease

Tsipotis, E., Maremanda, A., Zeiser, L. B., Connolly, C., Sharma, S., Dudley-Brown, S., Frey, S., Lazarev, M., Melia, J. M., Parian, A. M., Segev, D. L., Truta, B., Yu, H., Werbel, W. A. & Selaru, F. M., Aug 2023, In: Medicina (Lithuania). 59, 8, 1487.

Research output: Contribution to journal › Article › peer-review

Open Access

Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance

CCA Model Consortium, Jul 2023, In: Nature Reviews Gastroenterology and Hepatology. 20, 7, p. 462-480 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Initial Clinical Outcomes Using Umbilical Cord-Derived Tissue Grafts to Repair Anovaginal Fistula

Godoy-Brewer, G. M., Owodunni, O. P., Parian, A. M., De Castro Duraes, L., Selaru, F. M. & Gearhart, S. L., Feb 1 2023, In: Diseases of the colon and rectum. 66, 2, p. 299-305 7 p.

Research output: Contribution to journal › Article › peer-review

Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo

Li, L., Shapiro, R. L., Joo, M. K., Josyula, A., Hsueh, H. T., Gutierrez, O. B., Halpert, G., Akshintala, V., Chen, H., Curtis, S., Better, M., Davison, C., Hu, H., Almario, J. A. N., Steinway, S. N., Hunt, K., Del Sesto, R. E., Izzi, J., Salimian, K. J., Ensign, L. M., & 1 othersSelaru, F. M., May 2023, In: Gastroenterology. 164, 6, p. 937-952.e13

Research output: Contribution to journal › Article › peer-review

Open Access

Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection

Vaughan, H. J., Zamboni, C. G., Luly, K. M., Li, L., Gabrielson, K. L., Hassan, L. F., Radant, N. P., Bhardwaj, P., Selaru, F. M., Pomper, M. G. & Green, J. J., 2023, In: International journal of nanomedicine. 18, p. 2525-2537 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

PSMA-Targeted PET Radiotracer [¹⁸F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease

Ismail, M. S., Peters, D. E., Rowe, S., Salavati, A., Sharma, S., Anders, R. A., Pomper, M., Slusher, B. S. & Selaru, F. M., 2023, In: Clinical and Experimental Gastroenterology. 16, p. 237-247 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Superior Efficacy of Infliximab Versus Adalimumab for First-Line Treatment of Crohn’s Perianal Fistulae

Maas, L., Gao, R., Cusumano, V., Spartz, E., Chowdhury, R., Krishna, M., Lazarev, M., Melia, J., Selaru, F., Sharma, S., Limketkai, B. & Parian, A., Oct 2023, In: Digestive diseases and sciences. 68, 10, p. 3994-4000 7 p.

Research output: Contribution to journal › Article › peer-review

2022

Antibody Response 3 Months after 2-Dose SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease

Tsipotis, E., Frey, S., Connolly, C., Werbel, W. A., Chowdhury, R., Dudley-Brown, S., Melia, J. M., Parian, A. M., Truta, B., Yu, H., Selaru, F. M., Segev, D. L. & Lazarev, M., May 1 2022, In: American Journal of Gastroenterology. 117, 5, p. 798-801 4 p.

Research output: Contribution to journal › Article › peer-review

Autonomous Untethered Microinjectors for Gastrointestinal Delivery of Insulin

Ghosh, A., Liu, W., Li, L., Pahapale, G. J., Choi, S. Y., Xu, L., Huang, Q., Zhang, R., Zhong, Z., Selaru, F. M. & Gracias, D. H., Oct 25 2022, In: ACS Nano. 16, 10, p. 16211-16220 10 p.

Research output: Contribution to journal › Article › peer-review

Biostimulatory Micro-Fragmented Nanofiber-Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling

Yao, Z. C., Yang, Y. H., Kong, J., Zhu, Y., Li, L., Chang, C., Zhang, C., Yin, J., Chao, J., Selaru, F. M., Reddy, S. K. & Mao, H. Q., Sep 8 2022, In: Small. 18, 36, 2202309.

Research output: Contribution to journal › Article › peer-review

Open Access

Prognostic Value of Lymph Node Ratio in Patients with Resected Synchronous Colorectal Liver Metastases and Less Than 12 Examined Lymph Nodes

Alexandrescu, S. T., Selaru, F. M., Diaconescu, A. S., Zlate, C. A., Blanita, D., Grigorie, R. T., Zarnescu, N. O., Herlea, V. & Popescu, I., Jan 2022, In: Journal of Gastrointestinal Surgery. 26, 1, p. 141-149 9 p.

Research output: Contribution to journal › Article › peer-review

Quaternary nanoparticles enable sustained release of bortezomib for hepatocellular carcinoma

Li, L., Zhang, Y., Zhou, Y., Hu, H., Hu, Y., Georgiades, C., Mao, H. Q. & Selaru, F. M., Dec 2022, In: Hepatology. 76, 6, p. 1660-1672 13 p.

Research output: Contribution to journal › Article › peer-review

2021

A patient-like swine model of gastrointestinal fibrotic strictures for advancing therapeutics

Li, L., Itani, M. I., Salimian, K. J., Li, Y., Gutierrez, O. B., Hu, H., Fayad, G., Donet, J. A., Joo, M. K., Ensign, L. M., Kumbhari, V. & Selaru, F. M., Jun 25 2021, In: Scientific reports. 11, 1, p. 13344 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Electroacupuncture at st36 relieves visceral hypersensitivity via the ngf/trka/trpv1 peripheral afferent pathway in a rodent model of post-inflammation rectal hypersensitivity

Chen, Y., Cheng, J., Zhang, Y., Chen, J. D. Z. & Seralu, F. M., 2021, In: Journal of Inflammation Research. 14, p. 325-339 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Endoscopic-mediated, biliary hydrodynamic injection mediating clinically relevant levels of gene delivery in pig liver

Kruse, R. L., Huang, Y., Shum, T., Bai, L., Ding, H., Wang, Z. Z., Selaru, F. M. & Kumbhari, V., Dec 2021, In: Gastrointestinal endoscopy. 94, 6, p. 1119-1130.e4

Research output: Contribution to journal › Article › peer-review

Open Access

Parameters of biliary hydrodynamic injection during endoscopic retrograde cholangio-pancreatography in pigs for applications in gene delivery

Huang, Y., Kruse, R. L., Ding, H., Itani, M. I., Morrison, J., Wang, Z. Z., Selaru, F. M. & Kumbhari, V., Apr 2021, In: PloS one. 16, 4 April 2021, e0249931.

Research output: Contribution to journal › Article › peer-review

Open Access

Protein synthesis inhibitor omacetaxine is effective against hepatocellular carcinoma

Li, L., Halpert, G., Lerner, M. G., Hu, H., Dimitrion, P., Weiss, M. J., He, J., Philosophe, B., Burkhart, R., Burns, W. R., Wesson, R. N., Cameron, A. M. G., Wolfgang, C. L., Georgiades, C., Kawamoto, S., Azad, N. S., Yarchoan, M., Meltzer, S. J., Oshima, K., Ensign, L. M., & 2 othersBader, J. S. & Selaru, F. M., Jun 22 2021, In: JCI Insight. 6, 12, e138197.

Research output: Contribution to journal › Article › peer-review

Open Access

Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis

Chen, Y., Guo, Y., Gharibani, P., Chen, J., Selaru, F. M. & Chen, J. D. Z., Dec 2021, In: Scientific reports. 11, 1, 8284.

Research output: Contribution to journal › Article › peer-review

Open Access

Ustekinumab is effective for perianal fistulising Crohn's disease: A real-world experience and systematic review with meta-analysis

Brewer, G. M. G., Salem, G., Afzal, M. A., Limketkai, B. N., Haq, Z., Tajamal, M., Melia, J., Lazarev, M., Selaru, F. M. & Parian, A. M., Dec 1 2021, In: BMJ Open Gastroenterology. 8, 1, e000702.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Gastrointestinal-resident, shape-changing microdevices extend drug release in vivo

Ghosh, A., Li, L., Xu, L., Dash, R. P., Gupta, N., Lam, J., Jin, Q., Akshintala, V., Pahapale, G., Liu, W., Sarkar, A., Rais, R., Gracias, D. H. & Selaru, F. M., Oct 28 2020, In: Science Advances. 6, 44, abb4133.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Potential of electrical neuromodulation for inflammatory bowel disease

Cheng, J., Shen, H., Chowdhury, R., Abdi, T., Selaru, F. & Chen, J. D. Z., Aug 1 2020, In: Inflammatory bowel diseases. 26, 8, p. 1119-1130 12 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

2019

Human primary liver cancer organoids reveal intratumor and interpatient drug response heterogeneity

Li, L., Knutsdottir, H., Hui, K., Weiss, M. J., He, J., Philosophe, B., Cameron, A. M., Wolfgang, C. L., Pawlik, T. M., Ghiaur, G., Ewald, A. J., Mezey, E., Bader, J. S. & Selaru, F. M., Jan 24 2019, In: JCI Insight. 4, 2, Y.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

2018

Exosome miR-335 as a novel therapeutic strategy in hepatocellular carcinoma

Wang, F., Li, L., Piontek, K., Sakaguchi, M. & Selaru, F. M., Mar 2018, In: Hepatology. 67, 3, p. 940-954 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer

Hirosawa, T., Ishida, M., Ishii, K., Kanehara, K., Kudo, K., Ohnuma, S., Kamei, T., Motoi, F., Naitoh, T., Selaru, F. M. & Unno, M., Nov 2018, In: PloS one. 13, 11, e0206643.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Successful liver-directed gene delivery by ERCP-guided hydrodynamic injection (with videos)

Kumbhari, V., Li, L., Piontek, K., Ishida, M., Fu, R., Khalil, B., Garrett, C. M., Liapi, E., Kalloo, A. N. & Selaru, F. M., Oct 2018, In: Gastrointestinal endoscopy. 88, 4, p. 755-763.e5

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2017

Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model

Li, L., Piontek, K., Ishida, M., Fausther, M., Dranoff, J. A., Fu, R., Mezey, E., Gould, S. J., Fordjour, F. K., Meltzer, S. J., Sirica, A. E. & Selaru, F. M., Feb 1 2017, In: Hepatology. 65, 2, p. 501-514 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

2016

Isolation and profiling of microRNA-containing exosomes from human bile

Li, L., Piontek, K. B., Kumbhari, V., Ishida, M. & Selaru, F. M., Jun 13 2016, In: Journal of Visualized Experiments. 2016, 112, e54036.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers

Robles, A. I., Traverso, G., Zhang, M., Roberts, N. J., Khan, M. A., Joseph, C., Lauwers, G. Y., Selaru, F. M., Popoli, M., Pittman, M. E., Ke, X., Hruban, R. H., Meltzer, S. J., Kinzler, K. W., Vogelstein, B., Harris, C. C. & Papadopoulos, N., Apr 1 2016, In: Gastroenterology. 150, 4, p. 931-943 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

125 Scopus citations

2015

MicroRNA-224 induces G1/S checkpoint release in liver cancer

An, F., Olaru, A. V., Mezey, E., Xie, Q., Li, L., Piontek, K. B. & Selaru, F. M., Aug 26 2015, In: Journal of Clinical Medicine. 4, 9, p. 1713-1728 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

MicroRNAs in the biology and diagnosis of cholangiocarcinoma

Piontek, K. & Selaru, F. M., Feb 1 2015, In: Seminars in Liver Disease. 35, 1, p. 55-62 8 p.

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

Peng, H., Ishida, M., Li, L., Saito, A., Kamiya, A., Hamilton, J. P., Fu, R., Olaru, A. V., An, F., Popescu, I., Iacob, R., Dima, S., Alexandrescu, S. T., Grigorie, R., Nastase, A., Berindan-Neagoe, I., Tomuleasa, C., Graur, F., Zaharia, F., Torbenson, M. S., & 3 othersMezey, E., Lu, M. & Selaru, F. M., 2015, In: Oncotarget. 6, 8, p. 5666-5677 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

The genome-wide gene expression profiling to predict competitive endogenous RNA network in hepatocellular cancer

Peng, H., Lu, M. & Selaru, F. M., Jun 1 2015, In: Genomics Data. 4, p. 93-95 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2014

Human bile contains MicroRNA-laden extracellular vesicles that can be used for cholangiocarcinoma diagnosis

Li, L., Masica, D., Ishida, M., Tomuleasa, C., Umegaki, S., Kalloo, A. N., Georgiades, C., Singh, V. K., Khashab, M., Amateau, S., Li, Z., Okolo, P., Lennon, A. M., Saxena, P., Geschwind, J. F., Schlachter, T., Hong, K., Pawlik, T. M., Canto, M., Law, J., & 13 othersSharaiha, R., Weiss, C. R., Thuluvath, P., Goggins, M., Shin, E. J., Peng, H., Kumbhari, V., Hutfless, S., Zhou, L., Mezey, E., Meltzer, S. J., Karchin, R. & Selaru, F. M., Sep 2014, In: Hepatology. 60, 3, p. 896-907 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

126 Scopus citations

Stimuli-responsive theragrippers for chemomechanical controlled release

Malachowski, K., Breger, J., Kwag, H. R., Wang, M. O., Fisher, J. P., Selaru, F. M. & Gracias, D. H., Jul 28 2014, In: Angewandte Chemie - International Edition. 53, 31, p. 8045-8049 5 p.

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Trends in pre-liver transplant screening for cholangiocarcinoma among patients with primary sclerosing cholangitis

Trilianos, P., Selaru, F., Li, Z. & Gurakar, A., Mar 2014, In: Digestion. 89, 2, p. 165-173 9 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2013

Biologic tissue sampling with untethered microgrippers

Gultepe, E., Yamanaka, S., Laflin, K. E., Kadam, S., Shim, Y., Olaru, A. V., Limketkai, B., Khashab, M. A., Kalloo, A. N., Gracias, D. H. & Selaru, F. M., Apr 2013, In: Gastroenterology. 144, 4, p. 691-693 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Biopsy with thermally-responsive untethered microtools

Gultepe, E., Randhawa, J. S., Kadam, S., Yamanaka, S., Selaru, F. M., Shin, E. J., Kalloo, A. N. & Gracias, D. H., Jan 25 2013, In: Advanced Materials. 25, 4, p. 514-519 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

135 Scopus citations

Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

Jiao, Y., Pawlik, T. M., Anders, R. A., Selaru, F. M., Streppel, M. M., Lucas, D. J., Niknafs, N., Guthrie, V. B., Maitra, A., Argani, P., Offerhaus, G. J. A., Roa, J. C., Roberts, L. R., Gores, G. J., Popescu, I., Alexandrescu, S. T., Dima, S., Fassan, M., Simbolo, M., Mafficini, A., & 16 othersCapelli, P., Lawlor, R. T., Ruzzenente, A., Guglielmi, A., Tortora, G., De Braud, F., Scarpa, A., Jarnagin, W., Klimstra, D., Karchin, R., Velculescu, V. E., Hruban, R. H., Vogelstein, B., Kinzler, K. W., Papadopoulos, N. & Wood, L. D., Dec 2013, In: Nature genetics. 45, 12, p. 1470-1473 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

397 Scopus citations

MicroRNA-224 negatively regulates p21 expression during late neoplastic progression in inflammatory bowel disease

Olaru, A. V., Yamanaka, S., Vazquez, C., Mori, Y., Cheng, Y., Abraham, J. M., Bayless, T. M., Harpaz, N., Selaru, F. M. & Meltzer, S. J., Mar 2013, In: Inflammatory bowel diseases. 19, 3, p. 471-480 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2012

Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma

Yamanaka, S., Campbell, N. R., An, F., Kuo, S. C., Potter, J. J., Mezey, E., Maitra, A. & Selaru, F. M., Jul 15 2012, In: Cell Cycle. 11, 14, p. 2729-2738 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

74 Scopus citations

MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer

Yamanaka, S., Olaru, A. V., An, F., Luvsanjav, D., Jin, Z., Agarwal, R., Tomuleasa, C., Popescu, I., Alexandrescu, S., Dima, S., Chivu-Economescu, M., Montgomery, E. A., Torbenson, M., Meltzer, S. J. & Selaru, F. M., Jul 2012, In: Digestive and Liver Disease. 44, 7, p. 589-596 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Silencing of miR-370 in Human Cholangiocarcinoma by Allelic Loss and Interleukin-6 Induced Maternal to Paternal Epigenotype Switch

An, F., Yamanaka, S., Allen, S., Roberts, L. R., Gores, G. J., Pawlik, T. M., Xie, Q., Ishida, M., Mezey, E., Ferguson-Smith, A. C., Mori, Y. & Selaru, F. M., Oct 22 2012, In: PloS one. 7, 10, e45606.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2011

Dynamic changes in the expression of MicroRNA-31 during inflammatory bowel disease-associated neoplastic transformation

Olaru, A. V., Selaru, F. M., Mori, Y., Vazquez, C., David, S., Paun, B., Cheng, Y., Jin, Z., Yang, J., Agarwal, R., Abraham, J. M., Dassopoulos, T., Harris, M., Bayless, T. M., Kwon, J., Harpaz, N., Livak, F. & Meltzer, S. J., Jan 2011, In: Inflammatory bowel diseases. 17, 1, p. 221-231 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma

Jain, S., Chang, T. T., Hamilton, J. P., Lin, S. Y., Lin, Y. J., Evans, A. A., Selaru, F. M., Lin, P. W., Chen, S. H., Block, T. M., Hu, C. T., Song, W., Meltzer, S. J. & Su, Y. H., Nov 2 2011, In: PloS one. 6, 11, e26799.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

MicroRNA-192 and-215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro

Jin, Z., Selaru, F. M., Cheng, Y., Kan, T., Agarwal, R., Mori, Y., Olaru, A. V., Yang, J., David, S., Hamilton, J. P., Abraham, J. M., Harmon, J., Duncan, M., Montgomery, E. A. & Meltzer, S. J., Mar 31 2011, In: Oncogene. 30, 13, p. 1577-1585 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Florin Selaru

Research output

Search results