Farhad Vesuna

2023

Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells

Mori, N., Jin, J., Krishnamachary, B., Mironchik, Y., Wildes, F., Vesuna, F., Barnett, J. D. & Bhujwalla, Z. M., 2023, In: Frontiers in Oncology. 13, 1068405.

Research output: Contribution to journal › Article › peer-review

Open Access

Twist alters the breast tumor microenvironment via choline kinase to facilitate an aggressive phenotype

Vesuna, F., Penet, M. F., Mori, N., Bhujwalla, Z. M. & Raman, V., Apr 2023, In: Molecular and Cellular Biochemistry. 478, 4, p. 939-948 10 p.

Research output: Contribution to journal › Article › peer-review

2022

RK-33, a small molecule inhibitor of host RNA helicase DDX3, suppresses multiple variants of SARS-CoV-2

Vesuna, F., Akhrymuk, I., Smith, A., Winnard, P. T., Lin, S. C., Panny, L., Scharpf, R., Kehn-Hall, K. & Raman, V., Aug 25 2022, In: Frontiers in Microbiology. 13, 959577.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Twist activates miR-22 to suppress estrogen receptor alpha in breast cancer

Vesuna, F., Lisok, A., van Diest, P. & Raman, V., Jun 2021, In: Molecular and Cellular Biochemistry. 476, 6, p. 2295-2306 12 p.

Research output: Contribution to journal › Article › peer-review

2020

Divergent organ-specific isogenic metastatic cell lines identified using multi-omics exhibit differential drug sensitivity

Winnard, P. T., Vesuna, F., Muthukumar, S. & Raman, V., Nov 2020, In: PloS one. 15, 11 November, e0242384.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33

Tantravedi, S., Vesuna, F., Winnard, P. T., Martin, A., Lim, M., Eberhart, C. G., Berlinicke, C., Raabe, E., van Diest, P. J. & Raman, V., Jan 2019, In: Translational Oncology. 12, 1, p. 96-105 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Targeting RNA helicase DDX3 in stem cell maintenance and teratoma formation

Kerr, C. L., Bol, G. M., Vesuna, F. & Raman, V., 2019, In: Genes and Cancer. 10, 1-2, p. 11-20 10 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

2018

Global Effects of DDX3 Inhibition on Cell Cycle Regulation Identified by a Combined Phosphoproteomics and Single Cell Tracking Approach

Heerma van Voss, M. R., Kammers, K., Vesuna, F., Brilliant, J., Bergman, Y., Tantravedi, S., Wu, X., Cole, R. N., Holland, A., van Diest, P. J. & Raman, V., Jun 2018, In: Translational Oncology. 11, 3, p. 755-763 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Targeting mitochondrial translation by inhibiting DDX3: A novel radiosensitization strategy for cancer treatment

Heerma Van Voss, M. R., Vesuna, F., Bol, G. M., Afzal, J., Tantravedi, S., Bergman, Y., Kammers, K., Lehar, M., Malek, R., Ballew, M., Ter Hoeve, N., Abou, D., Thorek, D., Berlinicke, C., Yazdankhah, M., Sinha, D., Le, A., Abrahams, R., Tran, P. T., Van Diest, P. J., & 1 othersRaman, V., Jan 4 2018, In: Oncogene. 37, 1, p. 63-74 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2017

Combination treatment using DDX3 and PARP inhibitors induces synthetic lethality in BRCA1-proficient breast cancer

Heerma van Voss, M. R., Brilliant, J. D., Vesuna, F., Bol, G. M., van der Wall, E., van Diest, P. J. & Raman, V., Mar 1 2017, In: Medical Oncology. 34, 3, 33.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Genomic pathways modulated by Twist in breast cancer

Vesuna, F., Bergman, Y. & Raman, V., Jan 13 2017, In: BMC cancer. 17, 1, 52.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

Nuclear DDX3 expression predicts poor outcome in colorectal and breast cancer

Heerma Van Voss, M. R., Vesuna, F., Bol, G. M., Meeldijk, J., Raman, A., Offerhaus, G. J., Buerger, H., Patel, A. H., van der Wall, E., van Diest, P. J. & Raman, V., Jul 17 2017, In: OncoTargets and Therapy. 10, p. 3501-3513 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Organ-specific isogenic metastatic breast cancer cell lines exhibit distinct Raman spectral signatures and metabolomes

Winnard, P. T., Zhang, C., Vesuna, F., Kang, J. W., Garry, J., Dasari, R. R., Barman, I. & Raman, V., 2017, In: Oncotarget. 8, 12, p. 20266-20287 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

Role of DDX3 in the pathogenesis of inflammatory bowel disease

Tantravedi, S., Vesuna, F., Winnard, P. T., van Voss, M. R. H., van Diest, P. J. & Raman, V., 2017, In: Oncotarget. 8, 70, p. 115280-115289 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2016

RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3

Xie, M., Vesuna, F., Tantravedi, S., Bol, G. M., Van Voss, M. R. H., Nugent, K., Malek, R., Gabrielson, K., Van Diest, P. J., Tran, P. T. & Raman, V., Nov 1 2016, In: Cancer Research. 76, 21, p. 6340-6350 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

2015

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

Heerma van Voss, M. R., Vesuna, F., Trumpi, K., Brilliant, J., Berlinicke, C., de Leng, W., Kranenburg, O., Offerhaus, J. G., Bürger, H., van der Wall, E., van Diest, P. J. & Raman, V., 2015, In: Oncotarget. 6, 29, p. 28312-28326 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

miRNA expression patterns in normal breast tissue and invasive breast cancers of BRCA1 and BRCA2 germ-line mutation carriers

Vos, S., Vesuna, F., Raman, V., van Diest, P. J. & van der Groep, P., 2015, In: Oncotarget. 6, 31, p. 32115-32137 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

Xie, M., Vesuna, F., Botlagunta, M., Bol, G. M., Irving, A., Bergman, Y., Hosmane, R. S., Kato, Y., Winnard, P. T. & Raman, V., 2015, In: Oncotarget. 6, 30, p. 29901-29913 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Targeting DDX3 with a small molecule inhibitor for lung cancer therapy

Bol, G. M., Vesuna, F., Xie, M., Zeng, J., Aziz, K., Gandhi, N., Levine, A., Irving, A., Korz, D., Tantravedi, S., Heerma van Voss, M. R., Gabrielson, K., Bordt, E. A., Polster, B. M., Cope, L., van der Groep, P., Kondaskar, A., Rudek, M. A., Hosmane, R. S., van der Wall, E., & 3 othersvan Diest, P. J., Tran, P. T. & Raman, V., May 1 2015, In: EMBO Molecular Medicine. 7, 5, p. 648-669 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

101 Scopus citations

2013

The Twist box domain is required for Twist1-induced prostate cancer metastasis

Gajula, R. P., Chettiar, S. T., Williams, R. D., Thiyagarajan, S., Kato, Y., Aziz, K., Wang, R., Gandhi, N., Wild, A. T., Vesuna, F., Ma, J., Salih, T., Cades, J., Fertig, E., Biswal, S., Burns, T. F., Chung, C. H., Rudin, C. M., Herman, J. M., Hales, R. K., & 3 othersRaman, V., An, S. S. & Tran, P. T., Nov 2013, In: Molecular Cancer Research. 11, 11, p. 1387-1400 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2012

GDPD5 inhibition alters the choline phospholipid metabolite profile of breast cancer cells toward a less malignant metabolic profile

Döpkens, M., Greenwood, T. R., Vesuna, F., Raman, V., Leibfritz, D. & Glunde, K., 2012, In: Biomedical Spectroscopy and Imaging. 1, 1, p. 3-15 13 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer

Cao, M. D., Döpkens, M., Krishnamachary, B., Vesuna, F., Gadiya, M. M., Lønning, P. E., Bhujwalla, Z. M., Gribbestad, I. S. & Glunde, K., Sep 2012, In: NMR in biomedicine. 25, 9, p. 1033-1042 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

The transcription factor encyclopedia.

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y. C., Dickman, C. T. D., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H. P., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W. F., Kist, R., Wilson, M. S. C., Marco-Ferreres, R., & 79 othersBrosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D. C., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M. M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperrière, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W. Z., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P. S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, G. N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., LeBrun, D. P., Biswal, S., Harvey, C. J., DeBruyne, J. P., Hogenesch, J. B. & Hevner, R. F., 2012, In: Genome biology. 13, 3, p. R24

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Twist contributes to hormone resistance in breast cancer by downregulating estrogen receptor-α

Vesuna, F., Lisok, A., Kimble, B., Domek, J., Kato, Y., Van Der Groep, P., Artemov, D., Kowalski, J., Carraway, H., Van Diest, P. & Raman, V., Jul 5 2012, In: Oncogene. 31, 27, p. 3223-3234 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

2011

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells

Botlagunta, M., Krishnamachary, B., Vesuna, F., Winnard, P. T., Bol, G. M., Patel, A. H. & Raman, V., 2011, In: PloS one. 6, 3, e17563.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

Novel, broad spectrum anticancer agents containing the tricyclic 5:7:5-fused diimidazodiazepine ring system

Kondaskar, A., Kondaskar, S., Kumar, R., Fishbein, J. C., Muvarak, N., Lapidus, R. G., Sadowska, M., Edelman, M. J., Bol, G. M., Vesuna, F., Raman, V. & Hosmane, R. S., Mar 10 2011, In: ACS Medicinal Chemistry Letters. 2, 3, p. 252-256 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

2009

Interleukin-6 induces an epithelial-mesenchymal transition phenotype in human breast cancer cells

Sullivan, N. J., Sasser, A. K., Axel, A. E., Vesuna, F., Raman, V., Ramirez, N., Oberyszyn, T. M. & Hall, B. M., Aug 20 2009, In: Oncogene. 28, 33, p. 2940-2947 8 p.

Research output: Contribution to journal › Article › peer-review

493 Scopus citations

Peptides derived from type IV collagen, CXC chemokines, and thrombospondin-1 domain-containing proteins inhibit neovascularization and suppress tumor growth in MDA-MB-231 breast cancer xenografts

Koskimaki, J. E., Karagiannis, E. D., Rosca, E. V., Vesuna, F., Winnard, P. T., Raman, V., Bhujwalla, Z. M. & Popel, A. S., Dec 2009, In: Neoplasia. 11, 12, p. 1285-1291 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression

Vesuna, F., Lisok, A., Kimble, B. & Raman, V., Dec 2009, In: Neoplasia. 11, 12, p. 1318-1328 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

155 Scopus citations

2008

Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model

Winnard, P. T., Botlagunta, M., Kluth, J. B., Mukadam, S., Krishnamachary, B., Vesuna, F. & Raman, V., Oct 2008, In: Cancer Gene Therapy. 15, 10, p. 645-654 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1α signaling in a human prostate cancer model

Glunde, K., Shah, T., Winnard, P. T., Raman, V., Takagi, T., Vesuna, F., Artemov, D. & Bhujwalla, Z. M., Jan 1 2008, In: Cancer Research. 68, 1, p. 172-180 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

103 Scopus citations

Oncogenic role of DDX3 in breast cancer biogenesis

Botlagunta, M., Vesuna, F., Mironchik, Y., Raman, A., Lisok, A., Winnard, P., Mukadam, S., Van Diest, P., Chen, J. H., Farabaugh, P., Patel, A. H. & Raman, V., Jun 26 2008, In: Oncogene. 27, 28, p. 3912-3922 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer

Vesuna, F., van Diest, P., Chen, J. H. & Raman, V., Mar 7 2008, In: Biochemical and Biophysical Research Communications. 367, 2, p. 235-241 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

232 Scopus citations

2007

Contributing factors of temozolomide resistance in MCF-7 tumor xenograft models

Kato, Y., Okollie, B., Raman, V., Vesuna, F., Zhao, M., Baker, S. D., Bhujwalla, Z. M. & Artemov, D., Jun 2007, In: Cancer Biology and Therapy. 6, 6, p. 891-897 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2006

HOXA5 regulates hMLH1 expression in breast cancer cells

Duriseti, S., Winnard, P. T., Mironchik, Y., Vesuna, F., Raman, A. & Raman, V., Apr 2006, In: Neoplasia. 8, 4, p. 250-258 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

2005

Enhanced green fluorescent protein as an alternative control reporter to Renilla luciferase

Vesuna, F., Winnard, P. & Raman, V., Jul 15 2005, In: Analytical biochemistry. 342, 2, p. 345-347 3 p.

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer

Mironchik, Y., Winnard, P. T., Vesuna, F., Kato, Y., Wildes, F., Pathak, A. P., Kominsky, S., Artemov, D., Bhujwalla, Z., Van Diest, P., Burger, H., Glackin, C. & Raman, V., Dec 1 2005, In: Cancer Research. 65, 23, p. 10801-10809 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

231 Scopus citations

2002

Detection and evaluation of non-recombinants in cDNA libraries by multiple cloning region PCR

Bandyopadhyay, D. & Vesuna, F. D., 2002, In: BioTechniques. 32, 1, p. 88-92 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Farhad Vesuna

Research output

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