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Evan O'Brien

Assistant Professor

20142026

Research activity per year

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  • Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets

    Munguba, H., Arefin, A., Hasegawa, R., Posa, L., Romano, G. R., Peddada, T. N., Donatelle, A., Singh, A., Gutzeit, V. A., Vijay, A., Vaddi, P., Kristt, M., Shaver, D., Hoque, S., Broichhagen, J., Stujenske, J. M., Lee, F. S., O’Brien, E., Levitz, J. & Liston, C., Apr 30 2026, In: Cell. 189, 9, p. 2612-2632.e24

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A cryptic pocket in CB1 drives peripheral and functional selectivity

    Rangari, V. A., O’Brien, E. S., Powers, A. S., Slivicki, R. A., Bertels, Z., Appourchaux, K., Aydin, D., Ramos-Gonzalez, N., Mwirigi, J., Lin, L., Mangutov, E., Sobecks, B. L., Awad-Agbaria, Y., Uphade, M. B., Aguilar, J., Peddada, T. N., Shiimura, Y., Huang, X. P., Folarin-Hines, J. & Payne, M. & 9 others, Kalathil, A., Varga, B. R., Kobilka, B. K., Pradhan, A. A., Cameron, M. D., Kumar, K. K., Dror, R. O., Gereau, R. W. & Majumdar, S., Apr 3 2025, In: Nature. 640, 8057, p. 265-273 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects

    Tummino, T. A., Iliopoulos-Tsoutsouvas, C., Braz, J. M., O’Brien, E. S., Stein, R. M., Craik, V., Tran, N. K., Ganapathy, S., Liu, F., Shiimura, Y., Tong, F., Ho, T. C., Radchenko, D. S., Moroz, Y. S., Rosado, S. R., Bhardwaj, K., Benitez, J., Liu, Y., Kandasamy, H. & Normand, C. & 8 others, Semache, M., Sabbagh, L., Glenn, I., Irwin, J. J., Kumar, K. K., Makriyannis, A., Basbaum, A. I. & Shoichet, B. K., Dec 2025, In: Nature communications. 16, 1, 2237.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • A µ-opioid receptor modulator that works cooperatively with naloxone

    O’Brien, E. S., Rangari, V. A., El Daibani, A., Eans, S. O., Hammond, H. R., White, E., Wang, H., Shiimura, Y., Krishna Kumar, K., Jiang, Q., Appourchaux, K., Huang, W., Zhang, C., Kennedy, B. J., Mathiesen, J. M., Che, T., McLaughlin, J. P., Majumdar, S. & Kobilka, B. K., Jul 18 2024, In: Nature. 631, 8021, p. 686-693 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Correction to: Stepwise activation of a metabotropic glutamate receptor (Nature, (2024), 629, 8013, (951-956), 10.1038/s41586-024-07327-x)

    Krishna Kumar, K., Wang, H., Habrian, C., Latorraca, N. R., Xu, J., O’Brien, E. S., Zhang, C., Montabana, E., Koehl, A., Marqusee, S., Isacoff, E. Y. & Kobilka, B. K., May 23 2024, In: Nature. 629, 8013, p. E13

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access
View all 16 Research outputs