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Evan O'Brien

Assistant Professor

20142025

Research activity per year

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  • A cryptic pocket in CB1 drives peripheral and functional selectivity

    Rangari, V. A., O’Brien, E. S., Powers, A. S., Slivicki, R. A., Bertels, Z., Appourchaux, K., Aydin, D., Ramos-Gonzalez, N., Mwirigi, J., Lin, L., Mangutov, E., Sobecks, B. L., Awad-Agbaria, Y., Uphade, M. B., Aguilar, J., Peddada, T. N., Shiimura, Y., Huang, X. P., Folarin-Hines, J. & Payne, M. & 9 others, Kalathil, A., Varga, B. R., Kobilka, B. K., Pradhan, A. A., Cameron, M. D., Kumar, K. K., Dror, R. O., Gereau, R. W. & Majumdar, S., Apr 3 2025, In: Nature. 640, 8057, p. 265-273 9 p., 107847.

    Research output: Contribution to journal › Article › peer-review

  • Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects

    Tummino, T. A., Iliopoulos-Tsoutsouvas, C., Braz, J. M., O’Brien, E. S., Stein, R. M., Craik, V., Tran, N. K., Ganapathy, S., Liu, F., Shiimura, Y., Tong, F., Ho, T. C., Radchenko, D. S., Moroz, Y. S., Rosado, S. R., Bhardwaj, K., Benitez, J., Liu, Y., Kandasamy, H. & Normand, C. & 8 others, Semache, M., Sabbagh, L., Glenn, I., Irwin, J. J., Kumar, K. K., Makriyannis, A., Basbaum, A. I. & Shoichet, B. K., Dec 2025, In: Nature communications. 16, 1, 2237.

    Research output: Contribution to journal › Article › peer-review

  • A µ-opioid receptor modulator that works cooperatively with naloxone

    O’Brien, E. S., Rangari, V. A., El Daibani, A., Eans, S. O., Hammond, H. R., White, E., Wang, H., Shiimura, Y., Krishna Kumar, K., Jiang, Q., Appourchaux, K., Huang, W., Zhang, C., Kennedy, B. J., Mathiesen, J. M., Che, T., McLaughlin, J. P., Majumdar, S. & Kobilka, B. K., Jul 18 2024, In: Nature. 631, 8021, p. 686-693 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Correction to: Stepwise activation of a metabotropic glutamate receptor (Nature, (2024), 629, 8013, (951-956), 10.1038/s41586-024-07327-x)

    Krishna Kumar, K., Wang, H., Habrian, C., Latorraca, N. R., Xu, J., O’Brien, E. S., Zhang, C., Montabana, E., Koehl, A., Marqusee, S., Isacoff, E. Y. & Kobilka, B. K., May 23 2024, In: Nature. 629, 8013, p. E13

    Research output: Contribution to journal › Comment/debate › peer-review

    Open Access

  • Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

    Zhao, J., Elgeti, M., O’Brien, E. S., Sár, C. P., EI Daibani, A., Heng, J., Sun, X., White, E., Che, T., Hubbell, W. L., Kobilka, B. K. & Chen, C., May 9 2024, In: Nature. 629, 8011, p. 474-480 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
View all 15 Research outputs