Emily Barron-Casella

2024

A genetic-association study of circulating coagulation factor VIII and von Willebrand factor levels

Trans-Omics for Precision Medicine (TOPMed) program & INVENT Consortium, 2024, (Accepted/In press) In: Blood.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Apr 27 2023, In: Nature. 616, 7958, p. 755-763 9 p.

Research output: Contribution to journal › Article › peer-review

Clonal haematopoiesis and risk of chronic liver disease

NHLBI TOPMed Hematology Working Group, Apr 27 2023, In: Nature. 616, 7958, p. 747-754 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Epigenome-wide DNA methylation association study of circulating IgE levels identifies novel targets for asthma

NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sep 2023, In: EBioMedicine. 95, 104758.

Research output: Contribution to journal › Article › peer-review

Open Access

Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

Li, X., Quick, C., Zhou, H., Gaynor, S. M., Liu, Y., Chen, H., Selvaraj, M. S., Sun, R., Dey, R., Arnett, D. K., Bielak, L. F., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Correa, A., Cupples, L. A., Curran, J. E., & 404 othersde Vries, P. S., Duggirala, R., Freedman, B. I., Göring, H. H. H., Guo, X., Haessler, J., Kalyani, R. R., Kooperberg, C., Kral, B. G., Lange, L. A., Manichaikul, A., Martin, L. W., McGarvey, S. T., Mitchell, B. D., Montasser, M. E., Morrison, A. C., Naseri, T., O’Connell, J. R., Palmer, N. D., Peyser, P. A., Psaty, B. M., Raffield, L. M., Redline, S., Reiner, A. P., Reupena, M. S., Rice, K. M., Rich, S. S., Sitlani, C. M., Smith, J. A., Taylor, K. D., Vasan, R. S., Willer, C. J., Wilson, J. G., Yanek, L. R., Zhao, W., Rotter, J. I., Natarajan, P., Peloso, G. M., Li, Z., Lin, X., Abe, N., Abecasis, G., Aguet, F., Albert, C., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Ardlie, K., Dan Arking, A., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Ayas, N., Balasubramanian, A., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Becker, L., Beer, R., Beitelshees, A., Benjamin, E., Benos, T., Bezerra, M., Blackwell, T., Blue, N., Bowler, R., Broeckel, U., Broome, J., Brown, D., Bunting, K., Burchard, E., Bustamante, C., Buth, E., Cardwell, J., Carey, V., Carrier, J., Carson, A., Carty, C., Casaburi, R., Casas Romero, J. P., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y. C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Chen, Y. D. I., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Chung, R. H., Clish, C., Comhair, S., Conomos, M., Cornell, E., Crandall, C., Crapo, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., David, S., Davis, C., Daya, M., de Andrade, M., de las Fuentes, L., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Dinh, H., Doddapaneni, H., Duan, Q., Dugan-Perez, S., Durda, J. P., Dutcher, S. K., Eaton, C., Ekunwe, L., El Boueiz, A., Ellinor, P., Emery, L., Erzurum, S., Farber, C., Farek, J., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Geiger, H., Gelb, B., Geraci, M., Germer, S., Gerszten, R., Ghosh, A., Gibbs, R., Gignoux, C., Gladwin, M., Glahn, D., Gogarten, S., Gong, D. W., Graw, S., Gray, K. J., Grine, D., Gross, C., Gu, C. C., Guan, Y., Gupta, N., Hall, M., Han, Y., Hanly, P., Harris, D., Hawley, N. L., He, J., Ben Heavner, H., Heckbert, S., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hixson, J., Hobbs, B., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Hu, J., Hung, Y. J., Huston, H., Hwu, C. M., Irvin, M. R., Jackson, R., Jain, D., Jaquish, C., Johnsen, J., Johnson, A., Johnson, C., Johnston, R., Jones, K., Kang, H. M., Kaplan, R., Kardia, S., Kelly, S., Kenny, E., Kessler, M., Khan, A., Khan, Z., Kim, W., Kimoff, J., Kinney, G., Konkle, B., Kramer, H., Lange, C., Lange, E., Laurie, C., Laurie, C., LeBoff, M., Lee, J., Lee, S., Lee, W. J., LeFaive, J., Levine, D., Levy, D., Lewis, J., Li, X., Li, Y., Lin, H., Lin, H., Liu, S., Liu, Y., Liu, Y., Loos, R. J. F., Lubitz, S., Lunetta, K., Luo, J., Magalang, U., Mahaney, M., Make, B., Manning, A., Manson, J. A., Marton, M., Mathai, S., Mathias, R., May, S., McArdle, P., McDonald, M. L., McFarland, S., McGoldrick, D., McHugh, C., McNeil, B., Mei, H., Meigs, J., Menon, V., Mestroni, L., Metcalf, G., Meyers, D. A., Mignot, E., Mikulla, J., Min, N., Minear, M., Minster, R. L., Moll, M., Momin, Z., Montgomery, C., Muzny, D., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Nekhai, S., Nelson, S. C., Neltner, B., Nessner, C., Nickerson, D., Nkechinyere, O., North, K., O’Connor, T., Ochs-Balcom, H., Okwuonu, G., Pack, A., Paik, D. T., Pankow, J., Papanicolaou, G., Parker, C., Peralta, J. M., Perez, M., Perry, J., Peters, U., Phillips, L. S., Pleiness, J., Pollin, T., Post, W., Becker, J. P., Boorgula, M. P., Preuss, M., Qasba, P., Qiao, D., Qin, Z., Rafaels, N., Rajendran, M., Rao, D. C., Rasmussen-Torvik, L., Ratan, A., Reed, R., Reeves, C., Regan, E., Robillard, R., Robine, N., Dan Roden, R., Roselli, C., Ruczinski, I., Runnels, A., Russell, P., Ruuska, S., Ryan, K., Sabino, E. C., Saleheen, D., Salimi, S., Salvi, S., Salzberg, S., Sandow, K., Sankaran, V. G., Santibanez, J., Schwander, K., Schwartz, D., Sciurba, F., Seidman, C., Seidman, J., Sériès, F., Sheehan, V., Sherman, S. L., Shetty, A., Shetty, A., Sheu, W. H. H., Shoemaker, M. B., Silver, B., Silverman, E., Skomro, R., Smith, A. V., Smith, J., Smith, N., Smith, T., Smoller, S., Snively, B., Snyder, M., Sofer, T., Sotoodehnia, N., Stilp, A. M., Storm, G., Streeten, E., Su, J. L., Sung, Y. J., Sylvia, J., Szpiro, A., Taliun, D., Tang, H., Taub, M., Taylor, M., Taylor, S., Telen, M., Thornton, T. A., Threlkeld, M., Tinker, L., Tirschwell, D., Tishkoff, S., Tiwari, H., Tong, C., Tracy, R., Tsai, M., Vaidya, D., Van Den Berg, D., VandeHaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wang, F. F., Wang, H., Wang, J., Watson, K., Watt, J., Weeks, D. E., Weinstock, J., Weir, B., Weiss, S. T., Weng, L. C., Wessel, J., Williams, K., Williams, L. K., Wilson, C., Winterkorn, L., Wong, Q., Wu, J., Xu, H., Yang, I., Yu, K., Zekavat, S. M., Zhang, Y., Zhao, S. X., Zhu, X., Ziv, E., Zody, M. & Zoellner, S., Jan 2023, In: Nature genetics. 55, 1, p. 154-164 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Dec 1 2022, In: Nature Methods.

Research output: Contribution to journal › Article › peer-review

Open Access

Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

TOPMed Anthropometry Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mar 2022, In: Nature genetics. 54, 3, p. 263-273 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals

Tahir, U. A., Katz, D. H., Avila-Pachecho, J., Bick, A. G., Pampana, A., Robbins, J. M., Yu, Z., Chen, Z. Z., Benson, M. D., Cruz, D. E., Ngo, D., Deng, S., Shi, X., Zheng, S., Eisman, A. S., Farrell, L., Hall, M. E., Correa, A., Tracy, R. P., Durda, P., & 410 othersTaylor, K. D., Liu, Y., Johnson, W. C., Guo, X., Yao, J., Chen, Y. D. I., Manichaikul, A. W., Ruberg, F. L., Blaner, W. S., Jain, D., Bouchard, C., Sarzynski, M. A., Rich, S. S., Rotter, J. I., Wang, T. J., Wilson, J. G., Clish, C. B., Natarajan, P., Gerszten, R. E., Abe, N., Abecasis, G., Aguet, F., Albert, C., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Ardlie, K., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Ayas, N., Balasubramanian, A., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Barwick, L., Beaty, T., Beck, G., Becker, D., Becker, L., Beer, R., Beitelshees, A., Benjamin, E., Benos, T., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Blue, N., Boerwinkle, E., Bowden, D. W., Bowler, R., Brody, J., Broeckel, U., Broome, J., Brown, D., Bunting, K., Burchard, E., Bustamante, C., Buth, E., Cade, B., Cardwell, J., Carey, V., Carrier, J., Carson, A., Carty, C., Casaburi, R., Romero, J. P. C., Casella, J., Castaldi, P., Chaffin, M., Chang, C., Chang, Y. C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Chung, R. H., Comhair, S., Conomos, M., Cornell, E., Crandall, C., Crapo, J., Cupples, L. A., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., David, S., Davis, C., Daya, M., de Andrade, M., Fuentes, L. D. L., de Vries, P., DeBaun, M., Deka, R., DeMeo, D., Devine, S., Dinh, H., Doddapaneni, H., Duan, Q., Dugan-Perez, S., Duggirala, R., Dutcher, S. K., Eaton, C., Ekunwe, L., El Boueiz, A., Ellinor, P., Emery, L., Erzurum, S., Farber, C., Farek, J., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Frazar, C., Fu, M., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, S., Gao, Y., Gass, M., Geiger, H., Gelb, B., Geraci, M., Germer, S., Ghosh, A., Gibbs, R., Gignoux, C., Gladwin, M., Glahn, D., Gogarten, S., Gong, D. W., Goring, H., Graw, S., Gray, K. J., Grine, D., Gross, C., Gu, C. C., Guan, Y., Gupta, N., Haessler, J., Han, Y., Hanly, P., Harris, D., Hawley, N. L., He, J., Heavner, B., Heckbert, S., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hixson, J., Hobbs, B., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Hu, J., Hung, Y. J., Huston, H., Hwu, C. M., Irvin, M. R., Jackson, R., Jaquish, C., Johnsen, J., Johnson, A., Johnston, R., Jones, K., Kang, H. M., Kaplan, R., Kardia, S., Kelly, S., Kenny, E., Kessler, M., Khan, A., Khan, Z., Kim, W., Kimoff, J., Kinney, G., Konkle, B., Kooperberg, C., Kramer, H., Lange, C., Lange, E., Lange, L., Laurie, C., Laurie, C., LeBoff, M., Lee, J., Lee, S., Lee, W. J., LeFaive, J., Levine, D., Levy, D., Lewis, J., Li, X., Li, Y., Lin, H., Lin, H., Lin, X., Liu, S., Liu, Y., Loos, R. J. F., Lubitz, S., Lunetta, K., Luo, J., Magalang, U., Mahaney, M., Make, B., Manning, A., Manson, J. A., Martin, L., Marton, M., Mathai, S., Mathias, R., May, S., McArdle, P., McDonald, M. L., McFarland, S., McGarvey, S., McGoldrick, D., McHugh, C., McNeil, B., Mei, H., Meigs, J., Menon, V., Mestroni, L., Metcalf, G., Meyers, D. A., Mignot, E., Mikulla, J., Min, N., Minear, M., Minster, R. L., Mitchell, B. D., Moll, M., Momin, Z., Montasser, M. E., Montgomery, C., Muzny, D., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Naseri, T., Nekhai, S., Nelson, S. C., Neltner, B., Nessner, C., Nickerson, D., Nkechinyere, O., North, K., O’Connell, J., O’Connor, T., Ochs-Balcom, H., Okwuonu, G., Pack, A., Paik, D. T., Palmer, N., Pankow, J., Papanicolaou, G., Parker, C., Peloso, G., Peralta, J. M., Perez, M., Perry, J., Peters, U., Peyser, P., Phillips, L. S., Pleiness, J., Pollin, T., Post, W., Becker, J. P., Boorgula, M. P., Preuss, M., Psaty, B., Qasba, P., Qiao, D., Qin, Z., Rafaels, N., Raffield, L., Rajendran, M., Ramachandran, V. S., Rao, D. C., Rasmussen-Torvik, L., Ratan, A., Redline, S., Reed, R., Reeves, C., Regan, E., Reiner, A., Reupena, M. S., Rice, K., Robillard, R., Robine, N., Dan Roden, R., Roselli, C., Ruczinski, I., Runnels, A., Russell, P., Ruuska, S., Sabino, E. C., Saleheen, D., Salimi, S., Salvi, S., Salzberg, S., Sandow, K., Sankaran, V. G., Santibanez, J., Schwander, K., Schwartz, D., Sciurba, F., Seidman, C., Seidman, J., SÃ©riÃ¨s, F., Sheehan, V., Sherman, S. L., Shetty, A., Shetty, A., Sheu, W. H. H., Shoemaker, M. B., Silver, B., Silverman, E., Skomro, R., Smith, A. V., Smith, J., Smith, J., Smith, N., Smith, T., Smoller, S., Snively, B., Snyder, M., Sofer, T., Sotoodehnia, N., Stilp, A. M., Storm, G., Streeten, E., Su, J. L., Sung, Y. J., Sylvia, J., Szpiro, A., Taliun, D., Tang, H., Taub, M., Taylor, M., Taylor, S., Telen, M., Thornton, T. A., Threlkeld, M., Tinker, L., Tirschwell, D., Tishkoff, S., Tiwari, H., Tong, C., Tsai, M., Vaidya, D., Van Den Berg, D., VandeHaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wang, F. F., Wang, H., Wang, J., Watson, K., Watt, J., Weeks, D. E., Weinstock, J., Weir, B., Weiss, S. T., Weng, L. C., Wessel, J., Willer, C., Williams, K., Williams, L. K., Wilson, C., Winterkorn, L., Wong, Q., Wu, J., Xu, H., Yanek, L., Yang, I., Yu, K., Zekavat, S. M., Zhang, Y., Zhao, S. X., Zhao, W., Zhu, X., Ziv, E., Zody, M. & Zoellner, S., Dec 2022, In: Nature communications. 13, 1, 4923.

Research output: Contribution to journal › Article › peer-review

Open Access

Whole genome sequence analysis of blood lipid levels in >66,000 individuals

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2022, In: Nature communications. 13, 1, 5995.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Oct 2021, In: Nature genetics. 53, 10, p. 1504-1516 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & FinnGen, Dec 1 2021, In: Nature communications. 12, 1, 2182.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), Dec 2021, In: Genome Medicine. 13, 1, 66.

Research output: Contribution to journal › Article › peer-review

Open Access

Genome sequencing unveils a regulatory landscape of platelet reactivity

NHLBI Trans-Omics for Precision (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3626.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic discovery in sickle cell disease: Elevated neurogranin levels in children with sickle cell disease

Lance, E. I., Faulcon, L. M., Fu, Z., Yang, J., Whyte-Stewart, D., Strouse, J. J., Barron-Casella, E., Jones, K., Van Eyk, J. E., Casella, J. F. & Everett, A. D., Sep 2021, In: Proteomics - Clinical Applications. 15, 5, 2100003.

Research output: Contribution to journal › Article › peer-review

Open Access

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Feb 11 2021, In: Nature. 590, 7845, p. 290-299 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2021, In: Nature communications. 12, 1, 3506.

Research output: Contribution to journal › Article › peer-review

Open Access

Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program

TOPMed Sleep Working Group & NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 2021, In: Genome Medicine. 13, 1, 136.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Brain-derived neurotrophic factor levels in pediatric sickle cell disease

Lance, E. I., Barron-Casella, E., Everett, A. D. & Casella, J. F., Feb 1 2020, In: Pediatric Blood and Cancer. 67, 2, e28076.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium & TOPMed Lipids Working Group, Sep 1 2020, In: Nature genetics. 52, 9, p. 969-983 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Inherited causes of clonal haematopoiesis in 97,691 whole genomes

NHLBI Trans-Omics for Precision Medicine Consortium, Oct 29 2020, In: Nature. 586, 7831, p. 763-768 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2019

Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma

National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium, Dec 1 2019, In: CHEST. 156, 6, p. 1068-1079 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2018

Deep-coverage whole genome sequences and blood lipids among 16,324 individuals

NHLBI TOPMed Lipids Working Group, Dec 1 2018, In: Nature communications. 9, 1, 3391.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Zekavat, S. M., Ruotsalainen, S., Handsaker, R. E., Alver, M., Bloom, J., Poterba, T., Seed, C., Ernst, J., Chaffin, M., Engreitz, J., Peloso, G. M., Manichaikul, A., Yang, C., Ryan, K. A., Fu, M., Johnson, W. C., Tsai, M., Budoff, M., Ramachandran, V. S., Cupples, L. A., & 323 othersRotter, J. I., Rich, S. S., Post, W., Mitchell, B. D., Correa, A., Metspalu, A., Wilson, J. G., Salomaa, V., Kellis, M., Daly, M. J., Neale, B. M., McCarroll, S., Surakka, I., Esko, T., Ganna, A., Ripatti, S., Kathiresan, S., Natarajan, P., Abe, N., Abecasis, G., Albert, C., Allred, N. P., Almasy, L., Alonso, A., Ament, S., Anderson, P., Anugu, P., Applebaum-Bowden, D., Arking, D., Arnett, D. K., Ashley-Koch, A., Aslibekyan, S., Assimes, T., Auer, P., Avramopoulos, D., Barnard, J., Barnes, K., Barr, R. G., Barron-Casella, E., Beaty, T., Becker, D., Becker, L., Beer, R., Begum, F., Beitelshees, A., Benjamin, E., Bezerra, M., Bielak, L., Bis, J., Blackwell, T., Blangero, J., Boerwinkle, E., Borecki, I., Bowler, R., Brody, J., Broeckel, U., Broome, J., Bunting, K., Burchard, E., Cardwell, J., Carty, C., Casaburi, R., Casella, J., Chang, C., Chasman, D., Chavan, S., Chen, B. J., Chen, W. M., Chen, Y. D. I., Cho, M., Choi, S. H., Chuang, L. M., Chung, M., Cornell, E., Crandall, C., Crapo, J., Curran, J., Curtis, J., Custer, B., Damcott, C., Darbar, D., Das, S., David, S., Davis, C., Daya, M., Andrade, M. D., Debaun, M., Deka, R., Demeo, D., Devine, S., Do, R., Duan, Q., Duggirala, R., Durda, P., Dutcher, S., Eaton, C., Ekunwe, L., Ellinor, P., Emery, L., Farber, C., Farnam, L., Fingerlin, T., Flickinger, M., Fornage, M., Franceschini, N., Fullerton, S. M., Fulton, L., Gabriel, S., Gan, W., Gao, Y., Gass, M., Gelb, B., Geng, X., Germer, S., Gignoux, C., Gladwin, M., Glahn, D., Gogarten, S., Gong, D. W., Goring, H., Gu, C. C., Guan, Y., Guo, X., Haessler, J., Hall, M., Harris, D., Hawley, N., He, J., Heavner, B., Heckbert, S., Hernandez, R., Herrington, D., Hersh, C., Hidalgo, B., Hixson, J., Hokanson, J., Hong, E., Hoth, K., Hsiung, C., Huston, H., Hwu, C. M., Irvin, M. R., Jackson, R., Jain, D., Jaquish, C., Jhun, M. A., Johnsen, J., Johnson, A., Johnston, R., Jones, K., Kang, H. M., Kaplan, R., Kardia, S., Kaufman, L., Kelly, S., Kenny, E., Kessler, M., Khan, A., Kinney, G., Konkle, B., Kooperberg, C., Kramer, H., Krauter, S., Lange, C., Lange, E., Lange, L., Laurie, C., Laurie, C., Leboff, M., Lee, S. S., Lee, W. J., Lefaive, J., Levine, D., Levy, D., Lewis, J., Li, Y., Lin, H., Lin, K. H., Liu, S., Liu, Y., Loos, R., Lubitz, S., Lunetta, K., Luo, J., Mahaney, M., Make, B., Manson, J. A., Margolin, L., Martin, L., Mathai, S., Mathias, R., McArdle, P., McDonald, M. L., McFarland, S., McGarvey, S., Mei, H., Meyers, D. A., Mikulla, J., Min, N., Minear, M., Minster, R. L., Montasser, M. E., Musani, S., Mwasongwe, S., Mychaleckyj, J. C., Nadkarni, G., Naik, R., Nekhai, S., Nickerson, D., North, K., O'connell, J., O'connor, T., Ochs-Balcom, H., Pankow, J., Papanicolaou, G., Parker, M., Parsa, A., Penchev, S., Peralta, J. M., Perez, M., Perry, J., Peters, U., Peyser, P., Phillips, L., Phillips, S., Pollin, T., Becker, J. P., Boorgula, M. P., Preuss, M., Prokopenko, D., Psaty, B., Qasba, P., Qiao, D., Qin, Z., Rafaels, N., Raffield, L., Rao, D. C., Rasmussen-Torvik, L., Ratan, A., Redline, S., Reed, R., Regan, E., Reiner, A., Rice, K., Roden, D., Roselli, C., Ruczinski, I., Russell, P., Ruuska, S., Sakornsakolpat, P., Salimi, S., Salzberg, S., Sandow, K., Sankaran, V., Scheller, C., Schmidt, E., Schwander, K., Schwartz, D., Sciurba, F., Seidman, C., Sheehan, V., Shetty, A., Shetty, A., Sheu, W. H. H., Shoemaker, M. B., Silver, B., Silverman, E., Smith, J., Smith, J., Smith, N., Smith, T., Smoller, S., Snively, B., Sofer, T., Sotoodehnia, N., Stilp, A., Streeten, E., Sung, Y. J., Sylvia, J., Szpiro, A., Sztalryd, C., Taliun, D., Tang, H., Taub, M., Taylor, K., Taylor, S., Telen, M., Thornton, T. A., Tinker, L., Tirschwell, D., Tiwari, H., Tracy, R., Vaidya, D., Vandehaar, P., Vrieze, S., Walker, T., Wallace, R., Walts, A., Wan, E., Wang, F. F., Watson, K., Weeks, D. E., Weir, B., Weiss, S., Weng, L. C., Willer, C., Williams, K., Williams, L. K., Wilson, C., Wong, Q., Xu, H., Yanek, L., Yang, I., Yang, R., Zaghloul, N., Zhang, Y., Zhao, S. X., Zhao, W., Zheng, X., Zhi, D., Zhou, X., Zody, M. & Zoellner, S., Dec 1 2018, In: Nature communications. 9, 1, 2606.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

2017

Identification of Aptamers That Bind to Sickle Hemoglobin and Inhibit Its Polymerization

Purvis, S. H., Keefer, J. R., Fortenberry, Y. M., Barron-Casella, E. A. & Casella, J. F., Dec 2017, In: Nucleic Acid Therapeutics. 27, 6, p. 354-364 11 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

2013

Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia

Bean, C. J., Boulet, S. L., Yang, G., Payne, A. B., Ghaji, N., Pyle, M. E., Hooper, W. C., Bhatnagar, P., Keefer, J., Barron-Casella, E. A., Casella, J. F. & Debaun, M. R., Oct 2013, In: British journal of haematology. 163, 2, p. 268-276 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Association between baseline fetal hemoglobin levels and incidence of severe vaso-occlusive pain episodes in children with sickle cell anemia

Bhatnagar, P., Keefer, J. R., Casella, J. F., Barron-Casella, E. A., Bean, C. J., Hooper, C. W., Payne, A. B., Arking, D. E. & Debaun, M. R., Oct 2013, In: Pediatric Blood and Cancer. 60, 10, p. E125-E127

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Genome-Wide Meta-Analysis of Systolic Blood Pressure in Children with Sickle Cell Disease

Bhatnagar, P., Barron-Casella, E., Bean, C. J., Milton, J. N., Baldwin, C. T., Steinberg, M. H., DeBaun, M., Casella, J. F. & Arking, D. E., Sep 12 2013, In: PloS one. 8, 9, e74193.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Thrombospondin-1 and L-selectin are associated with silent cerebral infarct in children with sickle cell anaemia

Faulcon, L. M., Fu, Z., Dulloor, P., Barron-Casella, E., Savage, W., Jennings, J. M., Van Eyk, J. E., Debaun, M., Casella, J. F. & Everett, A., Aug 2013, In: British journal of haematology. 162, 3, p. 421-424 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2012

A genome-wide association study of total Bilirubin and Cholelithiasis risk in sickle cell anemia

Milton, J. N., Sebastiani, P., Solovieff, N., Hartley, S. W., Bhatnagar, P., Arking, D. E., Dworkis, D. A., Casella, J. F., Barron-Casella, E., Bean, C. J., Hooper, W. C., DeBaun, M. R., Garrett, M. E., Soldano, K., Telen, M. J., Ashley-Koch, A., Gladwin, M. T., Baldwin, C. T., Steinberg, M. H. & Klings, E. S., Apr 27 2012, In: PloS one. 7, 4, e34741.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

Bean, C. J., Boulet, S. L., Ellingsen, D., Pyle, M. E., Barron-Casella, E. A., Casella, J. F., Payne, A. B., Driggers, J., Trau, H. A., Yang, G., Jones, K., Ofori-Acquah, S. F., Hooper, W. C. & DeBaun, M. R., Nov 1 2012, In: Blood. 120, 18, p. 3822-3828 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Magnetic resonance angiography-defined intracranial vasculopathy is associated with silent cerebral infarcts and glucose-6-phosphate dehydrogenase mutation in children with sickle cell anaemia

Thangarajh, M., Yang, G., Fuchs, D., Ponisio, M. R., Mckinstry, R. C., Jaju, A., Noetzel, M. J., Casella, J. F., Barron-Casella, E., Hooper, W. C., Boulet, S. L., Bean, C. J., Pyle, M. E., Payne, A. B., Driggers, J., Trau, H. A., Vendt, B. A., Rodeghier, M. & Debaun, M. R., Nov 2012, In: British journal of haematology. 159, 3, p. 352-359 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

2011

Elevation of IgE in children with sickle cell disease is associated with doctor diagnosis of asthma and increased morbidity

An, P., Barron-Casella, E. A., Strunk, R. C., Hamilton, R. G., Casella, J. F. & DeBaun, M. R., Jun 2011, In: Journal of Allergy and Clinical Immunology. 127, 6, p. 1440-1446 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients

Bhatnagar, P., Purvis, S., Barron-Casella, E., DeBaun, M. R., Casella, J. F., Arking, D. E. & Keefer, J. R., Apr 2011, In: Journal of Human Genetics. 56, 4, p. 316-323 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

2010

Hemoglobin depletion from plasma: Considerations for proteomic discovery in Sickle Cell disease and other hemolytic processes

Williams, L. M., Fu, Z., Dulloor, P., Yen, T., Barron-Casella, E., Savage, W., Van Eyk, J. E., Casella, J. F. & Everett, A., Dec 2010, In: Proteomics - Clinical Applications. 4, 12, p. 926-930 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

2007

The role of peroxisomal ABC transporters in the mouse adrenal gland: The loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage

Lu, J. F., Barron-Casella, E., Deering, R., Heinzer, A. K., Moser, A. B., DeMesy Bentley, K. L., Wand, G. S., McGuinness, M. C., Pei, Z., Watkins, P. A., Pujol, A., Smith, K. D. & Powers, J. M., Mar 2007, In: Laboratory Investigation. 87, 3, p. 261-272 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

1999

Construction of a human platelet alloantigen-1a epitope(s) within murine glycoprotein IIIa: Identification of residues critical to the conformation of the antibody binding site(s)

Barron-Casella, E. A., Nebbia, G., Rogers, O. C., King, K. E., Kickler, T. S. & Casella, J. F., May 1 1999, In: Blood. 93, 9, p. 2959-2967 9 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

1998

Identification of a human heavy chain antibody fragment directed against human platelet alloantigen 1a by phage display library

Okamoto, N., Kennedy, S. D., Barron-Casella, E. A., Casella, J. F., Inoko, H. & Kickler, T. S., 1998, In: Tissue Antigens. 51, 2, p. 156-163 8 p.

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

1996

Cap Z, a calcium insensitive capping protein in resting and activated platelets

Nachmias, V. T., Golla, R., Casella, J. F. & Barron-Casella, E., Jan 15 1996, In: FEBS Letters. 378, 3, p. 258-262 5 p.

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

1995

Quantitation of cap Z in conventional actin preparations and methods for further purification of actin

Casella, J. F., Barron‐Casella, E. A. & Torres, M. A., 1995, In: Cell Motility and the Cytoskeleton. 30, 2, p. 164-170 7 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Sequence analysis and chromosomal localization of human Cap Z: Conserved residues within the actin-binding domain may link Cap Z to gelsolin/severin and profilin protein families

Barron-Casella, E. A., Torres, M. A., Scherer, S. W., Heng, H. H. Q., Tsui, L. C. & Casella, J. F., Sep 15 1995, In: Journal of Biological Chemistry. 270, 37, p. 21472-21479 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

1994

Expression and purification of functional recombinant epitopes for the platelet antigens, Pl^A1 and Pl^A2

Barron-Casella, E. A., Kickler, T. S., Rogers, O. C. & Casella, J. F., Aug 15 1994, In: Blood. 84, 4, p. 1157-1163 7 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

1992

Conservation of the mammalian RNA polymerase II largest-subunit C-terminal domain

Barron-Casella, E. & Corden, J. L., Nov 1992, In: Journal of Molecular Evolution. 35, 5, p. 405-410 6 p.

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

1989

DNA recognition element required for PUF-I mediated cell-type-specific transcription of the rat prolactin gene

Sharp, Z. D., Helsel, S., Cao, Z., Barron, E. A. & Sanchez, Y., Apr 11 1989, In: Nucleic acids research. 17, 7, p. 2705-2722 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Dual functions of a cis-acting element within the rat prolactin gene promoter

Barron, E. A., Cao, Z., Schneider, B. G., Kraig, E., Carrillo, A. J. & Sharp, Z. D., 1989, In: Molecular and cellular biology. 9, 2, p. 817-819 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

1988

Prolactin upstream factor I mediates cell-specific transcription

Cao, Z., Barron, E. A. & Sharp, Z. D., 1988, In: Molecular and cellular biology. 8, 12, p. 5432-5438 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

1987

Reconstitution of cell-type-specific transcription of the rat prolactin gene in vitro.

Cao, Z. D., Barron, E. A., Carillo, A. J. & Sharp, Z. D., Oct 1987, In: Molecular and cellular biology. 7, 10, p. 3402-3408 7 p.

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

1982

Localization of sialic acid at the surface of embryonic myocardial cells

Barron, E. A., Markwald, R. R. & Nathan, R. D., Jul 1982, In: Journal of Molecular and Cellular Cardiology. 14, 7, p. 381-395 15 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

1980

Puromycin resistance in Chinese hamster cells: Genetic and biochemical studies of partially resistant, unstable clones

Morrow, J., Sammons, D. & Barron, E., Feb 1980, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 69, 2, p. 333-346 14 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

1978

Spontaneous mutation rate to thioguanine resistance is decreased in polyploid hamster cells

Morrow, J., Stocco, D. & Barron, E., Jul 1978, In: Journal of Cellular Physiology. 96, 1, p. 81-85 5 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

1977

Intermediate levels of resistance to puromycin in Chinese hamster cells

Morrow, J., Sammons, D., Stocco, D. & Barron, E., 1977, In: Journal of Cell Biology. 75, 2 II, p. 378A

Research output: Contribution to journal › Article › peer-review

Emily Barron-Casella

Research output

Search results