Betsy Luczak

2023

An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor

Reyes Gaido, O. E., Pavlaki, N., Granger, J. M., Mesubi, O. O., Liu, B., Lin, B. L., Long, A., Walker, D., Mayourian, J., Schole, K. L., Terrillion, C. E., Nkashama, L. J., Hulsurkar, M. M., Dorn, L. E., Ferrero, K. M., Huganir, R. L., Müller, F. U., Wehrens, X. H. T., Liu, J. O., Luczak, E. D., & 2 othersBezzerides, V. J. & Anderson, M. E., 2023, In: Science translational medicine. 15, 701, eabq7839.

Research output: Contribution to journal › Article › peer-review

CaMKII as a Therapeutic Target in Cardiovascular Disease

Reyes Gaido, O. E., Nkashama, L. J., Schole, K. L., Wang, Q., Umapathi, P., Mesubi, O. O., Konstantinidis, K., Luczak, E. D. & Anderson, M. E., Jan 20 2023, In: Annual Review of Pharmacology and Toxicology. 63, p. 249-272 24 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Oxidative stress–induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain

Rocco-Machado, N., Lai, L., Kim, G., He, Y., Luczak, E. D., Anderson, M. E. & Levine, R. L., Nov 2022, In: Journal of Biological Chemistry. 298, 11, 102579.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death

Umapathi, P., Mesubi, O. O., Banerjee, P. S., Abrol, N., Wang, Q., Luczak, E. D., Wu, Y., Granger, J. M., Wei, A. C., Reyes Gaido, O. E., Florea, L., Talbot, C. C., Hart, G. W., Zachara, N. E. & Anderson, M. E., Apr 27 2021, In: Circulation. 143, 17, p. 1687-1703 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms

Mesubi, O. O., Rokita, A. G., Abrol, N., Wu, Y., Chen, B., Wang, Q., Granger, J. M., Tucker-Bartley, A., Luczak, E. D., Murphy, K. R., Umapathi, P., Banerjee, P. S., Boronina, T. N., Cole, R. N., Maier, L. S., Wehrens, X. H., Pomerantz, J. L., Song, L. S., Ahima, R. S., Hart, G. W., & 2 othersZachara, N. E. & Anderson, M. E., Jan 19 2021, In: Journal of Clinical Investigation. 131, 2, e95747.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2020

CaMKII exacerbates heart failure progression by activating class I HDACs

Zhang, M., Yang, X., Zimmerman, R. J., Wang, Q., Ross, M. A., Granger, J. M., Luczak, E. D., Bedja, D., Jiang, H. & Feng, N., Dec 2020, In: Journal of Molecular and Cellular Cardiology. 149, p. 73-81 9 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII

Konstantinidis, K., Bezzerides, V. J., Lai, L., Isbell, H. M., Wei, A. C., Wu, Y., Viswanathan, M. C., Blum, I. D., Granger, J. M., Heims-Waldron, D., Zhang, D., Luczak, E. D., Murphy, K. R., Lu, F., Gratz, D. H., Manta, B., Wang, Q., Wang, Q., Kolodkin, A. L., Gladyshev, V. N., & 8 othersHund, T. J., Pu, W. T., Wu, M. N., Cammarato, A., Bianchet, M. A., Shea, M. A., Levine, R. L. & Anderson, M. E., Sep 1 2020, In: Journal of Clinical Investigation. 130, 9, p. 4663-4678 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

Luczak, E. D., Wu, Y., Granger, J. M., Joiner, M. L. A., Wilson, N. R., Gupta, A., Umapathi, P., Murphy, K. R., Reyes Gaido, O. E., Sabet, A., Corradini, E., Tseng, W. W., Wang, Y., Heck, A. J. R., Wei, A. C., Weiss, R. G. & Anderson, M. E., Dec 1 2020, In: Nature communications. 11, 1, 4416.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

2017

Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy

Luckey, S. W., Haines, C. D., Konhilas, J. P., Luczak, E. D., Messmer-Kratzsch, A. & Leinwand, L. A., Dec 1 2017, In: Experimental Biology and Medicine. 242, 18, p. 1820-1830 11 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Oxidized CaMKII promotes asthma through the activation of mast cells

Qu, J., Do, D. C., Zhou, Y., Luczak, E., Mitzner, W., Anderson, M. E. & Gao, P., Jan 12 2017, In: Journal of Clinical Investigation. 2, 1, e90139.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2015

Diet and sex modify exercise and cardiac adaptation in the mouse

Konhilas, J. P., Chen, H., Luczak, E., McKee, L. A., Regan, J., Watson, P. A., Stauffer, B. L., Khalpey, Z. I., McKinsey, T. A., Horn, T., LaFleur, B. & Leinwand, L. A., 2015, In: American Journal of Physiology - Heart and Circulatory Physiology. 308, 1, p. H135-H145

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Erratum: The mitochondrial uniporter controls fight or flight heart rate increases (Nature Communications (2015) 6 (6081)) doi: 10.1038/ncomms7081)

Wu, Y., Rasmussen, T. P., Koval, O. M., Joiner, M. L. A., Hall, D. D., Chen, B., Luczak, E. D., Wang, Q., Rokita, A. G., Wehrens, X. H. T., Song, L. S. & Anderson, M., Jun 3 2015, In: Nature communications. 6, 7241.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart

Rasmussen, T. P., Wu, Y., Joiner, M. L. A., Koval, O. M., Wilson, N. R., Luczak, E. D., Wang, Q., Chen, B., Gao, Z., Zhu, Z., Wagnerd, B. A., Soto, J., McCormick, M. L., Kutschke, W., Weiss, R. M., Yu, L., Boudreau, R. L., Abel, E. D., Zhan, F., Spitz, D. R., & 4 othersBuettner, G. R., Song, L. S., Zingmanb, L. V. & Anderson, M. E., Jul 21 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 29, p. 9129-9134 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

91 Scopus citations

The mitochondrial uniporter controls fight or flight heart rate increases

Wu, Y., Rasmussen, T. P., Koval, O. M., Joiner, M. L. A., Hall, D. D., Chen, B., Luczak, E. D., Wang, Q., Rokita, A. G., Wehrens, X. H. T., Song, L. S. & Anderson, M. E., Jan 20 2015, In: Nature communications. 6, 6081.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

2014

CaMKII oxidative activation and the pathogenesis of cardiac disease

Luczak, E. D. & Anderson, M. E., Aug 2014, In: Journal of Molecular and Cellular Cardiology. 73, p. 112-116 5 p.

Research output: Contribution to journal › Review article › peer-review

80 Scopus citations

Joiner et al. reply

Joiner, M. L. A., Koval, O. M., Li, J., He, B. J., Allamargot, C., Gao, Z., Luczak, E. D., Hall, D. D., Fink, B. D., Chen, B., Yang, J., Moore, S. A., Scholz, T. D., Strack, S., Mohler, P. J., Sivitz, W. I., Song, L. S. & Anderson, M. E., Sep 25 2014, In: Nature. 513, 7519, p. E3

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Oxidative activation of the Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) regulates vascular smooth muscle migration and apoptosis

Zhu, L. J., Klutho, P. J., Scott, J. A., Xie, L., Luczak, E. D., Dibbern, M. E., Prasad, A. M., Jaffer, O. A., Venema, A. N., Nguyen, E. K., Guan, X., Anderson, M. E. & Grumbach, I. M., Feb 2014, In: Vascular Pharmacology. 60, 2, p. 75-83 9 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2013

Asthma: CaMKII is essential for the proasthmatic effects of oxidation

Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., Hayden, P. J., Luczak, E. D., Dickey, D. D., Allamargot, C., Olivier, A. K., Meyerholz, D. K., Robison, A. J., Winder, D. G., Blackwell, T. S., Dworski, R., Sammut, D., Wagner, B. A., Buettner, G. R., Pope, R. M., & 9 othersMiller, F. J., Dibbern, M. E., Haitchi, H. M., Mohler, P. J., Howarth, P. H., Zabner, J., Kline, J. N., Grumbach, I. M. & Anderson, M. E., Jul 24 2013, In: Science translational medicine. 5, 195, 195ra97.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

Diabetes increases mortality after myocardial infarction by oxidizing CaMKII

Luo, M., Guan, X., Luczak, E. D., Lang, D., Kutschke, W., Gao, Z., Yang, J., Glynn, P., Sossalla, S., Swaminathan, P. D., Weiss, R. M., Yang, B., Rokita, A. G., Maier, L. S., Efimov, I. R., Hund, T. J. & Anderson, M. E., Mar 1 2013, In: Journal of Clinical Investigation. 123, 3, p. 1262-1274 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

160 Scopus citations

Erratum: Diabetes increases mortality after myocardial infarction by oxidizing CaMKII (Journal of Clinical Investigation (2013) 123:5 (2333) 10.1172/JCI70180)

Luo, M., Guan, X., Luczak, E. D., Lang, D., Kutschke, W., Gao, Z., Yang, J., Glynn, P., Sossalla, S., Swaminathan, P. D., Weiss, R. M., Yang, B., Rokita, A. G., Maier, L. S., Efimov, I. R., Hund, T. J. & Anderson, M. E., May 1 2013, In: Journal of Clinical Investigation. 123, 5, p. 2333 1 p.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Oxidized Ca²⁺/Calmodulin-Dependent Protein Kinase II Triggers Atrial Fibrillation

Purohit, A., Rokita, A. G., Guan, X., Chen, B., Koval, O. M., Voigt, N., Neef, S., Sowa, T., Gao, Z., Luczak, E. D., Stefansdottir, H., Behunin, A. C., Li, N., El-Accaoui, R. N., Yang, B., Swaminathan, P. D., Weiss, R. M., Wehrens, X. H. T., Song, L. S., Dobrev, D., & 2 othersMaier, L. S. & Anderson, M. E., Oct 15 2013, In: Circulation. 128, 16, p. 1748-1757 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

162 Scopus citations

Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II

Sierra, A., Zhu, Z., Sapay, N., Sharotri, V., Kline, C. F., Luczak, E. D., Subbotina, E., Sivaprasadarao, A., Snyder, P. M., Mohler, P. J., Anderson, M. E., Vivaudou, M., Zingman, L. V. & Hodgson-Zingman, D. M., Jan 18 2013, In: Journal of Biological Chemistry. 288, 3, p. 1568-1581 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The Multifunctional Ca²⁺/Calmodulin-Dependent Kinase IIδ (CaMKIIδ) Regulates Arteriogenesis in a Mouse Model of Flow-Mediated Remodeling

Scott, J. A., Klutho, P. J., El Accaoui, R., Nguyen, E., Venema, A. N., Xie, L., Jiang, S., Dibbern, M., Scroggins, S., Prasad, A. M., Luczak, E. D., Davis, M. K., Li, W., Guan, X., Backs, J., Schlueter, A. J., Weiss, R. M., Miller, F. J., Anderson, M. E. & Grumbach, I. M., Aug 8 2013, In: PloS one. 8, 8, e71550.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2012

CaMKII determines mitochondrial stress responses in heart

Joiner, M. L. A., Koval, O. M., Li, J., Julie He, B., Allamargot, C., Gao, Z., Luczak, E. D., Hall, D. D., Fink, B. D., Chen, B., Yang, J., Moore, S. A., Scholz, T. D., Strack, S., Mohler, P. J., Sivitz, W. I., Song, L. S. & Anderson, M. E., Nov 8 2012, In: Nature. 491, 7423, p. 269-273 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

252 Scopus citations

CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban

Wu, Y., Luczak, E. D., Lee, E. J., Hidalgo, C., Yang, J., Gao, Z., Li, J., H.T. Wehrens, X., Granzier, H. & Anderson, M. E., Sep 2012, In: Journal of Molecular and Cellular Cardiology. 53, 3, p. 429-436 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease

Haines, C. D., Harvey, P. A., Luczak, E. D., Barthel, K. K. B., Konhilas, J. P., Watson, P. A., Stauffer, B. L. & Leinwand, L. A., Sep 1 2012, In: Endocrinology. 153, 9, p. 4470-4479 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction

Singh, M. V., Swaminathan, P. D., Luczak, E. D., Kutschke, W., Weiss, R. M. & Anderson, M. E., May 2012, In: Journal of Molecular and Cellular Cardiology. 52, 5, p. 1135-1144 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

76 Scopus citations

2011

Catecholamine-independent heart rate increases require Ca ²⁺/calmodulin-dependent protein kinase II

Gao, Z., Singh, M. V., Hall, D. D., Koval, O. M., Luczak, E. D., Joiner, M. L. A., Chen, B., Wu, Y., Chaudhary, A. K., Martins, J. B., Hund, T. J., Mohler, P. J., Song, L. S. & Anderson, M. E., Jun 2011, In: Circulation: Arrhythmia and Electrophysiology. 4, 3, p. 379-387 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone

He, B. J., Joiner, M. L. A., Singh, M. V., Luczak, E. D., Swaminathan, P. D., Koval, O. M., Kutschke, W., Allamargot, C., Yang, J., Guan, X., Zimmerman, K., Grumbach, I. M., Weiss, R. M., Spitz, D. R., Sigmund, C. D., Blankesteijn, W. M., Heymans, S., Mohler, P. J. & Anderson, M. E., Dec 2011, In: Nature medicine. 17, 12, p. 1610-1618 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

157 Scopus citations

Oxidized CaMKII causes cardiac sinus node dysfunction in mice

Swaminathan, P. D., Purohit, A., Soni, S., Voigt, N., Singh, M. V., Glukhov, A. V., Gao, Z., He, B. J., Luczak, E. D., Joiner, M. L. A., Kutschke, W., Yang, J., Donahue, J. K., Weiss, R. M., Grumbach, I. M., Ogawa, M., Chen, P. S., Efimov, I., Dobrev, D., Mohler, P. J., & 2 othersHund, T. J. & Anderson, M. E., Aug 1 2011, In: Journal of Clinical Investigation. 121, 8, p. 3277-3288 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

142 Scopus citations

Remodeling the cardiac transcriptional landscape with diet

Luczak, E. D., Barthel, K. K. B., Stauffer, B. L., Konhilas, J. P., Cheung, T. H. & Leinwand, L. A., Jun 2011, In: Physiological Genomics. 43, 12, p. 772-780 9 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2010

Ca_V1.2 β-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizations

Koval, O. M., Guan, X., Wu, Y., Joiner, M. L., Gao, Z., Chen, B., Grumbach, I. M., Luczak, E. D., Colbran, R. J., Song, L. S., Hund, T. J., Mohler, P. J. & Anderson, M. E., Mar 16 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4996-5000 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

98 Scopus citations

2009

Sex-based cardiac physiology

Luczak, E. D. & Leinwand, L. A., Mar 2009, In: Annual review of physiology. 71, p. 1-18 18 p.

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

2006

Soy diet worsens heart disease in mice

Stauffer, B. L., Konhilas, J. P., Luczak, E. D. & Leinwand, L. A., Jan 2006, In: Journal of Clinical Investigation. 116, 1, p. 209-216 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Betsy Luczak

Research output

Search results