Research output per year
Research output per year
Search results
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2025
Structure of transmembrane AMPA receptor regulatory protein subunit γ2
Hale, W. D., Romero, A. M., Koylass, N., Warrick, C. R., Qiu, Z., Huganir, R. L. & Twomey, E. C., Dec 2025, In: Nature communications. 16, 1, 671.Research output: Contribution to journal › Article › peer-review
Open Access -
2024
Allosteric competition and inhibition in AMPA receptors
Hale, W. D., Montaño Romero, A., Gonzalez, C. U., Jayaraman, V., Lau, A. Y., Huganir, R. L. & Twomey, E. C., Nov 2024, In: Nature Structural and Molecular Biology. 31, 11, p. 1669-1679 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
C-SPAM: an open-source time-resolved specimen vitrification device with light-activated molecules
Montaño Romero, A., Bonin, C. & Twomey, E. C., Dec 14 2023, In: IUCrJ. 11, Pt 1, p. 16-22 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Aboard the ISS: intersubunit signaling revealed in the p97 ATPase
Twomey, E. C., Jul 2021, In: Nature Structural and Molecular Biology. 28, 7, p. 538-539 2 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Structural and functional insights into transmembrane AMPA receptor regulatory protein complexes
Twomey, E. C., Yelshanskaya, M. V. & Sobolevsky, A. I., Dec 2 2019, In: Journal of General Physiology. 151, 12, p. 1347-1356 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access4 Scopus citations -
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
Twomey, E. C., Ji, Z., Wales, T. E., Bodnar, N. O., Ficarro, S. B., Marto, J. A., Engen, J. R. & Rapoport, T. A., Aug 2 2019, In: Science. 365, 6452, eaax1033.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
2018
Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6
Singh, A. K., McGoldrick, L. L., Twomey, E. C. & Sobolevsky, A. I., Aug 15 2018, In: Science Advances. 4, 8, eaau6088.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors
Twomey, E. C., Yelshanskaya, M. V., Vassilevski, A. A. & Sobolevsky, A. I., Sep 5 2018, In: Neuron. 99, 5, p. 956-968.e4Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Opening of the human epithelial calcium channel TRPV6
McGoldrick, L. L., Singh, A. K., Saotome, K., Yelshanskaya, M. V., Twomey, E. C., Grassucci, R. A. & Sobolevsky, A. I., Jan 11 2018, In: Nature. 553, 7687, p. 233-237 5 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations -
Structural Mechanisms of Gating in Ionotropic Glutamate Receptors
Twomey, E. C. & Sobolevsky, A. I., Jan 23 2018, In: Biochemistry. 57, 3, p. 267-276 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access34 Scopus citations -
2017
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
Twomey, E. C., Yelshanskaya, M. V., Grassucci, R. A., Frank, J. & Sobolevsky, A. I., Sep 7 2017, In: Nature. 549, 7670, p. 60-65 6 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations -
Structural Bases of Desensitization in AMPA Receptor-Auxiliary Subunit Complexes
Twomey, E. C., Yelshanskaya, M. V., Grassucci, R. A., Frank, J. & Sobolevsky, A. I., May 3 2017, In: Neuron. 94, 3, p. 569-580.e5Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2016
Elucidation of AMPA receptor-stargazin complexes by cryo-electron microscopy
Twomey, E. C., Yelshanskaya, M. V., Grassucci, R. A., Frank, J. & Sobolevsky, A. I., Jul 1 2016, In: Science. 353, 6294, p. 83-86 4 p.Research output: Contribution to journal › Article › peer-review
Open Access73 Scopus citations -
2014
Characterization of temperature-sensing and PIP2-regulation of TRPV1 ion channel at the C-terminal domain using NMR spectroscopy and molecular dynamics simulations
Raymond, K. A., Twomey, E. C. & Wei, Y., Dec 2014, In: Journal of Integrated OMICS. 4, 2, p. 79-86 8 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
NMR spectroscopic characterization of death domain superfamily proteins: Structures, dynamics and interactions
Wei, Y. & Twomey, E. C., Jan 1 2014, Nuclear Magnetic Resonance (NMR): Theory, Applications and Technology. Nova Science Publishers, Inc., p. 83-110 28 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
1 Scopus citations -
2013
Substantial conformational change mediated by charge-triad residues of the death effector domain in protein-protein interactions
Twomey, E. C., Cordasco, D. F., Kozuch, S. D. & Wei, Y., Dec 31 2013, In: PloS one. 8, 12, e83421.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2012
High-definition NMR structure of PED/PEA-15 death effector domain reveals details of key polar side chain interactions
Twomey, E. C. & Wei, Y., Jul 20 2012, In: Biochemical and Biophysical Research Communications. 424, 1, p. 141-146 6 p.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
Profound conformational changes of PED/PEA-15 in ERK2 complex revealed by NMR backbone dynamics
Twomey, E. C., Cordasco, D. F. & Wei, Y., Dec 2012, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1824, 12, p. 1382-1393 12 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations