Dwight Bergles

2024

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K⁺ and maintains axonal health

Looser, Z. J., Faik, Z., Ravotto, L., Zanker, H. S., Jung, R. B., Werner, H. B., Ruhwedel, T., Möbius, W., Bergles, D. E., Barros, L. F., Nave, K. A., Weber, B. & Saab, A. S., 2024, (Accepted/In press) In: Nature neuroscience.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Cross-modality supervised image restoration enables nanoscale tracking of synaptic plasticity in living mice

Xu, Y. K. T., Graves, A. R., Coste, G. I., Huganir, R. L., Bergles, D. E., Charles, A. S. & Sulam, J., Jun 2023, In: Nature Methods. 20, 6, p. 935-944 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Loss of Astrocytic µ Opioid Receptors Exacerbates Aversion Associated with Morphine Withdrawal in Mice: Role of Mitochondrial Respiration

Murlanova, K., Jouroukhin, Y., Novototskaya-Vlasova, K., Huseynov, S., Pletnikova, O., Morales, M. J., Guan, Y., Kamiya, A., Bergles, D. E., Dietz, D. M. & Pletnikov, M. V., May 2023, In: Cells. 12, 10, 1412.

Research output: Contribution to journal › Article › peer-review

Open Access

MHC class i and MHC class ii reporter mice enable analysis of immune oligodendroglia in mouse models of multiple sclerosis

Harrington, E. P., Catenacci, R. B., Smith, M. D., Heo, D., Miller, C. E., Meyers, K. R., Glatzer, J., Bergles, D. E. & Calabresi, P. A., Apr 2023, In: eLife. 12, e82938.

Research output: Contribution to journal › Article › peer-review

Open Access

Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice

Lu, T. Y., Hanumaihgari, P., Hsu, E. T., Agarwal, A., Kawaguchi, R., Calabresi, P. A. & Bergles, D. E., Oct 2023, In: Nature neuroscience. 26, 10, p. 1739-1750 12 p.

Research output: Contribution to journal › Article › peer-review

Preservation of developmental spontaneous activity enables early auditory system maturation in deaf mice

Kersbergen, C. J., Babola, T. A., Kanold, P. O. & Bergles, D. E., Jun 2023, In: PLoS biology. 21, 6 June, e3002160.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Cell-specific regulation of gene expression using splicing-dependent frameshifting

Ling, J. P., Bygrave, A. M., Santiago, C. P., Carmen-Orozco, R. P., Trinh, V. T., Yu, M., Li, Y., Liu, Y., Bowden, K. D., Duncan, L. H., Han, J., Taneja, K., Dongmo, R., Babola, T. A., Parker, P., Jiang, L., Leavey, P. J., Smith, J. J., Vistein, R., Gimmen, M. Y., & 16 othersDubner, B., Helmenstine, E., Teodorescu, P., Karantanos, T., Ghiaur, G., Kanold, P. O., Bergles, D., Langmead, B., Sun, S., Nielsen, K. J., Peachey, N., Singh, M. S., Dalton, W. B., Rajaii, F., Huganir, R. L. & Blackshaw, S., Dec 2022, In: Nature communications. 13, 1, 5773.

Research output: Contribution to journal › Article › peer-review

Open Access

Deep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice

Guan, H., Li, D., Park, H. C., Li, A., Yue, Y., Gau, Y. A., Li, M. J., Bergles, D. E., Lu, H. & Li, X., Dec 2022, In: Nature communications. 13, 1, 1534.

Research output: Contribution to journal › Article › peer-review

Open Access

Deficient mitochondrial respiration in astrocytes impairs trace fear conditioning and increases naloxone-precipitated aversion in morphine-dependent mice

Murlanova, K., Jouroukhin, Y., Huseynov, S., Pletnikova, O., Morales, M. J., Guan, Y., Baraban, J. M., Bergles, D. E. & Pletnikov, M. V., Jul 2022, In: Glia. 70, 7, p. 1289-1300 12 p.

Research output: Contribution to journal › Article › peer-review

Developmental spontaneous activity promotes formation of sensory domains, frequency tuning and proper gain in central auditory circuits

Kersbergen, C. J., Babola, T. A., Rock, J. & Bergles, D. E., Nov 15 2022, In: Cell Reports. 41, 7, 111649.

Research output: Contribution to journal › Article › peer-review

Open Access

Olig2 Ablation in Immature Oligodendrocytes Does Not Enhance CNS Myelination and Remyelination

Wang, J., Yang, L., Jiang, M., Zhao, C., Liu, X., Berry, K., Waisman, A., Langseth, A. J., Novitch, B. G., Bergles, D. E., Nishiyama, A. & Lu, Q. R., Nov 9 2022, In: Journal of Neuroscience. 42, 45, p. 8542-8555 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Oligodendrocyte precursor cells ingest axons in the mouse neocortex

Buchanan, J. A., Elabbady, L., Collman, F., Jorstad, N. L., Bakken, T. E., Ott, C., Glatzer, J., Bleckert, A. A., Bodor, A. L., Brittain, D., Bumbarger, D. J., Mahalingam, G., Seshamani, S., Schneider-Mizell, C., Takeno, M. M., Torres, R., Yin, W., Hodge, R. D., Castro, M., Dorkenwald, S., & 22 othersIh, D., Jordan, C. S., Kemnitz, N., Lee, K., Lu, R., Macrina, T., Mu, S., Popovych, S., Silversmith, W. M., Tartavull, I., Turner, N. L., Wilson, A. M., Wong, W., Wu, J., Zlateski, A., Zung, J., Lippincott-Schwartz, J., Lein, E. S., Seung, H. S., Bergles, D. E., Reid, R. C. & da Costa, N. M., Nov 29 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, e2202580119.

Research output: Contribution to journal › Article › peer-review

Open Access

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

Heo, D., Ling, J. P., Molina-Castro, G. C., Langseth, A. J., Waisman, A., Nave, K. A., Möbius, W., Wong, P. C. & Bergles, D. E., Mar 2022, In: eLife. 11, e75230.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Automated in vivo Tracking of Cortical Oligodendrocytes

Xu, Y. K. T., Call, C. L., Sulam, J. & Bergles, D. E., Apr 12 2021, In: Frontiers in Cellular Neuroscience. 15, 667595.

Research output: Contribution to journal › Article › peer-review

Open Access

Cortical neurons exhibit diverse myelination patterns that scale between mouse brain regions and regenerate after demyelination

Call, C. L. & Bergles, D. E., Dec 1 2021, In: Nature communications. 12, 1, 4767.

Research output: Contribution to journal › Article › peer-review

Open Access

Dual metabotropic glutamate receptor signaling enables coordination of astrocyte and neuron activity in developing sensory domains

Kellner, V., Kersbergen, C. J., Li, S., Babola, T. A., Saher, G. & Bergles, D. E., Aug 18 2021, In: Neuron. 109, 16, p. 2545-2555.e7

Research output: Contribution to journal › Article › peer-review

Open Access

GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration

Khawaja, R. R., Agarwal, A., Fukaya, M., Jeong, H. K., Gross, S., Gonzalez-Fernandez, E., Soboloff, J., Bergles, D. E. & Kang, S. H., May 18 2021, In: Cell Reports. 35, 7, 109147.

Research output: Contribution to journal › Article › peer-review

Open Access

MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration

Philips, T., Mironova, Y. A., Jouroukhin, Y., Chew, J., Vidensky, S., Farah, M. H., Pletnikov, M. V., Bergles, D. E., Morrison, B. M. & Rothstein, J. D., Jan 12 2021, In: Cell Reports. 34, 2, 108610.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Multicolor fiber-optic two-photon endomicroscopy for brain imaging

Guan, H., Liang, W., Li, A., Gau, Y. T. A., Chen, D., Li, M. J., Bergles, D. E. & Li, X., Mar 1 2021, In: Optics Letters. 46, 5, p. 1093-1096 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Purinergic signaling controls spontaneous activity in the auditory system throughout early development

Babola, T. A., Li, S., Wang, Z., Kersbergen, C. J., Elgoyhen, A. B., Coate, T. M. & Bergles, D. E., Jan 27 2021, In: Journal of Neuroscience. 41, 4, p. 594-612 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2020

Changes in the oligodendrocyte progenitor cell proteome with ageing

de la Fuente, A. G., Queiroz, R. M. L., Ghosh, T., McMurran, C. E., Cubillos, J. F., Bergles, D. E., Fitzgerald, D. C., Jones, C. A., Lilley, K. S., Glover, C. P. & Franklin, R. J. M., Aug 2020, In: Molecular and Cellular Proteomics. 19, 8, p. 1281-1302 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release

Ye, L., Orynbayev, M., Zhu, X., Lim, E. Y., Dereddi, R. R., Agarwal, A., Bergles, D. E., Bhat, M. A. & Paukert, M., Dec 2020, In: Nature communications. 11, 1, 6157.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Inhibition of neutral sphingomyelinase 2 promotes remyelination

Yoo, S. W., Agarwal, A., Smith, M. D., Khuder, S. S., Baxi, E. G., Thomas, A. G., Rojas, C., Moniruzzaman, M., Slusher, B. S., Bergles, D. E., Calabresi, P. A. & Haughey, N. J., Sep 30 2020, In: Science Advances. 6, 40, eaba5210.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Persistent CyFIP1 expression is required to maintain the adult subventricular zone neurogenic niche

Habela, C. W., Yoon, K. J., Kim, N. S., Taga, A., Bell, K., Bergles, D. E., Maragakis, N. J., Ming, G. L. & Song, H., Mar 4 2020, In: Journal of Neuroscience. 40, 10, p. 2015-2024 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space

Babola, T. A., Kersbergen, C. J., Wang, H. C. & Bergles, D. E., Jan 2020, In: eLife. 9, e52160.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

Remyelination alters the pattern of myelin in the cerebral cortex

Orthmann-Murphy, J., Call, C. L., Molina-Castro, G. C., Hsieh, Y. C., Rasband, M. N., Calabresi, P. A. & Bergles, D. E., May 2020, In: eLife. 9, p. 1-61 61 p., e56621.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Throughput-Speed Product Augmentation for Scanning Fiber-Optic Two-Photon Endomicroscopy

Liang, W., Park, H. C., Li, K., Li, A., Chen, D., Guan, H., Yue, Y., Gau, Y. T. A., Bergles, D. E., Li, M. J., Lu, H. & Li, X., Dec 2020, In: IEEE transactions on medical imaging. 39, 12, p. 3779-3787 9 p., 9125994.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2019

Electrical and synaptic integration of glioma into neural circuits

Venkatesh, H. S., Morishita, W., Geraghty, A. C., Silverbush, D., Gillespie, S. M., Arzt, M., Tam, L. T., Espenel, C., Ponnuswami, A., Ni, L., Woo, P. J., Taylor, K. R., Agarwal, A., Regev, A., Brang, D., Vogel, H., Hervey-Jumper, S., Bergles, D. E., Suvà, M. L., Malenka, R. C., & 1 othersMonje, M., Sep 26 2019, In: Nature. 573, 7775, p. 539-545 7 p.

Research output: Contribution to journal › Article › peer-review

165 Scopus citations

Glutamatergic synaptic input to glioma cells drives brain tumour progression

Venkataramani, V., Tanev, D. I., Strahle, C., Studier-Fischer, A., Fankhauser, L., Kessler, T., Körber, C., Kardorff, M., Ratliff, M., Xie, R., Horstmann, H., Messer, M., Paik, S. P., Knabbe, J., Sahm, F., Kurz, F. T., Acikgöz, A. A., Herrmannsdörfer, F., Agarwal, A., Bergles, D. E., & 9 othersChalmers, A., Miletic, H., Turcan, S., Mawrin, C., Hänggi, D., Liu, H. K., Wick, W., Winkler, F. & Kuner, T., Sep 26 2019, In: Nature. 573, 7775, p. 532-538 7 p.

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

Miller, S. J., Philips, T., Kim, N., Dastgheyb, R., Chen, Z., Hsieh, Y. C., Daigle, J. G., Datta, M., Chew, J., Vidensky, S., Pham, J. T., Hughes, E. G., Robinson, M. B., Sattler, R., Tomer, R., Suk, J. S., Bergles, D. E., Haughey, N., Pletnikov, M., Hanes, J., & 1 othersRothstein, J. D., May 1 2019, In: Nature neuroscience. 22, 5, p. 741-752 12 p.

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination

Kirby, L., Jin, J., Cardona, J. G., Smith, M. D., Martin, K. A., Wang, J., Strasburger, H., Herbst, L., Alexis, M., Karnell, J., Davidson, T., Dutta, R., Goverman, J., Bergles, D. & Calabresi, P. A., Dec 1 2019, In: Nature communications. 10, 1, 3887.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Scopus citations

Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase

Xin, W., Mironova, Y. A., Shen, H., Marino, R. A. M., Waisman, A., Lamers, W. H., Bergles, D. E. & Bonci, A., May 21 2019, In: Cell Reports. 27, 8, p. 2262-2271.e5

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2018

Hair Cell Mechanotransduction Regulates Spontaneous Activity and Spiral Ganglion Subtype Specification in the Auditory System

Sun, S., Babola, T., Pregernig, G., So, K. S., Nguyen, M., Su, S. S. M., Palermo, A. T., Bergles, D. E., Burns, J. C. & Müller, U., Aug 23 2018, In: Cell. 174, 5, p. 1247-1263.e15

Research output: Contribution to journal › Article › peer-review

Open Access

75 Scopus citations

Homeostatic Control of Spontaneous Activity in the Developing Auditory System

Babola, T. A., Li, S., Gribizis, A., Lee, B. J., Issa, J. B., Wang, H. C., Crair, M. C. & Bergles, D. E., Aug 8 2018, In: Neuron. 99, 3, p. 511-524.e5

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

Hughes, E. G., Orthmann-Murphy, J. L., Langseth, A. J. & Bergles, D. E., May 1 2018, In: Nature neuroscience. 21, 5, p. 696-706 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

140 Scopus citations

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility

Larson, V. A., Mironova, Y., Vanderpool, K. G., Waisman, A., Rash, J. E., Agarwal, A. & Bergles, D. E., Mar 29 2018, In: eLife. 7, e34829.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

2017

Cell-Type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog

Langseth, A. J., Kim, J., Ugolino, J. E., Shah, Y., Hwang, H. Y., Wang, J., Bergles, D. E. & Brown, S. P., Dec 1 2017, In: Scientific reports. 7, 1, 5685.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

Changes in the excitability of neocortical neurons in a mouse model of amyotrophic lateral sclerosis are not specific to corticospinal neurons and are modulated by advancing disease

Kim, J., Hughes, E. G., Shetty, A. S., Arlotta, P., Goff, L. A., Bergles, D. E. & Brown, S. P., 2017, In: Journal of Neuroscience. 37, 37, p. 9037-9053 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Focus scanning with feedback-control for fiber-optic nonlinear endomicroscopy

Li, A., Liang, W., Guan, H., Gau, Y. T. A., Bergles, D. E. & Li, X., May 1 2017, In: Biomedical Optics Express. 8, 5, p. 2519-2527 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Image analysis of dynamic brain activity based on gray distance compensation

Wang, Y., Gau, YT. A., Le, H. N. D., Bergles, D. E. & Kang, J. U., Aug 19 2017, In: Applied Sciences (Switzerland). 7, 8, 858.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Lineage tracing reveals dynamic changes in oligodendrocyte precursor cells following cuprizone-induced demyelination

Baxi, E. G., DeBruin, J., Jin, J., Strasburger, H. J., Smith, M. D., Orthmann-Murphy, J. L., Schott, J. T., Fairchild, A. N., Bergles, D. E. & Calabresi, P. A., Dec 2017, In: Glia. 65, 12, p. 2087-2098 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

Myelinogenic plasticity of oligodendrocyte precursor cells following spinal cord contusion injury

Assinck, P., Duncan, G. J., Plemel, J. R., Lee, M. J., Stratton, J. A., Manesh, S. B., Liu, J., Ramer, L. M., Kang, S. H., Bergles, D. E., Biernaskie, J. & Tetzlaff, W., Sep 6 2017, In: Journal of Neuroscience. 37, 36, p. 8635-8654 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

58 Scopus citations

Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle

Wang, Q., Yue, W. W. S., Jiang, Z., Xue, T., Kang, S. H., Bergles, D. E., Mikoshiba, K., Offermanns, S. & Yau, K. W., Jun 19 2017, In: Current Biology. 27, 12, p. 1791-1800.e5

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

Agarwal, A., Wu, P. H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D. & Bergles, D. E., Feb 8 2017, In: Neuron. 93, 3, p. 587-605.e7

Research output: Contribution to journal › Article › peer-review

Open Access

147 Scopus citations

2016

Activity-dependent switch of gabaergic inhibition into glutamatergic excitation in astrocyte-neuron networks

Perea, G., Gómez, R., Mederos, S., Covelo, A., Ballesteros, J. J., Schlosser, L., Hernández-Vivanco, A., Martín-Fernández, M., Quintana, R., Rayan, A., Díez, A., Fuenzalida, M., Agarwal, A., Bergles, D. E., Bettler, B., Manahan-Vaughan, D., Martín, E. D., Kirchhoff, F. & Araque, A., Dec 24 2016, In: eLife. 5, DECEMBER2016, e20362.

Research output: Contribution to journal › Article › peer-review

Open Access

61 Scopus citations

Cell calcium signaling mediates capillary regulation of blood flow in the Retina

Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P. & Newman, E. A., Sep 7 2016, In: Journal of Neuroscience. 36, 36, p. 9435-9445 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

54 Scopus citations

Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Kim, Y. S., Anderson, M., Park, K., Zheng, Q., Agarwal, A., Gong, C., Saijilafu, Young, L. A., He, S., LaVinka, P. C., Zhou, F., Bergles, D., Hanani, M., Guan, Y., Spray, D. C. & Dong, X., Sep 7 2016, In: Neuron. 91, 5, p. 1085-1096 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

97 Scopus citations

Electrophysiological properties of NG2⁺ cells: Matching physiological studies with gene expression profiles

Larson, V. A., Zhang, Y. & Bergles, D. E., 2016, In: Brain research. 1638, p. 138-160 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

Ma, Z., Stork, T., Bergles, D. E. & Freeman, M. R., 2016, In: Nature. 539, 7629, p. 428-432 5 p.

Research output: Contribution to journal › Article › peer-review

94 Scopus citations

NMDA Receptors Enhance Spontaneous Activity and Promote Neuronal Survival in the Developing Cochlea

Zhang-Hooks, Y. X., Agarwal, A., Mishina, M. & Bergles, D. E., 2016, In: Neuron. 89, 2, p. 337-350 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Dwight Bergles

Research output

Search results