Donald MacGlashan

2025

Defining Optimal Basophil Passive Sensitisation Parameters

Alvarez-Arango, S., Dispenza, M. C., Chichester, K. L. & MacGlashan, D. W., Jan 2025, In: Clinical and Experimental Allergy. 55, 1, p. 75-83 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2024

A Skin Testing Strategy for Non–IgE-Mediated Reactions Associated With Vancomycin

Lyu, S., Oliver, E. T., Dispenza, M. C., Chichester, K., Hoffman, J., MacGlashan, D. W., Adkinson, N. F., Phillips, E. J. & Alvarez Arango, S., Nov 2024, In: Journal of Allergy and Clinical Immunology: In Practice. 12, 11, p. 3025-3033.e6

Research output: Contribution to journal › Article › peer-review

Peanut-specific IgG subclasses as biomarkers of peanut allergy in LEAP study participants

Baloh, C. H., Lim, N., Huffaker, M., Patel, P., Tversky, J., Du Toit, G., Lack, G., Laidlaw, T. M. & MacGlashan, D. W., Aug 2024, In: World Allergy Organization Journal. 17, 8, 100940.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A phase II study of Bruton’s tyrosine kinase inhibition for the prevention of anaphylaxis

Suresh, R. V., Dunnam, C., Vaidya, D., Wood, R. A., Bochner, B. S., MacGlashan, D. W. & Dispenza, M. C., Aug 15 2023, In: Journal of Clinical Investigation. 133, 16, e172335.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Biological screening of a unique drug library targeting MRGPRX2

Yang, F., Limjunyawong, N., Peng, Q., Schroeder, J. T., Saini, S., MacGlashan, D., Dong, X. & Gao, L., Oct 21 2022, In: Frontiers in immunology. 13, 997389.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Response of peripheral blood basophils in subjects with chronic spontaneous urticaria during treatment with omalizumab

MacGlashan, D., Saini, S. & Schroeder, J. T., Jun 2021, In: Journal of Allergy and Clinical Immunology. 147, 6, p. 2295-2304.e12

Research output: Contribution to journal › Article › peer-review

The efficacy of omalizumab treatment in chronic spontaneous urticaria is associated with basophil phenotypes

Johal, K. J., Chichester, K., Oliver, E. T., Devine, K. C., Bieneman, A. P., Schroeder, J. T., MacGlashan, D. W. & Saini, S. S., Jun 2021, In: Journal of Allergy and Clinical Immunology. 147, 6, p. 2271-2280.e8

Research output: Contribution to journal › Article › peer-review

Open Access

The relationship between released soluble FceRI-alpha and its cell surface density on human basophils

MacGlashan, D., Jan 2021, In: PloS one. 16, 1 January, e0245942.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Identifying regulatory pathways of spleen tyrosine kinase expression in human basophils

Peng, X., Zhao, M., Gao, L., Sen, R. & MacGlashan, D., Mar 2020, In: Journal of Allergy and Clinical Immunology. 145, 3, p. 947-957 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2019

Autoantibodies to IgE and FcεRI and the natural variability of spleen tyrosine kinase expression in basophils

MacGlashan, D., Mar 2019, In: Journal of Allergy and Clinical Immunology. 143, 3, p. 1100-1107.e11

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2018

Dependence of optimal histamine release on cell surface IgE density on human basophils: Nature of the stimulus

Nejad, A. S. & MacGlashan, D. W., Oct 1 2018, In: International archives of allergy and immunology. 177, 3, p. 181-191 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

2017

FceRI density and spontaneous secretion from human basophils

MacGlashan, D., Jul 2017, In: PloS one. 12, 7, e0179734.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Recovery from desensitization of IgE-dependent responses in human lung mast cells

Lewis, A., MacGlashan, D. W., Suvarna, S. K. & Peachell, P. T., Aug 2017, In: Clinical and Experimental Allergy. 47, 8, p. 1022-1031 10 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab

MacGlashan, D. W. & Saini, S. S., May 2017, In: Journal of Allergy and Clinical Immunology. 139, 5, p. 1680-1682.e10

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2016

Parameters determining the efficacy of CD32 to inhibit activation of FcϵRI in human basophils

MacGlashan, D. & Hamilton, R. G., Apr 1 2016, In: Journal of Allergy and Clinical Immunology. 137, 4, p. 1256-1258.e11

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Stability of syk protein and mRNA in human peripheral blood basophils

Macglashan, D., Sep 2016, In: Journal of Leukocyte Biology. 100, 3, p. 535-543 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2015

Expression profiling of human basophils: Modulation by cytokines and secretagogues

MacGlashan, D., May 11 2015, In: PloS one. 10, 5, e0126435.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2014

Regulation of IgE-mediated signalling in human basophils by CD32b and its role in Syk down-regulation

Macglashan, D., Moore, G. & Muchhal, U., May 2014, In: Clinical and Experimental Allergy. 44, 5, p. 713-723 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Relationship of IgE to basophil phenotypes in peanut-sensitized adults

McGowan, E. C., Savage, J. H., Courneya, J. P., Sterba, P. M., Parihar, S., Lin, J., Gimenez, G., Sampson, H. A., Schroeder, J., MacGlashan, D., Wood, R. A., Hamilton, R. G. & Saini, S., Sep 1 2014, In: The Journal of allergy and clinical immunology. 134, 3, p. 746-749.e6

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2013

Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation

Macglashan, D. W. & Saini, S. S., Oct 2013, In: Journal of Allergy and Clinical Immunology. 132, 4, p. 906-911.e4

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

2012

Development of a microarray-based method to detect exposure of human basophils to IL-3

MacGlashan, D., Nov 30 2012, In: Journal of Immunological Methods. 385, 1-2, p. 51-59 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Glycomic analysis of human mast cells, eosinophils and basophils

North, S. J., Von Gunten, S., Antonopoulos, A., Trollope, A., MacGlashan, D. W., Jang-Lee, J., Dell, A., Metcalfe, D. D., Kirshenbaum, A. S., Bochner, B. S. & Haslam, S. M., Jan 2012, In: Glycobiology. 22, 1, p. 12-22 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

Savage, J. H., Courneya, J. P., Sterba, P. M., Macglashan, D. W., Saini, S. S. & Wood, R. A., Nov 2012, In: Journal of Allergy and Clinical Immunology. 130, 5, p. 1123-1129e2

Research output: Contribution to journal › Article › peer-review

Open Access

106 Scopus citations

Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human Basophils

Macglashan, D., Oct 2012, In: International archives of allergy and immunology. 159, 3, p. 243-252 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

28 Scopus citations

Subthreshold desensitization of human basophils re-capitulates the loss of Syk and FcεRI expression characterized by other methods of desensitization

MacGlashan, J., Jul 2012, In: Clinical and Experimental Allergy. 42, 7, p. 1060-1070 11 p.

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Suppression of the basophil response to allergen during treatment with omalizumab is dependent on 2 competing factors

MacGlashan, D. W., Savage, J. H., Wood, R. A. & Saini, S. S., Nov 2012, In: Journal of Allergy and Clinical Immunology. 130, 5, p. 1130-1135e5

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

Surface plasmon resonance analysis of free IgE in allergic patients receiving omalizumab (Xolair)

Hamilton, R. G., Saini, S. S. & MacGlashan, D., Sep 28 2012, In: Journal of Immunological Methods. 383, 1-2, p. 54-59 6 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

2011

Cat allergen-induced blood basophil reactivity in vitro predicts acute human nasal allergen challenge responses in vivo

Paterniti, M., Kelly, D. C., Eckman, J. A., Sterba, P. M., Hamilton, R. G., Bochner, B. S., Macglashan, D. W. & Saini, S. S., Jul 2011, In: Clinical and Experimental Allergy. 41, 7, p. 963-969 7 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Characterization of syk expression in human lung mast cells: Relationship with function

Havard, S., Scola, A. M., Kay, L. J., Ishmael, S. S., MacGlashan, D. W. & Peachell, P. T., Mar 2011, In: Clinical and Experimental Allergy. 41, 3, p. 378-388 11 p.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

MacGlashan, D., Honigberg, L. A., Smith, A., Buggy, J. & Schroeder, J. T., Apr 2011, In: International immunopharmacology. 11, 4, p. 475-479 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

42 Scopus citations

2010

Effects of omalizumab on basophil and mast cell responses using an intranasal cat allergen challenge

Eckman, J. A., Sterba, P. M., Kelly, D., Alexander, V., Liu, M. C., Bochner, B. S., MacGlashan, D. W. & Saini, S. S., Apr 2010, In: Journal of Allergy and Clinical Immunology. 125, 4, p. 889-895.e7

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Expression of CD203c and CD63 in human basophils: Relationship to differential regulation of piecemeal and anaphylactic degranulation processes

MacGlashan, D., Sep 2010, In: Clinical and Experimental Allergy. 40, 9, p. 1365-1377 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

121 Scopus citations

IgE-dependent and IgE-independent stimulation of human basophils increases the presence of immature FcεRIα by reversing degradative pathways

Zaidi, A. K. & MacGlashan, D., Dec 2010, In: International archives of allergy and immunology. 154, 1, p. 15-24 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Regulation of FcεRI expression during murine basophil maturation: The interplay between IgE, cell division, and FcεRI synthetic rate

Zaidi, A. K. & MacGlashan, D. W., Feb 1 2010, In: Journal of Immunology. 184, 3, p. 1463-1474 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

Regulation of Syk kinase and FcRβ expression in human basophils during treatment with omalizumab

Zaidi, A. K., Saini, S. S. & MacGlashan, D. W., Apr 2010, In: Journal of Allergy and Clinical Immunology. 125, 4, p. 902-908.e7

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

Syk expression in peripheral blood leukocytes, CD34+ progenitors, and CD34-derived basophils

Ishmael, S. S. & MacGlashan, D. W., Feb 2010, In: Journal of Leukocyte Biology. 87, 2, p. 291-300 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

2009

Early signal protein expression profiles in basophils: A population study

Ishmael, S. & MacGlashan, D., Aug 1 2009, In: Journal of Leukocyte Biology. 86, 2, p. 313-325 13 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Expression of the high affinity IgE receptor by neutrophils of individuals with allergic asthma is both minimal and insensitive to regulation by serum IgE

Mora, J., Riggs, E. K., Fu, J., MacGlashan, D. W., Fox, S. A., Yu, B., Tobin, M. C. & Thomas, L. L., Jul 2009, In: Clinical Immunology. 132, 1, p. 132-140 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Polymerization of actin does not regulate desensitization in human basophils

MacGlashan, D. & Vilariño, N., Apr 1 2009, In: Journal of Leukocyte Biology. 85, 4, p. 627-637 11 p.

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

2008

A pH-stabilizing role of voltage-gated proton channels in IgE-mediated activation of human basophils

Musset, B., Morgan, D., Cherny, V. V., MacGlashan, D. W., Thomas, L. L., Ríos, E. & DeCoursey, T. E., Aug 5 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 31, p. 11020-11025 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

65 Scopus citations

Distinct characteristics of signal transduction events by histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced priming and activation of human basophils

Vonakis, B. M., MacGlashan, D. W., Vilariño, N., Langdon, J. M., Scott, R. S. & MacDonald, S. M., Feb 15 2008, In: Blood. 111, 4, p. 1789-1795 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs

Nassenstein, C., Kwong, K., Taylor-Clark, T., Kollarik, M., Macglashan, D. M., Braun, A. & Undem, B. J., Mar 15 2008, In: Journal of Physiology. 586, 6, p. 1595-1604 10 p.

Research output: Contribution to journal › Article › peer-review

218 Scopus citations

Induced loss of Syk in human basophils by non-IgE-dependent stimuli

MacGlashan, D. W., Ishmael, S., MacDonald, S. M., Langdon, J. M., Arm, J. P. & Sloane, D. E., Mar 15 2008, In: Journal of Immunology. 180, 6, p. 4208-4217 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Inducing an anergic state in mast cells and basophils without secretion

MacGlashan, D. & Undem, B. J., Jun 2008, In: Journal of Allergy and Clinical Immunology. 121, 6, p. 1500-1506.e4

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Inhibition of FcϵRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement

Yokoi, H., Choi, O. H., Hubbard, W., Lee, H. S., Canning, B. J., Lee, H. H., Ryu, S. D., von Gunten, S., Bickel, C. A., Hudson, S. A., MacGlashan, D. W. & Bochner, B. S., Feb 2008, In: Journal of Allergy and Clinical Immunology. 121, 2, p. 499-505.e1

Research output: Contribution to journal › Article › peer-review

105 Scopus citations

Prostaglandin-induced activation of nociceptive neurons via direct interaction with transient receptor potential A1 (TRPA1)

Taylor-Clark, T. E., Undem, B. J., MacGlashan, D. W., Ghatta, S., Carr, M. J. & McAlexander, M. A., Feb 2008, In: Molecular Pharmacology. 73, 2, p. 274-281 8 p.

Research output: Contribution to journal › Article › peer-review