David Pearse

2020

IGSF3 mutation identified in patient with severe COPD alters cell function and motility

Schweitzer, K. S., Jinawath, N., Yonescu, R., Ni, K., Rush, N., Charoensawan, V., Bronova, I., Berdyshev, E., Leach, S. M., Gillenwater, L. A., Bowler, R. P., Pearse, D. B., Griffin, C. A. & Petrache, I., Jun 23 2020, In: JCI Insight. 5, 14, e138101.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Does Use of Electronic Alerts for Systemic Inflammatory Response Syndrome (SIRS) to Identify Patients With Sepsis Improve Mortality?

Seetharaman, S., Wilson, C., Landrum, M., Qasba, S., Katz, M., Ladikos, N., Harris, J. E., Galiatsatos, P., Yousem, D. M., Knight, A. M., Pearse, D. B., Blanding, R., Bennett, R., Galai, N., Perl, T. M. & Sood, G., Jul 2019, In: American Journal of Medicine. 132, 7, p. 862-868 7 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

2018

Procalcitonin-guided antibiotic therapy reduces antibiotic use for lower respiratory tract infections in a United States medical center: Results of a clinical trial

Townsend, J., Adams, V., Galiatsatos, P., Pearse, D., Pantle, H., Masterson, M., Kisuule, F., Jacob, E., Kiruthi, C., Ortiz, P., Agbanlog, A., Jurao, R., Stern, S., Nayak, S., Melgar, M., Sama, J., Irwin, J., Mazidi, C., Psoter, K. & McKenzie, R., Dec 1 2018, In: Open Forum Infectious Diseases. 5, 12

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2016

CD36 mediates H₂O₂-induced calcium influx in lung microvascular endothelial cells

Suresh, K., Servinsky, L., Reyes, J., Undem, C., Zaldumbide, J., Rentsendorj, O., Modekurty, S., Dodd-o, J. M., Scott, A., Pearse, D. B. & Shimoda, L. A., Dec 2 2016, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 312, 1, p. L143-L153

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Occupational Asthma Due to Inhalation of Aerosolized Lipophilic Coating Materials

Suresh, K., Belchis, D., Askin, F., Pearse, D. B. & Terry, P. B., Oct 1 2016, In: Lung. 194, 5, p. 787-789 3 p.

Research output: Contribution to journal › Article › peer-review

2015

Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4

Suresh, K., Servinsky, L., Reyes, J., Baksh, S., Undem, C., Caterina, M., Pearse, D. B. & Shimoda, L. A., 2015, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 309, 12, p. L1467-L1477

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

2014

A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome

Hikmat, F., Pearse, D. B. & Damarla, M., Nov 1 2014, In: Canadian Respiratory Journal. 21, 6, p. 337-340 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages

Rentsendorj, O., D’Alessio, F. R. & Pearse, D. B., Nov 1 2014, In: Journal of Leukocyte Biology. 96, 5, p. 907-915 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase

Scott Stephens, R., Servinsky, L. E., Rentsendorj, O., Kolb, T. M., Pfeifer, A. & Pearse, D. B., Mar 15 2014, In: American Journal of Physiology - Cell Physiology. 306, 6, p. C559-C569

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

2013

A 32-year-old woman with dyspnea, lung cysts, and previous pneumothoraces

Kolb, T. M., King, L. S. & Pearse, D. B., Dec 2013, In: CHEST. 144, 6, p. 1964-1968 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

CD36 and Fyn Kinase Mediate Malaria-Induced Lung Endothelial Barrier Dysfunction in Mice Infected with Plasmodium berghei

Anidi, I. U., Servinsky, L. E., Rentsendorj, O., Stephens, R. S., Scott, A. L. & Pearse, D. B., Aug 15 2013, In: PloS one. 8, 8, e71010.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2012

Dieulafoy's disease of the bronchus

Kolb, T., Gilbert, C., Fishman, E., Terry, P., Pearse, D., Feller-Kopman, D. & Yarmus, L., Dec 1 2012, In: American journal of respiratory and critical care medicine. 186, 11, p. 1191 1 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome

Eberlein, M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Shlobin, O. A., Shelhamer, J. H., Reed, R. M., Pearse, D. B., Orens, J. B. & Brower, R. G., Feb 2012, In: CHEST. 141, 2, p. 451-460 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

55 Scopus citations

Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation

Eberlein, M., Reed, R. M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Iacono, A., Pearse, D. B., Fessler, H. E., Shah, A. S., Orens, J. B. & Brower, R. G., Nov 2012, In: Journal of Heart and Lung Transplantation. 31, 11, p. 1207-1213.e7

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase

D'Alessio, F. R., Tsushima, K., Aggarwal, N. R., Mock, J. R., Eto, Y., Garibaldi, B. T., Files, D. C., Avalos, C. R., Rodriguez, J. V., Waickman, A. T., Reddy, S. P., Pearse, D. B., Sidhaye, V. K., Hassoun, P. M., Crow, M. T. & King, L. S., Sep 1 2012, In: Journal of Immunology. 189, 5, p. 2234-2245 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

Schmidt, E. P., Yang, Y., Janssen, W. J., Gandjeva, A., Perez, M. J., Barthel, L., Zemans, R. L., Bowman, J. C., Koyanagi, D. E., Yunt, Z. X., Smith, L. P., Cheng, S. S., Overdier, K. H., Thompson, K. R., Geraci, M. W., Douglas, I. S., Pearse, D. B. & Tuder, R. M., Aug 2012, In: Nature medicine. 18, 8, p. 1217-1223 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

364 Scopus citations

2011

Idiopathic constrictive bronchiolitis with rapidly progressive bronchiectasis and Mycobacterium kansasii infection

Raparla, S., Schmidt, E. P. & Pearse, D. B., 2011, In: Respiratory Medicine CME. 4, 4, p. 172-174 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury

Gurkan, O. U., He, C., Zielinski, R., Rabb, H., King, L. S., Dodd-O, J. M., D'Alessio, F. R., Aggarwal, N., Pearse, D. & Becker, P. M., Dec 2011, In: Experimental Lung Research. 37, 10, p. 575-584 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

Rentsendorj, O., Damarla, M., Aggarwal, N. R., Choi, J. Y., Johnston, L., D'Alessio, F. R., Crow, M. T. & Pearse, D. B., Aug 2011, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 2, p. L161-L170

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Supranormal expiratory airflow after bilateral lung transplantation is associated with improved survival

Eberlein, M., Permutt, S., Brown, R. H., Brooker, A., Chahla, M. F., Bolukbas, S., Nathan, S. D., Pearse, D. B., Orens, J. B. & Brower, R. G., Jan 1 2011, In: American journal of respiratory and critical care medicine. 183, 1, p. 79-87 9 p.

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

2010

cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism

Stephens, R. S., Rentsendorj, O., Servinsky, L. E., Moldobaeva, A., Damico, R. & Pearse, D. B., Sep 2010, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 299, 3, p. L323-L333

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

2009

Activated protein C protects against ventilator-induced pulmonary capillary leak

Finigan, J. H., Boueiz, A., Wilkinson, E., Damico, R., Skirball, J., Hyun, H. P., Damarla, M., Hasan, E., Pearse, D. B., Reddy, S. P., Grigoryev, D. N., Cheadle, C., Esmon, C. T., Garcia, J. G. N. & Hassoun, P. M., Jun 2009, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 296, 6, p. L1002-L1011

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

2008

Macrophage migration inhibitory factor governs endothelial cell sensitivity to LPS-induced apoptosis

Damico, R. L., Chesley, A., Johnston, L., Bind, E. P., Amaro, E., Nijmeh, J., Karakas, B., Welsh, L., Pearse, D. B., Garcia, J. G. N. & Crow, M. T., Jul 1 2008, In: American journal of respiratory cell and molecular biology. 39, 1, p. 77-85 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

Role of vasodilator-stimulated phosphoprotein in cGMP-mediated protection of human pulmonary artery endothelial barrier function

Rentsendorj, O., Mirzapoiazova, T., Adyshev, D., Servinsky, L. E., Renné, T., Verin, A. D. & Pearse, D. B., Apr 2008, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4, p. L686-L697

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Soluble guanylyl cyclase contributes to ventilator-induced lung injury in mice

Schmidt, E. P., Damarla, M., Rentsendorj, O., Servinsky, L. E., Zhu, B., Moldobaeva, A., Gonzalez, A., Hassoun, P. M. & Pearse, D. B., Dec 2008, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 295, 6, p. L1056-L1065

Research output: Contribution to journal › Article › peer-review

Open Access

27 Scopus citations

The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse

Dodd-o, J. M., Hristopoulos, M. L., Kibler, K., Gutkowska, J., Mukaddam-Daher, S., Gonzalez, A., Welsh-Servinsky, L. E. & Pearse, D. B., Apr 2008, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4, p. L714-L723

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

2007

A 56-year-old man with choking, recurrent pneumonia, and weight loss

Eberlein, M. & Pearse, D. B., Apr 2007, In: CHEST. 131, 4, p. 1248-1251 4 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

2006

Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells

Moldobaeva, A., Welsh-Servinsky, L. E., Shimoda, L. A., Stephens, R. S., Verin, A. D., Tuder, R. M. & Pearse, D. B., May 2006, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 5, p. L919-L930

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Strain-specific differences in sensitivity to ischemia-reperfusion lung injury in mice

Dodd-o, J. M., Hristopoulos, M. L., Welsh-Servinsky, L. E., Tankersley, C. G. & Pearse, D. B., May 2006, In: Journal of applied physiology. 100, 5, p. 1590-1595 6 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

The structural basis of airways hyperresponsiveness in asthma

Brown, R. H., Pearse, D. B., Pyrgos, G., Liu, M. C., Togias, A. & Permutt, S., 2006, In: Journal of applied physiology. 101, 1, p. 30-39 10 p.

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

2005

Effects of tidal volume and respiratory frequency on lung lymph flow

Pearse, D. B., Searcy, R. M., Mitzner, W., Permutt, S. & Sylvester, J. T., Aug 2005, In: Journal of applied physiology. 99, 2, p. 556-563 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement

Kolosova, I. A., Mirzapoiazova, T., Adyshev, D., Usatyuk, P., Romer, L. H., Jacobson, J. R., Natarajan, V., Pearse, D. B., Garcia, J. G. N. & Verin, A. D., Jul 22 2005, In: Circulation research. 97, 2, p. 115-124 10 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

2004

Effect of bronchial artery blood flow on cardiopulmonary bypass-induced lung injury

Dodd-O, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Bethea, B. T., Cattaneo, S. M., Baumgartner, W. A. & Pearse, D. B., Feb 2004, In: American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2, p. H693-H700

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury

Dodd-O, J. M., Welsh, L. E., Salazar, J. D., Walinsky, P. L., Peck, E. A., Shake, J. G., Caparrelli, D. J., Ziegelstein, R. C., Zweier, J. L., Baumgartner, W. A. & Pearse, D. B., Aug 2004, In: American Journal of Physiology - Heart and Circulatory Physiology. 287, 2 56-2, p. H927-H936

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

Peng, X., Hassoun, P. M., Sammani, S., McVerry, B. J., Burne, M. J., Rabb, H., Pearse, D., Tuder, R. M. & Garcia, J. G. N., Jun 1 2004, In: American journal of respiratory and critical care medicine. 169, 11, p. 1245-1251 7 p.

Research output: Contribution to journal › Article › peer-review

420 Scopus citations

2003

Effect of cGMP on lung microvascular endothelial barrier dysfunction following hydrogen peroxide

Pearse, D. B., Shimoda, L. A., Verin, A. D., Bogatcheva, N., Moon, C., Ronnett, G. V., Welsh, L. E. & Becker, P. M., 2003, In: Endothelium: Journal of Endothelial Cell Research. 10, 6, p. 309-317 9 p.

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Effect of ischemia and reperfusion without airway occlusion on vascular barrier function in the in vivo mouse lung

Dodd-O, J. M., Hristopoulos, M. L., Faraday, N. & Pearse, D. B., Nov 2003, In: Journal of applied physiology. 95, 5, p. 1971-1978 8 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Pulmonary vascular permeability and ischemic injury in gelsolin-deficient mice

Becker, P. M., Kazi, A. A., Wadgaonkar, R., Pearse, D. B., Kwiatkowski, D. & Garcia, J. G. N., Apr 1 2003, In: American journal of respiratory cell and molecular biology. 28, 4, p. 478-484 7 p.

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

2002

Inhibition of inwardly rectifying K+ channels by cGMP in pulmonary vascular endothelial cells

Shimoda, L. A., Welsh, L. E. & Pearse, D. B., 2002, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 283, 2 27-2, p. L297-L304

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Plunc, a member of the secretory gland protein family, is up-regulated in nasal respiratory epithelium after olfactory bulbectomy

Sung, Y. K., Moon, C., Yoo, J. Y., Moon, C., Pearse, D., Pevsner, J. & Ronnett, G. V., Apr 12 2002, In: Journal of Biological Chemistry. 277, 15, p. 12762-12769 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access