Research output per year
Research output per year
- 1 - 50 out of 123 results
Search results
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2023
A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity
Zachos, N. C., Vaughan, H., Sarker, R., Est-Witte, S., Chakraborty, M., Baetz, N. W., Yu, H., Yarov-Yarovoy, V., McNamara, G., Green, J. J., Tse, C. M. & Donowitz, M., Oct 2023, In: Gastroenterology. 165, 4, p. 986-998.e11Research output: Contribution to journal › Article › peer-review
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SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca21-dependent manner by cAMP and ATP in intestinal epithelial cells
Sarker, R., Lin, R., Singh, V., Donowitz, M. & Tse, C. M., Jun 2023, In: American Journal of Physiology - Cell Physiology. 324, 6, p. C1263-C1273Research output: Contribution to journal › Article › peer-review
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The Air–Liquid Interface Reorganizes Membrane Lipids and Enhances the Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colonoid Monolayers
Tse, C. M., Zhang, Z., Lin, R., Sarker, R., Donowitz, M. & Singh, V., May 2023, In: International journal of molecular sciences. 24, 9, 8273.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity
Sarker, R., Tse, C. M., Lin, R., McNamara, G., Singh, V. & Donowitz, M., 2022, In: Cellular Physiology and Biochemistry. 56, 1, p. 39-49 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip
Yin, J., Sunuwar, L., Kasendra, M., Yu, H., Tse, C. M., Talbot, C. C., Boronina, T., Cole, R., Karalis, K. & Donowitz, M., Mar 2021, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 320, 3, p. G258-G271Research output: Contribution to journal › Article › peer-review
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2020
Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways
Johnson, K., Yin, J., In, J. G., Kulkarni, S., Pasricha, P., Tse, C. M. & Donowitz, M., Aug 2020, In: American Journal of Physiology - Cell Physiology. 319, 2, p. C321-C330Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin
Lee, B., Hong, G. S., Lee, S. H., Kim, H., Kim, A., Hwang, E. M., Kim, J., Lee, M. G., Yang, J. Y., Kweon, M. N., Tse, C. M., Mark, D. & Oh, U., Aug 1 2019, In: Experimental and Molecular Medicine. 51, 8, 91.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity
Tse, C. M., Yin, J., Singh, V., Sarker, R., Lin, R., Verkman, A. S., Turner, J. R. & Donowitz, M., Jan 1 2019, In: CMGH. 7, 3, p. 641-653 13 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea
Duan, T., Cil, O., Tse, C. M., Sarker, R., Lin, R., Donowitz, M. & Verkman, A. S., Oct 1 2019, In: FASEB Journal. 33, 10, p. 10924-10934 11 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
NHERF3 is necessary for Escherichia coli heat-stable enterotoxin-induced inhibition of NHE3: Differences in signaling in mouse small intestine and Caco-2 cells
Chen, T., Lin, R., Avula, L., Sarker, R., Yang, J., Cha, B., Tse, C. M., McNamara, G., Seidler, U., Waldman, S., Snook, A., Bijvelds, M. J. C., De Jonge, H. R., Li, X. & Donowitz, M., 2019, In: American Journal of Physiology - Cell Physiology. 317, 4, p. C737-C748Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Rapamycin-inspired macrocycles with new target specificity
Guo, Z., Hong, S. Y., Wang, J., Rehan, S., Liu, W., Peng, H., Das, M., Li, W., Bhat, S., Peiffer, B., Ullman, B. R., Tse, C. M., Tarmakova, Z., Schiene-Fischer, C., Fischer, G., Coe, I., Paavilainen, V. O., Sun, Z. & Liu, J. O., Mar 1 2019, In: Nature Chemistry. 11, 3, p. 254-263 10 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
2018
Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane
Singh, V., Yang, J., Yin, J., Cole, R., Tse, M., Berman, D. E., Small, S. A., Petsko, G. & Donowitz, M., Aug 1 2018, In: Journal of cell science. 131, 16, jcs.218610.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Enterohemorrhagic E. Coli (EHEC)—Secreted serine protease EspP stimulates electrogenic ion transport in human colonoid monolayers
Tse, C. M., In, J. G., Yin, J., Donowitz, M., Doucet, M., Foulke-Abel, J., Ruiz-Perez, F., Nataro, J. P., Zachos, N. C., Kaper, J. B. & Kovbasnjuk, O., Sep 2018, In: Toxins. 10, 9, 351.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers
Yin, J., Tse, C. M., Avula, L. R., Singh, V., Foulke-Abel, J., de Jonge, H. R. & Donowitz, M., 2018, In: CMGH. 5, 4, p. 591-609 19 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2017
A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands
Yin, J., Tse, C. M., Cha, B., Sarker, R., Zhu, X. C., Walentinsson, A., Greasley, P. J. & Donowitz, M., 2017, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 2, p. G129-G137Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins
Cil, O., Phuan, P. W., Gillespie, A. M., Lee, S., Tradtrantip, L., Yin, J., Tse, M., Zachos, N. C., Lin, R., Donowitz, M. & Verkman, A. S., Feb 2017, In: FASEB Journal. 31, 2, p. 751-760 10 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class i PDZ-binding motifs
Cha, B., Yang, J., Singh, V., Zachos, N. C., Sarker, R. I., Chen, T. E., Chakraborty, M., Tse, C. M. & Donowitz, M., May 19 2017, In: Journal of Biological Chemistry. 292, 20, p. 8279-8290 12 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Phosphorylation of NHE3-S719 regulates NHE3 activity through the formation of multiple signaling complexes
Sarker, R., Cha, B., Kovbasnjuk, O., Cole, R., Gabelli, S., Tse, C. M. & Donowitz, M., Jul 1 2017, In: Molecular biology of the cell. 28, 13, p. 1754-1767 14 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2016
Inhibition of human equilibrative nucleoside transporters by 4-((4-(2-fluorophenyl)piperazin-1-yl)methyl)-6-imino-N-(naphthalen-2-yl)-1,3,5-triazin-2-amine
Tang, P. C. T., Yang, C., Li, R. W. S., Lee, S. M. Y., Hoi, M. P. M., Chan, S. W., Kwan, Y. W., Tse, C. M. & Leung, G. P. H., 2016, In: European Journal of Pharmacology. 791, p. 544-551 8 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
2015
Allergen challenge sensitizes TRPA1 in vagal sensory neurons and afferent C-fiber subtypes in guinea pig esophagus
Liu, Z., Hu, Y., Yu, X., Xi, J., Fan, X., Tse, C. M., Myers, A. C., Pasricha, P. J., Li, X. & Yu, S., 2015, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 308, 6, p. G482-G488Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: Identification of a multifunctional phosphorylation site
Chen, T., Kocinsky, H. S., Cha, B., Murtazina, R., Yang, J., Tse, C. M., Singh, V., Cole, R., Aronson, P. S., De Jonge, H., Sarker, R. & Donowitz, M., Jan 23 2015, In: Journal of Biological Chemistry. 290, 4, p. 1952-1965 14 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations -
Functional expression of aquaporin-2 tagged with photoconvertible fluorescent protein in mpkCCD cells
Yip, K. P., Cha, B. J., Tse, C. M., Amin, M. E. & Amin, J., Jun 1 2015, In: Cellular Physiology and Biochemistry. 36, 2, p. 670-682 13 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Na-H exchanger isoform-2 (NHE2) mediates butyrate-dependent Na+ absorption in dextran sulfate sodium (DSS)-induced Colitis
Rajendran, V. M., Kumar, N. S. N., Tse, C. M. & Binder, H. J., Oct 16 2015, In: Journal of Biological Chemistry. 290, 42, p. 25487-25496 10 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity
Zhu, X. C., Sarker, R., Horton, J. R., Chakraborty, M., Chen, T. E., Ming Tse, C., Cha, B. & Donowitz, M., Jun 1 2015, In: American Journal of Physiology - Cell Physiology. 308, 9, p. C758-C766Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea
Janecke, A. R., Heinz-Erian, P., Yin, J., Petersen, B. S., Franke, A., Lechner, S., Fuchs, I., Melancon, S., Uhlig, H. H., Travis, S., Marinier, E., Perisic, V., Ristic, N., Gerner, P., Booth, I. W., Wedenoja, S., Baumgartner, N., Vodopiutz, J., Frechette-Duval, M. C., De Lafollie, J., & 13 others, Dec 1 2015, In: Human molecular genetics. 24, 23, p. 6614-6623 10 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3
Singh, V., Yang, J., Cha, B., Chen, T. E., Sarker, R., Yin, J., Avula, L. R., Tse, M. & Donowitz, M., Jun 1 2015, In: Molecular biology of the cell. 26, 11, p. 2030-2043 14 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity
Yang, J., Sarker, R., Singh, V., Sarker, P., Yin, J., Chen, T. E., Chaerkady, R., Li, X., Tse, C. M. & Donowitz, M., Aug 15 2015, In: Biochemical Journal. 470, 1, p. 77-90 14 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2014
AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal Stimulatory complex: Role of a novel Ser-rich NHE3 C-Terminal motif in NHE3 activity and trafficking
Singh, V., Lin, R., Yang, J., Cha, B., Sarker, R., Tse, C. M. & Donowitz, M., Feb 28 2014, In: Journal of Biological Chemistry. 289, 9, p. 5449-5461 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling
Cha, B., Chen, T., Sarker, R., Yang, J., Raben, D., Ming Tse, C., Kovbasnjuk, O. & Donowitz, M., Jul 1 2014, In: American Journal of Physiology - Cell Physiology. 307, 1, p. C55-C65Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol
Yang, J., Singh, V., Chen, T. E., Sarker, R., Xiong, L., Cha, B., Jin, S., Li, X., Ming Tse, C., Zachos, N. C. & Donowitz, M., 2014, In: Journal of Biological Chemistry. 289, 29, p. 20039-20053 15 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
2013
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells
Yang, J., Singh, V., Cha, B., Chen, T. E., Sarker, R., Murtazina, R., Jin, S., Zachos, N. C., Patterson, G. H., Tse, C. M., Kovbasnjuk, O., Li, X. & Donowitz, M., Jun 7 2013, In: Journal of Biological Chemistry. 288, 23, p. 16960-16974 15 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2012
6-mercaptopurine transport in human lymphocytes: Correlation with drug-induced cytotoxicity
Conklin, L. S., Cuffari, C., Okazaki, T., Miao, Y., Saatian, B., Chen, T. E., Tse, M., Brant, S. R. & Li, X., Feb 2012, In: Journal of Digestive Diseases. 13, 2, p. 82-93 12 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na +/H + exchanger 3 (NHE3) by a NHERF2 protein-dependent process
Zizak, M., Chen, T., Bartonicek, D., Sarker, R., Zachos, N. C., Cha, B., Kovbasnjuk, O., Korac, J., Mohan, S., Cole, R., Chen, Y., Tse, C. M. & Donowitz, M., Apr 13 2012, In: Journal of Biological Chemistry. 287, 16, p. 13442-13456 15 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Immunohistochemistry of affected tissue may guide cGVHD treatment decisions
Williams, K. M., Ostrow, L. W., Loeb, D. M., Chung, T., Cohn, R. D., Corse, A. M., Mammen, A. L. & Chen, A. R., May 2012, In: Bone marrow transplantation. 47, 5, p. 731-733 3 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2011
The spatial organization of proton and lactate transport in a rat brain tumor
Grillon, E., Farion, R., Fablet, K., de Waard, M., Tse, C. M., Donowitz, M., Rémy, C. & Coles, J. A., 2011, In: PloS one. 6, 2, e17416.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
2010
Epac1 mediates protein kinase A-independent mechanism of forskolinactivated intestinal chloride secretion
Hoque, K. M., Woodward, O. M., Van Rossum, D. B., Zachos, N. C., Chen, L., Leung, G. P. H., Guggino, W. B., Guggino, S. E. & Tse, C. M., Jan 2010, In: Journal of General Physiology. 135, 1, p. 43-58 16 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2
Lin, S., Yeruva, S., He, P., Singh, A. K., Zhang, H., Chen, M., Lamprecht, G., de Jonge, H. R., Tse, M., Donowitz, M., Hogema, B. M., Chun, J., Seidler, U. & Yun, C. C., Feb 2010, In: Gastroenterology. 138, 2, p. 649-658 10 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region
Mohan, S., Tse, C. M., Gabelli, S. B., Sarker, R., Cha, B., Fahie, K., Nadella, M., Zachos, N. C., Tu-Sekine, B., Raben, D., Amzel, L. M. & Donowitz, M., Nov 5 2010, In: Journal of Biological Chemistry. 285, 45, p. 34566-34578 13 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid
Cha, B., Zhu, X. C., Chen, W., Jones, M., Ryoo, S., Zachos, N. C., Chen, T. E., Lin, R., Sarker, R., Kenworthy, A. K., Tse, M., Kovbasnjuk, O. & Donowitz, M., Jul 15 2010, In: Journal of cell science. 123, 14, p. 2434-2443 10 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
2009
Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3
Govindarajan, R., Leung, G. P. H., Zhou, M., Tse, C. M., Wang, J. & Unadkat, J. D., Apr 2009, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 4, p. G910-G922Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells
Li, R. W. S., Seto, S. W., Au, A. L. S., Kwan, Y. W., Chan, S. W., Lee, S. M. Y., Tse, C. M. & Leung, G. P. H., Jun 10 2009, In: European Journal of Pharmacology. 612, 1-3, p. 15-20 6 p.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
2008
A purine-selective nucleobase/nucleoside transporter in PK15NTD cells
Hoque, K. M., Chen, L., Leung, G. P. H. & Tse, C. M., Jun 2008, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 294, 6, p. R1988-R1995Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes
Govindarajan, R., Endres, C. J., Whittington, D., LeCluyse, E., Pastor-Anglada, M., Tse, C. M. & Unadkat, J. D., Sep 2008, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 3, p. G570-G580Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
2007
Characterization of adenosine transport in H9c2 cardiomyoblasts
Leung, G. P. H., Tse, C. M. & Man, R. Y. K., Mar 20 2007, In: International Journal of Cardiology. 116, 2, p. 186-193 8 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Inhibition of human equilibrative nucleoside transporters by dihydropyridine-type calcium channel antagonists
Li, R. W. S., Tse, C. M., Man, R. Y. K., Vanhoutte, P. M. & Leung, G. P. H., Jul 30 2007, In: European Journal of Pharmacology. 568, 1-3, p. 75-82 8 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta
Govindarajan, R., Bakken, A. H., Hudkins, K. L., Lai, Y., Casado, F. J., Pastor-Anglada, M., Tse, C. M., Hayashi, J. & Unadkat, J. D., Nov 2007, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 293, 5, p. R1809-R1822Research output: Contribution to journal › Article › peer-review
114 Scopus citations -
Intranuclear protein transduction through a nucleoside salvage pathway
Hansen, J. E., Tse, C. M., Chan, G., Heinze, E. R., Nishimura, R. N. & Weisbart, R. H., Jul 20 2007, In: Journal of Biological Chemistry. 282, 29, p. 20790-20793 4 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) null mice: cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule
Murtazina, R., Kovbasnjuk, O., Zachos, N. C., Li, X., Chen, Y., Hubbard, A., Hogema, B. M., Steplock, D., Seidler, U., Hoque, K. M., Chung, M. T., De Jonge, H. R., Weinman, E. J. & Donowitz, M., Aug 24 2007, In: Journal of Biological Chemistry. 282, 34, p. 25141-25151 11 p.Research output: Contribution to journal › Article › peer-review
Open Access60 Scopus citations -
2006
The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: Dual role in NHE3 trafficking and mobility in the brush border
Cha, B., Tse, M., Yun, C., Kovbasnjuk, O., Mohan, S., Hubbard, A., Arpin, M. & Donowitz, M., Jun 2006, In: Molecular biology of the cell. 17, 6, p. 2661-2673 13 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Scopus citations -
2005
cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein
Cha, B., Kim, J. H., Hut, H., Hogema, B. M., Nadarja, J., Zizak, M., Cavet, M., Lee-Kwon, W., Lohmann, S. M., Smolenski, A., Tse, C. M., Yun, C., De Jonge, H. R. & Donowitz, M., Apr 29 2005, In: Journal of Biological Chemistry. 280, 17, p. 16642-16650 9 p.Research output: Contribution to journal › Article › peer-review
Open Access77 Scopus citations