Research output per year
Research output per year
- 1 - 50 out of 411 results
Search results
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2023
Arginine methylation of RNA-binding proteins is impaired in Huntington's disease
Ratovitski, T., Kamath, S. V., O'Meally, R. N., Gosala, K., Holland, C. D., Jiang, M., Cole, R. N. & Ross, C. A., Oct 15 2023, In: Human molecular genetics. 32, 20, p. 3006-3025 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Longitudinal imaging highlights preferential basal ganglia circuit atrophy in Huntington's disease
Liu, C. F., Younes, L., Tong, X. J., Hinkle, J. T., Wang, M., Phatak, S., Xu, X., Bu, X., Looi, V., Bang, J., Tabrizi, S. J., Scahill, R. I., Paulsen, J. S., Georgiou-Karistianis, N., Faria, A. V., Miller, M. I., Ratnanather, J. T. & Ross, C. A., 2023, In: Brain Communications. 5, 5, fcad214.Research output: Contribution to journal › Article › peer-review
Open Access -
Mixed longitudinal and cross-sectional analyses of deep gray matter and white matter using diffusion weighted images in premanifest and manifest Huntington's disease
Hu, B., Younes, L., Bu, X., Liu, C. F., Tilak Ratnanather, J., Paulsen, J., Georgiou-Karistianis, N., Miller, M. I., Ross, C. & Faria, A. V., Jan 2023, In: NeuroImage: Clinical. 39, 103493.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways
Zandi, P. P., Jaffe, A. E., Goes, F. S., Burke, E. E., Collado-Torres, L., Huuki-Myers, L., Seyedian, A., Lin, Y., Seifuddin, F., Pirooznia, M., Ross, C. A., Kleinman, J. E., Weinberger, D. R. & Hyde, T. M., Mar 2022, In: Nature neuroscience. 25, 3, p. 381-389 9 p.Research output: Contribution to journal › Article › peer-review
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Interaction of huntingtin with PRMTs and its subsequent arginine methylation affects HTT solubility, phase transition behavior and neuronal toxicity
Ratovitski, T., Jiang, M., O'meally, R. N., Rauniyar, P., Chighladze, E., Faragó, A., Kamath, S. V., Jin, J., Shevelkin, A. V., Cole, R. N. & Ross, C. A., May 15 2022, In: Human molecular genetics. 31, 10, p. 1651-1672 22 p.Research output: Contribution to journal › Article › peer-review
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Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway
Huang, Y., Huang, H., Zhou, L., Li, J., Chen, X., Thomas, J., He, X., Guo, W., Zeng, Y., Low, B. C., Liang, F., Zeng, J., Ross, C. A., Tan, E. K., Smith, W. & Pei, Z., Nov 15 2022, In: Human molecular genetics. 31, 22, p. 3886-3896 11 p.Research output: Contribution to journal › Article › peer-review
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Neuroprotective Effects of σ2R/TMEM97 Receptor Modulators in the Neuronal Model of Huntington's Disease
Jin, J., Arbez, N., Sahn, J. J., Lu, Y., Linkens, K. T., Hodges, T. R., Tang, A., Wiseman, R., Martin, S. F. & Ross, C. A., Oct 5 2022, In: ACS Chemical Neuroscience. 13, 19, p. 2852-2862 11 p.Research output: Contribution to journal › Article › peer-review
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2021
A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity
Khaled, H. G., Feng, H., Hu, X., Sun, X., Zheng, W., Li, P. P., Rudnicki, D., Ye, W., Chen, Y. C., Southall, N., Marugan, J., Ross, C. A., Ferrer, M., Henderson, M. J. & Margolis, R. L., Dec 2021, In: Scientific reports. 11, 1, 6157.Research output: Contribution to journal › Article › peer-review
Open Access -
A lrrk2 gtp binding inhibitor, 68, reduces lps‐induced signaling events and tnf‐α release in human lymphoblasts
Li, T., Ning, B., Kong, L., Dai, B., He, X., Thomas, J. M., Sawa, A., Ross, C. A. & Smith, W. W., Feb 2021, In: Cells. 10, 2, p. 1-12 12 p., 480.Research output: Contribution to journal › Article › peer-review
Open Access -
Ankyrin-G Heterozygous Knockout Mice Display Increased Sensitivity to Social Defeat Stress
Cordner, Z. A., Khambadkone, S. G., Zhu, S., Bai, J., Rasadokht Forti, R., Goodman, E., Tamashiro, K. L. K. & Ross, C. A., Dec 1 2021, In: Complex Psychiatry. 7, 3-4, p. 71-79 9 p.Research output: Contribution to journal › Article › peer-review
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Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Kedaigle, A. J., Fraenkel, E., Atwal, R. S., Wu, M., Gusella, J. F., MacDonald, M. E., Kaye, J. A., Finkbeiner, S., Mattis, V. B., Tom, C. M., Svendsen, C., King, A. R., Chen, Y., Stocksdale, J. T., Lim, R. G., Casale, M., Wang, P. H., Thompson, L. M., Akimov, S. S., Ratovitski, T., & 2 others, 2021, In: Human molecular genetics. 29, 11, p. 1757-1771 15 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Curcumin Reduced H2O2- and G2385R-LRRK2-Induced Neurodegeneration
Zhang, J., Li, K., Wang, X., Smith, A. M., Ning, B., Liu, Z., Liu, C., Ross, C. A. & Smith, W. W., Oct 15 2021, In: Frontiers in Aging Neuroscience. 13, 754956.Research output: Contribution to journal › Article › peer-review
Open Access -
Huntingtin-mediated axonal transport requires arginine methylation by PRMT6
Migazzi, A., Scaramuzzino, C., Anderson, E. N., Tripathy, D., Hernández, I. H., Grant, R. A., Roccuzzo, M., Tosatto, L., Virlogeux, A., Zuccato, C., Caricasole, A., Ratovitski, T., Ross, C. A., Pandey, U. B., Lucas, J. J., Saudou, F., Pennuto, M. & Basso, M., Apr 13 2021, In: Cell Reports. 35, 2, 108980.Research output: Contribution to journal › Article › peer-review
Open Access -
Huntingtin silencing delays onset and slows progression of Huntington's disease: A biomarker study
Liu, H., Zhang, C., Xu, J., Jin, J., Cheng, L., Miao, X., Wu, Q., Wei, Z., Liu, P., Lu, H., Van Zijl, P. C. M., Ross, C. A., Hua, J. & Duan, W., Oct 1 2021, In: Brain. 144, 10, p. 3101-3113 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics
Akimov, S. S., Jiang, M., Kedaigle, A. J., Arbez, N., Marque, L. O., Eddings, C. R., Ranum, P. T., Whelan, E., Tang, A., Wang, R., Devine, L. R., Talbot, C. C., Cole, R. N., Ratovitski, T., Davidson, B. L., Fraenkel, E. & Ross, C. A., Dec 15 2021, In: Human molecular genetics. 30, 24, p. 2469-2487 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington’s disease
Klinkmueller, P., Kronenbuerger, M., Miao, X., Bang, J., Ultz, K. E., Paez, A., Zhang, X., Duan, W., Margolis, R. L., Zijl, P. CM. V., Ross, C. A. & Hua, J., May 2021, In: Journal of Cerebral Blood Flow and Metabolism. 41, 5, p. 1119-1130 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant G2019S-LRRK2 Induces Abnormalities in Arteriolar Cerebral Blood Volume in Mouse Brains: An MRI Study
Ning, B., Guo, G., Gu, C., Xu, J., Bibic, A., He, X., Liu, H., Chen, L., Wei, Z., Duan, W., Liu, P., Lu, H., Van Zijl, P. C. M., Ross, C. A., Smith, W. & Hua, J., Feb 2021, In: Neurodegenerative Diseases. 20, 2-3, p. 65-72 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant-TMEM230-induced neurodegeneration and impaired axonal mitochondrial transport
Wang, X., Guo, G., Zhang, J., Aebez, N., Liu, Z., Liu, C. F., Ross, C. A. & Smith, W. W., Aug 15 2021, In: Human molecular genetics. 30, 16, p. 1535-1542 8 p.Research output: Contribution to journal › Article › peer-review
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Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation
Kim, N. S., Wen, Z., Liu, J., Zhou, Y., Guo, Z., Xu, C., Lin, Y. T., Yoon, K. J., Park, J., Cho, M., Kim, M., Wang, X., Yu, H., Salamuru, S., Christian, K. M., Hsu, K. S., Xia, M., Li, W., Ross, C. A., Margolis, R. L., & 3 others, Dec 1 2021, In: Nature communications. 12, 1, 1398.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2
Li, P. P., Moulick, R., Feng, H., Sun, X., Arbez, N., Jin, J., Marque, L. O., Hedglen, E., Chan, H. Y. E., Ross, C. A., Pulst, S. M., Margolis, R. L., Woodson, S. & Rudnicki, D. D., Nov 2021, In: Movement Disorders. 36, 11, p. 2519-2529 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice
Arbez, N., He, X. F., Huang, Y., Ren, M., Liang, Y., Nucifora, F. C., Wang, X., Pei, Z., Tessarolo, L., Smith, W. W. & Ross, C. A., Mar 13 2020, In: Human molecular genetics. 29, 4, p. 580-590 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions
Thomas, J. M., Wang, X., Guo, G., Li, T., Dai, B., Nucifora, L. G., Nucifora, F. C., Liu, Z., Xue, F., Liu, C., Ross, C. A. & Smith, W. W., Oct 1 2020, In: Journal of Cellular Physiology. 235, 10, p. 7309-7320 12 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease
Jiang, M., Zhang, X., Liu, H., Lebron, J., Alexandris, A., Peng, Q., Gu, H., Yang, F., Li, Y., Wang, R., Hou, Z., Arbez, N., Ren, Q., Dong, J. L., Whela, E., Wang, R., Ratovitski, T., Troncoso, J. C., Mori, S., Ross, C. A., & 2 others, May 28 2020, In: Human molecular genetics. 29, 8, p. 1340-1352 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model
Xu, X., Ng, B., Sim, B., Radulescu, C. I., Yusof, N. A. B. M., Goh, W. I., Lin, S., Lim, J. S. Y., Cha, Y., Kusko, R., Kay, C., Ratovitski, T., Ross, C., Hayden, M. R., Wright, G. & Pouladi, M. A., Sep 1 2020, In: Cell Death and Disease. 11, 9, 809.Research output: Contribution to journal › Article › peer-review
Open Access -
TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
Hegde, R. N., Chiki, A., Petricca, L., Martufi, P., Arbez, N., Mouchiroud, L., Auwerx, J., Landles, C., Bates, G. P., Singh-Bains, M. K., Dragunow, M., Curtis, M. A., Faull, R. L. M., Ross, C. A., Caricasole, A. & Lashuel, H. A., Sep 1 2020, In: EMBO Journal. 39, 17, e104671.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Transmembrane Protein 230 Mediates a Poly(ADP-ribose) Polymerase-1-Linked Apoptosis
Wang, X., Wu, T., Zhang, J., Guo, G., He, X. F., Pei, Z., Liu, Z., Liu, C. F., Ross, C. A. & Smith, W. W., Aug 7 2020, In: Frontiers in Aging Neuroscience. 12, 235.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2019
Altered brain iron content and deposition rate in Huntington’s disease as indicated by quantitative susceptibility MRI
Chen, L., Hua, J., Ross, C. A., Cai, S., van Zijl, P. C. M. & Li, X., Apr 2019, In: Journal of neuroscience research. 97, 4, p. 467-479 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Altered functional connectivity between sub-regions in the thalamus and cortex in schizophrenia patients measured by resting state BOLD fMRI at 7T
Hua, J., Blair, N. I. S., Paez, A., Choe, A., Barber, A. D., Brandt, A., Lim, I. A. L., Xu, F., Kamath, V., Pekar, J. J., van Zijl, P. C. M., Ross, C. A. & Margolis, R. L., Apr 2019, In: Schizophrenia Research. 206, p. 370-377 8 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Cysteamine Protects Neurons from Mutant Huntingtin Toxicity
Arbez, N., Roby, E., Akimov, S., Eddings, C., Ren, M., Wang, X. & Ross, C. A., 2019, In: Journal of Huntington's Disease. 8, 2, p. 129-143 15 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Differential Changes in Functional Connectivity of Striatum-Prefrontal and Striatum-Motor Circuits in Premanifest Huntington's Disease
Kronenbuerger, M., Hua, J., Bang, J. Y. A., Ultz, K. E., Miao, X., Zhang, X., Pekar, J. J., Van Zijl, P. C. M., Duan, W., Margolis, R. L. & Ross, C. A., Nov 1 2019, In: Neurodegenerative Diseases. 19, 2, p. 78-87 10 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Increased protein insolubility in brains from a subset of patients with schizophrenia
Nucifora, L. G., MacDonald, M. L., Lee, B. J., Peters, M. E., Norris, A. L., Orsburn, B. C., Yang, K., Gleason, K., Margolis, R. L., Pevsner, J., Tamminga, C. A., Sweet, R. A., Ross, C. A., Sawa, A. & Nucifora, F. C., 2019, In: American Journal of Psychiatry. 176, 9, p. 730-743 14 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories
Ross, C. A., Reilmann, R., Cardoso, F., McCusker, E. A., Testa, C. M., Stout, J. C., Leavitt, B. R., Pei, Z., Landwehrmeyer, B., Martinez, A., Levey, J., Srajer, T., Bang, J. & Tabrizi, S. J., Sep 1 2019, In: Movement Disorders Clinical Practice. 6, 7, p. 541-546 6 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Physiological and pathological roles of LRRK2 in the nuclear envelope integrity
Shani, V., Safory, H., Szargel, R., Wang, N., Cohen, T., Elghani, F. A., Hamza, H., Savyon, M., Radzishevsky, I., Shaulov, L., Rott, R., Lim, K. L., Ross, C. A., Bandopadhyay, R., Zhang, H. & Engelender, S., Dec 1 2019, In: Human molecular genetics. 28, 23, p. 3982-3996 15 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor
Eddings, C. R., Arbez, N., Akimov, S., Geva, M., Hayden, M. R. & Ross, C. A., Sep 2019, In: Neurobiology of Disease. 129, p. 118-129 12 p.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Regional subcortical shape analysis in premanifest Huntington's disease
Tang, X., Ross, C. A., Johnson, H., Paulsen, J. S., Younes, L., Albin, R. L., Ratnanather, J. T. & Miller, M. I., Apr 1 2019, In: Human Brain Mapping. 40, 5, p. 1419-1433 15 p.Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
Safety and efficacy of pridopidine in patients with Huntington's disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study
European Huntington's Disease Network & Huntington Study Group investigators, Feb 2019, In: The Lancet Neurology. 18, 2, p. 165-176 12 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2018
A new measure for end of life planning, preparation, and preferences in Huntington disease: HDQLIFE end of life planning
HDQLIFE Site Investigators and Coordinators, Jan 1 2018, In: Journal of neurology. 265, 1, p. 98-107 10 p.Research output: Contribution to journal › Article › peer-review
3 Scopus citations -
Evaluating cognition in individuals with Huntington disease: Neuro-QoL cognitive functioning measures
Lai, J. S., Goodnight, S., Downing, N. R., Ready, R. E., Paulsen, J. S., Kratz, A. L., Stout, J. C., McCormack, M. K., Cella, D., Ross, C., Russell, J. & Carlozzi, N. E., Mar 1 2018, In: Quality of Life Research. 27, 3, p. 811-822 12 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
G2019S LRRK2 increases stress susceptibility through inhibition of DAF-16 nuclear translocation in a 14-3-3 associated-manner in caenorhabditis elegans
Long, S., Guo, W., Hu, S., Su, F., Zeng, Y., Zeng, J., Tan, E. K., Ross, C. A. & Pei, Z., Nov 7 2018, In: Frontiers in Neuroscience. 12, NOV, 782.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
High and low levels of an NTRK2-driven genetic profile affect motor- and cognition-associated frontal gray matter in prodromal Huntington’s disease
PREDICT-HD Investigators and Coordinators of the Huntington, Jul 2018, In: Brain Sciences. 8, 7, 116.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation
Bowie, L. E., Maiuri, T., Alpaugh, M., Gabriel, M., Arbez, N., Galleguillos, D., Hung, C. L. K., Patel, S., Xia, J., Hertz, N. T., Ross, C. A., Litchfield, D. W., Sipione, S. & Truant, R., Jul 24 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 30, p. E7081-E7090Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F
Ayhan, F., Perez, B. A., Shorrock, H. K., Zu, T., Banez-Coronel, M., Reid, T., Furuya, H., Clark, H. B., Troncoso, J. C., Ross, C. A., Subramony, S. H., Ashizawa, T., Wang, E. T., Yachnis, A. T. & Ranum, L. P. W., Oct 1 2018, In: EMBO Journal. 37, 19, e99023.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Whole-brain segmentation and change-point analysis of anatomical brain mri—application in premanifest huntington's disease
Wu, D., Faria, A. V., Younes, L., Ross, C. A., Mori, S. & Miller, M. I., Jun 9 2018, In: Journal of Visualized Experiments. 2018, 136, e57256.Research output: Contribution to journal › Article › peer-review
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2017
Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease
Gomez-Pastor, R., Burchfiel, E. T., Neef, D. W., Jaeger, A. M., Cabiscol, E., McKinstry, S. U., Doss, A., Aballay, A., Lo, D. C., Akimov, S. S., Ross, C. A., Eroglu, C. & Thiele, D. J., Feb 13 2017, In: Nature communications. 8, 14405.Research output: Contribution to journal › Article › peer-review
Open Access51 Scopus citations -
Abnormal grey matter arteriolar cerebral blood volume in schizophrenia measured with 3D inflow-based vascular-space-occupancy MRI at 7T
Hua, J., Brandt, A. S., Lee, S. W., Blair, N. I. S., Wu, Y., Lui, S., Patel, J., Faria, A. V., Lim, I. A. L., Unschuld, P. G., Pekar, J. J., Van Zijl, P. C. M., Ross, C. A. & Margolis, R. L., 2017, In: Schizophrenia bulletin. 43, 3, p. 620-632 13 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Analysis of differential gene expression mediated by clozapine in human postmortem brains
Lee, B. J., Marchionni, L., Andrews, C. E., Norris, A. L., Nucifora, L. G., Wu, Y. C., Wright, R. A., Pevsner, J., Ross, C. A., Margolis, R. L., Sawa, A. & Nucifora, F. C., Jul 2017, In: Schizophrenia Research. 185, p. 58-66 9 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease
McGarry, A., McDermott, M., Kieburtz, K., DeBlieck, E. A., Beal, F., Marder, K., Ross, C., Shoulson, I., Gilbert, P., Mallonee, W. M., Guttman, M., Wojcieszek, J., Kumar, R., LeDoux, M. S., Jenkins, M., Rosas, H. D., Nance, M., Biglan, K., Como, P., Dubinsky, R. M., & 40 others, Jan 10 2017, In: Neurology. 88, 2, p. 152-159 8 p.Research output: Contribution to journal › Article › peer-review
Open Access59 Scopus citations -
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
The HD iPSC Consortium, May 1 2017, In: Nature neuroscience. 20, 5, p. 648-660 13 p.Research output: Contribution to journal › Article › peer-review
95 Scopus citations -
Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder
Zhu, S., Cordner, Z. A., Xiong, J., Chiu, C. T., Artola, A., Zuo, Y., Nelson, A. D., Kim, T. Y., Zaika, N., Woolums, B. M., Hess, E. J., Wang, X., Chuang, D. M., Pletnikov, M. M., Jenkins, P. M., Tamashiro, K. L. & Ross, C. A., Sep 26 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 39, p. 10479-10484 6 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Scopus citations -
Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington's disease
The PREDICT-HD Investigators and Coordinators of the Huntington Study Group, Oct 2017, In: Human Brain Mapping. 38, 10, p. 5035-5050 16 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations