Challice Bonifant

Research output

Research output per year 1998 2022 2023 2024

• 30 Article
• 8 Review article
• 3 Letter
• 1 Chapter
• 2 More
  • 1 Comment/debate
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Longitudinal plasma proteomics in CAR T–cell therapy patients implicates neutrophils and NETosis in the genesis of CRS

  Flora, C., Olesnavich, M., Zuo, Y., Sandford, E., Madhukar, R., Rozwadowski, M., Sugur, K., Ly, A., Canbaz, A. A., Shedeck, A., Li, G., Geer, M. J., Yanik, G. A., Ghosh, M., Frame, D. G., Bonifant, C. L., Jain, T., Knight, J. S., Choi, S. W. & Tewari, M., Mar 26 2024, In: Blood Advances. 8, 6, p. 1422-1426 5 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
• 2023

  CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine

  Karantanos, T., Teodorescu, P., Arvanitis, M., Perkins, B., Jain, T., DeZern, A. E., Dalton, W. B., Christodoulou, I., Paun, B. C., Varadhan, R., Esteb, C., Rajkhowa, T., Bonifant, C., Gondek, L. P., Levis, M. J., Yegnasubramanian, S., Ghiaur, G. & Jones, R. J., Jul 2023, In: Haematologica. 108, 7, p. 1886-1899 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GATA2 Deficiency 100%
  • Azacitidine 95%
  • Myelodysplastic Syndromes 81%
  • Myeloid Cells 73%
  • Methyltransferases 57%

• HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL

  McNerney, K. O., Si Lim, S. J., Ishikawa, K., Dreyzin, A., Vatsayan, A., Chen, J. J., Baggott, C., Prabhu, S., Pacenta, H. L., Philips, C., Rossoff, J., Stefanski, H. E., Talano, J. A., Moskop, A., Verneris, M., Myers, D., Karras, N. A., Brown, P., Bonifant, C. L., Qayed, M., & 13 othersHermiston, M., Satwani, P., Krupski, C., Keating, A. K., Baumeister, S. H. C., Fabrizio, V. A., Chinnabhandar, V., Egeler, E., Mavroukakis, S., Curran, K. J., Mackall, C. L., Laetsch, T. W. & Schultz, L. M., Jun 2023, In: Blood Advances. 7, 12, p. 2758-2771 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tisagenlecleucel 100%
  • Hemophagocytic Lymphohistiocytosis 70%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 52%
  • Young Adult 43%
  • B-Lymphocytes 41%

• Improving the anti-acute myeloid leukemia activity of CD123-specific engager T cells by MyD88 and CD40 costimulation

  Vaidya, A., Doherty, E., Wu, X., Huang, S., Hebbar, N., Thanekar, U., Bonifant, C. L., Cheng, C., Gottschalk, S. & Velasquez, M. P., Apr 2023, In: Haematologica. 108, 4, p. 1039-1052 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • T-Lymphocytes 64%
  • Chimeric Antigen Receptors 21%
  • Dimerization 18%
  • Antigens 10%

• Mediport use as an acceptable standard for CAR T cell infusion

  Eylon, M., Prabhu, S., John, S., King, M. J. M., Bhatt, D., Curran, K. J., Erickson, C., Karras, N. A., Phillips, C. L., Satwani, P., Hermiston, M., Southworth, E., Baumeister, S. H. C., Talano, J. A., MacMillan, M. L., Rossoff, J., Bonifant, C. L., Myers, G. D., Rouce, R. H., Toner, K., & 20 othersDriscoll, T. A., Katsanis, E., Salzberg, D. B., Schiff, D., De Oliveira, S. N., Capitini, C. M., Pacenta, H. L., Pfeiffer, T., Shah, N. C., Huynh, V., Skiles, J. L., Fraint, E., McNerney, KO., Quigg, T. C., Krueger, J., Ligon, JA., Fabrizio, V. A., Baggott, C., Laetsch, T. W. & Schultz, L. M., 2023, In: Frontiers in immunology. 14, 1239132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chimeric Antigen Receptors 100%
  • T-Lymphocytes 45%
  • Cell- and Tissue-Based Therapy 16%
  • Central Venous Catheters 6%
  • Standard of Care 5%

• Novel banana lectin CAR-T cells to target pancreatic tumors and tumor-associated stroma

  McKenna, M. K., Ozcan, A., Brenner, D., Watanabe, N., Legendre, M., Thomas, D. G., Ashwood, C., Cummings, R. D., Bonifant, C., Markovitz, D. M. & Brenner, M. K., Jan 18 2023, In: Journal for immunotherapy of cancer. 11, 1, A10.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Musa 100%
  • Lectins 71%
  • T-Lymphocytes 42%
  • Pancreatic Stellate Cells 39%
  • Chimeric Antigen Receptors 25%

• The major clinical components of cancer immunotherapy (modulating cell-mediated immune mechanisms)

  Bonifant, C. L. & Burns, W., Jan 1 2023, Clinical Immuno-Oncology. Elsevier, p. 195-222.e7

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Immunotherapy 100%
  • Neoplasms 36%
  • Adoptive Transfer 26%
  • Immunity 18%
  • Food 15%

• The rapid and highly parallel identification of antibodies with defined biological activities by SLISY

  Lu, S., Mattox, A. K., Aitana Azurmendi, P., Christodoulou, I., Wright, K. M., Popoli, M., Chen, Z., Sur, S., Li, Y., Bonifant, C. L., Bettegowda, C., Papadopoulos, N., Zhou, S., Gabelli, S. B., Vogelstein, B. & Kinzler, K. W., Dec 2023, In: Nature communications. 14, 1, 17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • sequencing 100%
  • Immunosorbent 99%
  • Immunosorbents 95%
  • activity (biology) 93%
  • antibodies 86%
• 2022

  496 Study of Affinity Tuning in AML-Targeted CAR-NK Cells

  Rahnama, R., Kizerwetter, M., Yang, H., Christodoulou, I., Fearnow, A., Vorri, S., Spangler, J. & Bonifant, C., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S257

  Research output: Contribution to journal › Article › peer-review

  • Chimeric Antigen Receptors 100%
  • Natural Killer Cells 68%
  • Coculture Techniques 13%
  • Antigens 12%
  • Tumor Necrosis Factor Receptor Superfamily, Member 9 12%

• Engineering builds multipotency for iPSC-NKs

  Rahnama, R. & Bonifant, C. L., Dec 8 2022, In: Blood. 140, 23, p. 2414-2416 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Gene-Based Natural Killer Cell Therapies for the Treatment of Pediatric Hematologic Malignancies

  Rahnama, R., Christodoulou, I. & Bonifant, C. L., Aug 2022, In: Hematology/Oncology Clinics of North America. 36, 4, p. 745-768 24 p.

  Research output: Contribution to journal › Review article › peer-review

• High risk of relapsed disease in patients with NK/T-cell chronic active Epstein-Barr virus disease outside of Asia

  Davila Saldana, B. J., John, T., Bonifant, C., Buchbinder, D., Chandra, S., Chandrakasan, S., Chang, W., Chen, L., Elfassy, H. L., Geerlinks, A. V., Giller, R. H., Goyal, R., Hagin, D., Islam, S., Mallhi, K., Miller, H. K., Owen, W., Pacheco, M., Patel, N. C., Querfeld, C., & 9 othersQuigg, T., Richard, N., Schiff, D., Shereck, E., Stenger, E., Jordan, M. B., Heslop, H. E., Bollard, C. M. & Cohen, J. I., Jan 25 2022, In: Blood Advances. 6, 2, p. 452-459 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hematopoietic Stem Cell Transplantation 100%
  • Human Herpesvirus 4 92%
  • Natural Killer Cells 86%
  • Virus Diseases 68%
  • T-Lymphocytes 57%

• Impact of High Disease Burden on Survival in Pediatric Patients with B-ALL Treated with Tisagenlecleucel

  Ravich, J. W., Huang, S., Zhou, Y., Brown, P., Pui, C. H., Inaba, H., Cheng, C., Gottschalk, S., Triplett, B. M., Bonifant, C. L. & Talleur, A. C., Feb 2022, In: Transplantation and Cellular Therapy. 28, 2, p. 73.e1-73.e9

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tisagenlecleucel 100%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 52%
  • B-Lymphocytes 41%
  • Pediatrics 34%
  • Survival 29%

• Intravenous anakinra for tisagenlecleucel-related toxicities in children and young adults

  Dreyzin, A., Jacobsohn, D., Angiolillo, A., Wistinghausen, B., Schore, R. J., Perez, E., Wells, E., Terao, J., Bonifant, C., Rohatgi, R., Dave, H. & Vatsayan, A., 2022, In: Pediatric Hematology and Oncology. 39, 4, p. 370-378 9 p.

  Research output: Contribution to journal › Letter › peer-review

• Targeting glycans for CAR therapy: The advent of sweet CARs

  Raglow, Z., McKenna, M. K., Bonifant, C. L., Wang, W., Pasca di Magliano, M., Stadlmann, J., Penninger, J. M., Cummings, R. D., Brenner, M. K. & Markovitz, D. M., Sep 7 2022, In: Molecular Therapy. 30, 9, p. 2881-2890 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Adoptive Immunotherapy 100%
  • Polysaccharides 71%
  • Chimeric Antigen Receptors 63%
  • Antigen 63%
  • T-Lymphocytes 29%

• The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia

  Karantanos, T., Teodorescu, P., Perkins, B., Christodoulou, I., Esteb, C., Varadhan, R., Helmenstine, E., Rajkhowa, T., Paun, B. C., Bonifant, C., Dalton, W. B., Gondek, L. P., Moliterno, A. R., Levis, M. J., Ghiaur, G. & Jones, R. J., Feb 2022, In: Science Advances. 8, 7, eabl8952.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GATA2 Deficiency 100%
  • Chemokine Receptors 80%
  • Myelodysplastic Syndromes 40%
  • Fedratinib 34%
  • Granulocyte Colony-Stimulating Factor Receptors 28%

• Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models

  Mu-Mosley, H., Ostermann, L., Muftuoglu, M., Vaidya, A., Bonifant, C. L., Velasquez, M. P., Gottschalk, S. & Andreeff, M., May 9 2022, In: Frontiers in immunology. 13, 880108.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Interleukin-15 100%
  • Acute Myeloid Leukemia 75%
  • T-Lymphocytes 48%
  • Antigens 13%
  • Chimeric Antigen Receptors 5%
• 2021

  Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis

  Koldobskiy, M. A., Jenkinson, G., Abante, J., Rodriguez DiBlasi, V. A., Zhou, W., Pujadas, E., Idrizi, A., Tryggvadottir, R., Callahan, C., Bonifant, C. L., Rabin, K. R., Brown, P. A., Ji, H., Goutsias, J. & Feinberg, A. P., Apr 2021, In: Nature biomedical engineering. 5, 4, p. 360-376 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methylation 100%
  • Pediatrics 83%
  • Information analysis 79%
  • DNA Methylation 68%
  • Gene expression 67%

• Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities

  Christodoulou, I., Ho, W. J., Marple, A., Ravich, J. W., Tam, A., Rahnama, R., Fearnow, A., Rietberg, C., Yanik, S., Solomou, E. E., Varadhan, R., Koldobskiy, M. A. & Bonifant, C. L., Dec 12 2021, In: Journal for immunotherapy of cancer. 9, 12, e003894.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chimeric Antigen Receptors 100%
  • Interleukin-15 94%
  • Acute Myeloid Leukemia 70%
  • Natural Killer Cells 68%
  • Antigens 8%

• Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection

  Christodoulou, I., Rahnama, R., Ravich, J. W., Seo, J., Zolov, S. N., Marple, A. N., Markovitz, D. M. & Bonifant, C. L., Dec 23 2021, In: Frontiers in immunology. 12, 763460.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • SARS Virus 100%
  • Musa 98%
  • Chimeric Antigen Receptors 91%
  • Lectins 70%
  • Natural Killer Cells 62%
• 2020

  Improving CAR T-cells: The next generation

  Marple, A. H., Bonifant, C. L. & Shah, N. N., Jul 2020, In: Seminars in Hematology. 57, 3, p. 115-121 7 p.

  Research output: Contribution to journal › Review article › peer-review

  • Chimeric Antigen Receptors 100%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 48%
  • T-Lymphocytes 45%
  • Cell- and Tissue-Based Therapy 31%
  • Remission Induction 21%
  2 Scopus citations

• The Art and Science of Selecting a CD123-Specific Chimeric Antigen Receptor for Clinical Testing

  Riberdy, J. M., Zhou, S., Zheng, F., Kim, Y. I., Moore, J., Vaidya, A., Throm, R. E., Sykes, A., Sahr, N., Bonifant, C. L., Ryu, B., Gottschalk, S. & Velasquez, M. P., Sep 11 2020, In: Molecular Therapy - Methods and Clinical Development. 18, p. 571-581 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chimeric Antigen Receptors 100%
  • Art 86%
  • T-Lymphocytes 33%
  • Acute Myeloid Leukemia 12%
  • Interleukin-3 Receptor alpha Subunit 12%
  2 Scopus citations

• The future of cellular immunotherapy for childhood leukemia

  Bonifant, C. L. & Tasian, S. K., Feb 1 2020, In: Current opinion in pediatrics. 32, 1, p. 13-25 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Immunotherapy 100%
  • Leukemia 92%
  • Child 41%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 37%
  • Clinical Trials 36%
  4 Scopus citations
• 2019

  T-cell Activity against AML Improved by Dual-Targeted T Cells Stimulated through T-cell and IL7 Receptors

  Krawczyk, E., Zolov, S. N., Huang, K. & Bonifant, C. L., Apr 2019, In: Cancer Immunology Research. 7, 4, p. 683-692 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Interleukin-7 Receptors 100%
  • T-Cell Antigen Receptor 65%
  • Acute Myeloid Leukemia 61%
  • T-Lymphocytes 39%
  • Neoplasm Antigens 7%
  6 Scopus citations
• 2018

  Advances in immunotherapy for pediatric acute myeloid leukemia

  Bonifant, C. L., Velasquez, M. P. & Gottschalk, S., Jan 2 2018, In: Expert Opinion on Biological Therapy. 18, 1, p. 51-63 13 p.

  Research output: Contribution to journal › Review article › peer-review

  • Acute Myeloid Leukemia 100%
  • Immunotherapy 92%
  • Antigen 87%
  • Pediatrics 67%
  • Transplants 65%
  9 Scopus citations

• Programmed cell death protein 1 activation preferentially inhibits CD28.CAR–T cells

  Zolov, S. N., Rietberg, S. P. & Bonifant, C. L., Oct 2018, In: Cytotherapy. 20, 10, p. 1259-1266 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Programmed Cell Death 1 Receptor 100%
  • Chimeric Antigen Receptors 52%
  • T-Lymphocytes 43%
  • Tumor Necrosis Factor Receptor Superfamily, Member 7 11%
  • Ligands 10%
  31 Scopus citations

• Redirecting T cells to hematological malignancies with bispecific antibodies

  Velasquez, M. P., Bonifant, C. L. & Gottschalk, S., Jan 4 2018, In: Blood. 131, 1, p. 30-38 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Haematological 100%
  • Bispecific Antibodies 99%
  • blinatumomab 73%
  • Hematologic Neoplasms 71%
  • T-Lymphocytes 43%
  70 Scopus citations

• Work efficiency improvement of >90% after implementation of an annual inpatient blood products administration consent form

  Lindsay, H. L., Bhar, S., Bonifant, C., Sartain, S., Whittle, S. B., Lee-Kim, Y. & Shah, M. D., 2018, In: BMJ Open Quality. 7, 1, e000164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Consent Forms 100%
  • Inpatients 59%
  • efficiency 52%
  • Blood Transfusion 46%
  • Frustration 30%
  1 Scopus citations
• 2017

  A severe umbilical cord stem cell infusion reaction due to dextran in an atopic pediatric patient

  Cooling, L., Sankar, A., Mody, R., Yanik, G., Bonifant, C. & Choi, S. W., Jul 1 2017, In: Bone marrow transplantation. 52, 7, p. 1051-1053 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access
  1 Scopus citations
• 2016

  CD123-engager T cells as a novel immunotherapeutic for acute myeloid leukemia

  Bonifant, C. L., Szoor, A., Torres, D., Joseph, N., Velasquez, M. P., Iwahori, K., Gaikwad, A., Nguyen, P., Arber, C., Song, X. T., Redell, M. & Gottschalk, S., Sep 1 2016, In: Molecular Therapy. 24, 9, p. 1615-1626 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Myeloid Leukemia 100%
  • T-Lymphocytes 64%
  • Cord 43%
  • Effector 38%
  • Molecule 36%
  37 Scopus citations

• T cells expressing CD19-specific Engager Molecules for the Immunotherapy of CD19-positive Malignancies

  Velasquez, M. P., Torres, D., Iwahori, K., Kakarla, S., Arber, C., Rodriguez-Cruz, T., Szoor, A., Bonifant, C. L., Gerken, C., Cooper, L. J. N., Song, X. T. & Gottschalk, S., Jun 3 2016, In: Scientific reports. 6, 27130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunotherapy 100%
  • T-Lymphocytes 70%
  • Neoplasms 36%
  • Chimeric Antigen Receptors 19%
  • Neoplasm Antigens 15%
  29 Scopus citations

• Toxicity and management in CAR T-cell therapy

  Bonifant, C. L., Jackson, H. J., Brentjens, R. J. & Curran, K. J., Apr 20 2016, In: Molecular Therapy - Oncolytics. 3, p. 16011 1 p., 16011.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Chimeric Antigen Receptors 100%
  • Cell- and Tissue-Based Therapy 70%
  • T-Lymphocytes 45%
  • Cytokine Release Syndrome 29%
  • Anaphylaxis 20%
  373 Scopus citations
• 2014

  Detection of lymphoid and myeloid lineages in infantile B-cell acute lymphoblastic leukemia with mixed-lineage leukemia rearrangement by use of flow cytometry and cytogenetic analysis

  Gaikwad, A., Bonifant, C. L., Cubbage, M., Goltsova, T., Mudannayake, M., Ringrose, J., Punia, J., Lopez-Terrada, D. & Sheehan, A. M., Sep 1 2014, In: Clinical Lymphoma, Myeloma and Leukemia. 14, p. S2-S5

  Research output: Contribution to journal › Article › peer-review
  3 Scopus citations
• 2008

  Epitope tagging of endogenous genes in diverse human cell lines

  Kim, J. S., Bonifant, C., Bunz, F., Lane, W. S. & Waldman, T., 2008, In: Nucleic acids research. 36, 19, e127.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epitopes 100%
  • Cell Line 68%
  • Homologous Recombination 52%
  • Genes 46%
  • Proteins 34%
  24 Scopus citations
• 2007

  Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA

  Kim, J. S., Lee, C., Bonifant, C. L., Ressom, H. & Waldman, T., Jan 2007, In: Molecular and cellular biology. 27, 2, p. 662-677 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Growth 90%
  • p53 Genes 65%
  • Phosphatidylinositol 3-Kinase 60%
  • Tumor Suppressor Protein p14ARF 44%
  118 Scopus citations

• NHERFs, NEP, MAGUKs, and more: Interactions that regulate PTEN

  Bonifant, C. L., Kim, J. S. & Waldman, T., Nov 1 2007, In: Journal of cellular biochemistry. 102, 4, p. 878-885 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • sodium-hydrogen exchanger regulatory factor 100%
  • Phosphotransferases 45%
  • PTEN Phosphohydrolase 33%
  • Protein 24%
  • Phosphoric Monoester Hydrolases 24%
  18 Scopus citations
• 2006

  Antitumor activity of JS-K [O²-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O ²-aryl diazeniumdiolates in vitro and in vivo

  Shami, P. J., Saavedra, J. E., Bonifant, C. L., Chu, J., Udupi, V., Malaviya, S., Carr, B. I., Kar, S., Wang, M., Jia, L., Ji, X. & Keefer, L. K., Jul 13 2006, In: Journal of medicinal chemistry. 49, 14, p. 4356-4366 11 p.

  Research output: Contribution to journal › Article › peer-review

  • diazeniumdiolate 100%
  • Nitric Oxide 53%
  • Antitumor 52%
  • K 41 31%
  • In Vitro Techniques 24%
  96 Scopus citations
• 2005

  'Cables' suspends cancer in mice

  Bonifant, C. L. & Waldman, T., Aug 2005, In: Cancer Biology and Therapy. 4, 8, p. 864-865 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review
  3 Scopus citations

• Chemistry of the diazeniumdiolates: Z ⇌ E isomerism

  Wang, Y. N., Bohle, D. S., Bonifant, C. L., Chmurny, G. N., Collins, J. R., Davies, K. M., Deschamps, J., Flippen-Anderson, J. L., Keefer, L. K., Klose, J. R., Saavedra, J. E., Waterhouse, D. J. & Ivanic, J., Apr 20 2005, In: Journal of the American Chemical Society. 127, 15, p. 5388-5395 8 p.

  Research output: Contribution to journal › Article › peer-review

  • diazeniumdiolate 100%
  • Isomerism 91%
  • Isomers 83%
  • Negative ions 75%
  • Anions 60%
  16 Scopus citations
• 2004

  Nitric oxide prodrugs and metallochemotherapeutics: JS-K and CB-3-100 enhance arsenic and cisplatin cytolethality by increasing cellular accumulation

  Liu, J., Li, C., Qu, W., Leslie, E., Bonifant, C. L., Buzard, G. S., Saavedra, J. E., Keefer, L. K. & Waalkes, M. P., Jun 2004, In: Molecular cancer therapeutics. 3, 6, p. 709-714 6 p.

  Research output: Contribution to journal › Article › peer-review

  • diazeniumdiolate 100%
  • Arsenic 67%
  • Prodrugs 62%
  • Glutathione Transferase 60%
  • Cisplatin 50%
  63 Scopus citations
• 2003

  JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity

  Shami, P. J., Saavedra, J. E., Wang, L. Y., Bonifant, C. L., Diwan, B. A., Singh, S. V., Gu, Y., Fox, S. D., Buzard, G. S., Citro, M. L., Waterhouse, D. J., Davies, K. M., Ji, X. & Keefer, L. K., Apr 2003, In: Molecular cancer therapeutics. 2, 4, p. 409-417 9 p.

  Research output: Contribution to journal › Article › peer-review

  • diazeniumdiolate 100%
  • Nitric Oxide Donors 67%
  • Glutathione Transferase 60%
  • Antineoplastic Agents 54%
  • HL-60 Cells 52%
  147 Scopus citations
• 2001

  The secondary amine/nitric oxide complex ion R₂N[N(O)NO]^- as nucleophile and leaving group in S_NAr reactions

  Saavedra, J. E., Srinivasan, A., Bonifant, C. L., Chu, J., Shanklin, A. P., Flippen-Anderson, J. L., Rice, W. G., Turpin, J. A., Davies, K. M. & Keefer, L. K., May 4 2001, In: Journal of Organic Chemistry. 66, 9, p. 3090-3098 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Secondary Amine 100%
  • Nitric Oxide 95%
  • Nucleophile 87%
  • Displacement 54%
  • Meisenheimer Rearrangement 48%
  91 Scopus citations
• 1998

  Nitrosylation of sickle cell hemoglobin by hydroxyurea

  Xu, Y., Mull, C. D., Bonifant, C. L., Yasaki, G., Palmer, E. C., Shields, H., Ballas, S. K., Kim-Shapiro, D. B. & King, S. B., Sep 18 1998, In: Journal of Organic Chemistry. 63, 19, p. 6452-6453 2 p.

  Research output: Contribution to journal › Article › peer-review
  28 Scopus citations

• Time resolved absorption study of the reaction of hydroxyurea with sickle cell hemoglobin

  Kim-Shapiro, D. B., King, S. B., Bonifant, C. L., Kolibash, C. P. & Ballas, S. K., Mar 12 1998, In: Biochimica et Biophysica Acta - General Subjects. 1380, 1, p. 64-74 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Hydroxyurea 100%
  • Sickle Hemoglobin 96%
  • Methemoglobin 95%
  • Hemoglobin 63%
  • oxyhemoglobin S 53%
  39 Scopus citations