Barry Greenberg

Vitek, M. P., Araujo, J. A., Fosse, M., Greenberg, B. D., Howell, G. R., Rizzo, S. J. S., Seyfried, N. T., Tenner, A. J., Territo, P. R., Windisch, M., Bain, L. J., Ross, A., Carrillo, M. C., Lamb, B. T. & Edelmayer, R. M., 2020, In: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 6, 1, e12114.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

The utility of multivariate outlier detection techniques for data quality evaluation in large studies: An application within the ONDRI project

Sunderland, K. M., Beaton, D., Fraser, J., Kwan, D., McLaughlin, P. M., Montero-Odasso, M., Peltsch, A. J., Pieruccini-Faria, F., Sahlas, D. J., Swartz, R. H., Bartha, R., Black, S. E., Borrie, M., Corbett, D., Finger, E., Freedman, M., Greenberg, B., Grimes, D. A., Hegele, R. A., Hudson, C., & 13 othersLang, A. E., Masellis, M., McIlroy, W. E., Munoz, D. G., Munoz, D. P., Orange, J. B., Strong, M. J., Symons, S., Tartaglia, M. C., Troyer, A., Zinman, L., Strother, S. C. & Binns, M. A., May 15 2019, In: BMC medical research methodology. 19, 1, 102.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2018

The Toronto Cognitive Assessment (TorCA): Normative data and validation to detect amnestic mild cognitive impairment

Freedman, M., Leach, L., Carmela Tartaglia, M., Stokes, K. A., Goldberg, Y., Spring, R., Nourhaghighi, N., Gee, T., Strother, S. C., Alhaj, M. O., Borrie, M., Darvesh, S., Fernandez, A., Fischer, C. E., Fogarty, J., Greenberg, B. D., Gyenes, M., Herrmann, N., Keren, R., Kirstein, J., & 13 othersKumar, S., Lam, B., Lena, S., McAndrews, M. P., Naglie, G., Partridge, R., Rajji, T. K., Reichmann, W., Uri Wolf, M., Verhoeff, N. P. L. G., Waserman, J. L., Black, S. E. & Tang-Wai, D. F., Jul 18 2018, In: Alzheimer's Research and Therapy. 10, 1, 65.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

2017

Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI)

Montero-Odasso, M., Pieruccini-Faria, F., Bartha, R., Black, S. E., Finger, E., Freedman, M., Greenberg, B., Grimes, D. A., Hegele, R. A., Hudson, C., Kleinstiver, P. W., Lang, A. E., Masellis, M., McLaughlin, P. M., Munoz, D. P., Strother, S., Swartz, R. H., Symons, S., Tartaglia, M. C., Zinman, L., & 2 othersStrong, M. J. & McIlroy, W., 2017, In: Journal of Alzheimer's Disease. 59, 2, p. 707-721 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Scopus citations

The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

Farhan, S. M. K., Bartha, R., Black, S. E., Corbett, D., Finger, E., Freedman, M., Greenberg, B., Grimes, D. A., Hegele, R. A., Hudson, C., Kleinstiver, P. W., Lang, A. E., Masellis, M., McIlroy, W. E., McLaughlin, P. M., Montero-Odasso, M., Munoz, D. G., Munoz, D. P., Strother, S., Swartz, R. H., & 4 othersSymons, S., Tartaglia, M. C., Zinman, L. & Strong, M. J., Mar 1 2017, In: Canadian Journal of Neurological Sciences. 44, 2, p. 196-202 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Scopus citations

2011

Developing a global strategy to prevent Alzheimer's disease: Leon Thal Symposium 2010

Khachaturian, Z. S., Petersen, R. C., Snyder, P. J., Khachaturian, A. S., Aisen, P., De Leon, M., Greenberg, B. D., Kukull, W., Maruff, P., Sperling, R. A., Stern, Y., Touchon, J., Vellas, B., Andrieu, S., Weiner, M. W., Carrillo, M. C. & Bain, L. J., Mar 2011, In: Alzheimer's and Dementia. 7, 2, p. 127-132 6 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2010

Developing a national strategy to prevent dementia: Leon Thal Symposium 2009

Khachaturian, Z. S., Barnes, D., Einstein, R., Johnson, S., Lee, V., Roses, A., Sager, M. A., Shankle, W. R., Snyder, P. J., Petersen, R. C., Schellenberg, G., Trojanowski, J., Aisen, P., Albert, M. S., Breitner, J. C. S., Buckholtz, N., Carrillo, M., Ferris, S., Greenberg, B. D., Grundman, M., & 16 othersKhachaturian, A. S., Kuller, L. H., Lopez, O. L., Maruff, P., Mohs, R. C., Morrison-Bogorad, M., Phelps, C., Reiman, E., Sabbagh, M., Sano, M., Schneider, L. S., Siemers, E., Tariot, P., Touchon, J., Vellas, B. & Bain, L. J., Mar 2010, In: Alzheimer's and Dementia. 6, 2, p. 89-97 9 p.

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

2004

Mechanism of γ-secretase cleavage activation: Is γ-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Knappenberger, K. S., Tian, G., Ye, X., Sobotka-Briner, C., Ghanekar, S. V., Greenberg, B. D. & Scott, C. W., May 25 2004, In: Biochemistry. 43, 20, p. 6208-6218 11 p.

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Modulation of Notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation

Milano, J., McKay, J., Dagenais, C., Foster-Brown, L., Pognan, F., Gadient, R., Jacobs, R. T., Zacco, A., Greenberg, B. & Ciaccio, P. J., Nov 2004, In: Toxicological Sciences. 82, 1, p. 341-358 18 p.

Research output: Contribution to journal › Article › peer-review

437 Scopus citations

2003

Comparison of batch and perfusion culture in combination with pilot-scale expanded bed purification for the production of soluble recombinant β-secretase

Lüllau, E., Kanttinen, A., Hassel, J., Berg, M., Haag-Alvarsson, A., Cederbrant, K., Greenberg, B., Fenge, C. & Schweikart, F., 2003, In: Biotechnology Progress. 19, 1, p. 37-44 8 p.

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

The mechanism of γ-secretase. Multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

Tian, G., Ghanekar, S. V., Aharony, D., Shenvi, A. B., Jacobs, R. T., Liu, X. & Greenberg, B. D., Aug 1 2003, In: Journal of Biological Chemistry. 278, 31, p. 28968-28975 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

87 Scopus citations

2002

Linear non-competitive inhibition of solubilized human γ-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

Tian, G., Sobotka-Briner, C. D., Zysk, J., Liu, X., Birr, C., Sylvester, M. A., Edwards, P. D., Scott, C. D. & Greenberg, B. D., Aug 30 2002, In: Journal of Biological Chemistry. 277, 35, p. 31499-31505 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

Proteolysis of chimeric β-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid β-like peptides

Zhang, J., Ye, W., Wang, R., Wolfe, M. S., Greenberg, B. D. & Selkoe, D. J., Apr 26 2002, In: Journal of Biological Chemistry. 277, 17, p. 15069-15075 7 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2000

β-amyloid (Aβ)42(43), Aβ42, Aβ40 and apoE immunostaining of plaques in fatal head injury

Horsburgh, K., Cole, G. M., Yang, F., Savage, M. J., Greenberg, B. D., Gentleman, S. M., Graham, D. I. & Nicoll, J. A. R., 2000, In: Neuropathology and Applied Neurobiology. 26, 2, p. 124-132 9 p.

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

1999

Rank-order of potencies for inhibition of the secretion of Aβ40 and Aβ42 suggests that both are generated by a single γ-secretase

Durkin, J. T., Murthy, S., Husten, E. J., Trusko, S. P., Savage, M. J., Rotella, D. P., Greenberg, B. D. & Siman, R., Jul 16 1999, In: Journal of Biological Chemistry. 274, 29, p. 20499-20504 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

1998

Modulation of secreted β-amyloid β-peptide in brain by cholesterol

Howland, D. S., Trusko, S. P., Savage, M. J., Reaume, A. G., Lang, D. M., Hirsch, J. D., Maedas, N., Siman, R., Greenberg, B. D., Scott, R. W. & Flood, D. G., Jun 26 1998, In: Journal of Biological Chemistry. 273, 26, p. 16576-16582 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

225 Scopus citations

Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester

Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Reaume, A. G., Greenberg, B. D., Siman, R. & Scott, R. W., Mar 1 1998, In: Journal of Neuroscience. 18, 5, p. 1743-1752 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

210 Scopus citations

1997

Aβ₄₂ is the predominant form of amyloid β-protein in the brains of short-term survivors of head injury

Gentleman, S. M., Greenberg, B. D., Savage, M. J., Noori, M., Newman, S. J., Roberts, G. W., Griffin, W. S. T. & Graham, D. I., 1997, In: Neuroreport. 8, 6, p. 1519-1522 4 p.

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Heparin promotes β-secretase cleavage of the Alzheimer's amyloid precursor protein

Leveugle, B., Ding, W., Durkin, J. T., Mistretta, S., Eisle, J., Matic, M., Siman, R., Greenberg, B. D. & Fillit, H. M., Jun 7 1997, In: Neurochemistry International. 30, 6, p. 543-548 6 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Novel β-secretase cleavage of β-amyloid precursor protein in the endoplasmic reticulum/intermediate compartment of NT2N cells

Chyung, A. S. C., Greenberg, B. D., Cook, D. G., Doms, R. W. & Lee, V. M. Y., Aug 11 1997, In: Journal of Cell Biology. 138, 3, p. 671-680 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

134 Scopus citations

1996

Abundance of the longer Aβ₄₂ in neocortical and cerebrovascular amyloid β deposits in Swedish familial Alzheimer's disease and Down's syndrome

Kalaria, R. N., Cohen, D. L., Greenberg, B. D., Savage, M. J., Bogdanovic, N. E., Winblad, B., Lannfelt, L. & Adem, A., 1996, In: Neuroreport. 7, 8, p. 1377-1381 5 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

APP transgenesis: Approaches toward the development of animal models for Alzheimer disease neuropathology

Greenberg, B. D., Savage, M. J., Howland, D. S., Ali, S. M., Siedlak, S. L., Perry, G., Siman, R. & Scott, R. W., Jan 1 1996, In: Neurobiology of Aging. 17, 2, p. 153-171 19 p.

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Artifactual strain-specific signs of incipient brain amyloidosis in APP transgenic mice

Ali, S. M., Siedlak, S. L., Gonzalez-DeWhitt, P. A., Altman, R. A., Glendening, J. M., Lowery, D. E., Savage, M. J., Polites, H. G., Perry, G. & Greenberg, B. D., 1996, In: Neurobiology of aging. 17, 2, p. 223-234 12 p.

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Diffuse plaques contain C-terminal Aβ₄₂ and not Aβ₄₀: Evidence from cats and dogs

Cummings, B. J., Satou, T., Head, E., Milgram, N. W., Cole, G. M., Savage, M. J., Podlisny, M. B., Selkoe, D. J., Siman, R., Greenberg, B. D. & Cotman, C. W., 1996, In: Neurobiology of aging. 17, 4, p. 653-659 7 p.

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a 'humanized' Aβ sequence

Reaume, A. G., Howland, D. S., Trusko, S. P., Savage, M. J., Lang, D. M., Greenberg, B. D., Siman, R. & Scott, R. W., 1996, In: Journal of Biological Chemistry. 271, 38, p. 23380-23388 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

115 Scopus citations

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells: Evidence that cleavage at the "β-secretase" site occurs in the Golgi apparatus

Thinakaran, G., Teplow, D. B., Siman, R., Greenberg, B. & Sisodiat, S. S., Apr 19 1996, In: Journal of Biological Chemistry. 271, 16, p. 9390-9397 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

270 Scopus citations

Overexpression of a COOH-terminal fragment of β-amyloid precursor protein in HeLa cells results in accumulation in a pre-Golgi compartment and generation of an Aβ-like fragment

Kuentzel, S. L., Gonzalez-DeWhitt, P. A., Lowery, D. E., Altman, R. A., Leone, J. W., Heinrikson, R. L., Greenberg, B. D. & Raub, T. J., 1996, In: Amyloid. 3, 2, p. 86-99 14 p.

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

1995

An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease

Narindrasorasak, S., Altman, R. A., Gonzalez-DeWhitt, P., Greenberg, B. D. & Kisilevsky, R., 1995, In: Laboratory Investigation. 72, 3, p. 272-282 11 p.

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Authors' response to commentaries

Howland, D. S., Greenberg, B. D., Savage, M. J., Siman, R. & Scott, R. W., 1995, In: Neurobiology of aging. 16, 4, p. 715-718 4 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease

De Strooper, B., Craessaerts, K., Dewachter, I., Moechars, D., Greenberg, B., Van Leuven, F. & Van Den Berghe, H., Feb 24 1995, In: Journal of Biological Chemistry. 270, 8, p. 4058-4065 8 p.

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Elevated aβ levels in Alzheimer's disease brain are associated with selective accumulation of aβ42 in parenchymal amyloid plaques and both aβ40 and aβ42 in cerebrovascular deposits

Savage, M. J., Kawooya, J. K., Pinsker, L. R., Emmons, T. L., Mistretta, S., Siman, R. & Greenberg, B. D., 1995, In: Amyloid. 2, 4, p. 234-240 7 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Inhibitory action of amyloid precursor protein against human Hageman factor (factor XII)

Niwano, H., Embury, P. B., Greenberg, B. D. & Ratnoff, O. D., Feb 1995, In: Journal of Laboratory and Clinical Medicine. 125, 2, p. 251-256 6 p.

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Mutant and native human β-amyloid precursor proteins in transgenic mouse brain

Howland, D. S., Savage, M. J., Huntress, F. A., Wallace, R. E., Schwartz, D. A., Loh, T., Melloni, R. H., Degennaro, L. J., Greenberg, B. D., Siman, R., Swanson, M. E. & Scott, R. W., 1995, In: Neurobiology of aging. 16, 4, p. 685-699 15 p.

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

The COOH-terminus of the alzheimer amyloid aβ peptide: Differences in length influence the process of amyloid deposition in alzheimer brain, and tell us something about relationships among parenchymal and vessel-associated amyloid deposits

Greenberg, B. D., Jan 1 1995, In: Amyloid. 2, 3, p. 195-203 9 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

The gene for the serpin thrombin inhibitor (p17), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes

Carter, R. E., Cerosaletti, K. M., Burkin, D. J., Fournier, R. E. K., Jones, C., Greenberg, B. D., Citron, B. A. & Festoff, B. W., May 1 1995, In: Genomics. 27, 1, p. 196-199 4 p.

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

β-amyloid peptide and amyloid precursor proteins in olfactory mucosa of patients with alzheimer's disease, parkinson's disease, and down syndrome

Crino, P. B., Greenberg, B., Martin, J. A., Lee, V. M. Y., Hill, W. D. & Trojanowski, J. Q., Aug 1995, In: Annals of Otology, Rhinology & Laryngology. 104, 8, p. 655-661 7 p.

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

1994

Cholinesterase activity in the plaques, tangles and angiopathy of Alzheimer's disease does not emanate from amyloid

Geula, C., Greenberg, B. D. & Mesulam, M. M., May 2 1994, In: Brain research. 644, 2, p. 327-330 4 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Neurotrophic regulation of mouse muscle β‐amyloid protein precursor and α₁‐antichymotrypsin as revealed by axotomy

Akaaboune, M., Ma, J., Festoff, B. W., Greenberg, B. D. & Hantaï, D., May 1994, In: Journal of Neurobiology. 25, 5, p. 503-514 12 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Synthetic post‐translationally modified human Aβ peptide exhibits a markedly increased tendency to form β‐pleated sheets in vitro

FABIAN, H., SZENDREI, G. I., MANTSCH, H. H., GREENBERG, B. D. & ÖTVÖS, L., May 1994, In: European Journal of Biochemistry. 221, 3, p. 959-964 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Scopus citations

Toward an integrated discovery and development program in Alzheimer's disease: The amyloid hypothesis

Greenberg, B. D. & Murphy, M. F., 1994, In: Neurobiology of aging. 15, SUPPL. 2, p. 105-109 5 p.

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

1993

Binding of vascular heparan sulfate proteoglycan to Alzheimer's amyloid precursor protein is mediated in part by the N-terminal region of A4 peptide

Buée, L., Ding, W., Anderson, J. P., Narindrasorasak, S., Kisilevsky, R., Boyle, N. J., Robakis, N. K., Delacourte, A., Greenberg, B. & Fillit, H. M., Nov 12 1993, In: Brain research. 627, 2, p. 199-204 6 p.

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Barry Greenberg

Research output

Search results