Research output per year
Research output per year
- 29 results
Search results
-
2021
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Thompson, E. A., Cascino, K., Ordonez Suarez, A., Zhou, W., Vaghasia, A., Hamacher-Brady, A., Brady, N. R., Sun, I. H., Wang, R., Rosenberg, A. Z., Delannoy, M., Rothman, R., Fenstermacher, K., Sauer, L., Shaw Saliba, K., Bloch, E. M., Redd, A., Tobian, A. A. R., Horton, M., Smith, K., & 6 others, Mar 16 2021, In: Cell Reports. 34, 11, 108863.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Endolysosomal Targeting of Mitochondria Is Integral to BAX-Mediated Mitochondrial Permeabilization during Apoptosis Signaling
Wang, T. S., Coppens, I., Saorin, A., Brady, N. R. & Hamacher-Brady, A., Jun 22 2020, In: Developmental Cell. 53, 6, p. 627-645.e7Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response
Desai, R., East, D. A., Hardy, L., Faccenda, D., Rigon, M., Crosby, J., Alvarez, M. S., Singh, A., Mainenti, M., Hussey, L. K., Bentham, R., Szabadkai, G., Zappulli, V., Dhoot, G. K., Romano, L. E., Xia, D., Coppens, I., Hamacher-Brady, A., Paul Chapple, J., Abeti, R., & 4 others, Dec 2020, In: Science Advances. 6, 51, eabc9955.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Study of Microbial Extracellular Vesicles: Separation by Density Gradients, Protection Assays and Labelling for Live Tracking
Coelho, C., Vij, R., Smith, D. Q., Brady, N. R., Hamacher-Brady, A. & Casadevall, A., Jan 20 2020, In: Bio-protocol. 10, 2, e3502.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
EMBO Workshop: Membrane Contact Sites in Health and Disease
Bayer, E. M., Calì, T., Giordano, F., Hamacher-Brady, A. & Pellegrini, L., Jan 1 2019, In: Contact. 2Research output: Contribution to journal › Article › peer-review
Open Access -
Listeria monocytogenes virulence factors, including listeriolysin O, are secreted in biologically active extracellular vesicles
Coelho, C., Brown, L., Maryam, M., Vij, R., Smith, D. F. Q., Burnet, M. C., Kyle, J. E., Heyman, H. M., Ramirez, J., Prados-Rosales, R., Lauvau, G., Nakayasu, E. S., Brady, N. R., Hamacher-Brady, A., Coppens, I. & Casadevall, A., Jan 25 2019, In: Journal of Biological Chemistry. 294, 4, p. 1202-1217 16 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
2018
Dual role of HDAC10 in lysosomal exocytosis and DNA repair promotes neuroblastoma chemoresistance
Ridinger, J., Koeneke, E., Kolbinger, F. R., Koerholz, K., Mahboobi, S., Hellweg, L., Gunkel, N., Miller, A. K., Peterziel, H., Schmezer, P., Hamacher-Brady, A., Witt, O. & Oehme, I., Dec 1 2018, In: Scientific reports. 8, 1, 10039.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2017
Agent-based modeling of mitochondria links sub-cellular dynamics to cellular homeostasis and heterogeneity
Dalmasso, G., Zapata, P. A. M., Brady, N. R. & Hamacher-Brady, A., Jan 2017, In: PloS one. 12, 1, 0168198.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins
Rogov, V. V., Suzuki, H., Marinković, M., Lang, V., Kato, R., Kawasaki, M., Buljubašić, M., Šprung, M., Rogova, N., Wakatsuki, S., Hamacher-Brady, A., Dötsch, V., Dikic, I., Brady, N. R. & Novak, I., Dec 1 2017, In: Scientific reports. 7, 1, 1131.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
2016
Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
Ugolino, J., Ji, Y. J., Conchina, K., Chu, J., Nirujogi, R. S., Pandey, A., Brady, N. R., Hamacher-Brady, A. & Wang, J., Nov 2016, In: PLoS genetics. 12, 11, e1006443.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations -
Time course decomposition of cell heterogeneity in TFEB signaling states reveals homeostatic mechanisms restricting the magnitude and duration of TFEB responses to mTOR activity modulation
Zapata, P. A. M., Beese, C. J., J�nger, A., Dalmasso, G., Brady, N. R. & Hamacher-Brady, A., 2016, In: BMC cancer. 16, 1, 355.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2015
Autophagy capacity and sub-mitochondrial heterogeneity shape Bnip3-induced mitophagy regulation of apoptosis
Choe, S. C., Hamacher-Brady, A. & Brady, N. R., Aug 8 2015, In: Cell Communication and Signaling. 13, 1, 37.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Bax/Bak-dependent, Drp1-independent targeting of X-linked inhibitor of apoptosis protein (XIAP) into inner mitochondrial compartments counteracts Smac/DIABLO-dependent effector caspase activation
Hamacher-Brady, A. & Brady, N. R., Sep 4 2015, In: Journal of Biological Chemistry. 290, 36, p. 22005-22018 14 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Dengue virus inhibition of autophagic flux and dependency of viral replication on proteasomal degradation of the autophagy receptor p62
Metz, P., Chiramel, A., Chatel-Chaix, L., Alvisi, G., Bankhead, P., Mora-Rodríguez, R., Long, G., Hamacher-Brady, A., Brady, N. R. & Bartenschlager, R., 2015, In: Journal of virology. 89, 15, p. 8026-8041 16 p.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
Eling, N., Reuter, L., Hazin, J., Hamacher-Brady, A. & Brady, N. R., 2015, In: Oncoscience. 2, 5, p. 517-532 16 p.Research output: Contribution to journal › Article › peer-review
Open Access164 Scopus citations -
2014
Agent-based modeling of autophagy reveals emergent regulatory behavior of spatio-temporal autophagy dynamics
Börlin, C. S., Lang, V., Hamacher-Brady, A. & Brady, N. R., Sep 10 2014, In: Cell Communication and Signaling. 12, 1, 56.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase
Hamacher-Brady, A., Choe, S. C., Krijnse-Locker, J. & Brady, N. R., Dec 1 2014, In: Cell death and differentiation. 21, 12, p. 1862-1876 15 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2013
Histone deacetylase 10 promotes autophagy-mediated cell survival
Oehme, I., Linke, J. P., Böck, B. C., Milde, T., Lodrini, M., Hartenstein, B., Wiegand, I., Eckert, C., Roth, W., Kool, M., Kaden, S., Gröne, H. J., Schulte, J. H., Lindner, S., Hamacher-Brady, A., Brady, N. R., Deubzer, H. E. & Witt, O., Jul 9 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 28, p. E2592-E2601Research output: Contribution to journal › Article › peer-review
Open Access117 Scopus citations -
Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis
Zhu, Y., Massen, S., Terenzio, M., Lang, V., Chen-Lindner, S., Eils, R., Novak, I., Dikic, I., Hamacher-Brady, A. & Brady, N. R., Jan 11 2013, In: Journal of Biological Chemistry. 288, 2, p. 1099-1113 15 p.Research output: Contribution to journal › Article › peer-review
Open Access214 Scopus citations -
2012
Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in drosophila
Zhai, Z., Ha, N., Papagiannouli, F., Hamacher-Brady, A., Brady, N., Sorge, S., Bezdan, D. & Lohmann, I., Mar 2012, In: PLoS genetics. 8, 3, e1002582.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis
Reis, Y., Bernardo-Faura, M., Richter, D., Wolf, T., Brors, B., Hamacher-Brady, A., Eils, R. & Brady, N. R., Jan 17 2012, In: PloS one. 7, 1, e28694.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
2011
Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production
Hamacher-Brady, A., Stein, H. A., Turschner, S., Toegel, I., Mora, R., Jennewein, N., Efferth, T., Eils, R. & Brady, N. R., Feb 25 2011, In: Journal of Biological Chemistry. 286, 8, p. 6587-6601 15 p.Research output: Contribution to journal › Article › peer-review
Open Access157 Scopus citations -
Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy
Hundeshagen, P., Hamacher-Brady, A., Eils, R. & Brady, N. R., Jun 2 2011, In: BMC Biology. 9, 38.Research output: Contribution to journal › Article › peer-review
Open Access91 Scopus citations -
2010
Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole
Huang, C., Liu, W., Perry, C. N., Yitzhaki, S., Lee, Y., Yuan, H., Tsukada, Y. T., Hamacher-Brady, A., Mentzer, R. M. & Gottlieb, R. A., 2010, In: American Journal of Physiology - Heart and Circulatory Physiology. 298, 2, p. H570-H579Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
2007
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy
Hamacher-Brady, A., Brady, N. R., Logue, S. E., Sayen, M. R., Jinno, M., Kirshenbaum, L. A., Gottlieb, R. A. & Gustafsson, Å. B., Jan 2007, In: Cell death and differentiation. 14, 1, p. 146-157 12 p.Research output: Contribution to journal › Article › peer-review
Open Access455 Scopus citations -
The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores
Brady, N. R., Hamacher-Brady, A., Yuan, H. & Gottlieb, R. A., Jun 2007, In: FEBS Journal. 274, 12, p. 3184-3197 14 p.Research output: Contribution to journal › Article › peer-review
Open Access105 Scopus citations -
2006
Autophagy as a protective response to Bnip3-mediated apoptotic signaling in the heart
Hamacher-Brady, A., Brady, N. R., Gottlieb, R. A. & Gustafsson, Å. B., 2006, In: Autophagy. 2, 4, p. 307-309 3 p.Research output: Contribution to journal › Article › peer-review
Open Access86 Scopus citations -
Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
Hamacher-Brady, A., Brady, N. R. & Gottlieb, R. A., Oct 6 2006, In: Journal of Biological Chemistry. 281, 40, p. 29776-29787 12 p.Research output: Contribution to journal › Article › peer-review
Open Access441 Scopus citations -
Proapoptotic BCL-2 family members and mitochondrial dysfunction during ischemia/reperfusion injury, a study employing cardiac HL-1 cells and GFP biosensors
Brady, N. R., Hamacher-Brady, A. & Gottlieb, R. A., May 2006, In: Biochimica et Biophysica Acta - Bioenergetics. 1757, 5-6, p. 667-678 12 p.Research output: Contribution to journal › Article › peer-review
Open Access90 Scopus citations