Andrew Mould

Research output

Research output per year 2013 2015 2018 2021 2023 2023

• 24 Article
• 1 Short survey
• 1 Review article

Research output per year

Research output per year

Search results

• 2023

  Clinical Trial Protocol for BEACH: A Phase 2a Study of MW189 in Patients with Acute Nontraumatic Intracerebral Hemorrhage

  Avadhani, R., Ziai, W. C., Thompson, R. E., Mould, W. A., Lane, K., Nanni, A., Iacobelli, M., Sharrock, M. F., Sansing, L. H., Van Eldik, L. J. & Hanley, D. F., 2023, (Accepted/In press) In: Neurocritical care.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clinical Trial Protocols 100%
  • Cerebral Hemorrhage 70%
  • Edema 53%
  • Biomarkers 42%
  • Brain Edema 36%

• Decentralized clinical trials in the trial innovation network: Value, strategies, and lessons learned

  Hanley, D. F., Bernard, G. R., Wilkins, C. H., Selker, H. P., Dwyer, J. P., Dean, J. M., Benjamin, D. K., Dunsmore, S. E., Waddy, S. P., Wiley, K. L., Palm, M. E., Mould, W. A., Ford, D. F., Burr, J. S., Huvane, J., Lane, K., Poole, L., Edwards, T. L., Kennedy, N., Boone, L. R., & 4 othersBell, J., Serdoz, E., Byrne, L. M. & Harris, P. A., Jul 25 2023, In: Journal of Clinical and Translational Science. 7, 1, e170.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Clinical Trials 100%
  • Technology 66%
  • Coronavirus 64%
  • Social Media 63%
  • Translational Medical Research 57%

• Mechanisms to expedite pediatric clinical trial site activation: The DOSE trial experience

  Boutzoukas, A. E., Olson, R., Sellers, M. A., Fischer, G., Hornik, C. D., Alibrahim, O., Iheagwara, K., Abulebda, K., Bass, A. L., Irby, K., Subbaswamy, A., Zivick, E. E., Sweney, J., Stormorken, A. G., Barker, E. E., Lutfi, R., McCrory, M. C., Costello, J. M., Ackerman, K. G., Munoz Pareja, J. C., & 13 othersDean, J. M., Abdelsamad, N., Hanley, D. F., Mould, W. A., Lane, K., Stroud, M., Feger, B. J., Greenberg, R. G., Smith, P. B., Benjamin, D. K., Hornik, C. P., Zimmerman, K. O. & Becker, M. L., Feb 2023, In: Contemporary Clinical Trials. 125, 107067.

  Research output: Contribution to journal › Article › peer-review

  • Financial Management 100%
  • Clinical Trials 85%
  • Pediatrics 84%
  • TimeLine 56%
  • Opioid Analgesics 38%
• 2022

  Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume

  Sharrock, M. F., Mould, W. A., Hildreth, M., Ryu, E. P., Walborn, N., Awad, I. A., Hanley, D. F. & Muschelli, J., Sep 1 2022, In: Journal of Neuroimaging.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Deep Learning 100%
  • Cerebral Hemorrhage 78%
  • Clinical Trials 47%
  • Hemorrhage 46%
  • Uncertainty 44%

• Design and Protocol of the Renal Anhydramnios Fetal Therapy (RAFT) Trial

  Atkinson, M. A., Jelin, E. B., Baschat, A., Blumenfeld, Y. J., Chmait, R. H., O'Hare, E., Moldenhauer, J. S., Zaretsky, M. V., Miller, R. S., Ruano, R., Gonzalez, J. M., Johnson, A., Mould, W. A., Davis, J. M., Hanley, D. F., Keiser, A. M., Rosner, M. & Miller, J. L., Aug 2022, In: Clinical therapeutics. 44, 8, p. 1161-1171 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fetal Therapies 100%
  • Kidney 34%
  • Pregnancy 30%
  • Newborn Infant 16%
  • Safety 12%
• 2021

  3D Deep Neural Network Segmentation of Intracerebral Hemorrhage: Development and Validation for Clinical Trials

  Sharrock, M. F., Mould, W. A., Ali, H., Hildreth, M., Awad, I. A., Hanley, D. F. & Muschelli, J., Jul 2021, In: Neuroinformatics. 19, 3, p. 403-415 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intracranial Hemorrhages 100%
  • Cerebral Hemorrhage 95%
  • Deep neural networks 85%
  • Clinical Trials 57%
  • Computer Neural Networks 38%
  1 Scopus citations

• Early inflammatory cytokine expression in cerebrospinal fluid of patients with spontaneous intraventricular hemorrhage

  Ziai, W. C., Parry-Jones, A. R., Thompson, C. B., Sansing, L. H., Mullen, M. T., Murthy, S. B., Mould, A., Nekoovaght-Tak, S. & Hanley, D. F., Aug 2021, In: Biomolecules. 11, 8, 1123.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intraventricular 100%
  • Interleukin-1 57%
  • Interleukin-10 51%
  • Cerebrospinal Fluid 50%
  • Interleukin-6 44%

• Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials

  Polster, S. P., Carrión-Penagos, J., Lyne, S. B., Gregson, B. A., Cao, Y., Thompson, R. E., Stadnik, A., Girard, R., Money, P. L., Lane, K., McBee, N., Ziai, W., Mould, W. A., Iqbal, A., Metcalfe, S., Hao, Y., Dodd, R., Carlson, A. P., Camarata, P. J., Caron, J. L., & 5 othersHarrigan, M. R., Zuccarello, M., Mendelow, A. D., Hanley, D. F. & Awad, I. A., May 1 2021, In: Neurosurgery. 88, 5, p. 961-970 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Minimally Invasive Surgical Procedures 100%
  • Cerebral Hemorrhage 95%
  • Survival 49%
  • Risk Adjustment 20%
  • Craniotomy 5%

• Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials

  Polster, S. P., Carrión-Penagos, J., Lyne, S. B., Gregson, B. A., Cao, Y., Thompson, R. E., Stadnik, A., Girard, R., Money, P. L., Lane, K., McBee, N., Ziai, W., Mould, W. A., Iqbal, A., Metcalfe, S., Hao, Y., Dodd, R., Carlson, A. P., Camarata, P. J., Caron, J. L., & 5 othersHarrigan, M. R., Zuccarello, M., Mendelow, A. D., Hanley, D. F. & Awad, I. A., Dec 1 2021, In: Neurosurgery. 89, p. S125

  Research output: Contribution to journal › Short survey › peer-review

• Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned

  Mansour, A., Loggini, A., El Ammar, F., Alvarado-Dyer, R., Polster, S., Stadnik, A., Das, P., Warnke, P. C., Yamini, B., Lazaridis, C., Kramer, C., Mould, W. A., Hildreth, M., Sharrock, M., Hanley, D. F., Goldenberg, F. D. & Awad, I. A., Sep 2021, In: Journal of Stroke and Cerebrovascular Diseases. 30, 9, 105996.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cerebral Hemorrhage 100%
  • Artificial Intelligence 73%
  • Reading 32%
  • Clinical Trials 24%
  • Needs Assessment 21%
• 2020

  Haptoglobin is associated with increased early perihematoma edema progression in spontaneous intracranial hemorrhage

  Halstead, M. R., Mould, W. A., Sheth, K. N., Rosand, J., Thompson, R., Levy, A., Hanley, D. F., Goldstein, J. N. & Nyquist, P., Oct 1 2020, In: International Journal of Stroke. 15, 8, p. 899-908 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Haptoglobins 100%
  • Intracranial Hemorrhages 89%
  • Edema 64%
  • Phenotype 29%
  • Hemoglobins 11%

• Primary intraventricular hemorrhage outcomes in the CLEAR III trial

  Nelson, S. E., Mould, W. A., Gandhi, D., Thompson, R. E., Salter, S., Dlugash, R., Awad, I. A., Hanley, D. F. & Ziai, W., Oct 1 2020, In: International Journal of Stroke. 15, 8, p. 872-880 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hemorrhage 100%
  • Tissue Plasminogen Activator 34%
  • Glasgow Outcome Scale 21%
  • National Institutes of Health (U.S.) 16%
  • Stroke 11%
  1 Scopus citations
• 2019

  Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial

  MISTIE III Investigators, Mar 9 2019, In: The Lancet. 393, 10175, p. 1021-1032 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Minimally Invasive Surgical Procedures 100%
  • Cerebral Hemorrhage 95%
  • Safety 51%
  • Hemorrhage 7%
  • Bacterial Infections 7%
  192 Scopus citations

• Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure

  Awad, I. A., Polster, S. P., Carrión-Penagos, J., Thompson, R. E., Cao, Y., Stadnik, A., Money, P. L., Fam, M. D., Koskimäki, J., Girard, R., Lane, K., McBee, N., Ziai, W., Hao, Y., Dodd, R., Carlson, A. P., Camarata, P. J., Caron, J. L., Harrigan, M. R., Gregson, B. A., & 212 othersMendelow, A. D., Zuccarello, M., Hanley, D. F., Abdul-Rahim, A., Abou-Hamden, A., Abraham, M., Ahmed, A., Alba, C. A., Aldrich, E. F., Ali, H., Altschul, D., Amin-Hanjani, S., Anderson, C. S., Anderson, D., Ansari, S., Antezana, D., Ardelt, A., Arikan, F., Avadhani, R., Baguena, M., Baker, A., Barrer, S. J., Barzo, P., Becker, K. J., Bergman, T., Betz, J. F., Bistran-Hall, A. J., Boström, A., Braun, J., Brindley, P., Broaddus, W. C., Brown, R., Buki, A., Bulters, D., Cao, B., Carhuapoma, J. R., Chalela, J., Chang, T., Chicoine, M. R., Chorro, I. M., Chowdhry, S., Cobb, C., Corral, L., Csiba, L., Davies, J., Dawson, J., Díaz, A. T., Dierdeyn, C. P., Diringer, M., Dlugash, R., Ecker, R., Economas, T., Enriquez, P., Ezer, E., Fan, Y., Feng, H., Franz, D., Freeman, W. D., Fusco, M., Galicich, W., Gandhi, D., Gelea, M. L., Goldstein, J., Gonzalez, A. C., Grabarits, C., Greenberg, S., Gress, D., Gu, E., Gupta, G., Hall, C., Harnof, S., Hernandez, F. M., Hoesch, R., Hoh, B. L., Houser, J., Hu, R., Huang, J., Huang, Y., Hussain, M. A., Insinga, S., Jadhav, A., Jaffe, J., Jahromi, B. S., Jallo, J., James, M., James, R. F., Janis, S., Jankowitz, B., Jeon, E., Jichici, D., Jonczak, K., Jonker, B., Karlen, N., Kase, C. S., Keric, N., Kerz, T., Kitagawa, R., Knopman, J., Koenig, C., Krishnamurthy, S., Kumar, A., Kureshi, I., Laidlaw, J., Lakhanpal, A., Latorre, J. G., Ledoux, D., Lees, K. R., Leifer, D., Leiphart, J., Lenington, S., Li, Y., Lopez, G., Lovick, D., Lumenta, C., Luo, J., Maas, M. B., MacDonald, J., MacKenzie, L., Madan, V., Majkowski, R., Major, O., Malhorta, R., Malkoff, M., Mangat, H., Maswadeh, A., Matouk, C., Mayo, S. W., McArthur, K., McCaul, S., Medow, J., Mezey, G., Mighty, J., Miller, D., Mitchell, P., Mohan, K. K., Mould, W. A., Muir, K., Muñoz, L., Nakaji, P., Nee, A., Nekoovaght-Tak, S., Nyquist, P., O'Kane, R., Okasha, M., O'Kelly, C., Ostapkovich, N., Pandey, A., Parry-Jones, A., Patel, H., Perla, K. R., Pollack, A., Pouratian, N., Quinn, T., Rajajee, V., Reddy, K., Rehman, M., Reimer, R., Rincon, F., Rosenblum, M., Rybinnik, I., Sanchez, B., Sansing, L., Sarabia, R., Schneck, M., Schuerer, L., Schel, D., Schweitzer, J., Seder, D. B., Seyfried, D., Sheth, K., Spiotta, A., Stechison, M., Sugar, E. A., Szabo, K., Tamayo, G., Tanczos, K., Taussky, P., Teitelbaum, J. S., Terry, J., Testai, F., Thomas, K., Thompson, C. B., Thompson, G., Torner, J. C., Tran, H., Tucker, K., Ullman, N., Ungar, L., Unterberg, A., Varelas, P., Vargas, N. M., Vatter, H., Venkatasubramanian, C., Vermillion, K., Vespa, P., Vollmer, D., Wang, W., Wang, Y., Wang, Y., Wen, J., Whitworth, L. T., Willis, B., Wilson, A., Wolfe, S., Wrencher, M., Wright, S. E., Xu, Y., Yanase, L., Yenokyan, G., Yi, X., Yu, Z. & Zomorodi, A., Jun 1 2019, In: Clinical Neurosurgery. 84, 6, p. 1157-1168 12 p., nyz077.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Minimally Invasive Surgical Procedures 100%
  • Physical Functional Performance 97%
  • Cerebral Hemorrhage 95%
  • Tissue Plasminogen Activator 94%
  • Hematoma 55%
  33 Scopus citations
• 2018

  Fibrinolytic for treatment of intraventricular hemorrhage: A meta-analysis and systematic review

  Baker, A. D., Rivera Perla, K. M., Yu, Z., Dlugash, R., Avadhani, R., Mould, W. A., Ziai, W., Thompson, R. E., Staykov, D. & Hanley, D. F., Jan 1 2018, In: International Journal of Stroke. 13, 1, p. 11-23 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Meta-Analysis 100%
  • Systematic Reviews 98%
  • Glasgow Outcome Scale 89%
  • Hemorrhage 86%
  • Mortality 44%
  9 Scopus citations

• Retrospective methods analysis of semiautomated intracerebral hemorrhage volume quantifcation from a selection of the STICH II cohort (early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas)

  Haley, M. D., Gregson, B. A., Andrew Mould, W., Hanley, D. F. & Mendelow, A. D., 2018, In: Stroke. 49, 2, p. 325-332 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cerebral Hemorrhage 100%
  • Hematoma 86%
  • Conservative Treatment 82%
  • Random Allocation 13%
  • Software 5%
  7 Scopus citations

• Symptomatic hemorrhagic complications in clot lysis: Evaluation of accelerated resolution of intraventricular hemorrhage phase III clinical trial (CLEAR III): A posthoc root-cause analysis

  Fam, M. D., Stadnik, A., Zeineddine, H. A., Girard, R., Mayo, S., Dlugash, R., McBee, N., Lane, K., Mould, W. A., Ziai, W., Hanley, D. & Awad, I. A., Dec 1 2018, In: Clinical neurosurgery. 83, 6, p. 1260-1267 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Root Cause Analysis 100%
  • Phase III Clinical Trials 77%
  • Hemorrhage 41%
  • Tissue Plasminogen Activator 34%
  • Safety 11%
  1 Scopus citations

• The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial

  for the CLEAR investigators, Aug 1 2018, In: Neurocritical care. 29, 1, p. 23-32 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Catheters 100%
  • Hemorrhage 82%
  • Incidence 61%
  • Tomography 18%
  • Platelet Aggregation Inhibitors 15%
  7 Scopus citations
• 2017

  Surgical performance in minimally invasive surgery plus recombinant tissue plasminogen activator for intracerebral hemorrhage evacuation phase III clinical trial

  Fam, M. D., Hanley, D., Stadnik, A., Zeineddine, H. A., Girard, R., Jesselson, M., Cao, Y., Money, L., Mcbee, N., Bistran-Hall, A. J., Andrew Mould, W., Lane, K., Camarata, P. J., Zuccarello, M. & Awad, I. A., Nov 1 2017, In: Neurosurgery. 81, 5, p. 860-865 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Phase III Clinical Trials 100%
  • Minimally Invasive Surgical Procedures 93%
  • Cerebral Hemorrhage 89%
  • Tissue Plasminogen Activator 88%
  • Hematoma 77%
  27 Scopus citations

• Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial

  CLEAR III Investigators, Feb 11 2017, In: The Lancet. 389, 10069, p. 603-611 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Tissue Plasminogen Activator 100%
  • Placebos 64%
  • Stroke 63%
  • Hemorrhage 60%
  • Odds Ratio 30%
  175 Scopus citations
• 2016

  Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial

  Hanley, D. F., Thompson, R. E., Muschelli, J., Rosenblum, M., McBee, N., Lane, K., Bistran-Hall, A. J., Mayo, S. W., Keyl, P., Gandhi, D., Morgan, T. C., Ullman, N., Mould, W. A., Carhuapoma, J. R., Kase, C., Ziai, W., Thompson, C. B., Yenokyan, G., Huang, E., Broaddus, W. C., & 14 othersGraham, R. S., Aldrich, E. F., Dodd, R., Wijman, C., Caron, J. L., Huang, J., Camarata, P., Mendelow, A. D., Gregson, B., Janis, S., Vespa, P., Martin, N., Awad, I. & Zuccarello, M., Nov 1 2016, In: The Lancet Neurology. 15, 12, p. 1228-1237 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Minimally Invasive Surgical Procedures 100%
  • Cerebral Hemorrhage 95%
  • Tissue Plasminogen Activator 94%
  • Safety 51%
  • Hemorrhage 28%
  165 Scopus citations
• 2015

  Edema Extension Distance: Outcome Measure for Phase II Clinical Trials Targeting Edema after Intracerebral Hemorrhage

  Parry-Jones, A. R., Wang, X., Sato, S., Mould, W. A., Vail, A., Anderson, C. S. & Hanley, D. F., Jun 4 2015, In: Stroke. 46, 6, p. e137-e140

  Research output: Contribution to journal › Article › peer-review
  12 Scopus citations

• Identification of hematomas in mild traumatic brain injury using an index of quantitative brain electrical activity

  Prichep, L. S., Naunheim, R., Bazarian, J., Mould, W. A. & Hanley, D., Jan 1 2015, In: Journal of neurotrauma. 32, 1, p. 17-22 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Concussion 100%
  • Hematoma 73%
  • Traumatic Intracranial Hemorrhage 56%
  • Traumatic Brain Injury 55%
  • Brain 38%
  8 Scopus citations

• Validated automatic brain extraction of head CT images

  Muschelli, J., Ullman, N. L., Mould, W. A., Vespa, P., Hanley, D. F. & Crainiceanu, C. M., Jul 1 2015, In: NeuroImage. 114, p. 379-385 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Head 100%
  • Tomography 93%
  • Brain 67%
  • Masks 34%
  • Intracranial Hemorrhages 14%
  39 Scopus citations
• 2013

  Minimally invasive surgery plus recombinant tissuetype plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema

  Mould, W. A., Carhuapoma, J. R., Muschelli, J., Lane, K., Morgan, T. C., McBee, N. A., Bistran-Hall, A. J., Ullman, N. L., Vespa, P., Martin, N. A., Awad, I., Zuccarello, M. & Hanley, D. F., Mar 2013, In: Stroke. 44, 3, p. 627-634 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Plasminogen Activators 100%
  • Minimally Invasive Surgical Procedures 95%
  • Cerebral Hemorrhage 91%
  • Tissue Plasminogen Activator 80%
  • Edema 68%
  220 Scopus citations

• Use of brain electrical activity for the identification of hematomas in mild traumatic brain injury

  Hanley, D. F., Chabot, R., Mould, W. A., Morgan, T., Naunheim, R., Sheth, K. N., Chiang, W. & Prichep, L. S., Dec 15 2013, In: Journal of neurotrauma. 30, 24, p. 2051-2056 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain Concussion 100%
  • Hematoma 73%
  • Traumatic Brain Injury 48%
  • Brain 38%
  • Blood Volume 30%
  11 Scopus citations