Research output per year
Research output per year
- 1 - 50 out of 81 results
Search results
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2024
SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity
Araki, Y., Rajkovich, K. E., Gerber, E. E., Gamache, T. R., Johnson, R. C., Tran, T. H. N., Liu, B., Zhu, Q., Hong, I., Kirkwood, A. & Huganir, R., Mar 1 2024, In: Science. 383, 6686, eadk1291.Research output: Contribution to journal › Article › peer-review
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Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex
Mesik, L., Parkins, S., Severin, D., Grier, B. D., Ewall, G., Kotha, S., Wesselborg, C., Moreno, C., Jaoui, Y., Felder, A., Huang, B., Johnson, M. B., Harrigan, T. P., Knight, A. E., Lani, S. W., Lemaire, T., Kirkwood, A., Hwang, G. M. & Lee, H-K., Mar 13 2024, In: Journal of Neuroscience. 44, 11, e0784232024.Research output: Contribution to journal › Article › peer-review
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2023
Dysregulation of ErbB4 Signaling Pathway in the Dorsal Hippocampus after Neonatal Hypoxia-Ischemia and Late Deficits in PV+ Interneurons, Synaptic Plasticity and Working Memory
Spahic, H., Parmar, P., Miller, S., Emerson, P. C., Lechner, C., St. Pierre, M., Rastogi, N., Nugent, M., Duck, S. A., Kirkwood, A. & Chavez-Valdez, R., Jan 2023, In: International journal of molecular sciences. 24, 1, 508.Research output: Contribution to journal › Article › peer-review
Open Access -
mGluR-dependent plasticity in rodent models of Alzheimer’s disease
Valdivia, G., Ardiles, A. O., Idowu, A., Salazar, C., Lee, H. K., Gallagher, M., Palacios, A. G. & Kirkwood, A., 2023, In: Frontiers in Synaptic Neuroscience. 15, 1123294.Research output: Contribution to journal › Article › peer-review
Open Access -
Mouse models of SYNGAP1-related intellectual disability
Araki, Y., Gerber, E. E., Rajkovich, K. E., Hong, I., Johnson, R. C., Lee, H. K., Kirkwood, A. & Huganir, R. L., 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 37, e2308891120.Research output: Contribution to journal › Article › peer-review
Open Access -
NMDA Receptor–Arc Signaling Is Required for Memory Updating and Is Disrupted in Alzheimer's Disease
Yang, L., Liu, W., Shi, L., Wu, J., Zhang, W., Chuang, Y. A., Redding-Ochoa, J., Kirkwood, A., Savonenko, A. V. & Worley, P. F., Nov 1 2023, In: Biological psychiatry. 94, 9, p. 706-720 15 p.Research output: Contribution to journal › Article › peer-review
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2022
Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces
Hong, S. Z., Mesik, L., Grossman, C. D., Cohen, J. Y., Lee, B., Lee, H. K., Hell, J. W. & Kirkwood, A., Dec 2022, In: Nature communications. 13, 1, 3202.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity
Severin, D., Hong, S. Z., Roh, S. E., Huang, S., Zhou, J., Bridi, M. C. D., Hong, I., Murase, S., Robertson, S., Haberman, R. P., Huganir, R. L., Gallagher, M., Quinlan, E. M., Worley, P. & Kirkwood, A., Sep 14 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 37, e2105388118.Research output: Contribution to journal › Article › peer-review
Open Access -
A Multisubcellular Compartment Model of AMPA Receptor Trafficking for Neuromodulation of Hebbian Synaptic Plasticity
Mihalas, S., Ardiles, A., He, K., Palacios, A. & Kirkwood, A., Aug 11 2021, In: Frontiers in Synaptic Neuroscience. 13, 703621.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Afterhyperpolarization amplitude in CA1 pyramidal cells of aged Long-Evans rats characterized for individual differences
Severin, D., Gallagher, M. & Kirkwood, A., Dec 2020, In: Neurobiology of aging. 96, p. 43-48 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits
Bridi, M. C. D., Zong, F. J., Min, X., Luo, N., Tran, T., Qiu, J., Severin, D., Zhang, X. T., Wang, G., Zhu, Z. J., He, K. W. & Kirkwood, A., Feb 19 2020, In: Neuron. 105, 4, p. 621-629.e4Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Dynamic Recovery from Depression Enables Rate Encoding in Inhibitory Synapses
Bridi, M. S., Shin, S., Huang, S. & Kirkwood, A., Mar 27 2020, In: iScience. 23, 3, 100940.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex
Huang, S. & Kirkwood, A., Sep 30 2020, In: Frontiers in Cellular Neuroscience. 14, 571133.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance
Hong, S., Huang, S., Severin, D. & Kirkwood, A., May 2020, In: eLife. 9, p. 1-20 20 p., e54455.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
2019
Ionic current correlations are ubiquitous across phyla
Tran, T., Unal, C. T., Severin, D., Zaborszky, L., Rotstein, H. G., Kirkwood, A. & Golowasch, J., Dec 1 2019, In: Scientific reports. 9, 1, 1687.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Reduced cognitive performance in aged rats correlates with increased excitation/inhibition ratio in the dentate gyrus in response to lateral entorhinal input
Tran, T., Bridi, M., Koh, M. T., Gallagher, M. & Kirkwood, A., Oct 2019, In: Neurobiology of aging. 82, p. 120-127 8 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
2018
Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model
Chavez-Valdez, R., Emerson, P., Goffigan-Holmes, J., Kirkwood, A., Martin, L. J. & Northington, F. J., Aug 2018, In: Hippocampus. 28, 8, p. 617-630 14 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Enhanced postsynaptic inhibitory strength in hippocampal principal cells in high-performing aged rats
Tran, T., Gallagher, M. & Kirkwood, A., Oct 2018, In: Neurobiology of aging. 70, p. 92-101 10 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Light Affects Mood and Learning through Distinct Retina-Brain Pathways
Fernandez, D. C., Fogerson, P. M., Lazzerini Ospri, L., Thomsen, M. B., Layne, R. M., Severin, D., Zhan, J., Singer, J. H., Kirkwood, A., Zhao, H., Berson, D. M. & Hattar, S., Sep 20 2018, In: Cell. 175, 1, p. 71-84.e18Research output: Contribution to journal › Article › peer-review
Open Access108 Scopus citations -
Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone
Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severin, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., Hogberg, H. T., Freeman, D., Kirkwood, A., Hartung, T. & Smirnova, L., Aug 1 2018, In: Archives of Toxicology. 92, 8, p. 2587-2606 20 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Two distinct mechanisms for experience-dependent homeostasis
Bridi, M. C. D., De Pasquale, R., Lantz, C. L., Gu, Y., Borrell, A., Choi, S. Y., He, K., Tran, T., Hong, S. Z., Dykman, A., Lee, H. K., Quinlan, E. M. & Kirkwood, A., Jun 1 2018, In: Nature neuroscience. 21, 6, p. 843-850 8 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2017
Brief novel visual experience fundamentally changes synaptic plasticity in the mouse visual cortex
Li, S., Wang, L., Tie, X., Sohya, K., Lin, X., Kirkwood, A. & Jiang, B., Sep 27 2017, In: Journal of Neuroscience. 37, 39, p. 9353-9360 8 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
CDK5 downregulation enhances synaptic plasticity
Posada-Duque, R. A., Ramirez, O., Härtel, S., Inestrosa, N. C., Bodaleo, F., González-Billault, C., Kirkwood, A. & Cardona-Gómez, G. P., Jan 1 2017, In: Cellular and Molecular Life Sciences. 74, 1, p. 153-172 20 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
Endogenous Gαq-Coupled Neuromodulator Receptors Activate Protein Kinase A
Chen, Y., Granger, A. J., Tran, T., Saulnier, J. L., Kirkwood, A. & Sabatini, B. L., Dec 6 2017, In: Neuron. 96, 5, p. 1070-1083.e5Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
Experience-dependent homeostasis of ‘noise’ at inhibitory synapses preserves information coding in adult visual cortex
Gao, M., Whitt, J. L., Huang, S., Lee, A., Mihalas, S., Kirkwood, A. & Lee, H. K., Mar 5 2017, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 372, 1715Research output: Contribution to journal › Article › peer-review
Open Access10 Scopus citations -
2016
Metabotropic glutamate receptors induce a form of LTP controlled by translation and arc signaling in the hippocampus
Wang, H., Ardiles, A. O., Yang, S., Tran, T., Posada-Duque, R., Valdivia, G., Baek, M., Chuang, Y. A., Palacios, A. G., Gallagher, M., Worley, P. & Kirkwood, A., Feb 3 2016, In: Journal of Neuroscience. 36, 5, p. 1723-1729 7 p.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Neuregulin-dependent regulation of fast-spiking interneuron excitability controls the timing of the critical period
Gu, Y., Tran, T., Murase, S., Borrell, A., Kirkwood, A. & Quinlan, E. M., Oct 5 2016, In: Journal of Neuroscience. 36, 40, p. 10285-10295 11 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
2015
Brief dark exposure reduces tonic inhibition in visual cortex
Huang, S., Hokenson, K., Bandyopadhyay, S., Russek, S. J. & Kirkwood, A., Dec 2 2015, In: Journal of Neuroscience. 35, 48, p. 15916-15920 5 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Defective age-dependent metaplasticity in a mouse model of alzheimer’s disease
Megill, A., Tran, T., Eldred, K., Lee, N. J., Wong, P. C., Hoe, H. S., Kirkwood, A. & Lee, H. K., Aug 12 2015, In: Journal of Neuroscience. 35, 32, p. 11346-11357 12 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
Distinct Eligibility Traces for LTP and LTD in Cortical Synapses
He, K., Huertas, M., Hong, S. Z., Tie, X. X., Hell, J. W., Shouval, H. & Kirkwood, A., Nov 4 2015, In: Neuron. 88, 3, p. 528-538 11 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
2014
Associative Hebbian synaptic plasticity in primate visual cortex
Huang, S., Rozas, C., Treviño, M., Contreras, J., Yang, S., Song, L., Yoshioka, T., Lee, H. K. & Kirkwood, A., 2014, In: Journal of Neuroscience. 34, 22, p. 7575-7579 5 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Failed stabilization for long-term potentiation in the auditory cortex of Fmr1 knockout mice
Yang, S., Yang, S., Park, J. S., Kirkwood, A. & Bao, S., Aug 12 2014, In: PloS one. 9, 8, e104691.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice
Wang, H., Megill, A., Wong, P. C., Kirkwood, A. & Lee, H. K., Mar 17 2014, In: PloS one. 9, 3, e92279.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2013
Adrenergic gating of hebbian spike-timing-dependent plasticity in cortical interneurons
Huang, S., Huganir, R. L. & Kirkwood, A., 2013, In: Journal of Neuroscience. 33, 32, p. 13171-13178 8 p.Research output: Contribution to journal › Article › peer-review
Open Access32 Scopus citations -
A tetra(Ethylene Glycol) derivative of benzothiazole aniline enhances ras-mediated spinogenesis
Megill, A., Lee, T., DiBattista, A. M., Min Song, J., Spitzer, M. H., Rubinshtein, M., Habib, L. K., Capule, C. C., Mayer, M., Scott Turner, R., Kirkwood, A., Yang, J., Pak, D. T. S., Lee, H. K. & Hoe, H. S., May 29 2013, In: Journal of Neuroscience. 33, 22, p. 9306-9318 13 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Integrity of mGluR-LTD in the associative/commissural inputs to CA3 correlates with successful aging in rats
Yang, S., Megill, A., Ardiles, A. O., Ransom, S., Tran, T., Koh, M. T., Lee, H. K., Gallagher, M. & Kirkwood, A., 2013, In: Journal of Neuroscience. 33, 31, p. 12670-12678 9 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Obligatory role for the immediate early gene NARP in critical period plasticity
Gu, Y., Huang, S., Chang, M. C., Worley, P., Kirkwood, A. & Quinlan, E. M., Jul 24 2013, In: Neuron. 79, 2, p. 335-346 12 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Scopus citations -
Octodon degus (Molina 1782): A model in comparative biology and biomedicine
Ardiles, A. O., Ewer, J., Acosta, M. L., Kirkwood, A., Martinez, A., Ebensperger, L., Bozinovic, F., Lee, T. M. & Palacios, A. G., 2013, In: Cold Spring Harbor Protocols. 8, 4, p. 312-318 7 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
2012
Aberrant light directly impairs mood and learning through melanopsin-expressing neurons
Legates, T. A., Altimus, C. M., Wang, H., Lee, H. K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T. & Hattar, S., Nov 22 2012, In: Nature. 491, 7425, p. 594-598 5 p.Research output: Contribution to journal › Article › peer-review
273 Scopus citations -
Dark exposure extends the integration window for spike-timing-dependent plasticity
Guo, Y., Huang, S., de Pasquale, R., McGehrin, K., Lee, H. K., Zhao, K. & Kirkwood, A., Oct 24 2012, In: Journal of Neuroscience. 32, 43, p. 15027-15035 9 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Scopus citations -
Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Ardiles, Á. O., Tapia-Rojas, C. C., Mandal, M., Alexandre, F., Kirkwood, A., Inestrosa, N. C. & Palacios, A. G., Aug 21 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 34, p. 13835-13840 6 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Pull-Push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex
Huang, S. Y., Treviño, M., He, K., Ardiles, A., dePasquale, R., Guo, Y., Palacios, A., Huganir, R. & Kirkwood, A., Feb 9 2012, In: Neuron. 73, 3, p. 497-510 14 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
2011
Iron mediates N-Methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity
Muñoz, P., Humeres, A., Elgueta, C., Kirkwood, A., Hidalgo, C. & Núñez, M. T., Apr 15 2011, In: Journal of Biological Chemistry. 286, 15, p. 13382-13392 11 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Scopus citations -
Single-cell persistent activity in anterodorsal thalamus
Kulkarni, M., Zhang, K. & Kirkwood, A., Jul 12 2011, In: Neuroscience Letters. 498, 3, p. 179-184 6 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region
Lorca, R. A., Rozas, C., Loyola, S., Moreira-Ramos, S., Zeise, M. L., Kirkwood, A., Huidobro-Toro, J. P. & Morales, B., Apr 2011, In: European Journal of Neuroscience. 33, 7, p. 1175-1185 11 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
2010
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure
Huang, S., Gu, Y., Quinlan, E. M. & Kirkwood, A., Dec 8 2010, In: Journal of Neuroscience. 30, 49, p. 16636-16642 7 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations -
Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction
Zhang, D., Zhang, C., Ho, A., Kirkwood, A., SüDhof, T. C. & Shen, J., Dec 2010, In: Journal of Neurochemistry. 115, 5, p. 1215-1221 7 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Self-organized criticality occurs in non-conservative neuronal networks during 'up' states
Millman, D., Mihalas, S., Kirkwood, A. & Niebur, E., Oct 2010, In: Nature Physics. 6, 10, p. 801-805 5 p.Research output: Contribution to journal › Article › peer-review
Open Access116 Scopus citations -
The maturation of GABAergic transmission in visual cortex requires endocannabinoid-mediated LTD of inhibitory inputs during a critical period
Jiang, B., Huang, S., de Pasquale, R., Millman, D., Song, L., Lee, H. K., Tsumoto Tadaharu, T. & Kirkwood Alfredo, A., Apr 2010, In: Neuron. 66, 2, p. 248-259 12 p.Research output: Contribution to journal › Article › peer-review
Open Access81 Scopus citations -
2009
Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
Savonenko, A., Munoz, P., Melnikova, T., Wang, Q., Liang, X., Breyer, R. M., Montine, T. J., Kirkwood, A. & Andreasson, K., May 2009, In: Experimental Neurology. 217, 1, p. 63-73 11 p.Research output: Contribution to journal › Article › peer-review
Open Access46 Scopus citations